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Single-cell omics: experimental workflow, data analyses and applications

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Investigation on attitude disturbance control and vibration suppression for fuel-fille flexibl spacecraft

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Acta Mechanica Sinica 2015年第4期31卷 581-588页

作者： xiao-Juan Song Bao-zeng Yue Wen-jun Wu School of Aerospace Engineering Beijing Institute of Technology School of Automobile and Traffi Engineering Guangxi University of Science and Technology

This paper is mainly focused on the attitude dynamics and control of a fuel-filled flexible spacecraft sub- jected to the thermal payload during eclipse transitions. The flexible appendages are considered as Euler-Bernoulli beams, and the sloshing liquid is modeled as in two modes multi-spring-mass models; the governing equations of this coupled system are developed by using Hamilton＇s prin- ciple. Numerical results show that the spacecraft attitude responses consist of a quasi-static displacement and superim- posed vibration. Then, we design an adaptive sliding mode and use the Lyapunov approach control law to control the attitude disturbance and suppress the thermal jitter and liq- uid sloshing for the fuel filled flexible spacecraft subject to the thermal payload. Numerical results are presented to verify the efficiency of the hybrid control methods. The results show that the adaptive sliding mode method might be effective to handle the steady-state errors and the Lyapunov control algo- rithm would suppress the residual vibration.

关键词： Fuel-filled flexible spacecraft Thermalpayload Adaptive sliding mode Lyapunov approachcontrol law

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世界创意农业模式在海南省全域旅游田园综合体建构中的应用研究

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江西农业学报 2017年第11期29卷 146-150页

作者：张海东徐小俊曾小红刘晓光叶露孙继华中国热带农业科学院科技信息研究所海南海口571101

阐述了美国、法国、荷兰等国创意农业的不同发展模式,从资源、技术和市场3个角度深入分析了文化创意产业和田园综合体建构在海南创建全域旅游示范省进程中的融合路径,探讨了农产品深度开发、区域品牌组合和创意农业园3种创意农业在全域... 详细信息

阐述了美国、法国、荷兰等国创意农业的不同发展模式,从资源、技术和市场3个角度深入分析了文化创意产业和田园综合体建构在海南创建全域旅游示范省进程中的融合路径,探讨了农产品深度开发、区域品牌组合和创意农业园3种创意农业在全域旅游田园综合体建构中的应用模式,最后提出了创意农业参与田园综合体建构的原则。

关键词：创意农业田园综合体全域旅游

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Two New Multi-component BKP Hierarchies

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Communications in Theoretical Physics 2009年第2期51卷 193-199页

作者： WU Hong-Xia LIU xiao-jun zeng Yun-Bo Department of Mathematics School of Science Jimei University Xiamen China361021 Department of Mathematics China Agricultural University Beijing China100083 Department of Mathematical Sciences Tsinghua University Beijing China100084

We firstly propose two kinds of new multi-component BKP （mcBKP） hierarchy based on the eigenfunction symmetry reduction and nonstandard reduction, respectively. The first one contains two types of BKP equation with self-consistent sources whose Lax representations are presented. The two mcBKP hierarchies both admit reductions to the k-constrained BKP hierarchy and to integrable （1＋1）-dimensional hierarchy with self-consistent sources, which include two types of SK equation with self-consistent sources and of hi-directional SK equations with self-consistent

关键词： multi-component BKP hierarchy BKP equation with self-consistent sources κ-constrained BKPhierarchy n-reduction of mcBKP Lax representation

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First Principles Study of AI-Li Intermetallic Compounds

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Chinese Journal of Chemical Physics 2012年第6期25卷 659-665,I0003页

作者： Hai-li Yu xiao-hui Duan Yong-jun Ma Min zeng State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials :SouthwestUniversity of Science and Technology Mianyang 621010 China

The structural properties, heats of formation, elastic properties, and electronic structures of four compositions of binary A1-Li intermetallics, A13Li, A1Li, A12Li3, and A14Li9, are ana- lyzed in detail by using density functional theory. The calculated formation heats indicate a strong chemical interaction between A1 and Li for all the A1-Li intermetallics. In partic- ular, in the Li-rich A1-Li compounds, the thermodynamic stability of intermetallics linearly decreases with increasing concentration ***. According to the computational single crystal elastic constants, all the four A1-Li intermetallic compounds considered here are mechani- cally stable. The polycrystalline elastic modulus and Poisson＇s ratio have been deduced by using Voigt, Reuss, and Hill approximations, and the calculated ratios of bulk modulus to shear modulus indicate that the four compositions of binary A1-Li intermetallics are brittle materials. With the increase of Li concentration, the bulk modulus of A1-Li intermetallics decreases in a linear manner.

关键词： First principles A1-Li intermetallic compound Mechanical property Forma-tion heat Elastic properties

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang zeng jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Nonclasssical Properties in Two-Mode Fields Resonantly Interacting with a Three-Level -Type Atom

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Communications in Theoretical Physics 2007年第4X期48卷 721-724页

作者： SU Wan-jun zeng xiao-Meng ZHONG Zhi-Rong Department of Electronic Science and Applied Physics Fuzhou University Fuzhou 350002 China

Some noclassical properties in electromagnetic field are investigated for the interaction of two-modes initially taken in coherent-state representation with the three-level -type atom, such as squeezing properties and violation of the Cauchy-Schwartz inequality. The enhancement of field squeezing is found by selective atomic measurement. The Cauchy-Schwartz inequality is violated by the application of the classical field followed by detection in excited state.

关键词： nonclassical properties two-mode coherent states resonant interaction selective atomic measurement

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Decomposing the Radicals of Polynomial Ideals by Rational Univariate Representations

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Journal of Systems Science & Complexity 2023年第6期36卷 2703-2724页

作者： xiao Shuijing zeng Guangxing Department of Mathematics Nanchang UniversityNanchang330031China

In this paper,the notion of rational univariate representations with variables is ***,the ideals,created by given rational univariate representations with variables,are *** merit of these created ideals is that some of their algebraic properties can be easily *** the aid of the theory of valuations,some related results are *** on these results,a new approach is presented for decomposing the radical of a polynomial ideal into an intersection of prime ideals.

关键词： Polynomial ideal rational univariate representation(RUR) valuation ring Wu's method

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An overview on integrated localization and communication towards 6G

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Science China(Information Sciences) 2022年第3期65卷 5-50页

作者： Zhiqiang xiao Yong zeng National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories

While the fifth generation(5 G) cellular system is being deployed worldwide, researchers have started the investigation of the sixth generation(6 G) mobile communication networks. Although the essential requirements and key usage scenarios of 6 G are yet to be defined, it is believed that 6 G should be able to provide intelligent and ubiquitous wireless connectivity with Terabits per second(Tbps) data rate and submillisecond(sub-ms) latency over three-dimensional(3 D) network coverage. To achieve such goals, acquiring accurate location information of the mobile terminals is becoming extremely useful, not only for locationbased services but also for improving wireless communication performance in various ways such as channel estimation, beam alignment, medium access control, routing, and network optimization. On the other hand, the advancement of communication technologies also brings new opportunities to greatly improve the localization performance, as exemplified by the anticipated centimeter-level localization accuracy in 6 G by extremely large-scale multiple-input multiple-output(MIMO) and millimeter wave(mm Wave) *** this regard, a unified study on integrated localization and communication(ILAC) is necessary to unlock the full potential of wireless networks for dual purposes. While there are extensive studies on wireless localization or communications separately, the research on ILAC is still in its infancy. Therefore, this article aims to give a tutorial overview on ILAC towards 6 G wireless networks. After a holistic survey on wireless localization basics, we present the state-of-the-art results on how wireless localization and communication inter-play with each other in various network layers, together with the main architectures and techniques for localization and communication co-design in current two-dimensional(2 D) and future 3 D networks with aerial-ground integration. Finally, we outline some promising future research directions for ILAC.

关键词： wireless localization integrated localization and communication cellular networks B5G 6G

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The Invertibility of Rational Univariate Representations

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Journal of Systems Science & Complexity 2022年第6期35卷 2430-2451页

作者： xiao Shuijing zeng Guangxing Department of Mathematics Nanchang UniversityNanchang 330031China

In this paper,the so-called invertibility is introduced for rational univariate representations,and a characterization of the invertibility is *** is shown that the rational univariate representations,obtained by both Rouillier’s approach and Wu’s method,are ***,the ideal created by a given rational univariate representation is *** results on invertible rational univariate representations and created ideals are *** on these results,a new approach is presented for decomposing the radical of a zero-dimensional polynomial ideal into an intersection of maximal ideals.

关键词： Invertibility polynomial ideal rational univariate representation(RUR) Wu’s method zero-dimensional

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