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Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

Zoological Research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia Guang-Hui Chen Ting-Ting Shu Qi-Yong Lou Xia Jin Jiang-Yan He Wu-Han xiao Gang Zhai zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

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Event-based nonfragile state estimation for memristive recurrent neural networks with stochastic cyber-attacks and sensor saturations

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Chinese Physics B 2024年第7期33卷 126-135页

作者：邵晓光张捷鲁延娟 School of Automation Nanjing University of Science and TechnologyNanjing 210094China School of Electronics and Information Engineering Changchun University of Science and TechnologyChangchun 130022China

This paper addresses the issue of nonfragile state estimation for memristive recurrent neural networks with proportional delay and sensor saturations. In practical engineering, numerous unnecessary signals are transmitted to the estimator through the networks, which increases the burden of communication bandwidth. A dynamic event-triggered mechanism,instead of a static event-triggered mechanism, is employed to select useful data. By constructing a meaningful Lyapunov–Krasovskii functional, a delay-dependent criterion is derived in terms of linear matrix inequalities for ensuring the global asymptotic stability of the augmented system. In the end, two numerical simulations are employed to illustrate the feasibility and validity of the proposed theoretical results.

关键词： memristor-based neural networks proportional delays dynamic event-triggered mechanism sensor saturations

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Is recovery enhancement after gastric cancer surgery really a safe approach for elderly patients?

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1334-1343页

作者： Zi-Wei Li xiao-juan Luo Fei Liu Xu-Rui Liu Xin-Peng Shu Yue Tong Quan Lv xiao-Yu Liu Wei zhang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Endoscopy Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400012China

BACKGROUND This study aimed to evaluate the safety of enhanced recovery after surgery(ERAS)in elderly patients with gastric cancer(GC).AIM To evaluate the safety of ERAS in elderly patients with *** The PubMed,EMBASE,and Cochrane Library databases were used to search for eligible studies from inception to April 1,*** mean difference(MD),odds ratio(OR)and 95%confidence interval(95%CI)were pooled for *** quality of the included studies was evaluated using the Newcastle-Ottawa Scale *** used Stata(V.16.0)software for data *** This study consists of six studies involving 878 elderly *** analyzing the clinical outcomes,we found that the ERAS group had shorter postoperative hospital stays(MD=-0.51,I2=0.00%,95%CI=-0.72 to-0.30,P=0.00);earlier times to first flatus(defecation;MD=-0.30,I²=0.00%,95%CI=-0.55 to-0.06,P=0.02);less intestinal obstruction(OR=3.24,I2=0.00%,95%CI=1.07 to 9.78,P=0.04);less nausea and vomiting(OR=4.07,I2=0.00%,95%CI=1.29 to 12.84,P=0.02);and less gastric retention(OR=5.69,I2=2.46%,95%CI=2.00 to 16.20,P=0.00).Our results showed that the conventional group had a greater mortality rate than the ERAS group(OR=0.24,I2=0.00%,95%CI=0.07 to 0.84,P=0.03).However,there was no statistically significant difference in major complications between the ERAS group and the conventional group(OR=0.67,I2=0.00%,95%CI=0.38 to 1.18,P=0.16).CONCLUSION Compared to those with conventional recovery,elderly GC patients who received the ERAS protocol after surgery had a lower risk of mortality.

关键词： Enhanced recovery after surgery Gastric cancer Elderly Mortality

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Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

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Rare Metals 2024年第8期43卷 3876-3892页

作者： Fei Chai Fei-Ping Zhao zhan Hu Shi-Yi Wen Ben-Hammouda Samia Ze-Lin Fu Xin-Ting Lai Yan-Jie Liang xiao-Bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

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Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis:A case report

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World Journal of Radiology 2024年第6期16卷 232-240页

作者： zhan-Rong zhang Feng Chen Hui-juan Chen Department of Radiology The Affiliated Hainan Hospital of Hainan Medical University(Hainan General Hospital)Haikou 570311Hainan ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is characterized by diabetes insipidus and is an uncommon *** biopsies still have a certain degree of diagnostic *** present a case in which LCH initially affected the pituitary *** resulted in a misdiagnosis of chronic inflammation upon pathological *** SUMMARY A 25-year-old female exhibited symptoms of diabetes *** resonance imaging revealed an enhanced foci in the pituitary *** surgical resection of the pituitary lesion,the pathological diagnosis was chronic ***,the patient later experienced bone destruction in the skull and lower limb *** the lower limb bone lesion was compared with the initial pituitary lesion,the final diagnosis was modified to *** patient was treated with multiple chemotherapy ***,the patient’s condition gradually worsened,and she eventually passed away at *** LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

关键词： Langerhans cell histiocytosis Pituitary gland Diabetes insipidus Multi-system Misdiagnosis Magnetic resonance imaging Case report

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Endoscopic-ultrasound-guided biliary drainage with placement of electrocautery-enhanced lumen-apposing metal stent for palliation of malignant biliary obstruction:Updated meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 907-920页

作者： Zu-Xiang Peng Fang-Fang Chen Wen Tang Xu Zeng Hong-juan Du Ru-Xian Pi Hong-Ming Liu xiao-xiao Lu Department of Hepatobiliary Surgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Oncology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Gastroenterology and Hepatobiliary Surgery People’s Hospital of Fenggang CountyGuizhou 564200Guizhou ProvinceChina Hepatobiliary and Pancreatic Tumor Center Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Endoscopic ultrasound-guided biliary drainage using electrocautery-enhanced(ECE)delivery of lumen-apposing metal stent(LAMS)is gradually being re-cognized as a viable palliative technique for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography(ERCP)***,most of the studies that have assessed its efficacy and safety were small and *** meta-analyses of six or fewer studies that were published 2 years ago were therefore underpowered to yield convincing *** To update the efficacy and safety of ECE-LAMS for treatment of biliary ob-struction after ERCP *** We searched PubMed,EMBASE,and Scopus databases from the inception of the ECE technique to May 13,*** outcome measure was pooled technical success rate,and secondary outcomes were pooled rates of clinical success,re-intervention,and adverse ***-analysis was performed using a random-effects model following Freeman-Tukey double-arcsine transformation in R soft-ware(version 4.1.3).RESULTS Fourteen eligible studies involving 620 participants were ultimately *** pooled rate of technical success was 96.7%,and clinical success was 91.0%.Adverse events were reported in 17.5%of *** reinter-vention rate was 7.3%.Subgroup analyses showed results were generally *** ECE-LAMS has favorable success with acceptable adverse events in relieving biliary obstruction when ERCP is *** consistency of results across most subgroups suggested that this is a generalizable approach.

关键词： Biliary obstruction Biliary drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography failure

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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo xiao Yuqi Liang Ga Liu Lingshuang Wang zhan zhang Libin Qiu Haiting Xu Sean Carr xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

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Evaluation of physicochemical and functional properties of protein isolates from 5 edible mushroom species

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Food Science and Human Wellness 2024年

作者： Zheng Qian Mengdie Yang xiao Chen Qiping zhan Lei Zhong Qiuhui Hu Liyan Zhao Key Laboratory of Edible Mushroom Processing， Ministry of Agriculture and Rural Affairs， College of Food Science and Technology， Nanjing Agricultural University College of Food Science and Engineering， Nanjing University of Finance and Economics

Edible mushroom proteins are the promising ones with the advantages of complete essential amino acid profile and multiple functional activities. To reinforce their applications in functional food development， this study comprehensively evaluated the physicochemical and functional properties of protein isolates from 5 mushroom species， i.e.， Pleurotus eryngii (PEP)， Pleurotus ostreatus (POP)， Lentinula edodes (LEP)， Flammulina velutipes (FVP) and Hypsizygus marmoreus (HMP). Results showed that PEP， LEP， FVP， POP and HMP exhibited better protein solubility (PS)， water holding capacity (WHC)， emulsifying capacity (EAI)， and foaming capacity (FC) than those of soybean protein and pea protein isolates. PEP (51.95%) and POP (49.15%) had a higher amount of β-sheet structure. Principal component analysis and correlation analysis showed that the seven proteins could be divided into 3 clusters， and WHC， EAI and FC were significantly positively correlated with PS and β-sheet. The least gelation concentration of PEP (16%) and FVP (16%) at pH 6.0 and 7.0 was similar to PPI， and PEP showed better hardness， springiness and rheological properties than other proteins gels. Overall， our study showed that 5 edible mushroom proteins possessed excellent functionalities (except for gelling capacity)， which provided novel insights on unexploited sources of mushroom proteins used as protein-based foods in the food industry.

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Prediction of Pediatric Sepsis Using a Deep Encoding Network with Cross Features

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 131-140页

作者：陈潇张瑞汤心溢钱娟 University of Chinese Academy of Sciences Beijing 100084China Shanghai Institute of Technical Physics of the Chinese Academy of Sciences Key Laboratory of Infrared Detection and Imaging TechnologyShanghai 200083China Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China

Sepsis poses a serious threat to health of children in pediatric intensive care *** mortality from pediatric sepsis can be effectively reduced through in-time diagnosis and therapeutic *** bacilliculture detection method is too time-consuming to receive timely *** this research,we propose a new framework:a deep encoding network with cross features(CF-DEN)that enables accurate early detection of *** features are automatically constructed via the gradient boosting decision tree and distilled into the deep encoding network(DEN)we *** DEN is aimed at learning sufficiently effective representation from clinical test *** layer of the DEN fltrates the features involved in computation at current layer via attention mechanism and outputs the current prediction which is additive layer by layer to obtain the embedding feature at last *** framework takes the advantage of tree-based method and neural network method to extract effective representation from small clinical dataset and obtain accurate prediction in order to prompt patient to get timely *** evaluate the performance of the framework on the dataset collected from Shanghai Children's Medical *** with common machine learning methods,our method achieves the increase on F1-score by 16.06%on the test set.

关键词： pediatric sepsis gradient boosting decision tree cross feature neural network deep encoding network with cross features(CF-DEN)

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Early postoperative complications after transverse colostomy closure,a retrospective study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 807-815页

作者： Fei Liu xiao-juan Luo Zi-Wei Li xiao-Yu Liu Xu-Rui Liu Quan Lv Xin-Peng Shu Wei zhang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Endoscopy Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400012China

BACKGROUND Ostomy is a common surgery usually performed to protect patients from clinical symptoms caused by distal anastomotic leakage after colorectal cancer(CRC)surgery and perforation or to relieve intestinal *** To analyze the complications after transverse colostomy *** Patients who underwent transverse colostomy closure from Jan 2015 to Jan 2022 were retrospectively enrolled in a single clinical *** differences between the complication group and the no complication group were *** regression analyses were conducted to find independent factors for overall complications or incision *** A total of 102 patients who underwent transverse colostomy closure were enrolled in the current ***(68.6%)patients underwent transverse colostomy because of CRC related *** complications occurred in 30(29.4%)patients and the most frequent complication occurring after transverse colostomy closure was incision infection(46.7%).The complication group had longer hospital stays(P<0.01).However,no potential risk factors were identified for overall complications and incision *** The most frequent complication occurring after transverse colostomy closure surgery in our center was incision *** operation time,interval from transverse colostomy to reversal,and method of anastomosis might have no impact on the postoperative *** should pay more attention to aseptic techniques.

关键词： Transverse colostomy closure Surgery Complications A single clinical centre Risk factors

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