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Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan Wang Kun Jiang qiao xia xia Kang Shan Wang Ji-Hong Yu Wen-Feng Ni xiao-Qin Qi Ying-Na Zhang Jin-Bao Han Gang Liu lei Hou Zhi-Chun Feng Liu-Ming huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Senior Department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in *** designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of *** Using the 16S ribosomal DNA(rDNA)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time *** The beta diversities of the NP,NN,and NC groups were all *** comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-Shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of Streptococcus increased significantly at the E4 time *** Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small *** sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： Microbiota Necrotizing enterocolitis-Small intestine 16S rDNA

Experimental observation of multiple topological nodal structure in LaSb_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 138-145页

作者： Yuxi qiao Fuyi Wang Huaiqiang Wang Zicheng Tao Zhicheng Jiang Zhengtai Liu Soohyun Cho Fayuan Zhang Qingkai Meng Wei xia Yichen Yang Zhe huang Jishan Liu Zhonghao Liu Zengwei Zhu Shan qiao Yanfeng Guo Haijun Zhang Dawei Shen State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China National Synchrotron Radiation Laboratory and School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China School of Physics and Technology Nanjing Normal UniversityNanjing 210023China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Institute of High-Pressure Physics School of Physical Science and Technology Ningbo UniversityNingbo 315211China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Unconventional fermions in the immensely studied topological semimetals are the source for rich exotic topological ***,using symmetry analysis and first-principles calculations,we propose the coexistence of multiple topological nodal structure in LaSb_(2),including topological nodal surfaces,nodal lines and in particular eightfold degenerate nodal points,which have been scarcely observed in a single ***,utilizing angle-resolved photoemission spectroscopy,we confirm the existence of nodal surfaces and eightfold degenerate nodal points in LaSb_(2).The intriguing multiple topological nodal structure might play a crucial role in giving rise to the large linear *** work renews the insights into the exotic topological phenomena in LaSb_(2).

关键词： eightfold degenerate points multiple topological nodal structure angle-resolved photoemission spectroscopy linear unsaturated magnetoresistance

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Single Ti atoms coupled with Ti-O clusters enable low temperature hydrogen cycling by sodium alanate

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Rare Metals 2024年第6期43卷 2671-2681页

作者： Zhuang-He Ren Xin Zhang Wen-Xuan Zhang Zhen-Guo huang Li-Mei Yang Ya-Xiong Yang Zheng-Long Li Juan Li Wen-Ping Sun Ming-xia Gao Hong-ge Pan Yong-Feng Liu State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China School of Civil&Environmental Engineering.University of Technology Sydney Sydney2007 NSWAustralia Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an 710021China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China

Ti-based catalysts are known to improve the hydrogen storage performance of NaAlH4by facilitating the dissociation/recombination of H-H and Al-H *** catalytic activity of metallic Ti species strongly depends on its particle size and *** clusters and even single atoms are therefore highly desirable,but their controllable fabrication has been highly *** rein,we demonstrate a novel facile sonochemical synthesis of a Ti-O clusters featuring single Ti atom catalyst at room *** reducing TiCl_(4)by MgBu_(2)with ultrasound instead of heating as driving force,numerous single Ti atoms coupled with Ti-O clusters with Ti loading on graphene(Ti_(1)/Ti-O@G)up to 22.6 wt%have been successfully *** prepared Ti_(1)/Ti-O@G contributes high reactivity and superior catalytic activity,therefore enabling full dehydrogenation of NaAlH_(4)at 80℃in thermogravimetric mode and re-hydrogenation at 30℃and 10 MPa with 4.9 wt% H_(2).This fact indicates for the first time that single Ti atom catalyst with high loading is highly effective in catalyzing hydrogen cycling of NaAlH4at remarkably reduced temperatures.

关键词： Hydrogen storage Nanocatalysis Transition metals Single Ti atoms NaAlH_(4)

Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang Bo Chen Hong-Yi Zhang Zhen-Hua Chen Yao-Bo huang Xue-Qing Ye Ya-Hua Yuan Yu-xia Duan Jun He Jian-qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-xiang Gu xian-xia Yan Hong-Wei Fan Ming-Ming Zhang Yu qiao xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin Yan-Ping Wang Ying-Lan Xie Gui-Hua Tian xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang qiao huang xiang-Ying Ren Ying-Yue Rao Yun-Yun Wang Meng-Qian Yuan xian-Tao Zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for Evidence Based Traditional Chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

中国内陆沿海地区1986—2015年极端气候指数对生态系统脆弱性的影响

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北京师范大学学报（自然科学版） 2024年第3期60卷 438-446页

作者：乔世荣徐霞黄奕钦北京师范大学地理科学学部自然资源学院北京师范大学地表过程与资源生态国家重点实验室北京

基于1986-2015年气象数据、净初级生产力(NPP)数据集,计算了典型极端气候指数和生态系统脆弱性,从时间和空间2个维度分析NPP以及极端气候的时空变化特征,揭示中国内陆沿海地区陆地生态系统脆弱性空间分布特征,进一步探讨不同生态系统脆... 详细信息

基于1986-2015年气象数据、净初级生产力(NPP)数据集,计算了典型极端气候指数和生态系统脆弱性,从时间和空间2个维度分析NPP以及极端气候的时空变化特征,揭示中国内陆沿海地区陆地生态系统脆弱性空间分布特征,进一步探讨不同生态系统脆弱性对极端气候指数的响应特征.结果表明:1)1986-2015年,中国内陆沿海地区呈现偏暖的趋势,平均温度上升1.2℃,具体表现为暖昼时间(Tx90p)、暖夜时间(Tn90p)呈增加趋势,冷昼时间(Tx10p)、冷夜时间(Tn10p)则呈减少趋势,每日气温极值(TXx、TNx、TXn、TNn)呈增加趋势,气温日较差(DTR)呈降低趋势,夜间气温上升幅度大于日间;极端降水呈现南增北减的空间分布特征. 2)陆地生态系统脆弱性呈现出显著的地理空间差异性,脆弱性最高的地区位于北部,东北地区中部以及华北地区存在明显的高脆弱性区域,具体表现为该区域恢复力较低. 3)极端气候指数与陆地生态系统脆弱性之间具有显著的关联性,均表现为显著的负相关,日夜温差(DTR)与陆地生态系统的脆弱性呈显著正相关.

关键词：中国沿海地区生态系统脆弱性极端气候净初级生产力(NPP)

Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCuSi

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang Bo Chen Hong-Yi Zhang Zhen-Hua Chen Yao-Bo huang Xue-Qing Ye Ya-Hua Yuan Yu-xia Duan Jun He Jian-qiao Meng School of Physics Central South University Shanghai Institute of Applied Physics Chinese Academy of Sciences

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb4 f spectral for surface and bulk in the Kondo lattice YbCu2Si2. Our study quantitatively distinguishes between the surface and bulk hybridization processes, revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo temperature. Additionally, we found that the effective surface Kondo temperature is much lower than that of the bulk. These findings offer valuable insights into the understanding of heavy fermion physics.

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施氮对库尔勒香梨园土壤真菌群落的影响

中国土壤与肥料 2024年第06期 56-69页

作者：李伟黄战谢文歌张曦瑜冯雷徐巧柴仲平新疆农业大学资源与环境学院新疆土壤与植物生态过程实验室

探究长期不同氮素水平对库尔勒香梨园土壤（0～20 cm土层）真菌群落结构组成及多样性的影响，为库尔勒香梨生产过程中合理施用氮肥提供理论依据。以长期施肥试验为基础，采用高通量测序技术，研究氮肥施用量分别为N 0、150、300和450 kg... 详细信息

探究长期不同氮素水平对库尔勒香梨园土壤（0～20 cm土层）真菌群落结构组成及多样性的影响，为库尔勒香梨生产过程中合理施用氮肥提供理论依据。以长期施肥试验为基础，采用高通量测序技术，研究氮肥施用量分别为N 0、150、300和450 kg/hm2（分别表示为N0、N1、N2和N3）的4个处理下库尔勒香梨园土壤理化性质与土壤真菌群落结构组成以及群落多样性的关系。结果表明，各施肥处理土壤中优势真菌门类均为子囊菌门、担子菌门、被孢菌门；优势真菌属类均为曲霉属、顶孢霉属、链格孢属、葡孢霉属、假裸囊属，碳氮含量和土壤理化性质能显著影响微生物的群落组成，高氮施肥能够增加真菌的丰富度。中高氮（N 300～450 kg/hm2）施肥能够提高真菌多样性及群落中的物种分布均匀度，土壤真菌群落生物多样性主要与碳氮组分含量、电导率、pH间存在显著相关关系（P<0.05）。

关键词：库尔勒香梨氮肥微生物多样性真菌土壤理化性质