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Paravertebral block's effect on analgesia and inflammation in advanced gastric cancer patients undergoing transarterial chemoembolization and microwave ablation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 196-204页

作者： Ying-Fen Xiong Ben-Zhong Wei Yu-feng Wang xiao-feng li Cong liu Department of Anesthesiology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Anesthesiology Nanjing Gulou Hospital Group Yizheng HospitalYangzhou 211400Jiangsu ProvinceChina Nuclear Medicine Department Xuzhou Cancer HospitalXuzhou 221000Jiangsu ProvinceChina Department of Radiology Xuzhou Cancer HospitalXuzhou 221000Jiangsu ProvinceChina Department of Minimally Invasive Oncology Xuzhou New Health Hospital(Xuzhou Hospital Affiliated to Jiangsu University)Xuzhou 221000Jiangsu ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)combined with microwave ablation(MWA)is an effective treatment strategy for patients with advanced gastric cancer and liver ***,it may cause severe postoperative pain and inflammatory *** paravertebral block(PVB)is a regional anesthetic technique that provides analgesia to the thoracic and abdominal *** To evaluate the effect of PVB on postoperative analgesia and inflammatory response in patients undergoing TACE combined with MWA for advanced gastric cancer and liver *** Sixty patients were randomly divided into PVB and control *** PVB group received ultrasound-guided PVB with 0.375%ropivacaine preoperatively,whereas the control group received intravenous analgesia with *** primary outcome was the visual analog scale(VAS)score for pain at 6 h,12 h,24 h,and 48 h after the *** outcomes were the dose of sufentanil used,incidence of adverse events,and levels of inflammatory markers(white blood cell count,neutrophil percentage,C-reactive protein,and procalcitonin)before and after the *** The PVB group had significantly lower VAS scores at 6 h,12 h,24 h,and 48 h after the procedure compared with the control group(Pliver metastasis treated with TACE combined with MWA.

关键词： Transarterial chemoembolization Microwave ablation Paravertebral block Visual analog scale Sufentanil Inflammatory markers

Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao Rong Ming-Zheng Tang Song-Hua liu xiao-feng li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 liver cancer Differentially expressed genes Hub genes Pathogenesis

The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zhao Jing-Jing Guo feng Zhu Na-Na Zhang xiao-feng li Hai-Tao liu Fei Wang Yong-Qiang Deng Cheng-feng Qin College of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of life Sciences Southwest Forestry UniversityKunming650224China

Guaico Culex virus(GCXV)is a newly identified segmented Jingmenvirus from Culex *** in Central and South *** genome of GCXV is composed of four or five single-stranded positive RNA ***,the infection kinetics and transmission capability of GCXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GCXVs(4S and 5S)that contained four and five RNA segments,respectively,in C6/36 *** in vitro characterization revealed that the two GCXVs exhibited comparable replication kinetics,protein expression and viral ***,GCXV RNAs were detected in the bodies,salivary glands,midguts and ovaries of Culex quinquefasciatus at 4–10 days after oral *** addition,two GCXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GCXVs with four or five RNA segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico Culex virus(GCXV) Jingmenvirus Culex quinquefasciatus Vertical transmission

ZIF-8-functionalized polymer electrolyte with enhanced performance for high-temperature solid-state lithium metal batteries

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Rare Metals 2024年第3期43卷 984-994页

作者： Jin-Fang Zhang Yuan-Yuan Wang xiao-feng li Gen-Yan Zhang Ying li Rong liu Sheng-liang Hu Tuo-Ping Hu Ruth Knibbe Qing-Bing Xia School of Materials Science and Engineering North University of ChinaTaiyuan030051China School of Energy and Power Engineering North University of ChinaTaiyuan030051China School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQLD4072Australia

Solid polymer electrolytes(SPEs)with high ionic conductivity are desirable for solid-state lithium metal batteries(SSLMBs)to achieve enhanced safety and energy *** nanofillers into a polymeric matrix to develop nanocomposite solid electrolytes(NCSEs)has become a promising method for improving the ionic conductivity of the ***,a novel ZIF-8-functionalized NCSE was prepared for high-temperature S SLMB s using an in situ radical polymerization *** is found that the ZIF-8 nanoparticles could reduce the crystallinity of polymer segments and offer a Lewis acid surface that promotes the dissociation of lithium bis(trifluoromethanesulfonyl)imide(liTFSI)and stabilizes the TFSI^(-) anion ***,the as-prepared NCSE exhibits an outstanding ionic conductivity of 1.63×10^(-3)S·cm^(-1),an electrochem ical stability window of 5.0 V at 80℃,and excellent interface compatibility with lithium metal anode with a stable polarization over 2000 ***,the assembled SSLMBs with liFePO_(4)cathode show dendrite-free li-metal surface,good rate capability,and stable cycling stability with a capacity retention of 70%over 1000 cycles at a high temperature of 80℃.This work provides valuable insights into promoting the ionic conductivity of SPEs.

关键词： lithium metal batteries Metal-organic frameworks Solid polymer electrolytes lithium metal anode Interfacial compatibility

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-Hua liu Ming-Zheng Tang Zhi-Hang Wu Guo-Rong Ma xiao-feng li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis liver cancer

1-9年级学生的“物质”核心概念学习进阶研究

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化学教育（中英文） 2024年第3期45卷 10-18页

作者：李小峰梁珊珊郑长龙重庆幼儿师范高等专科学校儿童早期发展学院重庆404047 东北师范大学化学教育研究所吉林长春130024

在梳理9个国家或地区科学课程文件基础上,建构了义务教育阶段学生的“物质”核心概念学习进阶理论预设模型和工具检验模型,开发了29个测评项目对其进行了检验。通过SPSS24.0对其克隆巴赫系数进行检验,通过Winsteps3.72.0对其分离度、项... 详细信息

在梳理9个国家或地区科学课程文件基础上,建构了义务教育阶段学生的“物质”核心概念学习进阶理论预设模型和工具检验模型,开发了29个测评项目对其进行了检验。通过SPSS24.0对其克隆巴赫系数进行检验,通过Winsteps3.72.0对其分离度、项目和被试信度、试题难度、模型误差、项目拟合度等进行了检验。510个测评对象来自全国8个省的15所中小学,包括城区学校和农村学校。通过2次测评,最后形成了义务教育阶段学生的“物质”核心概念学习进阶的5个水平。总体上来看,学生的“物质”核心概念理解水平随着年级阶段递增,其中有3个重要的时间节点,分别是4年级、7至8年级和9年级,学生的“物质”核心概念理解在这些时间节点上都有质的飞跃,其概念理解呈现由物理性质和变化向化学性质和变化、由宏观向微观进阶的趋势,研究还发现,学生的“物质”核心概念理解水平不是绝对按照年级阶段递增,会出现一定的跳跃性、波动性。

关键词：学习进阶物质核心概念科学教育义务教育

不同制式地铁车站公共区PM_(2.5)污染特征

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中国环境科学 2024年第5期44卷 2399-2406页

作者：纪文静曾俊杰李晓锋北京科技大学土木与资源工程学院北京100083 清华大学建筑学院北京100084

为了解屏蔽门和安全门制式地铁车站公共区PM_(2.5)的污染特征,分别选取不同制式地铁车站,同步采集分析车站公共区及室外的PM_(2.5)浓度及成分,并利用PMF法解析公共区PM_(2.5)的来源组成.结果显示,屏蔽门车站公共区PM_(2.5)的平均浓度显... 详细信息

为了解屏蔽门和安全门制式地铁车站公共区PM_(2.5)的污染特征,分别选取不同制式地铁车站,同步采集分析车站公共区及室外的PM_(2.5)浓度及成分,并利用PMF法解析公共区PM_(2.5)的来源组成.结果显示,屏蔽门车站公共区PM_(2.5)的平均浓度显著低于安全门车站,但高于站外大气PM_(2.5)浓度.安全门车站公共区中Fe、Cu元素的站内外浓度比(I/O比)分别为32和9,远超屏蔽门车站Fe、Cu的I/O比(16和4).依据源解析结果将公共区PM_(2.5)来源区分为站内源和站外源,安全门车站中站内源贡献达74%,产生的元素浓度和为40.1μg/m^(3),而屏蔽门车站中站内源贡献为69%,产生的元素浓度和仅18.8μg/m^(3).此外,两类车站中站内源对站内重金属元素贡献均超过80%,但安全门车站中站内源产生的重金属浓度为36.9μg/m^(3),而屏蔽门车站仅为17.5μg/m^(3),相比安全门降低53%.因此,屏蔽门制式相比安全门制式可以显著降低地铁车站公共区PM_(2.5)质量浓度及PM_(2.5)中重金属元素含量.

关键词：地铁车站细颗粒物源解析重金属

胃癌模型大鼠胃黏膜组织Cyclin D1、c-Myc、CKIT的表达意义及其与胃癌病变程度的相关性

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临床和实验医学杂志 2024年第8期23卷 789-793页

作者：李雨李小风张扬黑龙江中医药大学附属第一医院肿瘤科黑龙江哈尔滨150040 黑龙江中医药大学研究生学院黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院消化科黑龙江哈尔滨150040

目的探讨胃癌模型大鼠胃黏膜组织细胞周期蛋白D1(cyclinD1)、c-Myc、CKIT的表达意义及其与胃癌病变程度的相关性。方法选择48只健康成年雌性大鼠,按照随机数字表法将其分为对照组、研究1组、研究2组、研究3组,每组各12只。研究1组、研究... 详细信息

目的探讨胃癌模型大鼠胃黏膜组织细胞周期蛋白D1(cyclinD1)、c-Myc、CKIT的表达意义及其与胃癌病变程度的相关性。方法选择48只健康成年雌性大鼠,按照随机数字表法将其分为对照组、研究1组、研究2组、研究3组,每组各12只。研究1组、研究2组、研究3组均制备成胃癌模型。对照组给予等量0.9%氯化钠溶液,第24周处死取材;研究1组、研究2组、研究3组制备成胃癌大鼠后分别于第8、16、24周取材。分析各组大鼠一般情况及胃黏膜组织病理切片,采用蛋白质印迹法检测胃黏膜组织Cyclin D1、c-Myc、CKIT蛋白的表达,采用逆转录聚合酶链式反应(RT-PCR)法测定胃黏膜组织Cyclin D1、c-Myc、CKIT mRNA的表达,采用Spearman分析法测定胃黏膜组织Cyclin D1、c-Myc、CKIT表达与胃癌病变程度相关性。结果对照组大鼠胃黏膜完整正常,外膜层、肌层、黏膜下层、黏膜层等结构清晰,且无炎症细胞浸润;研究1组大鼠胃黏膜组织与对照组大鼠接近,不存在炎症细胞,且黏膜腺体结构基本正常;研究2组大鼠胃黏膜组织存在破损,细胞核变大,基底部部分腺体细胞形态异常,存在轻度异型性,为早期胃癌;研究3组大鼠胃黏膜组织增加破损,核质比变大,细胞形态不规则,部分腺体存在扩张,黏膜下层及肌层存在炎症细胞浸润,为胃癌进展期。研究1组、研究2组、研究3组胃黏膜组织Cyclin D1、c-Myc、CKIT蛋白均呈显著高于对照组,差异均有统计学意义(Plin D1、c-Myc、CKIT蛋白在研究1组、研究2组、研究3组中逐渐升高趋势。研究1组、研究2组、研究3组胃黏膜组织Cyclin D1、c-Myc、CKIT mRNA均呈显著高于对照组,差异均有统计学意义(Plin D1、c-Myc、CKIT mRNA在研究1组、研究2组、研究3组中逐渐升高趋势。采用Spearman相关性结果分析显示,胃黏膜组织Cyclin D1、c-Myc、CKIT表达与胃癌病变程度呈正相关(r=0.382、0.781、0.993,均Plin D1、c-Myc、CKIT呈高表达,其与胃癌病变程度密切相关。

关键词：胃癌模型胃黏膜组织 Cyclin D1 c-Myc CKIT 胃癌病变程度相关性

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数字经济对农业农村现代化的影响研究

当代金融研究 2024年第3期7卷 31-44页

作者：李潇锋周昊祥新疆财经大学金融学院新疆乌鲁木齐830012

在数字化转型的浪潮中,数字经济在推动乡村振兴、实现农业农村现代化中发挥着重要作用。选取2011-2021年中国30个省份的数据,运用固定效应模型实证检验数字经济对农业农村现代化的影响,并将研发强度和农村金融发展水平作为中介变量探究... 详细信息

在数字化转型的浪潮中,数字经济在推动乡村振兴、实现农业农村现代化中发挥着重要作用。选取2011-2021年中国30个省份的数据,运用固定效应模型实证检验数字经济对农业农村现代化的影响,并将研发强度和农村金融发展水平作为中介变量探究其中的间接传导机制,研究发现:数字经济发展水平的提高对农业农村现代化具有显著的促进作用,同时通过增强研发强度、提升农村金融发展水平间接推动农业农村现代化建设。异质性分析结果表明,数字经济对农业农村现代化的促进作用存在明显的区域差异,东部地区最显著,中部地区次之,西部地区不显著。基于此,应大力支持数字经济发展,为农业农村现代化做好数字支持;发挥数字经济支持研发强度和农村金融发展的作用,为农业农村现代化做好技术支撑和金融支持;缩小地区经济发展差距,协调推进不同区域农业农村现代化进程。

关键词：数字经济农业农村现代化研发强度农村金融

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