检索结果-南通市图书馆

World Journal of Gastroenterology 2017年第27期23卷 4978-4985页

作者： Zhi-Jian Liu xiao-long ge Shi-Chao Ai Hong-Kan Wang Feng Sun Li Chen Wen-Xian Guan Department of Gastrointestinal Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical School Sir Run Run Shaw Hospital Zhejiang University School of Medicine First Affiliated Hospital of Zhejiang University School of Medicine

AIM To find an accurate and simple predictor for postoperative short-term complications after gastrectomy. METHODS Two hundred and twenty-three patients undergoing gastric cancer resection between October 1,2015 and September 30,2016 were enrolled in this study. Univariate and multivariate analyses were used toidentify risk factors for complications after gastrectomy. The cutoff values and diagnostic accuracy were examined by receiver operating characteristic *** Sixty-two(27.8%) patients had short-term complications after gastric cancer resection. The postoperative decrease in serum albumin(?ALB) was an independent risk factor for complications(OR = 17.957,95%CI: 6.073-53.095,P longed hospital stay(17.2 ± 10.8 d vs 14.1 ± 4.2 d,P = 0.007) and higher comprehensive complication index(P < 0.001) than those with ?ALB < 14.0%.CONCLUSION Postoperative ?ALB with a cutoff of 14.0% can be used to recognize patients who have high risk of short-term complications following gastric cancer resection.

关键词： Gastric cancer Postoperative complications Gastrectomy Serum albumin Predictor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

渗流地层人工冻结温度场和渗流场之数值研究

煤炭学报 2007年第1期32卷 24-28页

作者：周晓敏肖龙阁北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083 中国科学院武汉岩土力学研究所

提出了地层冻结过程的渗流场和温度场的耦合机理和渗透系数的耦合作用,建立了冻土和融土统一的微分方程数学模型,对冻、融土的热参数渗流系数进行了光滑的曲线回归,解决了非线性耦合有限元数值计算难题,实现了渗流地层人工冻结过程的数... 详细信息

提出了地层冻结过程的渗流场和温度场的耦合机理和渗透系数的耦合作用,建立了冻土和融土统一的微分方程数学模型,对冻、融土的热参数渗流系数进行了光滑的曲线回归,解决了非线性耦合有限元数值计算难题,实现了渗流地层人工冻结过程的数值仿真技术,数字可视化地研究了在渗流作用下的井筒冻结温度场和渗流场分布和发展规律.

关键词：渗流地层温度场耦合场有限元

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da long xiao Yu Zhi-Xiang Xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

考虑走滑断裂活动影响的公路隧道初始地应力场反演分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国公路学报 2022年第9期35卷 321-330页

作者：寇昊何川吴枋胤杨文波汪波肖龙鸽西南交通大学交通隧道工程教育部重点实验室四川成都610031 中国建筑股份有限公司北京100029

为了使跨活动断裂带区域地应力反演结果更加符合实际,提出了考虑走滑断裂活动影响的公路隧道初始地应力场反演思路。通过在断裂带与两侧岩体之间建立接触单元,采用边界位移荷载实现了断裂带两侧岩体的相对挤压及滑动作用。依托华坪至丽... 详细信息

为了使跨活动断裂带区域地应力反演结果更加符合实际,提出了考虑走滑断裂活动影响的公路隧道初始地应力场反演思路。通过在断裂带与两侧岩体之间建立接触单元,采用边界位移荷载实现了断裂带两侧岩体的相对挤压及滑动作用。依托华坪至丽江高速公路东马场1号隧道工程,对比分析了采用常规边界荷载和考虑走滑边界荷载2种情况下隧址区地应力场的反演结果。研究结果表明:考虑走滑边界荷载反演得到的地应力场更加符合实际且精度更高;常规边界荷载的最大残差为2.29 MPa,而走滑边界荷载的最大残差仅为0.66 MPa,其残差平方和也均小于常规边界荷载;在断裂带附近,考虑走滑活动影响的最大、最小水平应力值相对常规边界均有所减小,上盘岩体垂直应力也相对减小,下盘岩体受上盘岩体的影响垂直应力相对增大,符合跨断层岩体区域实际地应力场的分布规律;隧址区整体表现为水平应力大于垂直应力,以水平构造应力为主。

关键词：隧道工程初始地应力场回归反演走滑断裂边界荷载滑动摩擦因数

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

特大断面浅埋暗挖隧道十字岩柱开挖技术模型试验研究

在线全文

学校读者我要写书评

暂无评论

岩土力学 2017年第10期38卷 2780-2788页

作者：刘泉声彭星新雷广峰王俊涛张静肖龙鸽中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 武汉大学土木建筑工程学院岩土与结构工程安全湖北省重点实验室湖北武汉430072 中国科学院大学北京100049 中建南方投资有限公司广东深圳518022

特大断面浅埋暗挖隧道是一种新型隧道,目前尚无相应的设计施工技术规范与标准可循。以重庆市轨道交通3号线红旗河沟车站隧道为工程背景,结合以前施工方法的优缺点,提出了一种新的施工方法十字岩柱法。为了解这种施工方法在施工过程中隧... 详细信息

特大断面浅埋暗挖隧道是一种新型隧道,目前尚无相应的设计施工技术规范与标准可循。以重庆市轨道交通3号线红旗河沟车站隧道为工程背景,结合以前施工方法的优缺点,提出了一种新的施工方法十字岩柱法。为了解这种施工方法在施工过程中隧道围岩位移和应力的变化情况,采用地质力学模型试验方法进行研究。试验对监测断面的位移和应力进行系统监测,全方位地了解各开挖步隧道围岩各处的应力与位移变化情况。选取工程背景现场的地质参数,采用ABAQUS软件建立数值分析模型,将数值计算与试验实测结果进行对比,两者的位移与应力变化规律基本一致,这表明模型试验实测的数据比较准确地揭示了隧道围岩位移及应力变化规律。其研究工作可对今后类似工程的施工提供经验和指导。

关键词：隧道工程特大断面超浅埋十字岩柱模型试验

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang xiao-ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 73-81页

作者： xiao-long Zhou Wei-Jin Jiang Ji Yu Mao-Jun Yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(Pgest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

Recent Advances in Fibrous Materials for Hydroelectricity generation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can ge Duo Xu xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion