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HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module

World Journal of Gastroenterology 2012年第13期18卷 1485-1495页

作者： Ren-Xian Tang Fan-Yun Kong Bao-Feng Fan xiao-mei liu Hong-Juan You Peng Zhang Kui-Yang Zheng Department of Pathogenic Biology and Lab of Infection and Immunology Xuzhou Medical CollegeXuzhou 221002Jiangsu ProvinceChina

AIM： To investigate the possible mechanism by which hepatitis B virus X protein （HBx） mediates apoptosis of HepG2 cells. METHODS： HBx expression vector pcDNA3.1-X was transfected into HepG2 cells to establish an HBx high- expression cellular model as pcDNA3.1-X transfected group. The pcDNA3.1-X and pSilencer3.1-shHBX （HBx antagonist） were cotransfected into HepG2 cells to es- tablish an HBx low-expression model as RNAi group. Untransfected HepG2 cells and HepG2 cells transfected with negative control plasmid were used as controls. Apoptosis rate, the expression of Fas/FasL signaling pathway-related proteins and the phosphorylation lev- els of MLK3, MKK7 and JNKs, which are upstream molecules of death receptor pathways and belong to the family of mitogen-activated protein kinases （MAPKs）,were measured in each group RESULTS： Compared with HepG2 cell group and RNAi group, apoptosis rate, the expression of Fas and FasL proteins, and the activation of MLK3, MKK7 and 3NKs were increased in the pcDNA3.1-X transfected group. The activation of JNKs and expression of FasL protein were inhibited in the pcDNA3.1-X transfected group when treated with a known JNK inhibitor, SP600125. When authors treated pcDNA3.1-X transfected group with K252a, a known MLK3 inhibitor, the activation of MLK3, MKK7 and 3NKs as well as expression of FasL protein was inhibited. Furthermore, cell apoptosis rate was also significantly declined in the presence of K252a in the pcDNA3.1-X transfected group. CONCLUSION： HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression.

关键词： Hepatitis B virus X protein MLK3 FasL HepG2cell Apoptosis

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Effect and Prognostic Analysis of Treatment for Acute Myeloid Leukemia Using Chinese Drugs Combined with Chemotherapy

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Chinese Journal of Integrative Medicine 2009年第3期15卷 193-197页

作者：胡晓梅刘锋郑春梅李柳刘池张姗姗肖海燕杨晓红王洪志许勇钢胡乃平麻柔 Department of Hematology Xiyuan Hospital China Academy of Chinese Medical Sciences

Objective:To observe the clinical efficacy of Chinese drugs combined with chemotherapy in the treatment of acute myeloid leukemia(AML) and to investigate the prognostic relevance of the main parameters in AML treated with integrative ***:Forty AML patients hospitalized at the authors hospital were treated with Chinese drugs and *** routine examination,immunophenotype and karyotype analyses were carried *** clinical efficacy was observed and the prognostic factors were analyzed...

关键词： acute myeloid leukemia treatment integrative medicine prognosis immunophenotype cytogenetics

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A New Result on Delay-dependent Robust Stabilization for Uncertain Systems with Time-delay

A New Result on Delay-dependent Robust Stabilization for Unc...

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2009中国控制与决策会议

作者： xiao-mei liu,Tian-Cheng Wang,Sheng-Tao Li College of Mathematics and Information,Ludong University,Yantai 264025

The problem of delay-dependent robust stabilization for uncertain system with time-delay is considered. A Lyapunov-Krasovskii functional is designed by splitting the whole time-delay interval into some subintervals and defining different energy functions in every *** with linear matrix inequalities(LMI) technique,a delay-dependent stability criterion is derived in terms of LMI to ensure that the nominal system is *** on the criterion,the problem is solved via state feedback controller,guaranteeing the resultant closed-loop system is robustly ***,a numerical example is given to illustrate the effectiveness of the proposed method.

关键词： delay-dependent uncertain system linear matrix inequality(LMIs)

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding Huang Yunyi Yiyu liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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Neuronal PAS domain protein 3 plays a critical role in lung development and homeostasis

Neuronal PAS domain protein 3 plays a critical role in lung ...

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2012全国发育生物学大会

作者： Zhong-Xia Wu,xiao-mei liu,Mary E.Sunday,Shu-Tang Zhou Institute of Zoology,Chinese Academy of Sciences,Beijing 100101

Trachealess(Trh),a member of bHLH-PAS transcription factor family,is the master regulator of formation of Drosophila respiratory *** proteins regulating Drosophila tracheogenesis downstream from Trh include Breathless(FGFR),Branchless(FGF),Sprouty and *** genes regulating Drosophila tracheogenesis have been demonstrated to have their functional homologs in the mammalian lung development,but the mammalian homolog of trh has not been previously *** phylogram analysis and amino acid sequence alignment,neuronal PAS domain protein 3(NPAS3) shares most similarity to Trh,particularly in the conserved bHLH and PAS *** a murine genomic DNA library using trh oligonucleotides has also identified ***3 mRNA peaks in embryonic lungs from E10.5 to E13.5,with abundant immunostaining in airway epithelial ***3-null mice have reduced lung branching morphogenesis but are viable *** 3-null newborns die within 48 h in respiratory distress and with diminished ***3 heterozygous mice have a milder lung phenotype,surviving postnatally,but show characteristics of emphysema and airways hyperreactivity(AHR),similar to premature infants with bronchopulmonary dysplasia(BPD). NPAS3 appears to regulate the expression of genes involved in the multiple signal pathways,including Shh,Fgf9,Fgf10, Bmp4 and *** FGF10 rescues branching morphogenesis in Npas3-deficient ***3 up-regulates Shh and Spry2 in promoter reporter assays. Conclusions:Our data indicate that NPAS3 is the functional mammalian homolog of Drosophila Trachealess,playing a critical role in mammalian lung development and ***3 haploinsufficiency may lead to the pathogenesis of newborn lung diseases like BPD as well as lung diseases in later life such as emphysema and asthma.

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Design,Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine Derivatives with Anticonvulsant Activity

Design,Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine De...

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2011年全国药物化学学术会议——药物的源头创新

作者： Guo-Hua Gong xiao-mei liu Cheng-Xi Wei Zhe-Shan Quan~* College of Pharmacy,Yanbian University,Yanji,Jilin,133000,China,

＜正＞Aim to find new compounds with stronger anticonvulsant activity and lower neurotoxicity,a novel series of 6-substituted-pyrido[3,2-d]pyridazine derivatives was synthesized using furo[3,4-b] pyridine-5,7-dione as the starting *** anticonvulsant activities were evaluated by the maximal electroshock test（MES） and their neurotoxicities were measured by the rotarod ***

关键词： Pyrido[3,2-d]pyridazine Anticonvulsant Maximal electroshock Neurotoxicity

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放松训练对住院急性心肌梗死病人的干预研究

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实用护理杂志 2003年第11期19卷 56-57页

作者：周晓荣李小妹刘美丽李宁高春燕西安交通大学第二医院急诊科陕西西安710004 西安交通大学护理系陕西西安710061 西安交通大学第一医院心脏内科陕西西安710061

放松训练是心理治疗方法的一种,它通过将注意力集中在呼吸、声音、运动、想象等方面来降低病人对周围环境的感应能力,以减低交感神经的活动,使肌肉松弛,心理放松[1].将放松训练作为一种补充替代疗法应用于临床进行了不断的研究,但将其... 详细信息

放松训练是心理治疗方法的一种,它通过将注意力集中在呼吸、声音、运动、想象等方面来降低病人对周围环境的感应能力,以减低交感神经的活动,使肌肉松弛,心理放松[1].将放松训练作为一种补充替代疗法应用于临床进行了不断的研究,但将其应用于住院急性心肌梗死病人的研究不多.本研究旨在探讨放松训练对住院急性心肌梗死病人的干预效果,为在整体护理中缺乏干预手段的临床护士提供护理措施的借鉴.

关键词：放松训练急性心肌梗死状态焦虑

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坛紫菜多糖对两种突变剂诱导的大蒜根尖细胞损伤的保护作用（英文）

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现代食品科技 2017年第3期33卷 40-46页

作者：张忠山王晓梅刘重斌湖州师范学院生命科学学院浙江湖州313000

研究发现从红藻坛紫菜中提取的多糖具有优异的抗氧化活性。本文研究了坛紫菜多糖及其硫酸衍生物对两种突变剂环磷酰胺和丝裂霉素C诱导的大蒜根尖细胞微核率、有丝分裂指数和染色体畸变率的影响作用,以及抗脂质过氧化作用。结果表明,两... 详细信息

研究发现从红藻坛紫菜中提取的多糖具有优异的抗氧化活性。本文研究了坛紫菜多糖及其硫酸衍生物对两种突变剂环磷酰胺和丝裂霉素C诱导的大蒜根尖细胞微核率、有丝分裂指数和染色体畸变率的影响作用,以及抗脂质过氧化作用。结果表明,两种多糖均表现出明显地抑制微核和染色体畸变作用,明显地提高有丝分裂指数。其影响作用具有明显的剂量依赖性。当多糖浓度为100 mg/L时,多糖表现出最大抑制效应或增强效应。同时,硫酸化衍生物表现出比原料多糖更优异的抗细胞内脂质过氧化作用。分析表明坛紫菜多糖表现出的抗突变作用与抗脂质过氧化作用具有一定关系。同时也表明硫酸基对于抗突变作用的间接影响。结果显示坛紫菜多糖具有成为抗突变活性物质的潜力。

关键词：坛紫菜多糖大蒜根尖环磷酰胺丝裂霉素-C

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng xiao-Jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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