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Solid-phase Synthesis of Unsaturated β-Dicarbonyl Compounds from Polymer-supported 4-(Phenylseleno)morpholine

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Chinese Chemical Letters 2004年第9期15卷 1009-1010页

作者： xiao ling liu Xing Cong WANG Shou Ri SHENG Xian HUANG Department of Chemistry Jiangxi Normal UniversityNanchang 330027 Department of Chemistry Zhejiang University(Xixi Campus)Hangzhou 310028

The solid-phase synthesis of unsaturated ?dicarbonyl compounds has been reported.

关键词： Solid phase organic synthesis 4-(phenylseleno)morpholine α-formylcycloanone unsaturated β-dicarbonyl compound.

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Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis

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Current Medical Science 2018年第3期38卷 499-504页

作者： Fan ZHANG xiao-ling liu Wan WANG Hong-ling DONG Yu-fang XIA Li-ping RUAN Li-ping liu Department of Obstetrics and Gynecology Wuhan 6th Hospital Affiliated to Jianghan University Wuhan 430000 China Department of Obstetrics and Gynecology Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430000 China

The aim of this study was to investigate the expression of macrophage migration inhibitory factor （MMIF）, hypoxia-inducible factor- 1 α（HIF- 1α ）and vascular endothelial growth factor （VEGF） in the serum and endometrial tissues of patients with endometriosis （EM） and the clinical significance. Eighty EM patients [American Reproductive Association stage Ⅰ （n=20）, stage Ⅱ （n=22）, stage Ⅲ （n=21） and stage Ⅳ （n=17）] were enrolled and divided into mild （10- 14 points, n=28）, moderate （16-24 points, n=27） and severe （26-30 points, n=25） dysmenorrhea groups. The control group included 40 healthy women of childbearing age who underwent routine healthcare examinations in the enrolment period. The expression of MMIF, HIF- 1α and VEGF in the serum and endometrial tissues was measured by enzyme-linked immunosorbent assay and Western blotting, respectively. Meanwhile, the sensitivity and specificity of serum MMIF, HIF-1α, and VEGF when separately used as single indexes or jointly used as one index were examined as well. The results showed that serum concentrations of MMIF, HIF-1α, and VEGF were significantly higher in EM patients than in controls （P〈0.05）. The expression of all three proteins in both serum and endometrial tissues increased significantly with the R-AFS stage （P〈0.05） and with dysmenorrheal severity （P〈0.05）. The sensitivity and specificity of the combined detection of serum MMIF, HIF-1α, and VEGF levels were significantly higher than those of single index detection （P〈0.05）. In conclusion, the expression of MMIF, HIF-1α, and VEGF in the serum and endometrial tissues may be used to assess the stage of EM and the severity of dysmenorrhea. Combined evaluation of MMIF, HIF-1α, and VEGF significantly improves the diagnostic sensitivity and specificity.

关键词： macrophage migration inhibitory factor hypoxia-inducible factor-1α vascular endothelial growth factor endometriosis diagnosis

Traceless solid-phase synthesis of 3-substituted isoxazoles from polystyrene-supported vinyl selenide

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Chinese Chemical Letters 2007年第1期18卷 1-3页

作者： Qin Xin Shou Ri Sheng Shu Ying Lin xiao ling liu Xian Huang College of Chemistry and Chemical Engineering Jiangxi Normal University Nanchang 330027 China Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028 China

A novel facile procedure for traceless solid-phase synthesis of 3-substituted isoxazoles in good yields and with excellent purities using polymer-supported vinyl selenide has been developed.

关键词： Solid phase organic synthesis Polystyrene-supported vinyl selenide Isoxazole

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Solid-phase synthesis of (Z)-allyl iodides from 3-acetoxy-2-methylene-alkanoates with recyclable polymer-supported selenium bromide

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Chinese Chemical Letters 2007年第4期18卷 377-379页

作者： Shou Ri Sheng Ming Gang Hu Qin Xin xiao ling liu Xian Huang College of Chemistry and Chemical Engineering Jiangxi Normal University 330027 Nanchang China Department of Chemistry Zhefiang University Xixi Campus 310028 Hangzhou China

Reaction of polystyrene-supported lithium selenide with 3-acetoxy-2-methylene-alkanoates afforded the corresponding allyl selenide resins and subsequent cleavage from the polymer by treating with methyl iodide to furnish （Z）-allyl iodides in good yields and high purities. The polymeric selenium reagent can be regenerated and reused. So it is a environmentally benign reagent.

关键词： Solid phase organic synthesis Polystyrene-supported selenium bromide (Z)-Allyl iodide

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Scleral tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case report

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1986-1987页

作者： Ying Huang Bing Lin Li-Na Ge xiao-ling liu Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Citation:Huang Y,Lin B,Ge LN,liu *** tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case *** J Ophthalmol 2021;14(12):1986-1987 Dear Editor,We present a case of scleral tunnel leakage induced by injection of dexamethasone intravitreal implant(Ozurdex®)for recurrent Vogt-Koyanagi-Harada(VKH)*** informed consent was obtained by the patient to allow publication of the present case and any related image and this case study is in accordance with the tenets of the Declaration of Helsinki.

关键词： injection Vogt implant

Lactic acid bacteria act as potent interventions in improving hyperuricemia: a review

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Food Science and Human Wellness 2024年

作者： Qing-ling Wu xiao-Dong Pei Tian-Tian Gao xiao-ling liu Cheng-Hua Wang College of Light Industry and Food Engineering， Guangxi University

Hyperuricemia (HUA) is characterized by elevated levels of uric acid (UA) in the bloodstream， resulting from either excessive production or insufficient excretion of UA within the body. If left untreated， progressive or persistent HUA can lead to gout， causing significant harm to human health. Lactic acid bacteria (LAB)， generally recognized as safe (GRAS) probiotics， have been shown to alleviate symptoms associated with gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease while supporting overall bodily functions and health. Recently， LAB has emerged as a potentially safe， cost-effective and efficient treatment for HUA. This comprehensive review aims to explore the current literature on the mechanisms through which LAB controls HUA. These mechanisms include suppressing purine metabolism， absorbing purine compounds， modulating microbiota to maintain host global purine homeostasis， reducing intestinal permeability， producing metabolites that alleviate HUA symptoms， promoting the expression of urate excretory proteins and inhibiting the expression of urate reabsorption proteins. The findings presented in this review provide a framework for further investigation into how probiotic LAB can alleviate HUA by influencing UA metabolism and elucidating their underlying action mechanisms.

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Extraskeletal Ewing sarcoma of the stomach:A rare case report

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World Journal of Clinical Cases 2023年第1期11卷 201-209页

作者： Qiang Shu Jia-Nong Luo xiao-ling liu Min Jing Ting-Gang Mou Fei Xie Department of Hepatic-Biliary-Pancreatic Surgery Neijiang First People’s Hospital Affiliated to Chongqing Medical UniversityNeijiang 641000Sichuan ProvinceChina Department of Hospital Infection Management Neijiang Hospital of Traditional Chinese MedicineNeijiang 641000Sichuan ProvinceChina Department of Pathology Neijiang First People’s Hospital Affiliated to Chongqing Medical UniversityNeijiang 641000Sichuan ProvinceChina

BACKGROUND Extraskeletal Ewing sarcoma(EES)is a rare and highly malignant small round cell tumor associated with a poor clinical *** sarcoma(ES)involving the stomach is an uncommon presentation and can be easily confused with other small round cell *** herein present a rare case of ES involving the gastric *** SUMMARY We report a case of gastric ES in a 19-year-old female patient who initially presented with a complaint of a tender epigastric mass for 5 ***-enhanced abdominal computed tomography revealed a soft-tissue-density mass with a diameter of 8.5 cm between the liver and stomach;the mass was connected to the gastric ***,the mass was surgically excised *** histopathological,immunophenotype and molecular analysis,the mass was identified to be a primary gastric *** EES is an aggressive tumor with poor ***,early diagnosis and timely intervention are essential for a good *** is imperative for us to raise awareness about this rare *** resection is still the best treatment option.

关键词： Stomach neoplasms Extraskeletal Ewing’s sarcoma CD99 FLI-1 Case report

Focal choroidal excavation: a preliminary interpretation based on clinic and review

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 513-521页

作者： Guang-Hui liu Bing Lin Xin-Quan Sun Zi-Fang He Ji-Rong Li Rong Zhou xiao-ling liu School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Department of Ophthalmology Affiliated People's Hospital to Fujian University of Traditional Chinese Medicine Department of Ophthalmology China-Japan Friendship Hospital

AIM: To describe the clinical and imaging characteristics associated with focal choroidal excavation(FCE), analyze the possible complication, and interpret its probable ***: Retrospective descriptive case series of 37 eyes of 32 patients with FCE. Findings of spectral-domain optical coherence tomography(SD-OCT),fluorescein angiography, indocyanine green angiography,and clinical features were analyzed. RESULTS: All patients were Chinese. Five patients(15.6%) were bilaterally involved. Patients’ ages ranged from 7 to 66 y. Refractive error ranged between +2.0 D and 11.0 D. Mean best-corrected visual acuity was 0.6(range, 0.1 to 1.2). Fundus examinations exhibited mild-moderate localized pigmentary disturbances in the corresponding area of 17 eyes. Fluorescein angiography performed in 18 patients showed varying degrees of hyperfluorescence and hypofluorescence related to a range of retinal pigment epithelium(RPE) *** green angiography performed in 7 patients showed hypofluorescence at the excavation. SD-OCT demonstrated choroidal excavation in all 37 ***-nine eyes showed a single lesion of FCE, and three eyes showed 2-3 separated lesions. Fifteen eyes showed separation between the photoreceptor tips andRPE consistent with nonconforming FCE. Central serous chorioretinopathy(CSC, n =1) and choroidal neovascularization(CNV, n =1) developed during ***: FCE could be interpreted as congenital focal choroidal dysplasia involving the RPE,choriocapillaris, and photoreceptor associated with the faulty anatomy. The abnormal anatomy of FCE was similar to anatomy at risk of CSC and CNV.

关键词： focal choroidal excavation dysplasia optical coherence tomography etiology

Optical coherence tomography angiography characteristics of exudative and non-exudative treatmentnaive pachychoroid neovasculopathy

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2027-2033页

作者： Chun Yang Zu-Hua Sun Ting-Ye Zhou Wei-Wei Zheng xiao-ling liu Bing Lin Eye Hospital of Wenzhou Medical University Wenzhou 325000Zhejiang ProvinceChina

AIM:To describe the optical coherence tomography angiography(OCTA)characteristics of exudative and nonexudative treatment-naïve pachychoroid neovasculopathy(PNV).METHODS:Thirty-five patients with exudative treatmentnaïve PNV and 13 with non-exudative treatment-naïve PNV between March 2020 and December 2021 were *** patients underwent ophthalmologic examination,including fluorescein angiography(FA),indocyanine green angiography(ICGA),spectral-domain OCT,and *** clinical data of the patients were retrospectively ***:The study included 51 eyes from 46 patients,of whom 33(71.7%)were *** central macular thickness(CMT)in the exudative PNV group was significantly higher than that in the non-exudative PNV group(383.97±132.16μm vs 213.13±51.63μm;P<0.001).The maximum height of flat irregular pigment epithelial detachments(FIPED)was 45.40±11.86μm in the non-exudative PNV group,significantly lower than the 71.58±20.91μm(P<0.001)in the exudative PNV *** area of PNV of the non-exudative PNV group was,significantly larger than that of the exudative PNV group(1.06±0.84 mm2 vs 0.63±0.80 mm2,P=0.016).There was a significant difference in PNV morphology between the two groups(P<0.001).Multivariate logistic regression analysis found that the maximum height of FIPED(OR=1.156,95%CI:1.019-1.312;P=0.024)and microvascular branches(OR=69.412,95%CI:3.538-1361.844;P=0.005)were independent predictors of PNV ***:The OCTA imaging finds that there are significant differences in CMT,maximum height of FIPED,PNV area,and morphology of exudative PNV and non-exudative PNV *** can accurately identify the clinical and imaging features of exudative and nonexudative treatment-naïve PNV,and distinguish PNV activity.

关键词： optical coherence tomography angiography pachychoroid neovasculopathy type 1 choroidal neovascularization