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Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia

Neural Regeneration Research 2020年第2期15卷 332-341页

作者： Ning-Wei Zhu xiao-lan yin Ren Lin xiao-lan Fan Shi-Jie Chen Yuan-Ming Zhu xiao-Zhen Zhao Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Pharmacy Zhejiang Pharmaceutical CollegeNingboZhejiang ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina

Oxidative stress is involved in the pathogenesis of vascular dementia. Studies have shown that lycopene can significantly inhibit oxidative stress;therefore, we hypothesized that lycopene can reduce the level of oxidative stress in vascular dementia. A vascular dementia model was established by permanent bilateral ligation of common carotid arteries. The dosage groups were treated with lycopene(50, 100 and 200 mg/kg) every other day for 2 months. Rats without bilateral carotid artery ligation were prepared as a sham group. To test the ability of learning and memory, the Morris water maze was used to detect the average escape latency and the change of search strategy. Hematoxylin-eosin staining was used to observe changes of hippocampal neurons. The levels of oxidative stress factors, superoxide dismutase and malondialdehyde, were measured in the hippocampus by biochemical detection. The levels of reactive oxygen species in the hippocampus were observed by dihydroethidium staining. The distribution and expression of oxidative stress related protein, neuron-restrictive silencer factor, in hippocampal neurons were detected by immunofluorescence histochemistry and western blot assays. After 2 months of drug administration,(1) in the model group, the average escape latency was longer than that of the sham group, and the proportion of straight and tend tactics was lower than that of the sham group, and the hippocampal neurons were irregularly arranged and the cytoplasm was hyperchromatic.(2) The levels of reactive oxygen species and malondialdehyde in the hippocampus of the model group rats were increased, and the activity of superoxide dismutase was decreased.(3) Lycopene(50, 100 and 200 mg/kg) intervention improved the above changes, and the lycopene 100 mg/kg group showed the most significant improvement effect.(4) Neuron-restrictive silencer factor expression in the hippocampus was lower in the sham group and the lycopene 100 mg/kg group than in the model group.(5) Th

关键词： bilateral carotid artery ligation lycopene hippocampus learning and memory malondialdehyde neuron neuron-restrictive silencer factor reactive oxygen species superoxide dismutase

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Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study

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World Journal of Gastroenterology 2017年第30期23卷 5589-5601页

作者： Lin Lv Feng-Yun Wang Xiang-Xue Ma Zhen-Hua Li Sui-Ping Huang Zhao-Hong Shi Hai-Jie Ji Li-Qun Bian Bei-Hua Zhang Ting Chen xiao-lan yin Xu-Dong Tang Department of Gastroenterology Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Gastroenterology Guangdong Province Traditional Chinese Medical Hospital Department of Gastroenterology Wuhan Integrated TCM and Western Medicine Hospital

AIM To assess the efficacy and safety of a Chinese herbal medicine (CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia (FD). METHODS We performed a randomized, double-blind, placebo-controlled trial with patients from three centers. Two hundred and sixteen subjects diagnosed with FD according to ROME. criteria and confirmed by upper gastrointestinal endoscopy and spleen-deficiency and Qi-stagnation syndrome were selected to receive Xiangsha Liujunzi granules or placebo for 4 wk in a 2: 1 ratio by blocked randomization. The subjects also received follow-up after the 4-wk intervention. Herbal or placebo granules were dissolved in 300 mL of water. Participants in both groups were administered 130 mL (45 degrees C) three times a day. Participants were evaluated prior to and following 4 wk of the intervention in terms of changes in the postprandial discomfort severity scale (PDSS) score, clinical global impression (CGI) scale score, hospital anxiety and depression scale (HADS) score, traditional Chinese medicine symptoms score (SS), scores of various domains of the 36-item short form health survey (SF-36), gastric emptying (GE) and any observed adverse effects. RESULTS Compared with the placebo group, patients in the CHM group showed significant improvements in the scores of PDSS, HADS, SS, SF-36 and CGI scale (P < 0.05 or P < 0.01). They also showed the amelioration in the GE rates of the proximal stomach and distal stomach (P < 0.05 or P < 0.01). CONCLUSION Xiangsha Liujunzi granules offered significant symptomatic improvement in patients with FD.

关键词： Functional dyspepsia Chinese herbal medicine Xiangsha Liujunzi Efficacy Randomized controlled trial

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Mechanism of Traditional Chinese Medicine on Intestinal Mucosal Immunity in Chronic Intestinal Diseases

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 20-30页

作者： Lin Lv Feng-Yun Wang Xiang-Xue Ma Ting Chen Hai-Jie Ji Zheng-Yi Chen Ya-Xin Tian Li-Qun Bian Bei-Hua Zhang xiao-lan yin Xu-Dong Tang Gastroenterology Department Xiyuan Hospital of China Academy of Chinese Medical Sciences School of China Academy of Chinese Medical Sciences

Although irritable bowel syndrome(IBS) and inflammatory bowel disease(IBD) are clinically common diseases with unclear pathogenesis, both of them are related to the immune system. With progress in studies on their pathogenesis, the two diseases are currently believed to be associated with the presence of intestinal inflammation and intestinal mucosal immune disorder. In recent years, a new approach for the prevention and treatment of chronic intestinal disease is to protect the complete structure and normal immunity of the intestinal mucosal barrier during the treatment of intestinal diseases. However, traditional Chinese medicine(TCM) may have more advantages in regulating the imbalance of the intestinal immune microenvironment, as various single herbs and compounds of TCM have been investigated from the perspective of immune regulation. The use of TCM is prevalent in China. The effectiveness of these therapies appears to be supported by preliminary evidence and clinical experience, although the mechanisms that underlie these effects will require further research. In this paper, with common chronic bowel diseases including IBS, ulcerative colitis and Crohn's disease as the research objects, the relationship between TCM and immunity was explored from the perspectives of the pathogenesis of intestinal mucosal immune injury, the correlation between TCM syndromes and immune disorders, and TCM immune regulation. Moreover, the problems and limitations of the present study were pointed out, and several suggestions were proposed. The purpose of this article is to explore the potential mechanism of TCM on intestinal mucosal immunity in chronic intestinal diseases.

关键词： Irritable Bowel Syndrome Inflammatory Bowel Disease Immune Disorder TCM Immune Regulation

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数学建模进入中学课程的意义与价值

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数学教育学报 2023年第3期32卷 8-12页

作者：兰小银朱文芳北京师范大学数学科学学院北京100875

数学建模是解决现实问题的重要方法与手段,依赖数学理论基础的教学离不开实际问题的解决,离不开实践,其过程是对数学素质教育的开拓与创新.数学建模的教学走入各高等院校和中学常务教学的任务当中,对人才培养、国家人才复兴、经济振兴... 详细信息

数学建模是解决现实问题的重要方法与手段,依赖数学理论基础的教学离不开实际问题的解决,离不开实践,其过程是对数学素质教育的开拓与创新.数学建模的教学走入各高等院校和中学常务教学的任务当中,对人才培养、国家人才复兴、经济振兴有着重要的现实意义与实际价值.研究表明:数学建模进入中学课程是认识和推动数学建模在国家关键领域发展的迫切应用,在发挥和落实数学建模提升人的综合能力方面具有重要作用,是把握好数学建模对人才培养课程发展的需要,是以数学建模为抓手带动教学方式的根本性变革,是抓住课程改革促进创新式教学内容发展的重要契机.

关键词：数学建模中学课程数学课程标准

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Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang Guo Di lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua Guo Guanglei Wu Pengfei yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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脾虚一号方对脾虚型FD大鼠肝脏异柠檬酸脱氢酶的影响

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世界华人消化杂志 2016年第32期24卷 4362-4369页

作者：吕林王凤云唐旭东马祥雪尹晓岚石啸双中国中医科学院西苑医院博士后流动站北京市100091 中国中医科学院西苑医院消化科北京市100091 北京中医药大学研究生院北京市100029 中国中医科学院研究生院北京市100700

目的探讨脾虚型功能性消化不良(functional dyspepsia,FD)大鼠肝组织异柠檬酸脱氢酶(isocitrate dehydrogenase,IDH)蛋白、mR NA表达及脾虚一号方干预.方法70只10日龄♂S D大鼠随机分为正常对照组(n=10)、FD模型组(n=10)、脾虚型FD模型... 详细信息

目的探讨脾虚型功能性消化不良(functional dyspepsia,FD)大鼠肝组织异柠檬酸脱氢酶(isocitrate dehydrogenase,IDH)蛋白、mR NA表达及脾虚一号方干预.方法70只10日龄♂S D大鼠随机分为正常对照组(n=10)、FD模型组(n=10)、脾虚型FD模型组(n=50).正常组给予2%蔗糖溶液灌胃,0.2 mL/只·d,连续6 d;FD模型组、脾虚证FD模型组给予0.1%蔗糖碘乙酰胺蔗糖溶液灌胃,0.2 mL/只·d,连续6 d.脾虚证FD模型组正常饲料喂养至6周龄后叠加改良小平台站立,连续14 d.造模结束后随机分为脾虚证FD模型组(n=10)、多潘立酮组(n=10)、中药低、中、高剂量组(各10只),连同正常组、FD模型组,分别给予蒸馏水1 mL/100 g·d、多潘立酮0.3125 mg/100 g·d、脾虚一号方0.1275 g/100 g·d、0.255 g/100 g·d、0.51 g/100 g·d,灌胃14 d.采用RT-PCR、Western blot和免疫组织化学方法检测肝脏组织IDH蛋白、m RNA表达量.结果与双模型组相比,免疫组织化学中正常组、多潘立酮组、脾虚一号方低、中、高剂量组IDH蛋白平均光密度值均明显升高,差异有统计学意义(P<0.05,P<0.01);Western-blot方法检测中正常组、多潘立酮组、脾虚一号方高剂量组、单模型组IDH蛋白表达量升高,差异有统计学意义(P<0.05,P<0.01);RTP C R方法检测正常组、多潘立酮组、脾虚一号方高剂量组IDH m RNA升高最显著,差异有统计学意义(P<0.01).结论脾虚型FD大鼠存在能量代谢降低现象,脾虚一号方改善脾虚情况可能是通过提高IDH蛋白及m RNA的表达,增加脾虚证大鼠能量代谢.

关键词：脾虚证功能性消化不良异柠檬酸脱氢酶中医

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

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用手性醇改性的铝锂试剂对芳酮的不对称还原

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西南师范大学学报（自然科学版） 2003年第2期28卷 243-246页

作者：杨晓兰尹承烈重庆医科大学基础医学院重庆400016 北京师范大学化学系北京100875

为开发新型手性铝锂试剂,探讨双不对称诱导效应,选用含杂原子的光学活性氨基醇为辅助配体,与1,2,5,6 二丙酮甘露醇共同修饰LiAlH4,对潜手性芳酮进行不对称还原,得到光学活性醇;通过与α D 乙酰氧基 L 丙酰氯生成非对映异构体酯,经气相... 详细信息

为开发新型手性铝锂试剂,探讨双不对称诱导效应,选用含杂原子的光学活性氨基醇为辅助配体,与1,2,5,6 二丙酮甘露醇共同修饰LiAlH4,对潜手性芳酮进行不对称还原,得到光学活性醇;通过与α D 乙酰氧基 L 丙酰氯生成非对映异构体酯,经气相色谱分析,对映体过量在43 6%～77 7%之间。结果表明辅助配体的绝对构型、空间位阻、β位杂原子对光学产率均有影响。

关键词：芳酮不对称还原铝锂试剂手性醇双不对称诱导效应光学活性非对映异构体

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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