检索结果-南通市图书馆

Rare Metals 2024年第4期43卷 1570-1579页

作者： Gang Dong Cong Huang Fei-Yang Chen Xue-Qin liu Zhen li xiao-li su Tao Zeng Yun-Xia Chen Yi-Huang Chen Yang Wang School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen333403China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China

Given the clean and inexhaustible solar energy from solar light,photocatalytic ammonia synthesis is extremely ***,high electron-hole recombination rates and insufficient active sites severely limited N2 photoreaction ***,we designed and fabricated FeCu alloy nanoparticles anchored on carbon nitride nanosheets with excellent photocatalyt ic ammonia synthesis *** a coupler between Fe and carbon nitride,Cu promotes the separation of photogenerated charge carriers in carbon nitride under solar light irradiation,and renters the semiconductor a forceful electron donor for the Fe active *** accumulated electrons at Fe sites furtherly facilitated the adsorption and activation of the molecular ***,the uniform dispersed FeCu alloy nanoparticles were on carbon nitride nanosheets enhanced the stability of photocataly tic nitrogen reduction reaction,making the artificial photocataly tic ammonia synthesis more sustainable for *** work highlights that a direct electron transfer channel can be used to regulate the photochemical nitrogen fixation network.

关键词： Photocatalytic N_2 fixation Carbon nitride FeCu alloy Active sites Hydrogenation pathway

Abnormal expression of hepatomas and circulating telomerase and its clinical values

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 544-549页

作者： Wei Wu, Deng-Fu Yao, li-Wei Qiu, Xin-Hua Wu, Ming Yao, xiao-Qin su and li Zou Nantong, China Research Center of Clinical Molecular Biology, Affiliated Hospital, Nantong University, Nantong 226001, China Research Center of Clinical Molecular Biology Affiliated Hospital Nantong University Nantong 226001 China.

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide. Te-lomerase is reactivated in various types of malignant tumors and may contribute to the development of HCC. To evaluate the role of telomerase in formation and development of HCC, we analyzed its expression status in different parts of HCC tissues and peripheral blood mono-nuclear cells (PBMCs) , and explored its clinical implications for diagnosis of HCC. METHODS: Total RNAs and telomerase were extracted from HCC and their non-cancerous tissues, and both relationships were analyzed between them. The expression of telomerase reverse transcriptase (hTERT) mRNA and telomerase activities in liver tissues and PBMCs were detected by RT-PCR and telomeric repeat amplification protocol (TRAP)-EliSA, respectively. The diagnostic values of telomerase in PBMCs were investigated in the diagnosis and differentiation of HCC. REsuLTS: The specific activities of telomerase were 18.25 ±15.02 A/μg RNA in HCC tissues, and significantly higher than those in their non-cancerous tissues (8.16 ± 6.22 A/μg RNA, P liver and lower than 53.77 ± 52.02 μg/mg wet liver in their non-cancerous parts (P liver diseases and control group. The enzyme activities were significantly higher in HCC than in any other groups (P lization treatment than before the treatment (P sues and circulating PBMCs could be a useful marker to the diagnosis and prognosis of HCC.

关键词： telomerase peripheral blood TRAP-EliSA hepatocellular carcinoma

Inhibition of Alveolar Macrophage Pyroptosis Reduces lipopolysaccharide-induced Acute Lung Injury in Mice

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第19期128卷 2638-2645页

作者： Dong-Dong Wu Pin-Hua Pan Ben liu xiao-li su Le-Meng Zhang Hong-Yi Tan ZU Cao Zuo-Ren Zhou Hai-Tao li Hao-Si li li Huang Yuan-Yuan li Department of Pulmonary and Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Thoracic Medicine Hunan Cancer HospitalAffiliated to Xiangya Medical SchoolCentral South UniversityChangshaHunan 410013China

Background：Pyroptosis is the term for caspase-l-dependent cell death associated with pro-inflammatory *** role of alveolar macrophage （AM） pyroptosis in the pathogenesis of the acute lung injury and acute respiratory distress syndrome （Ali/ARDS） remains ***：C57BL/6 wild-type mice were assigned to sham,lipopolysaccharide （LPS）＋ vehicle,LPS ＋ acetyl-tyrosyl-valyl-alanyl-aspartyl-chloromethylketone （Ac-YVAD-CMK） and LPS ＋ Z-Asp-Glu-Val-Asp-fluoromethylketone *** were given intraperitoneal （IP） injections of *** were IP injected 1 h before LPS *** were sacrificed 16 h after LPS administration,and AMs were *** blot analysis for active caspase-1 and cleaved caspase-3,evaluation of lung injury and a cytokine release analysis were *** were treated with LPS and adenosine triphosphate （ATP）;caspase-l-dependent cell death was evaluated using flow cytometry;the apoptosis-associated speck-like protein containing a caspase recruitment domain （ASC） pyroptosomes were examined by ***：The expression of activated caspase-1 in AMs was enhanced following LPS challenge compared with the sham *** the ex vivo study,the caspase-1/propidium iodide-positive cells,caspase-1 specks and ASC pyroptosomes were up-regulated in AMs following LPS/ATP *** specific caspase-1 inhibitor Ac-YVAD-CMK inhibited the activation of caspase-1 and pyroptotic cell ***-YVAD-CMK also reduced the lung injury,pulmonary edema and total protein in bronchoalveolar lavage fluid （BALF）.In addition,Ac-YVAD-CMK significantly inhibited interleukin-β （IL-lβ） release both in serum and BALF and reduced the levels of IL-18,tumor necrosis factor-α （TNF-α）,High Mobility Group Box 1 （HMGB1） in BALF during LPS-induced Ali/***：This study reported AM pyroptosis during LPS-induced Ali/ARDS in mice and has demonstrated that Ac-YVAD-CMK can prevent AM-induced pyroptosis and lung *** preliminary fi

关键词： Acute Lung Injury/Acute Respiratory Distress Syndrome Alveolar Macrophage Caspase-1 Pyroptosis

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua li xiao-Jiang li su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

邻域粗糙集融合贝叶斯神经网络在医疗决策中的应用研究

在线全文

学校读者我要写书评

暂无评论

工业工程与管理 2016年第5期21卷 141-147,159页

作者：王效俐刘潇苏强同济大学经济与管理学院上海200092

为提高医疗决策的效率和有效性，建立了邻域粗糙集融合贝叶斯神经网络的组合医疗决策模型。首先，通过邻域粗糙集对医疗决策系统进行知识约简，去除系统中冗余、干扰的指标，提取关键指标，并将约简后的指标作为神经网络模型的输入指标... 详细信息

为提高医疗决策的效率和有效性，建立了邻域粗糙集融合贝叶斯神经网络的组合医疗决策模型。首先，通过邻域粗糙集对医疗决策系统进行知识约简，去除系统中冗余、干扰的指标，提取关键指标，并将约简后的指标作为神经网络模型的输入指标；之后针对BP神经网络容易过拟合的缺点，采用贝叶斯正则化方法对神经网络进行优化，提高输出指标的预测效果和效率。最后，通过一个心脏病医疗诊断实例对模型的应用实现效果加以分析及验证，结果表明，模型测试集分类准确率达到了88．89％；并将实验结果同几种常见的属性选择方法、分类模型以及2008~2014年的8个历史参考文献进行了对比。

关键词：医疗决策邻域粗糙集贝叶斯正则化神经网络

解放西藏农奴合理性的经济学研究--基于估算出的农业生产函数

在线全文

学校读者我要写书评

暂无评论

中国藏学 2011年第2期 22-31页

作者：大西広(日) 李晓苏日本京都大学研究生院不详

文章借用第二手数据,并应用道格拉斯生产函数,通过研究西藏封建农奴制后期的生产率,没有大道理,没有典型个案,用经济学最基本的理论说明当时的制度确实阻碍了生产力的发展,其土崩瓦解有合理性。一位学者用此方法说明民主改革这样重大政... 详细信息

文章借用第二手数据,并应用道格拉斯生产函数,通过研究西藏封建农奴制后期的生产率,没有大道理,没有典型个案,用经济学最基本的理论说明当时的制度确实阻碍了生产力的发展,其土崩瓦解有合理性。一位学者用此方法说明民主改革这样重大政治举措的合理性,值得借鉴。

关键词：西藏封建农奴制农奴解放经济学研究农业生产

在线全文

学校读者我要写书评

暂无评论

剑麻纤维砂浆抗渗防裂性能试验

土木工程与管理学报 2017年第2期34卷 99-103页

作者：卢小丽苏洁李丽平武汉工程科技学院工程学院湖北武汉430200 中国地质大学工程学院湖北武汉430074

为研究普通水泥砂浆掺入剑麻纤维后抗渗防裂性能,用平板法进行早期收缩裂缝试验,并取相同配合比进行抗渗性能试验。研究不同长度、不同体积掺量的剑麻纤维对砂浆早期收缩性能和抗渗性能的影响,并开展剑麻纤维影响抗渗性能和早期抗裂性... 详细信息

为研究普通水泥砂浆掺入剑麻纤维后抗渗防裂性能,用平板法进行早期收缩裂缝试验,并取相同配合比进行抗渗性能试验。研究不同长度、不同体积掺量的剑麻纤维对砂浆早期收缩性能和抗渗性能的影响,并开展剑麻纤维影响抗渗性能和早期抗裂性能的相关性研究。试验结果表明,0.05%体积掺量、长度6 mm的剑麻纤维抗渗防裂效果均为最佳,裂缝降低系数为98.81%,最大渗水压力提高78.8%。剑麻纤维水泥砂浆抗渗性能与抗裂性能两种耐久性能具有正相关性,即抗裂性能越高,抗渗性能越好。因为剑麻纤维均匀地分布在水泥砂浆基体之中,它可以阻碍集料的分层和离析,保证水泥基材料早期的泌水性,抑制水泥基材料的干缩从而阻止沉降裂纹的产生,且能约束基体变形并阻碍基体的错位运动。

关键词：剑麻纤维试验研究抗渗性能抗裂性能相关性

Quantum public-key crypto via EPR pairs

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei li Jian-Hong Shi Tan li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

社区180例冠心病患者危险因素调查分析

职业与健康 2010年第6期26卷 685-686页

作者：李晓苏天津市红桥区新村医院 300130

目的调查分析社区内冠心病的各种危险因素,提高认知率,为控制和预防冠心病提供一定的科学依据。方法利用天津市红桥区社区医院下社区健康普查及临床病例随访收集资料;依据冠心病的诊断标准,确定180例社区冠心病患者为研究对象。结果社... 详细信息

目的调查分析社区内冠心病的各种危险因素,提高认知率,为控制和预防冠心病提供一定的科学依据。方法利用天津市红桥区社区医院下社区健康普查及临床病例随访收集资料;依据冠心病的诊断标准,确定180例社区冠心病患者为研究对象。结果社区冠心病患者男性占56.7%,女性占43.3%。高血压(60.0%)、高血脂(57.8%)、高盐饮食(78.9%)、糖尿病(36.7%)、肥胖(32.2%)、吸烟(28.9%)、饮酒(25.0%)、缺乏运动(28.3%)、心理因素(29.4%)、家族史(27.8%)为冠心病的危险因素。结论社区冠心病患者多有不健康生活饮食方式,高血压、高血脂、高盐饮食及糖尿病、肥胖是该社区居民冠心病的最主要危险因素,应实施有针对性的干预措施。

关键词：社区冠心病危险因素

在线全文

学校读者我要写书评

暂无评论

灵帝卖官考论

南京晓庄学院学报 2007年第4期23卷 70-74页

作者：李晓苏华东师范大学历史系上海200062

卖官做为一种特殊的选官形式,自秦汉至明清无朝无之,而灵帝卖官因其空前性又时常被世人提及。灵帝朝的现状、灵帝少年遭遇及其生母的影响导致灵帝朝规模空前的卖官现象的产生,如此规模的卖官给灵帝朝带来了严重的后果。

关键词：东汉汉灵帝卖官俸禄