检索结果-南通市图书馆

Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

引用

National Science Review 2024年第7期11卷 106-125页

作者： Yan-Nong Dou yuan liu Wen-Qun Ding Qing li Hua Zhou ling li Meng-Ting Zhao Zheng-Yi-Qi li Jing yuan xiao-Fei Wang Wang-yuan Zou Anan li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Impaired pericyte-Müller glia interaction via PDGFRβsuppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury

引用

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1800-1808页

作者： Wei Xu li-Jin Cui xiao-Ying Yang xiao-yuan Cui Jian Guo Guo-Xing Xu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350212Fujian ProvinceChina Fujian Institute of Ophthalmology Fuzhou 350001Fujian ProvinceChina

AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retinal pericytes on photoreceptor loss and Müller glial ***:Sprague-Dawley rats were exposed to intense light to induce retinal *** antibody against PDGFRβwere deployed to block the signaling pathway in retinal pericytes through intravitreal *** histology and Müller glial reaction were assessed following light *** vitro,normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line(rMC-1)to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas(SHRs).RESULTS:PDGFRβblockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor *** upregulation of GFAP and p-STAT3,observed after intense light exposure,was significantly inhibited in the PDGFRβblockage *** ther upregulation of cytokines monocyte chemoattractant protein 1(MCP-1)and interleukin-1β(IL-1β)was also observed following PDGFRβ*** the in vitro coculture system,the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen(PCNA)expression,while Müller cells exhibited neuron-like morphology and expressed ***,PDGFRβblockage in retinal pericytes abolished these cellular responses to light-induced damage,consistent with the in vivo PDGFRβblockage ***:Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal *** of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.

关键词： pericyte Müller glia light-induced retinal injury platelet-derived growth factor receptorβ signal pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation between pre-anesthesia anxiety and emergence agitation in non-small cell lung cancer surgery patients

引用

World Journal of Psychiatry 2024年第6期14卷 930-937页

作者： Fen Yan li-Hua yuan xiao He Kai-Feng Yu Department of Anesthesiology Wuhan Pulmonary HospitalWuhan Institute for Tuberculosis ControlWuhan 430000Hubei ProvinceChina

BACKGROUND Preoperative anxiety is a common emotional problem during the perioperative period and may adversely affect postoperative *** agitation(EA)is a common complication of general anesthesia that may increase patient discomfort and hospital stay and may be associated with the development of postoperative ***-anesthetic anxiety may be associated with the development of EA,but studies in this area are *** To determine the relationship between pre-anesthetic anxiety and EA after radical surgery in patients with non-small cell lung cancer(NSCLC).METHODS Eighty patients with NSCLC undergoing surgical treatment between June 2020 and June 2023 were conveniently *** used the Hospital Anxiety and Depression Scale’s(HADS)anxiety subscale(HADS-A)to determine patients’anxiety at four time points(T1-T4):Patients’preoperative visit,waiting period in the surgical waiting room,after entering the operating room,and before anesthesia induction,*** Riker Sedation-Agitation Scale(RSAS)examined EA after *** plots of HADS-A and RSAS scores assessed the correlation between patients’pre-anesthesia anxiety status and *** performed a partial correlation analysis of HADS-A scores with RSAS *** NSCLC patients’HADS-A scores gradually increased at the four time points:7.33±2.03 at T1,7.99±2.22 at T2,8.05±2.81 at T3,and 8.36±4.17 at *** patients’postoperative RSAS score was 4.49±1.18,and 27 patients scored≥5,indicating that 33.75%patients had ***-A scores at T3 and T4 were significantly higher in patients with EA(9.67±3.02 vs 7.23±2.31,12.56±4.10 vs 6.23±2.05,P<0.001).Scatter plots showed the highest correlation between HADS-A and RSAS scores at T3 and *** correlation analysis showed a strong positive correlation between HADS-A and RSAS scores at T3 and T4(r=0.296,0.314,P<0.01).CONCLUSION Agitation during anesthesia recovery in patients undergoing radical resection for NSCLC correlated with anxie

关键词： Non-small cell lung cancer Operative treatment Anesthesiology department Pre-anesthetic anxiety Emergence agitation Correlation study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

引用

World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-Fu yuan Qin Cao xiao-Yan Chen yuan-Ye Jiang Wen-Min Dong li-li Guo Department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China Department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(Plinesterase levels were higher in lean-type MAFLD patients than in healthy indi-viduals(Plipoprotein and apolipoprotein A-1 were lower in lean-type MAFLD patients than in healthy individuals(Plism of fatty acids were found with P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Artificial Electric Field Surface by Wave-Driven Triboelectricity on Anti-Bioadhesion for Riser Protection

引用

China Ocean Engineering 2024年第3期38卷 483-490页

作者： YI Peng QIU Hong-yuan li Yong CAI Bao-ping Javad MOSTAGHIMI ZHANGWen-jie xiao Wen-sheng College of Mechanical and Electrical Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Equipment Technology Co. Ltd.Tianjin 300450China Department of Mechanical&Industrial Engineering University of TorontoToronto ONM5S3G8Canada

Biofouling has been a persistent problem in marine riser system, resulting in energy waste and equipment damage. Inthis study, a kind of water wave-driven contact-mode flexible triboelectric nanogeneration has been prepared byusing graphene-doped PDMS as dielectric friction material. When the graphene content is 2%, the average outputvoltage can reach 46 V under the contact frequency 10 Hz. The flexible triboelectric nanogeneration encapsulationmodule is impinged by water waves to generate alternating microelectric field on the riser surface and destroy theadhesion conditions of microorganisms during the biofilm stage. In the biofouling experiments at different stages, thebiofouling area of the platymonas subcordiformis has been reduced by 53%, 62% and 61%. It provides a new ideafor effective treatment of biofouling of mussels, oysters and barnacles attached to risers.

关键词： wave-drive triboelectric nanogeneration alternating microelectric field anti-biofouling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation on cutting performance of novel PDC cutter for pipe jacking machine

引用

Underground Space 2024年第1期14卷 34-52页

作者： Long-Chuan Deng Yi-Xiang yuan xiao-Zhao li Qian-Wei Zhuang Chi Zhang Yi-Wei Chen School of Earth Sciences and Engineering Nanjing UniversityNanjingJiangsu 210023China Shanghai Tunnel Engineering Co.Ltd. Shanghai 200232China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China

It is inevitable to cut reinforced concrete(RC)appeared in cross passage of city metro by cutting tools when constructing in densely populated *** previous cutters employed to cut RC are insufficient and easily damaged,so a new polycrystalline diamond compact(PDC)cutter is used to solve this *** on the theoretical analysis of cutting mechanism,both circular and tapered PDC cutters with cutting edge angle of 90and negative front rack angle of 10are used to cut *** peeling and breaking patterns of cutting concrete are proposed,the nodular and grainy chips are the preferred modes in cutting steel *** LS-DYNA is employed to investigate the cutting performance in *** simulation results show that the average and peak cutting forces increase with the growth of penetration depth,cutting speed,and roundness,and subsequently the recommended penetration depth less than 1.2 mm is obtained to cut RC due to the existence of steel ***,the linear cutting platform is adopted to investigate the force ability and damage state of PDC *** is concluded that the cutting force increases abruptly and fluctuates heavily when cutting the coarse *** patterns occurred in both numerical and experimental results are generally ***,the steel bar is pulled out and the PDC cutter is damaged at the penetration depth of 0.8 mm,while a good cut occurs at the penetration depth of 0.3 *** tapered PDC cutter with a relatively low cutting force is prone to be broken compared with circular PDC *** is suggested that the circular PDC cutter at the penetration depth of 0.3 mm should be used to cut RC in practical engineering.

关键词： PDC cutter RC Pipe jacking machine linear cutting tests Damage and wear LS-DYNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated liNi_(0.9)Mn_(0.1)O_(2) toward power battery

引用

Rare Metals 2024年第2期43卷 658-670页

作者： Jia-Qi Peng yuan-yuan Wei Dong-Ming liu Yun li Bin Hu Bin Huang Jian-Wen Yang Shun-Hua xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(liBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Eco-friendly calcium alginate microspheres enable enhanced profile control and oil displacement

引用

Petroleum Science 2024年第3期21卷 1928-1943页

作者： xiao-Han Zhang Chang-Jing Zhou yuan-Xiang xiao Bo Hui Yong-Gang Xie Yu-Bin Su Xin-Ru li Jie Huang Mao-Chang liu International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiPR.China Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil&Gas Reservoirs School of Petroleum EngineeringXi'an Shiyou UniversityXi'an 710065ShaanxiPR.China Oil&Gas Technology Research Institute Changqing Oilfield Branch CompanyPetroChinaXi'an710021ShaanxiPR China Suzhou Academy of Xi'an Jiaotong University Suzhou215123JiangsuPR China

Polymer microspheres(PMs),such as polyacrylamide,have been widely applied for enhanced oil recovery(EOR),yet with environmental ***,we report a microfluid displacement technology containing a bio-based eco-friendly material,i.e.,calcium alginate(CaAlg)microspheres for *** dominant mechanisms responsible for EOR over Ca Alg fluid have been verified,including the microscopic oil displacement efficacy augmented by regulating capillary force(determined by the joint action of interfacial tension and wettability between different phases)and macroscopic sweep volume increment through profile control and mobility ratio *** comprehensive effectiveness can be further impacted when the CaAlg microsphere is embellished ulteriorly by using appropriate amount of sodium dodecyl sulfonate(SDS).The core flooding and nuclear magnetic resonance(NMR)tests demonstrate that CaAlg-SDS microsphere can balance the interphase property regulation(wettability alteration and IFT reduction)and rheology properties,enabling simultaneous profile control and oil *** introduction of SDS will have a negative impact on rheological properties,which is not favored for *** results show that the involvement of 4-m M SDS will provide the best behavior,with an EOR rate of 34.38%.This cost-effective and environmentally-friendly bio-microspherebased microfluidic displacement technology is expected to achieve“green”oil recovery in future oilfield exploitation.

关键词： Calcium alginate microspheres Wettability Interfacial tension Rheology Viscoelasticity Enhanced oil recovery(EOR)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Skeletal phenotypes and molecular mechanisms in aging mice

引用

Zoological Research 2024年第4期45卷 724-746页

作者： Qiao Guan yuan Zhang Zhi-Kun Wang xiao-Hua liu Jun Zou ling-li Zhang School of Exercise and Health Shanghai University of SportShanghai 200438China College of Athletic Performance Shanghai University of SportShanghai 200438China

Aging is an inevitable physiological process,often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health *** on skeletal diseases caused by aging in humans is challenging due to lengthy study durations,difficulties in sampling,regional variability,and substantial ***,mice are preferred for such studies due to their similar motor system structure and function to humans,ease of handling and care,low cost,and short generation *** this review,we present a comprehensive overview of the characteristics,limitations,applicability,bone phenotypes,and treatment methods in naturally aging mice and prematurely aging mouse models(including SAMP6,POLG mutant,LMNA,SIRT6,ZMPSTE24,TFAM,ERCC1,WERNER,and KL/KL-deficient mice).We also summarize the molecular mechanisms of these aging mouse models,including cellular DNA damage response,senescence-related secretory phenotype,telomere shortening,oxidative stress,bone marrow mesenchymal stem cell(BMSC)abnormalities,and mitochondrial ***,this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

联合ADC组学标签和激素受体预测乳腺癌新辅助化疗病理完全化解

引用

中国CT和MRI杂志 2024年第1期22卷 88-90页

作者：李小苑杨志企陈湘光陈寿让温伟华杨宇扬戴卓智陈小凤梅州市人民医院乳腺外科广东梅州514031 广东省临床分子诊断与抗体药物工程技术研究中心广东梅州514031 梅州市人民医院影像科广东梅州514031 汕头市中心医院影像科广东汕头515031

目的探讨使用联合ADC图组学标签和激素受体模型来预测乳腺癌新辅助化疗(NC)病理完全缓解的价值。方法共收集了165例NC前行DWI检查女性乳腺癌患者资料,年龄在28-70岁之间。基于ADC共提取了396个组学特征并进行特征筛选。比较病理完全缓... 详细信息

目的探讨使用联合ADC图组学标签和激素受体模型来预测乳腺癌新辅助化疗(NC)病理完全缓解的价值。方法共收集了165例NC前行DWI检查女性乳腺癌患者资料,年龄在28-70岁之间。基于ADC共提取了396个组学特征并进行特征筛选。比较病理完全缓解和病理部分缓解组间临床特征的差异。将有差异临床特征和最优影像组学特征纳入logistic回归以建立模型。使用ROC曲线和决策曲线来评估模型的效能。结果在训练集和测试集中,激素受体表达状态在病理完全缓解和病理部分缓解组间的差异均具有统计学意义(P<0.05)。基于ADC图组学标签模型在训练集和测试集中预测乳腺癌NC病理完全缓解的曲线下面积(AUC)分别为0.785和0.639。基于联合ADC图组学标签和激素受体建立的联合模型在训练集和测试集中预测乳腺癌NC病理完全缓解的AUC分别为0.904和0.789。联合模型的临床获益高于基于ADC图组学标签模型。结论联合ADC图学标签和激素受体建立的联合模型对预测乳腺癌NC病理完全缓解具有较好的价值。

关键词：乳腺癌表观扩散系数激素受体影像组学新辅助化疗

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：