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Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： li-Wen Tan Jun-li Wan Chun-Hua Zhu Hong Xu Zheng-Kun Xia li-Zhi Chen xiao-Chuan Wu Fang Wang xiao-Rong liu Cheng-Guang Zhao xiao-zhong li Jian-Hua Mao xiao-Wen Wang Wen-Yan Huang Yu-Hong li Jian-Jiang Zhang Shi-Pin Feng Jun Yang Jiao-Jiao liu Chun-lin Gao li-Ping Rong Lan-Jun Shuai Ke Xu He-Jia Zhang Qiu li Ai-Hua Zhang Mo Wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by liability to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(Pline,the predictive model had higher accuracy(0.86 versus 0.58,P<0.001)and a lower coefficient of variation(0.07 versus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis

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RCEP中日本市场准入例外安排的决定因素——基于政治经济学的分析框架

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亚太经济 2024年第2期 61-73页

作者：吕建兴李孝忠广州大学经济与统计学院广州510006 东北农业大学经济管理学院哈尔滨150030

区域全面经济伙伴关系协定(RCEP)是对近些年逆全球化、贸易保护主义的有力对冲,也是中日首个双边互惠安排。梳理日本在RCEP中产品层面的关税减让模式,并基于政治经济学的分析框架,利用线性概率模型实证分析日本将部分产品纳入关税减让... 详细信息

区域全面经济伙伴关系协定(RCEP)是对近些年逆全球化、贸易保护主义的有力对冲,也是中日首个双边互惠安排。梳理日本在RCEP中产品层面的关税减让模式,并基于政治经济学的分析框架,利用线性概率模型实证分析日本将部分产品纳入关税减让例外安排的决定因素。研究发现:(1)事实特征上,在RCEP中日本对外开放程度不高,FTA生效后仅有63%的产品关税立即降为0,24%的产品关税减让过渡期超过10年,另有13%的产品完全不参与降税。(2)实证分析发现,面临贸易创造的且有组织的进口竞争性产品易于通过利益集团影响贸易政策制定,从而更可能被纳入关税减让的例外安排;而深度嵌入全球价值链(GVC)且资源和市场“两头在外”的生产贸易模式,使得GVC参与度越高的产品越不容易被纳入关税减让的例外安排;但是关税减让过渡期和完全例外安排的决策机制是不同的,面临贸易创造的利益集团只能获得关税减让超长过渡期的保护,而GVC参与度越高的产品能获得更低概率的关税减让完全例外安排。

关键词：市场准入全球价值链利益集团保护策略

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Adaptive online prediction method based on LS-SVR and its application in an electronic system

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第12期13卷 881-890页

作者： Yang-ming GUO Cong-bao RAN xiao-lei li Jie-zhong MA School of Computer Science and Technology Northwestern Polytechnical University Xi'an 710072 China

Health trend prediction has become an effective way to ensure the safe operation of highly reliable systems,and online prediction is always necessary in many real *** simultaneously obtain better or acceptable online prediction accuracy and shorter computing time,we propose a new adaptive online method based on least squares support vector regression(LS-SVR).This method adopts two *** approach is that we delete certain support vectors by judging the linear correlation among the samples to increase the sparseness of the prediction *** approach can control the loss of useful information in sample data,improve the generalization capability of the prediction model,and reduce the prediction *** other approach is that we reduce the number of traditional LS-SVR parameters and establish a modified simple prediction *** approach can reduce the calculation time in the process of adaptive online *** and a certain electric system application indicate preliminarily that the proposed method is an effective prediction approach for its good prediction accuracy and low computing time.

关键词： Adaptive online prediction Least squares support vector regression(LS-SVR) Electronic system

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Overexpression of IQGAP1 in human pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 540-545页

作者： xiao-Xia Wang xiao-zhong li li-Qin Zhai Zhi-Rong liu Xian-Jiu Chen Yi Pei Department of Biochemistry and Molecular Biology Shanxi Medical University Department of Geriatric Oncology Shanxi Academy of Medical SciencesShanxi Dayi Hospital Department of Emergency Shanxi Provincial People's Hospital Department of Pathology Shanxi Provincial People's Hospital

BACKGROUND:Pancreatic cancer is a highly aggressive malignant tumor with the lowest survival rate.A better understanding of the molecular mechanisms which contribute to pancreatic cancer occurrence and progression will aid in the development of new approaches to the early diagnosis,prevention,and treatment of this deadly *** scaffold protein IQGAP1 shows elevated levels in a variety of cancer ***,we investigated whether or not IQGAP1 is also overexpressed in pancreatic ***:IQGAP1 expression was examined in pancreatic cancer and normal tissues adjacent to cancerous tissues(adjacent tissues)by Western blotting and real-time RT-PCR as well as in paraffin sections of tissue microarray by *** correlations between IQGAP1 expression and various clinicopathological characteristics were ***:Western blotting and real-time RT-PCR revealed that the levels of IQGAP1 protein and mRNA expression in pancreatic cancer tissues were significantly increased compared with adjacent *** analysis on tissue microarray showed that IQGAP1 protein expression was significantly higher in pancreatic cancer(80.0%,48/60)compared with adjacent tissues(18.3%,11/60)(P<0.001).Moreover,overexpression of IQGAP1 was shown to be associated with the grades of tumor differentiation(P<0.05).CONCLUSION:The overexpression of IQGAP1 may play an important role in pancreatic cancer occurrence and progression,and IQGAP1 may serve as a novel molecular target for the diagnosis and treatment of pancreatic cancer.

关键词： IQGAP1 pancreatic cancer tissue microarray immunohistochemistry

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mRNA vaccine technology for infectious diseases and beyond

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Science China(life Sciences) 2024年第10期67卷 2267-2270页

作者： Pei Hao xiao li Xuan li Wu zhong Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghai 200031China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The rise of mRNA vaccine technology Vaccines stand as one of the most significant medical advancements,playing a crucial role in the prevention of infectious diseases and the improvement of global *** triumph of smallpox vaccination stands as a towering achievement in the annals of healthcare,leading to the complete elimination of a oncedevastating disease and showcasing the efficacy of vaccination methods.

关键词： methods vaccination prevention

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Synthesis and Characterization of Novel Layered lithium Sodium Silicate (Silinaite) and the Mesoporous Materials from Silinaite

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Chinese Chemical Letters 2006年第4期17卷 525-528页

作者： Chun Hui ZHOU Hong Qiang GUO Hui Jun CAO xiao Nian li zhong Hua GE Jie li College of Chemical Engineering and Materials Science Zhejiang University of Technology Hangzhou 310032

Novel layered silinaite has been synthesized using an aqueous mixture of water glass, liOH and NaOH under hydrothermal crystallization. Subsequently transformation of silinaite into mesoporous materials （SDM） was achieved at mild condition using cetyltfimethylammonium bromide as structure-directing agents. The resulting samples were characterized by XRD, SEM, FTIR nitrogen adsorption-desorption isotherms and catalytic performance in bulky molecular involved reaction. The results revealed that synthesized mesoporous materials derived from the silinaite exhibited an ordered hexagonal crystal structure with average pore diameter 2.7 nm and BET surface area 817m^2/g. The SDM-supported ZnCl2 catalyst, prepared by impregnationevaporation method, retained the mesoporous structure and showed high selectivity in alkylation of benzene with benzyl chloride.

关键词： Silinaite mesoporous materials layered solid catalysts characterization.

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Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

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Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu LV xiaohu GE Yi zhong Qiang li Yong xiao School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling

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Postpolypectomy syndrome without abdominal pain led to sepsis/septic shock and gastrointestinal bleeding:A case report

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2343-2350页

作者： Fang-Zhi Chen lin Ouyang xiao-li zhong Jin-Xiu li Yan-Yan Zhou Department of Gastroenterology The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Critical Care Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Postpolypectomy syndrome(PPS)is a rare postoperative complication of colonic *** presents with abdominal pain and fever accompanied by coagulopathy and elevated inflammatory *** prognosis is usually good,and it only requires outpatient treatment or observation in a general ***-ever,it can be *** SUMMARY The patient was a 58-year-old man who underwent two colonic polypectomies,each resulting in life-threatening sepsis,septic shock,and *** of the notable manifestations was a rapid drop in blood pressure,an increase in heart rate,loss of consciousness,and heavy sweating,accompanied by shortness of breath and decreased oxygen in the finger *** on the criteria of organ dysfunction due to infection,we diagnosed him with *** patient also experienced severe gastrointestinal bleeding after the second ***,he did not complain of any abdominal pain throughout the course of the *** had significantly elevated concentrations of inflammatory markers and *** for the absence of abdominal pain,his fever,significant coagulopathy,and elevated inflammatory marker concentrations were all consistent with *** computed tomography and superior mesenteric artery computed tomography angiography showed no free air or vascular ***,the diagnosis of colon perforation was not *** final blood culture results indicated Moraxella *** patient was transferred to the intensive care unit and quickly improved after fluid resuscitation,antibiotic treatment,oxygen therapy,and blood *** PPS may induce dysregulation of the systemic inflammatory response,which can lead to sepsis or septic shock,even in the absence of abdominal pain.

关键词： Postpolypectomy syndrome Abdominal pain Sepsis Gastrointestinal bleeding Case report

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Low soil temperature and drought stress conditions at flowering stage affect physiology and pollen traits of rice

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Journal of Integrative Agriculture 2019年第8期18卷 1859-1870页

作者： RAO Gang-shun Umair Ashraf KONG Lei-lei MO Zhao-wen xiao li-zhong zhong Ke-you Fahd Rasul TANG Xiang-ru Department of Crop Science and Technology College of Agriculture South China Agricultural University/Scientific Observing and Experimental Station of Crop Cultivation in South China Minist ry of Agriculture and Rural Affairs Guangzhou 510642 P.R.China Department of Agronomy University of Agriculture Faisalabad 38040 Pakistan

Low temperature and drought stress are the major constraints in rice productivity worldwide. This study investigated the influence of low soil temperature and/or drought stress on physiology and pollen traits of two rice genotypes viz., Guinongzhan and Yueza 763 at flowering stage. The experiment included four treatments, i.e., under the greenhouse natural growth conditions (UC) taken as control, drought stress (DS), the soil water potential was kept at ?0.035 to ?0.045 MPa (DS), low soil temperature (LT) maintained at 19 to 21℃, combined LT and DS (LT+DS, LD). Results showed that LT, DS, and LD substantially reduced net photosynthetic rate (Pn) and the maximal photochemical efficiency of PSII (Fv/Fm), whilst transpiration rate (Tr) was markedly enhanced by under LT in both rice genotypes. The malondialdehyde (MDA) contents were enhanced under LT, DS, and LD in Guinongzhan, whilst the activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) were regulated by LT, DS, and LD in both rice genotypes. Furthermore, anther dehiscence rate, pollen numbers on stigma, pollen viability and pollen germination rate, and anther starch contents were obviously reduced under LT and DS of both rice genotypes. Stress conditions substantially reduced the yield and yield components, i.e., effective panicles, seed set percentage, grain/panicles, 1000-grain weight, and grain yield of both genotypes and the effects were more apparent in Guinongzhan than those in Yueza 763 whilst combined LT and DS proved more damaging than individual stress.

关键词： antioxidant enzymes cold stress pollen traits photosynthesis rice yield

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Progress in processing of porous titanium:a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： xiao-li Yang Xian-Feng Du Zhi-lin Xu zhong-Shuai liang li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi'an Jiaotong UniversityXi'an 710049China

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace,marine engineering and biomedical fields due to their high corrosion resistance,low density,good biocompatibility and excellent mechanical ***,in this paper,a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes)for fabricating porous titanium is firstly covered in terms of their working principles,capabilities,shortcomings and ***,the influencing factors of various methods on final pore structure of porous Ti are ***,a summary of the chemical methods(CM)to obtain the porous Ti is also provided,such as dealloying method and reduction ***,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

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