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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Computer-assisted Surgery for Scaphoid Fracture

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Current Medical Science 2018年第6期38卷 941-948页

作者： Zi-run xiao ge XIONG Department of Hand Surgery Beijing Jishuitan HospitalBeijing 100035China Department of Orthopaedic Surgery the 91st Central Hospital of Chinese People's Liberation ArmyHenan 454000China

The computer-assisted surgery (CAS)has significantly improved the accuracy, reliability and outcomes of traumatic,spinal,nerve surgery and many other operations with a less invasive *** application of CAS for scaphoid fractures remains *** related studies are scanty and most of them are cadaver *** intrinsic defects from the registration procedure,scan and immobilization of limbs may inevitably result in deviations. Some deviations become more obvious with operations of small bones (such as scaphoid)although they are acceptable for spine and other orthopedic *** reviewed the current literatures on the applications of CAS for scaphoid operation and summarized technical principles,scan and registration methods,immobilization of limbs and their *** the basis of the data,we analyzed the limitations of this technique and envisioned its future development.

关键词： computer-assisted surgery wrist scaphoid fracture

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Migration behavior of solid fuel particles during granulation process and its influence on combustion property

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Journal of Iron and Steel Research International 2023年第11期30卷 2153-2162页

作者： Zhi-yun Ji Yi-fan Wang xiao-hui Fan Gai-ge Zhao Min Gan Le-yun Tang Yong Tu xiao-long Wang Hao-xiang Zheng Xu-ling Chen xiao-xian Huang Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Iron ore sintering process is the main CO_(2) emission source throughout the integrate steelworks,which primarily comes from the combustion of solid *** the combustion efficiency and reducing the solid fuel consumption are important ways to reduce the CO_(2) emission in the sintering *** the efficient combustion of fuel,the migration behavior and combustion characteristics of solid fuel in the granulation process were *** results indicated that during the granulation process,fuel particles with size less than 0.5 mm mainly migrated into the granules with grain size of 1-3,3-5 and 5-8 mm;fuel particles with size of 0.5^(-1)mm mainly migrated into granules of 1-3 mm;fuel particles with size of 1-3,3-5 and 5-8 mm mainly entered the granules with the same grain *** the increase in fuel particles grain size from-0.5 to+8 mm,the combustion efficiency exhibited a firstly-increasing and then decreasing tendency,while the NO_(x) exhibited a decreasing *** reason can be described that finer fuel particles(-1 mm)easily distributed in the outer layer of the granules,which combusted fiercely due to its larger specific surface area,leading to the development of incomplete combustion and the conversion of fuel nitrogen;the combustion efficiency of larger fuel particles was restricted by the inner diffusion of O_(2),which then contributed to the reduction of NO_(x) under the inadequate combustion atmosphere.

关键词： Iron ore sintering Granulation Solid fuel distribution Pollutant emission Combustion efficiency

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Analysis of on-chip distributed interconnects based on Pade expansion

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控制理论与应用（英文版） 2009年第1期7卷 92-96页

作者： xiaopeng JI long ge Zhiquan WANG College of Automation. Nanjing University of Science and Technology Nanjing Jiangsu 210094 China

In this paper, on-chip interconnects are modeled as distributed parameter RLCG transmission lines, based on which the matrix ABCD of interconnects is deduced. With help of the ABCD matrix, a voltage transfer function of an interconnect system, consisting of a driver, interconnect line and load, is obtained analytically in the form of a transcendental function, and it is reduced to a finite order system based on high order Pade approximation. With the reduced-order transfer function, response waveforms with step input can be obtained, and signal delay can be calculated consequently. Two numerical experiments are conducted to demonstrate its efficiency.

关键词： Distributed interconnects ABCD matrix Transfer function Pade expansion Response waveform Signal delay

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Aphids as models for ecological and evolutionary studies

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Insect Science 2014年第3期21卷 247-250页

作者： xiao-Lei Huang ge-Xia Qiao Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China

Aphids （Hemiptera： Aphididae） are a group of phloemfeeding insects numbering more than 5 000 extant species（Favret, 2014a）. Most species have complex life cycles that include both asexual （viviparous parthenogenesis）and sexual reproduction. They display a high degree of intraspecific polyphenism with multiple phenotypes froman identical genotype, and they have specialized associations with their host plants （Blackman ＆ Eastop, 2000）.Some aphid species are gall-makers and even have evolved sociality with division of labor （Aoki, 1977; Stern ＆Foster, 1996）. Many aphid species are agricultural and forestry pests. They incur damage to plants and carryvector plant viruses （Blackman ＆ Eastop, 2000）. Due to their fascinating biological character and economic importance, aphids have long been popular animals for research in basic and applied biology, and are becominguseful research models for studying important questions in ecology and evolution, especially in the genomic era（Brisson ＆ Stem, 2006; Huang ＆ Qiao, 2006; Srinivasan ＆ Brisson, 2012）.

关键词： APHIDS EVOLUTION (Biology) INSECT ecology INSECT anatomy INSECTS RESEARCH

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A cellular scale numerical study of the effect of mechanical properties of erythrocytes on the near-wall motion of platelets

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Acta Mechanica Sinica 2014年第2期30卷 274-280页

作者： Jing Xu xiao-long Wang Yun-Qiao Liu xiao-Bo Gong MOE Key Laboratory of Hydrodynamics Department of Engineering MechanicsShanghai Jiao Tong University SJTU-CU ICRC Shanghai Jiao Tong University

The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.

关键词： Hemodynamics Fluid-membrane interaction Immersed boundary method Near-wall motion of platelet

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U-Pb geochronology of Detrital and Inherited Zircons in the Yidun Arc Belt, Eastern Tibet Plateau and Its Tectonic Implications

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Journal of Earth Science 2016年第3期27卷 461-473页

作者： Tao Wu long xiao Changqian Ma School of Earth Sciences Zhejiang University School of Earth Sciences China University of Geosciences State Key Laboratory of geological Processes and Mineral Resources China University of Geosciences

This paper reports geochronological data of detrital zircons from the country rock and sedimentary xenoliths of the Cilincuo pluton（79±0.7 Ma） in the southern Yidun arc belt and the inherited zircons from the Late Triassic granites in the eastern Yidun arc belt, eastern Tibet Plateau. Detrital zircons ages from the sedimentary xenoliths have four prominent peaks at 2.5–2.4 Ga, 1.9–1.8 Ga, 480–400 Ma, and 350–300 Ma, whereas those from the country rock exhibit another four prominent peaks at 1.9–1.8 Ga, 850–700 Ma, 480–400 Ma, and 300–250 Ma. Based on comparison with age data from previous studies, we suggest that the sedimentary xenoliths are from the Lanashan Formation and the major provenance of them is Qiangtang Block, Zhongza massif and South China Block, whereas the country rock belongs to the Lamaya Formation and the major provenance of them is similar to those of the neighbouring Songpan-Garzê terrane. In addition, the inherited zircons from the Late Triassic granites in the eastern Yidun arc belts have a prominent Neoproterozoic age population（900–700 Ma）, which suggests that there is an old basement with west Yangtze Craton affinity beneath the Triassic sediments. Combining with previous studies, we propose that the provenances of the formations vary from the Lanashan Formation to the Lamaya Formation which may indicate a record of the final closure of the Garzê-Litang Ocean.

关键词： Yidun arc belt Garzê-Litang Ocean basement detrital zircon inherited zircon

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Error Bounds for Glimm Difference Approximations for Scalar Conservation Laws Without Convexity

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1271-1282页

作者： xiao Ping YE long Wei LIN Department of Computer Science Zhongshan University Guangzhou 510275 P. R. China Department of Mathematics Zhongshan University Guangzhou 510275 P. R. China

In last century, D. Hoff and J. Smoller derived the error bounds for the Glimm difference approximations of the solutions to scalar conservation laws with convexity. Our work is to extend the corresponding result of t... 详细信息

关键词： error bounds Glimm's scheme non-convexity

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Numerical Investigation on the Influence of Nozzle Lip Thickness on the Flow Field and Performance of an Annular Jet Pump

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Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 59-67页

作者： long-Zhou xiao Xin-Ping long Xue-long Yang School of Power and Mechanical Engineering Wuhan University Key Lab of Jet Theory and New Technology of Hubei Province

The performance of an annular jet pump( AJP) is determined by its area ratio A( ratio of cross sectional area of throat and annular nozzle) and flow rate ratio q( ratio of primary and secondary flow rate,Qs/Qj),while the nozzle lip thickness is neglected in the present studies. This paper presents a study on the effect of the thickness on the flow field and performance of an AJP with A = 1. 75. With the increasing flow rate ratio and nozzle lip thickness,a small vortex forms at the nozzle lip and keeps on growing. However,as the flow rate ratio or nozzle lip thickness is extremely low,the vortex at the lip vanishes thoroughly. Moreover,the recirculation width varies conversely with the nozzle lip thickness when the flow rate ratio q ≤ 0. 13. While the deviation of the recirculation width with different nozzle lip thickness is negligible with q ≥ 0. 13. Additionally the existence of nozzle lip hinders the momentum exchange between the primary and secondary flow and leads to a mutation of velocity gradient near the nozzle exit,which shift the recirculation downstream. Finally,based on the numerical results of the streamwise and spanwise vortex distributions in the suction chamber, the characteristics of the mixing process and the main factors accounting for the AJP performance are clarified.

关键词： annular jet pump nozzle lip recirculation streamwise vortex spanwise vortex

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Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis:Efficacy comparison in a cohort study

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World Journal of Clinical Cases 2025年第5期13卷 13-21页

作者： Jun-Wen xiao Ping Yu Zhang Zhao Department of Stomatology Wuhan No.9 HospitalWuhan 430081Hubei ProvinceChina Department of Otorhinolaryngology People's Hospital of Xishui CountyHuanggang 438200Hubei ProvinceChina Department of Otorhinolaryngology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina

BACKGROUND Odontogenic maxillary sinusitis,often triggered by dental issues like periapical periodontitis,significantly contributes to chronic sinusitis,mainly affecting adults around 50 years old,emphasizing the need for a multidisciplinary diagnostic and treatment *** To investigate the therapeutic effect and clinical value of root canal therapy combined with nasal endoscopic surgery compared with simple root canal the-rapy in the treatment of severe odontogenic maxillary sinusitis caused by peria-pical *** The clinical data,diagnosis,and treatment of 200 patients with severe odonto-genic maxillary sinusitis caused by periapical periodontitis from October 2020 to October 2021 were analyzed *** them,63 patients were treated with simple root canal therapy as the control group,and 137 patients were treated with root canal therapy combined with nasal endoscopic surgery as the observation *** therapeutic effect,Lund-Kennedy endoscopic score,paranasal sinus Lund-Mackay score,complication rate,recurrence rate,and patient satisfaction were compared between the two *** First,we compared the effective rates:23 cases were cured,22 were improved,and 8 were ineffective in the control group,yielding a total effective rate of 84.90%.Meanwhile,97 cases were cured,34 improved,and 6 were ineffective in the observation group,resulting in a total effective rate of 95.62%.The observation group had a higher total effective rate compared with the control group(P0.05)was observed in this score between the two *** treatment,the Lund–Kennedy endoscopic score decreased in both *** Lund–Kennedy endoscopic score of the observation group at 3 and 6 mo after treatment was lower compared to that of the control group(P<0.05).Third,we compared the Lund–Mackay score of paranasal *** treatment,there was no si

关键词： Root canal therapy Nasal endoscopic surgery Periapical periodontitis Odontogenic maxillary sinusitis Therapeutic effect Clinical value

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