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Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

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Acta Pharmacologica Sinica 2004年第4期25卷 71-75页

作者： Yin-ye WANG, Zhi-yu TANG, Min DONG, xiao-yan liu, shi-qi PENG2 Department of Pharmacology, Department of Medicinal Chemistry, 2 Schoolof Pharmaceutical Sciences, Peking University, Beijing 100083, China Department of Pharmacology School of Pharmaceutical Sciences Peking University 北京 100083 Department of Medicinal Chemistry School of Pharmaceutical Sciences Peking University 北京 100083

AIM: To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS: Platelet aggregation was conducted by Born’s method; bleeding time was determined using tail’s bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess’ method; and cAMP, thromboxane B2 (TXB2) and 6-keto-PGF1α were assessed with commercial kits. RESULTS: The inhibition by PDR (15-60 mg/kg ig or 10 mg/kg iv) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after iv injection for rats (P<0.01), and its (15 mg/kg, ig) inhibition of ADP-induced platelet aggregation for rabbits during 6 h after administration were observed. PDR (15-60 mg/kg) prolonged the bleeding time of mice (P<0.05) and (30 mg/kg) increased NO concentration in plasma. On the other hand PDR did not change the contents of cAMP in platelet and TXB2 or 6-keto-PGF1α in plasma. CONCLUSION: PDR is a novel, oral effective platelet aggregation inhibitor and its action mechanism possibly related to increasing NO generation.

关键词： platelet aggregation bleeding time platelet adhesiveness polyaspartoyl L-arginine nitric oxide cyclic AMP Thromboxane B2 6-ketoprostaglandin F1 alpha

Degradation of Microbes for the Crude Oil Contaminants

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地球科学进展 2004年第S1期19卷 516-519页

作者： liu xiao-yan, shi Peng-fei, SUN De-zhi (Science school, Harbin Institute of Technology, Harbin 150001, China)

Production and storage-transportation of crude oil can not only give rise to soil pollution but also destroy ecological environment. Degradation of microbes for oily soil was studied with the instnunent, Geofina Hydrocarbon Meter (GHM), by experimental analysis qualitatively and quantitatively in the paper. Analytical result showed that the crude oil could be considerably degraded by eating-oil microbes in oily soil and the number of eating-oil microbes increased while the working hours of oil-well risi...

关键词： Microbes Crude oil Contaminants Degradation Experimental analysis

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可支持多级关键度任务的实时操作系统

系统工程与电子技术 2006年第4期28卷 615-619页

作者：杨仕平黄耕文刘校矢广州海格通信有限公司研发中心广东广州510656

为设计可支持多级关键度任务的军用实时操作系统MRTOS,首先分析了现有实时操作系统的调度机制。同时为定量描述任务的关键度,使用时间窗口来描述任务在有限时间范围内的时限错过情况。基于此描述,提出了改进型的最短紧急距离优先调度算... 详细信息

为设计可支持多级关键度任务的军用实时操作系统MRTOS,首先分析了现有实时操作系统的调度机制。同时为定量描述任务的关键度,使用时间窗口来描述任务在有限时间范围内的时限错过情况。基于此描述,提出了改进型的最短紧急距离优先调度算法,该算法可保证实时任务仅错过规定数量的时限,能有效支持不同关键度任务同时运行在同一计算机上,同时可在任务量瞬时过载的情况下保证关键任务优先得到执行。最后通过仿真对最短紧急距离优先调度算法进行了例证。

关键词：安全关键紧急距离多级关键度调度分析实时操作系统

A case report of localized gastric amyloidosis

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World Journal of Gastroenterology 2003年第11期9卷 2632-2634页

作者： Dan Wu Jian-Ying Lou Jian Chen Lun Fei Gui-Jie liu xiao-Yu shi Han-Ting Lin, Department of General Surgery, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, Zhejiang Province, China Department of General Surgery Second Affiliated Hospital Medical College of Zhejiang University Hangzhou 310009 Zhejiang Province China.

AIM: To elucidate the clinical and laboratory features of localized gastric amyloidosis via a rare report along with a review of related ***: The clinical manifestations, laboratory results and surgical treatment of a female patient with localized gastric amyloidosis in our hospital were summarized. The relevant literatures were reviewed on the etiology, clinical features, diagnosis, treatment and prognosis of this ***: The patient was lack of specific clinical manifestations and positive laboratory results. Prior to the treatment, she was suspected to be of malignization from gastric ulcer by both gastroscopy and endoscopic ultrasonography, which was denied by the gastric *** patient was treated with subtotal gastrectomy and clearance of perigastric lymph nodes. The postoperative pathological diagnosis determined the lesion to be the deposition of amyloid materials in the gastric mucosa,submucosa and blood vessel walls with intestinal metaplasia and atrophy of the gastric glands, in which no malignant tumor was found. Congo red staining with prior potassium permanganate incubation confirmed the AA type of amyloid in this case. Multiple biopsies from esophagus, remnant stomach, duodenum, colon and bone marrow in the followup survey showed no amyloidal deposition in these tissues and organs. Up to the present, no signs of recurrence have been found in this ***: Localized gastric amyloidosis, being rare in incidence, should be considered in the differentiation of gastric tumors, in which biopsy is the only means to confirm the diagnosis. Currently, surgical resection of pathological tissue and circumambient lymph nodes may be a preferable therapeutic strategy for the localized amyloidosis to prevent possible complications. Although with a benign prognosis,gastric amyloidosis possesses a recurrent tendency as suggested by the literatures.

关键词：胃淀粉样变性临床症状实验室检查诊断外科治疗病例报告

Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi liu Zhigang Li Xiangyin Lv Liping liu Yajing Chang Jiaming shi xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

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高可信赖实时操作系统的防危调度机制

电子科技大学学报 2006年第1期35卷 111-114页

作者：杨仕平桑楠熊光泽刘校矢电子科技大学计算机科学与工程学院成都610054

为增强实时操作系统的防危性,在分析现有调度机制的基础上,探讨了最大关键度优先的调度算法,该算法是一种混合型的优先级实时调度算法,由静态优先级、动态子优先级和静态子优先级3部分组成,综合了固定优先级调度算法和动态优先级调度算... 详细信息

为增强实时操作系统的防危性,在分析现有调度机制的基础上,探讨了最大关键度优先的调度算法,该算法是一种混合型的优先级实时调度算法,由静态优先级、动态子优先级和静态子优先级3部分组成,综合了固定优先级调度算法和动态优先级调度算法的优点,既可充分利用处理器资源,又能在发生瞬时过载时保证关键任务不受非关键任务的影响,从而增强了实时操作系统的防危性。

关键词：高可信赖关键度防危性调度算法实时操作系统

母亲温暖接纳与儿童学校态度的关系：有调节的中介效应

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中国临床心理学杂志 2019年第4期27卷 812-816,821页

作者：刘啸莳莫碧波李丹刘世宏上海师范大学心理系

目的:考察儿童学业自我概念在母亲温暖教养与儿童学校态度之间的中介作用,以及儿童社交回避对上述中介效应的调节。方法:以462名3、4、5年级小学生及其母亲为被试,采用母亲教养方式量表(CRPR)、儿童自我知觉量表(SPPC)、学校态度量表(SL... 详细信息

目的:考察儿童学业自我概念在母亲温暖教养与儿童学校态度之间的中介作用,以及儿童社交回避对上述中介效应的调节。方法:以462名3、4、5年级小学生及其母亲为被试,采用母亲教养方式量表(CRPR)、儿童自我知觉量表(SPPC)、学校态度量表(SLAQ)、社会焦虑量表(SAS)进行测量。结果:①母亲温暖接纳能够正向预测儿童的学校态度。②儿童学业自我概念在母亲温暖接纳和儿童的学校态度之间起部分中介作用。③母亲温暖接纳经由儿童学业自我概念影响学校态度的中介作用受儿童社交回避的调节。当儿童社交回避水平较高时,母亲温暖接纳的教养方式更能显著预测学业自我概念。结论:对于社交回避的儿童,提升母亲温暖的教养方式,可以更好的帮助孩子建立学业自我概念,进而促进他们形成积极的学校态度。

关键词：母亲教养方式社交回避学业自我概念学校态度

同伴压力知觉与青少年自杀意念:侵入性反刍和回避应对的链式中介作用

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中国临床心理学杂志 2019年第2期27卷 321-325,329页

作者：刘世宏许晓璠章益磊刘啸莳李丹上海师范大学心理学系上海200234

目的:探究侵入性反刍和回避应对策略在高中生同伴压力知觉与自杀意念之间的中介作用。方法:以上海高中生为被试,采用中学生应激源量表、青少年自杀意念量表、应对方式问卷、事件相关反刍量表以班级为单位进行团体施测,有效数据为1372份... 详细信息

目的:探究侵入性反刍和回避应对策略在高中生同伴压力知觉与自杀意念之间的中介作用。方法:以上海高中生为被试,采用中学生应激源量表、青少年自杀意念量表、应对方式问卷、事件相关反刍量表以班级为单位进行团体施测,有效数据为1372份。结果:①相关分析发现,同伴压力知觉、侵入性反刍、回避应对和自杀意念呈显著正相关;②链式中介效应检验表明,同伴压力知觉直接影响其自杀意念;同时存在三条间接路径:同伴压力知觉通过侵入性反刍和回避应对方式的链式中介作用影响自杀意念;同伴压力知觉通过侵入性反刍影响自杀意念;同伴压力知觉通过回避应对影响自杀意念。结论:侵入性反刍和回避应对方式在同伴压力知觉与高中生的自杀意念关系中起链式中介作用。

关键词：青少年同伴压力知觉自杀意念侵入性反刍回避应对

Regulation of alternative splicing of Bcl-x by IL-6,GM-CSF and TPA

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Cell Research 2004年第6期14卷 473-479页

作者： Chang You LI, Jia You CHU, Jian Kun YU, xiao Qin HUANG, xiao Juan liu, Li shi, Yan Chun CHE, Jiu Yong XIE Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China. Department of Physiology, Faculty of Medicine, University of Manitoba, 420 BMSB, 730 William Ave., Winnipeg, MB R3E 3J7, Canada. Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China Department of Physiology Faculty of Medicine University of Manitoba Winnipeg Canada

The splicing of many alternative exons in the precursor messenger RNA (pre-mRNA) is regulated by extracellular factors but the underlying molecular bases remain unclear. Here we report the differential regulation of Bcl-x pre-mRNA splicing by extracellular factors and their distinct requirements for pre-mRNA elements. In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. In U251 glioma cells, however, TPA efficiently increased the Bcl-xL level. These regulations were also seen for a transfected splicing reporter mini-gene. Further analyses of deletion mutants indicate that nucleotides 1-176 of the downstream intron are required for the IL-6 effect, whereas additional nucleotides 177-284 are essential for the GM-CSF effect. As for the TPA effect, only nucleotides 1-76 are required in the downstream intron. Thus,

关键词： alternative splicing bcl-x gene cytokine TPA pre-mRNA element.