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Journal of Environmental Sciences 2007年第10期19卷 1221-1227页

作者： liU xiao-li ZHANG shu-zhen State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

A hydroponic experiment was carried out to study intraspecific differences in the effects of different concentrations of cadmium （Cd）（0-10 mg/L） and arsenate （As（V））（0-8 mg/L） on the growth parameters and accumulation of Cd and As in six wheat varieties Jing- 9428, Duokang- 1, Jingdong- 11, Jing-411, Jingdong-8 and Zhongrnai-8. The endpoints of wheat seedlings, including seed germination, biomass, root length and shoot height, decreased with increasing the Cd and As concentrations. Significant differences in seed germination, biomass, root length, shoot height and the accumulation of Cd and As were observed between the treatments and among the varieties （p 〈 0.05）. The lethal dosage 50% were about 20, 80, 60, 60, 80 and 20 mg As/L for Jing-9428, Duokang-1, Jingdong-11, Jing-411, Jingdong-8 and Zhongrnai-8, respectively, and the corresponding values for Cd were about 30, 80, 20, 40, 60 and 10 mg Cd/L, respectively. Among the six varieties, Duokang-1 was found to be the most resistant to Cd and As toxicity, and Zhongrnai-8 was the most sensitive to Cd and As co-contamination. The resistance of the six varieties was found dependant on the seedling uptake of Cd and As. Duokang-1 was the most suitable for cultivation in Cd and As co-contaminated soils.

关键词： Cd As varieties co-contamination wheat seedling

Determination of n+1 Gamete Transmission Rate of Trisomics and Location of Gene Controlling 2n Gamete Formation in Chinese Cabbage(Brassica rapa)

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Journal of Integrative Plant Biology 2009年第1期51卷 29-34页

作者： Cheng-He Zhang xiao-Feng li shu-Xing Shen He Yuan shu-Xin Xuan College of Horticulture Agncultural University of Hebei Baoding 071001 China

A set of trisomics of Chinese cabbage was used for determining the n-I-1 gamete transmission rate and locating the gene controlling 2n gamete formation on the corresponding chromosome. The results showed that the transmission rates of extra chromosomes in different trisomics varied from 0% to 15.38% by male gametes and from 0% to 17.39% by female gametes. Of the nine F2 populations derived from the hybridizations between each trisomic and Bp058 （2n gamete material）, only Tri- 4xBp058 showed that the segregation ratio of plants without 2n gamete formation to plants with 2n gamete formation was 10.38：1, which fitted the expected segregation ratio of the trisomics （AAa） based on the 7.37% of n＋l gamete transmission through female and 5.88% through male. In other populations the segregation ratios varied from 2.48：1 to 3.72：1, which fitted the expected 3：1 segregation ratio of the bisomics （Aa）. These results suggested that the gene controlling 2n gamete formation in Chinese cabbage Bp058 was located on chromosome 4. Further trisomic analysis based on the chromosome segregation and the incomplete stochastic chromatid segregation indicated that the gene locus was tightly linked to the centromere.

关键词： Chinese cabbage gene location n+l gamete transmission primary trisomics 2n gametes.

Intravenous tirofiban therapy for patients with capsular warning syndrome

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Stroke & Vascular Neurology 2019年第1期4卷 22-27页

作者： Wei li Ya Wu xiao-shu li Cheng-Chun liu shu-Han Huang Chun-Rong liang Huan Wang li-li Zhang Zhi-Qiang Xu Yan-Jiang Wang Meng Zhang Department of Neurology Daping Hospital&Research Institute of SurgeryThe Army Military Medical UniversityChongqingChina

Background Capsular warning syndrome(CWS)is defined as recurrent episodes of transient ischaemic attacks≥3 times during a short time *** is no effective therapy to stop these ***,herein,report our experience of using intravenous tirofiban to treat *** All patients with CWS in our hospital from January 2013 to September 2017 were *** in tirofiban group(T-group)were treated by intravenous tirofiban at 0.4μg/kg/min for 30 min followed by 0.1-0.15μg/kg/min *** treatments(non-T-group)included thrombolytic,oral antiplatelet agents and *** haemorrhage(ICH),systematic bleeding,new attacks after treatment,National Institutes of Health Stroke Scale(NIHSS)scores at 24 hours and modified Rankin Scales(mRSs)at 3 months were *** statistics were used for *** Of 23 patients qualified(15 in T-group,8 in non-T-group),the duration of symptoms ranged from 2 to 100 min before *** treatment,in T-group,four patients(26.7%)had recurrent attacks,and NIHSS scores were 0 in 11 patients(73.3%)at 24 *** patients reached a favourable outcome(mRS≤2) at 3 *** non-T-group,five patients(62.5%)had new *** scores were 0 in two patients(25%)at 24 *** 3 months,seven patients(87.5%)reached a favourable *** ICH nor systematic bleeding or thrombocytopaenia occurred in both groups of *** Intravenous tirofiban can be a potentially effective and safe therapy to stop early symptomatic fluctuations and shorten the duration of functional deficits in patients with CWS.

关键词： patients Intravenous intravenous

Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study

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World Journal of Pediatrics 2018年第4期14卷 404-409页

作者： Fu-Bang li xiao-li shu Wei-Zhong Gu xiao-Xia Zhao Shou-Jiang Huang Hong Zhao Ke-Rong Peng Jin-Fa Tou Department of Gastroenterology Children's HospitalZhejiang University School of MedicineHangzhouChina Laboratory of Gastroenterology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of Pathology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of General Surgery Children's HospitalZhejiang University School of MedicineHangzhouChina

Background The pathogenesis of biliary atresia (BA) is associated with an inflammatory process involving the biliary tree. This study aimed to investigate the association of T-helper cell cytokine levels with age in patients with BA. Methods Twenty-eight patients with BA were divided into three groups according to their age (liver tissue specimens were obtained during surgery. We detected serum levels of interleukin (IL)-1β, IL-12p70, interferon (IFN)-γ, IL-6, IL-10, and transforming growth factor (TGF)-β1 and liver expression of IL-1β, IL-6, and TGF-β1. Results The serum levels of IL-1β, IL-12p70, IL-6, and IL-10 in patients aged ≥ 3 months were significantly higher than those in patients aged liver tissue of patients with BA. Conclusions The serum levels of IL-1β, IL-6, IL-10 and IL-12p70 showed significant age-related differences in patients with BA. Interpretation of the role of cytokines in BA needs to take patient's age into consideration.

关键词： Biliary atresia Cytokines Pathogenesis T-helper cell

Forest fire danger ratings in the 2040s for northeastern China

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Forestry Studies in China 2011年第2期13卷 85-96页

作者： TIAN xiao-rui shu li-fu WANG Ming-yu ZHAO Feng-jun Key Open Laboratory of Forest Protection of the State Forestry Administration Research Institute of Forest Ecology Environment and Protection Chinese Academy of Forestry Beijing 100091 E R. China

The average temperature of northeastern China is expected to increase 2.22 and 2.55℃ under two scenarios selected from the Intergovemmental Panel on Climate Change （IPCC）, i.e., A2 and B2, during the 2040s （2041-2050）, which will have an impact on fire activities in those areas. We calculated the output of regional climate models, using the Canadian Forest Fire Weather Index （FWI） on a scale of 50 km × 50 km. Meteorological data and fire weather index were interpolated to a scale of 1 km × 1 km by using ANUSPliN software. The results show that the model of Providing Regional Climate for Impacts Studies （PRECIS） had the ability to provide good temperature and precipitation estimates of the study area in the baseline period, by simulation. In the 2040s the mean FWI values of the study area will increase during most of the fire seasons under both selected scenarios, compared with the baseline period. Under scenario B2 the peak fire season will appear in advance. The changes of FWI ratio （2×CO2/l ×CO2） show that the potential burned areas will increase 20% under scenario B2 and lightly increase under scenario A2 in 2040s. The days of high, very high and extreme fire danger classes will add 5 and 18 d under scenarios A2 and B2, respectively. It suggests adapting the climate change through improving fuel management and enhancing the fighting abilities.

关键词： climate change forest fire danger fire season FWI northeastern China

Unfolded protein response and storage product accumulation in rice grains

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Seed Biology 2022年第1期1卷 33-37页

作者： Yu-Feng Zhou Tao Qing xiao-li shu Jian-Xiang liu State Key Laboratory of Rice Biology and Key Lab of the Ministry of Agriculture for Nuclear Agricultural Sciences Institute of Nuclear Agricultural SciencesZhejiang UniversityHangzhou 310029China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310029China

Secretory and transmembrane proteins start to synthesize and fold in the endoplasmic reticulum(ER).When the balance between protein folding demands and protein folding capability in the ER is broken,a well-conserved process known as the unfolded protein response(UPR)is induced to restore protein *** grain quality of rice(Oryza sativa L.),one of the most important crops that feed more than half of the world’s population,is determined by the accumulation of nutritional components,such as seed storage proteins(SSPs)and starches in the *** SSPs are synthesized in the secretory pathways of endosperms and their biosynthesis is subject to complex ***,we focus on summarizing recent advances in our understanding of the role of UPR in grain development,especially in SSP biosynthesis in rice,and provide future perspectives on unanswered questions on improving grain quality through modulating UPR in rice.

关键词： crops folding grains

Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B

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World Journal of Gastroenterology 2015年第27期21卷 8373-8381页

作者： Fang-Yuan Gao Yao liu xiao-shu li Xie-Qiong Ye Le Sun Ming-Fan Geng Rui Wang Hui-Min liu xiao-Bing Zhou li-li Gu Yan-Min liu Gang Wan Xian-Bo Wang Center of Integrative Medicine Beijing Ditan Hospital Capital Medical University Statistics Section Beijing Ditan Hospital Capital Medical University

AIM: To establish a clinical scoring model to predict risk of acute-on-chronic liver failure(ACLF) in chronic hepatitis B(CHB) ***: This was a retrospective study of 1457 patients hospitalized for CHB between October 2008 and October 2013 at the Beijing Ditan Hospital, Capital Medical University, China. The patients were divided into two groups: severe acute exacerbation(SAE) group(n = 382) and non-SAE group(n = 1075). The SAE group was classified as the high-risk group based on the higher incidence of ACLF in this group than in the non-SAE group(13.6% vs 0.4%). Two-thirds of SAE patients were randomly assigned to risk-model derivation and the other one-third to model validation. Univariate risk factors associated with the outcome were entered into a multivariate logistic regression model for screening independent risk factors. Each variable was assigned an integer value based on the regression coefficients, and the final score was the sum of these values in the derivation set. Model discrimination and calibration were assessed using area under the receiver operating characteristic curve and the Hosmer-Lemeshow test. RESULTS: The risk prediction scoring model includedthe following four factors: age ≥ 40 years, total bilirubin ≥ 171 μmol/L, prothrombin activity 40%-60%, and hepatitis B virus DNA > 107 copies/m L. The sum risk score ranged from 0 to 7; 0-3 identified patients with lower risk of ACLF, whereas 4-7 identified patients with higher risk. The Kaplan-Meier analysis showed the cumulative risk for ACLF and ACLF-related death in the two risk groups(0-3 and 4-7 scores) of the primary cohort over 56 d, and log-rank test revealed a significant difference(2.0% vs 33.8% and 0.8% vs 9.4%, respectively; both P lidation data sets, the model had good discrimination(C index = 0.857, 95% confidence interval: 0.800-0.913 and C index = 0.889, 95% confidence interval: 0.820-0.957, respectively) and calibration demonstrated by t

关键词： Acute-on-chronic liver failure Chronichepatitis B Prediction model Risk score Severe acuteexacerbation

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中国史学的雅俗分流与俗史学的复兴

中国人民大学学报 2005年第2期19卷 115-121页

作者：李小树中国人民大学历史系北京100872

俗史学是中国史学的真正源头,它在讲述内容、讲述主体、讲述对象、历史观念上都具有明显的民众性特征。中国史学雅俗分流的格局正式形成于夏王朝建立之后。雅史学在内容上和形式上与俗史学有很大的不同。虽然雅史学的长足进展对中国... 详细信息

俗史学是中国史学的真正源头,它在讲述内容、讲述主体、讲述对象、历史观念上都具有明显的民众性特征。中国史学雅俗分流的格局正式形成于夏王朝建立之后。雅史学在内容上和形式上与俗史学有很大的不同。虽然雅史学的长足进展对中国史学做出了重要贡献,但俗史学长期被排挤于主流史学之外, 对民众素质的提高和民族精神的塑造都十分不利。两宋时期,俗史学开始复兴。近代以来,俗史学更加受到重视。雅、俗共同繁荣的史学新局面的出现,必将把中国史学的发展推向一个新的高度。

关键词：俗史学雅史学雅俗分流复兴

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班固受贿写史辨疑

史学月刊 2005年第3期 12-16,105页

作者：李小树中国人民大学历史系北京100872

前人对班固“受金”写史之事说法不一,或信其为实,或疑其所无,或不置可否,但皆语焉不详。而如果班固在撰修《汉书》时受贿,则天子不宥,律令不许,士林不齿,怨家不饶,但这些事情却无一发生。合理的解释应当是:班固未曾在修史过程中收受过... 详细信息

前人对班固“受金”写史之事说法不一,或信其为实,或疑其所无,或不置可否,但皆语焉不详。而如果班固在撰修《汉书》时受贿,则天子不宥,律令不许,士林不齿,怨家不饶,但这些事情却无一发生。合理的解释应当是:班固未曾在修史过程中收受过贿赂。而所谓“受金”写史之说,其最大的可能是班固“受命”写史之事在辗转传抄过程中形成的讹误。

关键词：班固受金写史《汉书》

The Synthesis, Crystal Structure and Thermoanalysis of N-Salicylidene Glycine Tripyridine Nickel( Ⅱ )

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Chemical Research in Chinese Universities 1992年第3期8卷 309-313页

作者： CUI Xue-gui, liU De-xin, SUN Hong-jian, li xiao-yan and li shu-lan (Department of Applied Chemistry, Shandong University, Jinan, 250100)

Introduction Complexes of some Schiff bases with transition metals are widely used, for example, they can be used as anticancer medicine, preservative, complex reagent and the model of the biological oxygen carrier. So their syntheses, properties and application have been intensively studied. In order to study the relationship between the

关键词： Schiff base Nickel complex Crystal structure Thermoanalysis