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Radiofrequency ablation of hepatocellular carcinoma sized> 3 and ≤ 5 cm: Is ablative margin of more than 1 cm justified?

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World Journal of Gastroenterology 2013年第42期19卷 7389-7398页

作者： Shan Ke Xue-Mei Ding xiao-jun qian Yi-Ming Zhou Bao-Xin Cao Kun Gao Wen-Bing Sun Department of Hepatobiliary Surgery Chao-yang Hospital Affiliated to Capital Medical University Department of Radiology Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100043China Department of Interventional Medicine Chao-yang Hospital Affiliated to Capital Medical University

AIM:To investigate whether an ablative margin(AM)>1.0 cm might reduce chance of recurrence for patients with hepatocellular carcinoma(HCC)tumors 3.1to 5.0 cm in size,compared with an AM of 0.5-1.0 ***:From October 2005 to December 2012,936 consecutive patients with HCC who received radiofrequency ablation were *** these,281 patients,each with a single primary HCC tumor of 3.1 to5.0 cm in size on its greatest diameter,were included in the *** on the AM width,we categorized patients into the 0.5-1.0 cm group and the>1.0 cm *** tumor progression(LTP)-free survival,intrahepatic distant recurrence(IDR)-free survival and overall survival(OS)rates were obtained using the Kaplan-Meier ***:The 1-,2-,3-,4-,and 5-year LTP-free survival rates and IDR-free survival rates were significantly higher in the>1.0 cm group compared with the 0.5-1.0cm group(97.5%,86.3%,73.6%,49.5%and 26.4%vs 91.3%,78.4%,49.5%,27.8%,and 12.8%;95.1%,90.3%,77.0%,61.0%and 48.3%vs 95.2%,85.9%,62.6%,47.2%and 28.5%;P1.0 cm group(P=0.010).There were no significant differences in complication rates between the two *** univariate and multivariate analyses identified AM as an independent prognostic factor linked to LTP,IDR,and ***:For HCC tumors>3.0 cm and≤5.0cm,AM>1.0 cm could reduce chances of recurrence compared with AM of 0.5-1.0 cm,emphasizing the need for a more defensive strategy using AMs>1.0 cm for ablating HCC tumors of 3.1 to 5.0 cm.

关键词： Hepatocellular carcinoma Radiofrequency ablation Ablative margin Recurrence Survival

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Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm

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World Journal of Gastroenterology 2013年第39期19卷 6618-6624页

作者： jun Gao Xue-Mei Ding Shan Ke Yi-Ming Zhou xiao-jun qian Rui-Liang Ma Chun-Min Ning Zong-Hai Xin Wen-Bing Sun Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University Department of Radiology Beijing Chaoyang Hospital Affiliated to Capital Medical University Department of General Surgery 254 Hospital of PLA Department of General Surgery Chaoyang Central Hospital Department of General Surgery Zhanhua People’s Hospital

AIM:To investigate the rate of spontaneous passage of single and symptomatic common bile duct(CBD)stones≤10 mm in diameter in 4 wk with or without a2-wk course of ***:A multicenter,randomized,placebocontrolled trial was undertaken.A total of 197 patients who met the inclusion criteria were *** patients were assigned randomly to the control group and the other 100 to the anisodamine *** anisodamine group received intravenous infusions of anisodamine(10 mg every 8 h)for 2 *** control group received the same volume of 0.9%isotonic saline for 2 *** underwent imaging studies and liver-function tests every week for 4 *** rate of spontaneous passage of CBD stones was ***:The rate of spontaneous passage of CBD stones was significantly higher in the anisodamine group than that in the control group(47.0%vs 22.7%).Most(87.2%,41/47)stone passages in the anisodamine group occurred in the first 2 wk,and passages in the control group occurred at a comparable rate each *** significantly increasing the possibility of spontaneous passage by univariate logistic regression analyses were stone diameter(<5 mm vs≥5 mm and≤10 mm)and anisodamine *** logistic regression analyses revealed that these two factors were significantly associated with spontaneous ***:Two weeks of anisodamine administration can safely accelerate spontaneous passage of single and symptomatic CBD stones≤10 mm in diameter,especially for stones<5 mm.

关键词： Common bile duct stones Anisodamine Spontaneous passage Success rate Randomized controlled trial

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Treatment of malignant biliary obstruction by combined percutaneous transhepatic biliary drainage with local tumor treatment

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World Journal of Gastroenterology 2006年第2期12卷 331-335页

作者： xiao-jun qian Ren-You Zhai Ding-Ke Dai Ping Yu Li Gao Department of Interventional Radiology Beijing Chaoyang HospitalCapital University of Medical Sciences Beijing 100020 China Department of Radiotherapy Cancer Institute & Cancer Hospital Chinese Academy of Medical sciences Peking Union Medical College Beijing 100020 China

AIM： To evaluate the utility of local tumor therapy combined with percutaneous transhepatic bilian/drainage （PTBD） for malignant obstructive bilian/disease. METHODS： A total of 233 patients with malignant billan/obstruction were treated in our hospital with PTBD by placement of metallic stents and/or plastic tubes. After PTBD, 49 patients accepted brachytherapy or extraradiation therapy or arterial infusion chemotherapy. The patients were followed up with clinical and radiographic evaluation. The survival and stent patency rate were calculated by Kaplan-Meier survival analysis. RESULTS： Twenty-two patients underwent chemotherapy （11 cases of hepatic carcinoma, 7 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）, and 14 patients received radiotherapy （10 cases of cholangiocardnoma, 4 cases of pancreatic carcinoma）, and 13 patients accepted brachytherapy （7 cases of cholangiocarcinoma, 3 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）. The survival rate of the local tumor treatment group at 1, 3, 6, and 12 months was 97.96%, 95.92%, 89.80%, and 32.59% respectively, longer than that of the non treatment group. The patency rate at 1, 3, 6, and 12 months was 97.96%, 93.86%, 80.93%, and 56.52% respectively. The difference of patency rate was not significant between treatment group and non treatment group. CONCLUSION： Our results suggest that local tumor therapy could prolong the survival time of patients with malignant biliary obstruction, and may improve stent patency.

关键词： Obstructive jaundice PTBD Stent Chemotherapy Radiotherapy Brachytherapy

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网络的决策驱动报告模型探究

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制造业自动化 2010年第12期32卷 187-189页

作者：张加乐南京工业职业技术学院南京210046

21世纪是网络经济时代。网络经济的出现与深入发展给企业的生产、经营、管理、组织、服务等带来全面的挑战,它不仅改变了社会的经济环境和生产方式、企业的经营和管理方式、人们的思维方式和生活方式,而且影响着整个社会经济的发展。基... 详细信息

21世纪是网络经济时代。网络经济的出现与深入发展给企业的生产、经营、管理、组织、服务等带来全面的挑战,它不仅改变了社会的经济环境和生产方式、企业的经营和管理方式、人们的思维方式和生活方式,而且影响着整个社会经济的发展。基于传统工业经济下的会计理论己远远不能满足网络经济环境下的现代企业管理方式的需要。网络经济下会计的目标应不仅仅局限于满足外部信息使用者财务信息的需求,还应考虑满足用户广泛的非财务信息需求,并直接参与企业的数据分析、预测、计划、管理决策和控制。因此建立经济事项原始数据库,开发不同决策模型,财务报告目标是财务报告理论框架的核心,随着经济的发展和科学技术进步,财务报告目标经历了从"受托责任观"到"决策有用观"的转变由信息使用者按决策有用性原则,实时获得信息并根据信息使用者需要提供决策模型,是网络经济时代财务报告的新趋势,本文提出了"决策驱动"报告模式,并进行探讨。

关键词：网络经济决策模型决策驱动

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Fisl phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

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Signal Transduction and Targeted Therapy 2022年第1期7卷 200-214页

作者： Yan Yu xiao-Dan Peng xiao-jun qian Kai-Ming Zhang Xiang Huang Yu-Hong Chen Yun-Tian Li Gong-Kan Feng Hai-Liang Zhang Xue-Lian Xu Shun Li Xuan Li Jia Mai Zhi-Ling Li Yun Huangj Dong Yang Li-Huan Zhou Zhuo-Yan Zhong jun-Dong Li Rong Deng xiao-Feng Zhu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-Sen University Cancer CenterGuangzhou 510060China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001P.R.China Department of Medical Bioinformatics Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China fe First Affiliated Hospital of Xinxiang Medical College WeihuiHenan 453100China Department of Gynecological Oncology Sun Yat-Sen University Cancer CenterGuangzhou 510060China

Met tyrosine kinase,a receptor for a hepatocyte growth factor(HGF),plays a critical role in tumor growth,metastasis,and drug *** are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial *** mitochondrial dynamics are responsible for the progression and metastasis of many ***,using structured illumination microscopy(SIM)and high spatial and temporal resolution live cell imaging,we identified mitochondrial trafficking of receptor tyrosine kinase *** ton tacts betwee n activated Met kinase and mitochondria formed dramatically,and an intact HGF/Met axis was necessary for dysregulated mitochondrial fission and cancer cell ***,we found that Met directly phosphorylated outer mitochondrial membrane protein Fis1 at Tyr38(Fisl pY38).Fisl pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein・1(Drp1)to *** mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma(HCC)cells both in vitro and in *** findings reveal a novel and noncanonical pathway of Met receptor tyrosine kinase in the regulation of mitochondrial activities,which may provide a therapeutic target for metastatic HCC.

关键词： metastasis hepatocellular illumination

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煤矿企业供配电线路电气火灾监控系统

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煤炭技术 2013年第3期32卷 65-67页

作者：黄戎肖前军重庆工业职业技术学院自动化系重庆401120

针对煤矿企业电气火灾的特点,提出了一种利用计算机网络技术和智能控制技术的分布式主从测控系统,来提供对供配电线路的温度、电流、电压和漏电流信号进行自动检测。设计了一种基于RS485总线,以STM32单片机为控制器的电气火灾监控系统,... 详细信息

针对煤矿企业电气火灾的特点,提出了一种利用计算机网络技术和智能控制技术的分布式主从测控系统,来提供对供配电线路的温度、电流、电压和漏电流信号进行自动检测。设计了一种基于RS485总线,以STM32单片机为控制器的电气火灾监控系统,阐述了该系统的组成和软硬件设计。

关键词：煤矿企业电气火灾监控漏电流电流

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Feedback loops blockade potentiates antitumor activity of a novel AKT1 inhibitor DC120 in human liver cancer cells and nude mice xenografts

Feedback loops blockade potentiates antitumor activity of a ...

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2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

作者： Fen Yang Rong Deng Shao-Hua Chang xiao-jun qian xiao-Qi Wu Juan Qin Ting Sun Gong-Kan Feng Ke Ding xiao-Feng Zhu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical University Key Laboratory of Regenerative Biology and Institute of Chemical Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Graduate School Chinese Academy of Sciences

The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic ***,relief of feedback inhibition and enhancement of other survival pathways often attenuate anticancer effects of AKT *** this study,we found a novel 2-pyrimidyl-5-amidothiazole compound,DC120,as an ATP competitive AKT1 kinase inhibitor, suppressed proliferation and induced apoptosis in liver cancer both in vitro and in *** 120 also blocked phosphorylation of downstream molecules in the AKT signal pathway,such as

关键词： mTOR complexes MAPK pathway PI3K/AKT pathway AKT inhibitor Apoptosis

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水杨酸浸种对干旱胁迫下玉米种子萌发及幼苗生长的影响

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福建农业学报 2017年第6期32卷 583-586页

作者：肖小君黄倩罗陈勇王芳内江师范学院生命科学学院四川内江641100 四川省高等学校特色农业资源研究与利用重点实验室四川内江641100

采用10%PEG-6000模拟干旱胁迫,研究不同浓度(0、0.001、0.01、0.05、0.1、1.0和2.0mmol·L^(-1))的水杨酸浸种对干旱胁迫下玉米种子萌发及幼苗生长的影响。结果表明:与对照相比,10%PEG胁迫对玉米种子萌发及幼苗生长有明显的抑制作用,使... 详细信息

采用10%PEG-6000模拟干旱胁迫,研究不同浓度(0、0.001、0.01、0.05、0.1、1.0和2.0mmol·L^(-1))的水杨酸浸种对干旱胁迫下玉米种子萌发及幼苗生长的影响。结果表明:与对照相比,10%PEG胁迫对玉米种子萌发及幼苗生长有明显的抑制作用,使可溶性蛋白质含量明显降低,MDA含量升高,POD、CAT和SOD活性降低。适宜浓度水杨酸浸种对玉米种子萌发及幼苗生长有明显的促进作用,可溶性蛋白质含量增加,MDA含量降低,POD、CAT和SOD活性增强,其中以浓度为0.01~0.05mmol·L^(-1)效果最好。

关键词：水杨酸玉米种子干旱胁迫生理指标

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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Modeling the cholestenone 5alpha-reductase and characterization of potential active sites

Modeling the cholestenone 5alpha-reductase and characterizat...

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中国化学会第五届全国结构化学学术会议

作者： Ou Min-Rui Xu xiao-Ping Li jun-qian Department of Chembiology and Pharmaceuticas,Fuzhou University,Fuzhou,Fujian 350002,China

＜正＞cholestenone 5alpha-reductase of Human,encoded in the gene SRD5A,is an important key enzyme in the biosynthetic pathway from T to *** catalyzes the reduction of testosterone in position 4 and 5 using NADPH as a hydrogen *** to now,no X-ray structure of this cholestenone 5alpha-reductase or any structurally related enzyme is *** of the tertiary structure and possible active sites is,however,essential for understanding the catalysis mechanism and the substrate *** homology modeling techniques,secondary structure prediction tools,molecular dynamics simulations,and energy optimizations,a model with two putative active sites could be created and *** active site selected to be the most likely one for the docking of T and DHT is located near the N-terminus of the *** is widely accepted that residues forming an active site are usually evolutionary conserved within a family of enzymes. Multiple alignments of a multitude of related proteins clearly showed 100% conservation of the amino acid residues that form the first putative active site and therefore strongly support this ***,an additional highly conserved region in the amino acid sequence of the enzyme could be detected,which also can be considered a putative（or rudimentary）active site. This site is characterized by a high sequence similarity to the aforementioned site and may give some hints regarding the evolutionary origin of the *** quantum mechanical PM3 calculations have been performed to investigate the thermodynamics and kinetics of the catalysis *** models are a basis for developing inhibitors of this enzyme,which is crucial for the cure of BPH.

关键词： 5alpha-reductase Reduction Homology modeling Biocatalysis mechanism

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