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湖南省2023年新报告HIV感染者毒株亚型分布特征研究

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现代预防医学 2025年第1期52卷 160-166页

作者：胡敏邹潇白贺健梅郑军唐琪陈曦南华大学公共卫生学院湖南省疾病预防控制中心

目的分析湖南省2023年新报告HIV感染者的毒株亚型特点和变化趋势，了解湖南省HIV毒株分子流行规律。方法采集湖南省2023年新报告539例HIV感染者血样，提取RNA，采用巢式PCR扩增pol区基因，利用系统进化树与在线工具鉴定亚型和进行重... 详细信息

目的分析湖南省2023年新报告HIV感染者的毒株亚型特点和变化趋势，了解湖南省HIV毒株分子流行规律。方法采集湖南省2023年新报告539例HIV感染者血样，提取RNA，采用巢式PCR扩增pol区基因，利用系统进化树与在线工具鉴定亚型和进行重组分析。结果获得490例有效序列，以男性(77.55%,380/490)、汉族(90.20%,442/490)、异性性传播(72.04%,353/490)及60岁以上感染者(33.47%,164/490)为主。传播性耐药（transmitted drug resistance,TDR）耐药率为7.76%,TDR突变以非核苷酸反转录酶抑制剂（NNRTIs）为主。共检出16种亚型，CRF07＿BC占比最大，为41.22%(202/490)，其次CRF01＿AE占31.84%(156/490)、CRF08＿BC占8.98%(44/490)、CRF55＿01B占4.29%(21/490)、B占4.29%(21/490)、CRF85＿BC占2.45%(12/490)、C占1.84%(9/490)、URF占2.04%,10/490)。CRF07＿BC亚型检出07＿BC＿MSM和07＿BC＿other两个亚簇，分别占52.97%(107/202)、47.03%(95/202)。CRF01＿AE共检出7个亚簇，C1亚簇占比最高，为45.51%(71/156）。独特重组型(unique recombinant form,URF)在长沙市的病例报告数最多，为40.00%(4/10），以青年群体的同性传播为主，占80.00%(8/10);CRF85＿BC在邵阳市的病例报告数最多，为91.67%(11/12)，以老年人群的非婚商业异性性传播为主，占58.33%(7/12)。结论湖南省亚型分布呈多样化，较过去亚型地区分布与构成有一定的变化，出现了部分新的重组亚型，应进一步加强当地HIV亚型监测。

关键词： HIV RNA pol基因亚型

A Distributed and Adaptive Location Management Scheme for Hierarchical Mobility Management

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The Journal of China Universities of Posts and Telecommunications 2006年第1期13卷 34-39页

作者： hu xiao SONG Jun-de SONG mei ZHOU Wei School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

Hierarchical mobility management is sensitive to the failure of gateway mobility agents and prone to degrade performance on heavy loads. This paper proposes a distributed and adaptive location management scheme based on Hierarchical Mobile IPv6. This scheme can balance the loads of mobility anchor points and increase the robustness of the hierarchical structure to certain extents. In this scheme, the optimized IP paging scheme is adopted to reduce the paging signaling cost and improve the scalability of the hierarchical mobility management. We implement the distributed and adaptive location management scheme in a simulation platform and compare its performance with that of two other location management schemes. Our simulation results show that our scheme is capable of balancing the signaling and traffic loads of mobility ancher points, decreasing the average handover latency, and increasing the throughout of the visited networks.

关键词： HMM location management location update IP Paging distributed

Arsenic trioxide induces apoptosis in MOLT-4 and its daunorubicin-resistant cell line via depletion of intracellular glutathione,disruption of mitochondrial membrane potential and activation of caspase-3

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Arsenic trioxide induces apoptosis in MOLT-4 and its daunoru...

Folding encapsulation toward Lindqvist polyoxometalates within adaptive coordination cages for catalysis

第六届全国中西医结合血液病学术会议

作者： xiao-mei hu Toshihiko Hirano Kitaro Oka 1 National Therapeutic Center of Hematology of Traditional Chinese Medicine, XiYuan Hospital, China Academy of Traditional Chinese Medicine, Beijing, P. R. China, 100091 2 Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Purpose:To demonstrate that arsenic trioxide(AS2O3)induces apoptosis via mitochondri-al pathway in both parent T Iynlphoblastoid leukemia MOLT-4 cells and its daunorubicin(DNR)-resistant subline MOLT-4/DNR cells expre...

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Science China Chemistry 2025年第2期 561-569页

作者： Ying-mei Zhong Jin-Jin Xuan Xujie Qin Han xiao Zi-Jun Xia Li-Peng Zhou xiao-Qing Guo Yu-Hang hu Lu Zhang Chunsen Li Li-Xuan Cai Qing-Fu Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences College of Chemistry and Materials Science Fujian Normal University University of Chinese Academy of Sciences

In nature,enzymes at specific folded conformations exhibit high substrate complementarity,enabling them to efficiently and selectively catalyze biochemical *** by enzymes,coordination cages with conformational dynamics have been designed and are receiving increasing attention due to their versatile applications in allosteric guest binding and *** present here two enzyme-mimicking adaptive macrocycle-based coordination cages,Pd2L2～1 and Pd2L2～2,from macrocycle-based ligands （L1and L2） and the encapsulation and stabilization of Lindqvist polyoxometalates anions M6O192-（M=W or Mo） in neutral aqueous solution.X-ray crystallographic studies have verified the formation of 1:1 host-guest complexes of two Pd2L2cages and the W6O192-anion,via an induced-fit folding *** with the free host,Pd2L2～1 exhibited an induced-fit semi-folded conformation in the inclusion complex,while Pd2L2～2adopted an induced-fit fully-folded ***,the Mo6O19?Pd2L2host-guest complexes demonstrate high yield and selectivity in the oxidative decontamination reaction of the sulfur mustard simulant,2-chloroethyl ethyl *** work not only sheds light on the importance of conformational adaptability in enzyme-like systems but also paves the way for protecting labile POM clusters via host-guest encapsulation toward enhanced catalytic performance in aqueous solution.

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二氧化硅气凝胶光学性能及辐射探测性能研究

西安交通大学学报 2025年第2期59卷 127-133页

作者：燕奕宏张美盛亮唐灵芝纪富何佳洋胡光胡华四西安交通大学能源与动力工程学院西安710049 西北核技术研究院强脉冲辐射环境模拟与效应国家重点实验室西安710024

针对惯性约束聚变中高能γ射线探测存在的X射线影响,以及气体切伦科夫辐射体调控阈值复杂或部分切伦科夫辐射体不可调控阈值的问题,提出了使用硅气凝胶作为切伦科夫辐射体对γ射线进行探测的方法。首先,搭建透过率测量平台,测量了厚度为... 详细信息

针对惯性约束聚变中高能γ射线探测存在的X射线影响,以及气体切伦科夫辐射体调控阈值复杂或部分切伦科夫辐射体不可调控阈值的问题,提出了使用硅气凝胶作为切伦科夫辐射体对γ射线进行探测的方法。首先,搭建透过率测量平台,测量了厚度为1 cm的410 mg/cm^(3)硅气凝胶在250~800 nm波长范围内的透过率,得到了硅气凝胶的吸收散射系数;然后,使用最小偏差角的方法对硅气凝胶的折射率进行了测量,并对全波段折射率进行拟合;进而,将得到的吸收散射系数与折射率写入Geant4软件,在硅气凝胶探测系统中,对不同能量γ射线的能量响应进行了模拟计算;最后,在西北核技术研究院的^(60)Co源上搭建系统,分别对硅气凝胶及石英玻璃的发光强度进行了测量。结果表明:硅气凝胶净信号达到了11.67 nA,不确定度为3.8%;石英玻璃的净信号达到了373.67 nA,不确定度为3.2%。研究结果证实了硅气凝胶切伦科夫探测系统对γ射线探测的可行性,说明了硅气凝胶可作为切伦科夫辐射体应用于惯性约束聚变中的高能γ射线诊断。

关键词：惯性约束聚变 γ射线探测切伦科夫辐射体硅气凝胶

Pre-hospital application of REBOA for life-threatening hemorrhage

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Military Medical Research 2024年第5期11卷 789-791页

作者： xiao-mei Tian Wei hu Feng-Yong Liu Department of Interventional Radiology Senior Department of Oncologythe Fifth Medical Center of Chinese PLA General HospitalBeijing100039China Medical School of Chinese PLA Beijing100853China Department of Emergency the Fifth Medical Center of Chinese PLA General HospitalBeijing100039China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China

Dear Editor,Most battlefield casualties occur prior to the arrival of medical *** hemorrhage accounts for more than 90%of those potentially survivable battlefield casualties[1].In both military and civilian conditions,non-compressible torso hemorrhage always caused rapid exsanguination and high mortality rates before definitive treatment[2].More than half of the deaths due to non-compressible torso hemorrhage occur before hospital care can be provided[2].Therefore,early and rapid pre-hospital hemorrhage control is essential to reduce mortality.

关键词： Resuscitative endovascular balloon occlusion of the aorta(REBOA) Pre-hospital Endovascular Aortic balloon occlusion Trauma Hemorrhage Shock

Research status and development trend of MEMS S&A devices: A review

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Defence Technology（防务技术） 2021年第2期17卷 450-456页

作者： mei Li Tengjiang hu School of Foreign Studies Xi’an Medical UniversityChina State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityChina

MEMS Safety-and-Arming(S&A)device is the new generation of S&A device which integrates the mechanism of actuation and *** features of minimized structure and easy integration make it to be the indispensable support to the development of weapon miniaturization,integration and *** a key component in the new generation weapon system,the sound development of MEMS S&A devices will have a significant impact on the future national defense ***,the research status and development trend of MEMS S&A devices are introduced in this *** literature review on various MEMS S&A devices,it can be seen that the researches have evolved from individual components to system integration,and many prototypes have the potential for live-fire *** driven principles and structures of the MEMS S&A devices are compared and *** present,the MEMS S&A device can realize the mutual integration of the driving mechanism and the blocking mechanism on the micron *** the future,with the establishment of new design criteria,MEMS S&A devices will develop from prototypes to practical applications,which will further promote the integration and intelligent of weapon systems.

关键词： MEMS S&A device Driven principle

糖尿病患者胰岛素治疗自我管理量表的汉化及初步应用研究

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中华护理教育 2025年第1期22卷 109-115页

作者：陈艺文胡馨萍王赢梅花上海中医药大学研究生院上海市201203

目的对胰岛素治疗自我管理量表(Insulin Treatment Self-Management Scale,IT-SMS)进行汉化,并检验中文版IT-SMS信效度,为中国糖尿病患者提供胰岛素治疗自我管理的科学评估工具。方法采用Brislin翻译模式将源IT-SMS翻译成中文版,经跨文... 详细信息

目的对胰岛素治疗自我管理量表(Insulin Treatment Self-Management Scale,IT-SMS)进行汉化,并检验中文版IT-SMS信效度,为中国糖尿病患者提供胰岛素治疗自我管理的科学评估工具。方法采用Brislin翻译模式将源IT-SMS翻译成中文版,经跨文化调试、预调查,形成中文版IT-SMS。2023年10月—2024年3月,采用一般资料调查表、中文版IT-SMS,对便利选取的于上海市某三级甲等医院内分泌科门诊就诊或住院的糖尿病胰岛素治疗患者进行问卷调查,以评价中文版IT-SMS的信效度。结果中文版IT-SMS包含行为(8个条目)、认知(10个条目)、情绪(8个条目)、态度(5个条目)4个维度,共31个条目。全体一致量表水平的内容效度指数为0.974,条目水平的内容效度指数为0.833~1.000;经探索性因子分析共提取4个公因子,累计方差贡献率为59.902%。中文版IT-SMS的总Cronbach's α系数为0.928,重测信度系数为0.883,折半信度系数为0.763;各维度的Cronbach's α系数为0.873~0.919,重测信度系数为0.819~0.875,折半信度系数为0.858~0.923。结论中文版IT-SMS具有良好的信度和效度,适用于中国糖尿病患者胰岛素治疗自我管理水平的评估。

关键词：糖尿病胰岛素治疗自我管理量表信度效度

The morphology and dynamic viscoelasticity for PPS/low-melting temperature glass hybrids prepared by melt blending

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Chinese Chemical Letters 2012年第4期23卷 478-480页

作者： Li Na Zhang xiao hu Zhang Hong mei Yang Qiang Zheng Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationZhejiang UniversityHangzhou 310027China

Polyphenylene sulfides（PPS） and low-melting temperature glasses（LMTG） were used to prepare a PPS/LMTG organicinorganic hybrid material by melt *** etched surfaces of the hybrids were observed by scanning electron microscope （SEM） and the images showed different dispersed phase morphologies compared to traditional filled composites,which maybe induced by *** rheometric expanded system（ARES） was used to investigate the rheological behaviors of the hybrids and the results showed that the strain y dependence of dynamic storage modulus G＇ for the hybrids with high contents of LMTG did not appear Payne effect.

关键词： Polyphenylene sulfides Low-melting temperature glasses Melt blending Rheological behavior