检索结果-南通市图书馆

Identification of differential gene expressions in colorectal cancer and polyp by cDNA microarray

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第6期18卷 570-575页

作者： Yi-Chen Dai xiao-San Zhu Qing-Zhen Nan zhang-Xin Chen Jun-Pei Xie Yu-Ka Fu Yuan-Yuan Lin Qing-Na Lian Qiao-Fang Sang xiao-juan zhan Department of Gastroenterology Chenggong HospitalXiamen UniversityXiamen 361003Fujian ProvinceChina Department of Gastroenterology The 174th Hospital of the Chinese PLAWenyuan RoadXiamen 361003Fujian ProvinceChina Department of Gastroenterology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

AIM： TO screen the differential expressed genes in colorectal cancer and polyp tissue samples. METHODS： Tissue specimens containing 16 cases of colorectal adenocarcinoma and colorectal polyp vs nor- mal mucosae were collected and subjected to cDNA microarray and bioinformatical analyses. Quantitative reverse transcription-polymerase chain reaction （qRT- PCR） was used to confirm some of the cDNA microarray ***： The experimental data showed that eight genes were differentially expressed, most of which were upregulated in adenomatous polyp lesions. Forty-six genes expressions were altered in colorectal cancers, of which 29 were upregulated and 17 downregulated, as compared to the normal mucosae. In addition, 18 genes were similarly altered in both adenomatous polyps and colorectal cancer, qRT-PCR analyses confirmed the cDNA microarray data for four of those 18 genes： MTA1, PDCD4, TSC1 and PDGFRA. CONCLUSION： These differentially expressed genes likely represent biomarkers for early detection of co- Iorectal cancer and may be potential therapeutic targets after confirmed by further studies.

关键词： Colorectal polyp Colorectal cancer cDNA mi-croarray Quantitative reverse transcription-polymerasechain reaction

Creep-Resistant Covalent Adaptable Networks with Excellent SelfHealing and Reprocessing Performance via Phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie xiao-Rong Wang zhan-Hua Wang He-Sheng Xia State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adaptive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTIR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABP/PDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adaptive networks Self-healing polymer Dynamic covalent bond

维普期刊数据库

A comprehensive survey of federated transfer learning: challenges, methods and applications

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第6期18卷 186356-186356页

作者： GUO Wei ZHUANG Fuzhen zhan xiao TONG Yiqi DONG Jin Institute of Artificial Intelligence Beihang University SKLSDE School of Computer Science Beihang University School of Computer Science and Technology Shandong University Beijing Academy of Blockchain and Edge Computing

Federated learning (FL) is a novel distributed machine learning paradigm that enables participants to collaboratively train a centralized model with privacy preservation by eliminating the requirement of data sharing. In practice, FL often involves multiple participants and requires the third party to aggregate global information to guide the update of the target participant. Therefore, many FL methods do not work well due to the training and test data of each participant may not be sampled from the same feature space and the same underlying distribution. Meanwhile, the differences in their local devices (system heterogeneity), the continuous influx of online data (incremental data), and labeled data scarcity may further influence the performance of these methods. To solve this problem, federated transfer learning (FTL), which integrates transfer learning (TL) into FL, has attracted the attention of numerous researchers. However, since FL enables a continuous share of knowledge among participants with each communication round while not allowing local data to be accessed by other participants, FTL faces many unique challenges that are not present in TL. In this survey, we focus on categorizing and reviewing the current progress on federated transfer learning, and outlining corresponding solutions and applications. Furthermore, the common setting of FTL scenarios, available datasets, and significant related research are summarized in this survey.

关键词： federated transfer learning federated learning transfer learning survey

New clinical trial design in precision medicine:discovery,development and direction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： xiao-Peng Duan Bao-Dong Qin xiao-Dong Jiao Ke Liu zhan Wang Yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive

Practical effect of different teaching modes in teaching gastrointestinal surgery nursing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第1期16卷 166-172页

作者： xiao-juan Rong Zhen Ning Department of Nursing Medical College in Jiangxi University of TechnologyNanchang 330098Jiangxi ProvinceChina

BACKGROUND With the continuous development and progress of medical technology,the position of surgical nursing in the field of clinical medicine is becoming in-creasingly *** an important branch of the surgical field,the nursing requirements and difficulty of gastrointestinal surgery are also *** order to improve the teaching quality of nursing care in gastrointestinal surgery,many educators and researchers are actively exploring new teaching *** them,the teaching method case-based learning(CBL),scene-simulated learning(SSL),task-based learning(TBL),combining self-evaluation and training mode is considered as an effective *** method aims to help students to better master knowledge and skills and improve their comprehensive quality by cultivating their self-evaluation *** To explore the practical effect of CBL-SSL-TBL combined with training mode and student self-assessment in nursing teaching of gastrointestinal *** Seventy-one nursing interns in our hospital from December 2020 to December 2021 were *** to different teaching modes,they were divided into observation group CBL-SSL-TBL combined with training mode combined with student self-assessment and control group(conventional teaching mode),of which 36 were in observation group and 35 were in control *** results of operational skills,theoretical knowledge,nursing students'satisfaction,learning effectiveness questionnaire and teaching effect were compared between the two *** Compared between the two groups,the operational skills and theoretical knowledge scores of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).Compared between the two groups,the total satisfaction ratio of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Compared between the two groups,the observation group was lower tha

关键词： Gastrointestinal surgery Nursing teaching Teaching model Practical effect Learning ability

Structural insights, synthesis, and electrocatalysis of high entropy nanoparticles for fuel cell, metal-air battery, and water-splitting applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2024年第3期34卷 512-523页

作者： Xin Tong Hao Ye Yunrou Wu Xinxing zhan Manqi Gu Shixia Luo Jiangning Gong juan Tiana Yadian Xie School of Chemistry and Material Science Guizhou Normal University Center for the Physics of Low-Dimensional Materials School of Physics and Electronics School of Future Technology Henan University Key Laboratory of Low-Dimensional Materials and Big Data Guizhou Minzu University

High-entropy alloy nanoparticles(HEA-NPs) have recently sparked great interest in materials science. Their solidsolution states, derived from distinct HEA configurations, make them promising candidates for catalysts with exceptional activity, stability, and tunable performance. However, a comprehensive understanding of the underlying mechanisms governing their electrocatalytic behavior is still lacking, hindering the rational design of HEA electrocatalysts. This review summarizes the fundamental knowledge of HEA-NPs, including the structureactivity correlations of HEA-NPs, diverse synthesis strategies, and applications in electrochemical catalysis. The design strategies for guiding improvements in tunable performance were highlighted. The article concludes with insights, perspectives, and future directions, encapsulating the state-of-the-art knowledge and paving the way for further exploration in this dynamic field.

关键词： Electrochemical catalysis High-entropy alloy nanoparticles Structure-activity correlations Synthesis strategies

A New Species of the Genus Boulenophrys(Anura,Megophryidae)from Eastern Guangdong,China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Herpetological Research 2024年第1期15卷 12-21页

作者： Zhaochi ZENG Jian WANG Honghui CHEN Weiwen xiao Binbin zhan Yuanhang LI Shishi LIN Guangdong Polytechnic of Environmental Protection Engineering Foshan 528216GuangdongChina

A new horned toad species,Boulenophrys elongata ***.,is described from ***,Huidong County,eastern Guangdong,*** new species is phylogenetically closest to ***,which is restricted to the east of the Pearl River Estuary(i.e.,Shenzhen City and Hong Kong SAR).The new species can be distinguished from all recognized congeners by a combination of morphological characters and genetic divergences in the combined mitochondrial 16S,12S and CO1 *** recommend the new species be listed as Data Deficient(DD)in the IUCN categorization,pending further investigation.

关键词： Boulenophrys elongata sp.nov. Lianhua Mountains molecular phylogeny morphology taxonomy

维普期刊数据库

Temperature/electric field induced photoluminescence-modulation effect in dysprosium-doped barium titanate ferroelectric ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2024年第5期10卷 1117-1125页

作者： Lei Xia xiao Liu zhan Mao Yanbin Cai Jing Zhu Jiyang Xie Wanbiao Hu Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming650091China Electron Microscopy Center Yunnan UniversityKunming650091China University of Science and Technology of China Hefei230026China

Lanthanide(Ln^(3+))based ferroelectric phosphors,with an integration of PL emission and ferroelectric effect,are unveiling an exciting realm of possibilities for multifunctional ferroelectric-optic ***,how the ferroelectric host enables the tuning on the PL emissions through modulating the local structure(e.g.,lattice site,symmetry,strains etc.)of the Ln^(3+)activator is not established *** this work,a luminescent-ferroelectric material,***^(3+)doped BaTiO_(3) ceramic(Ba_(1–x)Dy_(x)TiO_(3)(x=0–0.07),abbr:BTO:Dy^(3+)),was explored to address the aforementioned *** BTO:Dy^(3+)ceramics were synthesized by a solid-state reaction *** crystal structure,photoluminescence(PL)and electric properties(dielectric constant,ferroelectric hysteresis and piezoelectric hysteresis loop)were systematically *** BTO:Dy^(3+)ceramics show two predominant emission peaks,corresponding to the blue magnetic dipole transition(477 nm,4F_(7/2)→6H_(15/2))and yellow electric dipole transition(573 nm,4F_(7/2)→6H_(13/2)),the intensity ration of which can be modulated by the ferroelectric polarization that causes the slight lattice *** a polarization-emission modulation combining with the Dy3+doping could accelerate the color change,from yellow to blue,which is characterized to detect the phase transition,with a method and mechanism were proposed,that is,the phase change is reflected by the PL characteristic peak intensity ***,the current results offer a convenient photoluminescence method for detecting the ferroelectric phase transition and a feasible approach to study the interaction between the photoluminescence and polarization in ferroelectric materials,for providing new insights for the development of multifunctional materials.

关键词： Photoluminescence Barium titanate Modulation Ferroelectric ceramics

Introducing electrolytic electrochemical polymerization for constructing protective layers on Ni-rich cathodes of Li-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2536-2545页

作者： Lin-Tao Dou Bei Li Hao-Long Nie Dong-Dong xiao Chao-Qun Shang xiao-Min Wang zhan-Hui zhang Katerina E.Aifantis Pu Hu School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205China Huairou Division Institute of PhysicsChinese Academy of SciencesBeijing 101400China Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32603USA

LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)is the most promising cathode for high-energy Li-ion batteries,despite its poor cycling stability that originates from the reactions that occur with the ***,to solve this interfacial issue,a facile electrolytic electrochemical polymerization process was introduced in this paper,and a uniform conductive electrolyte interface(polyaniline)was successfully constructed on the surface of the NCM811 porous electrode(PANI-NCM),which facilitated the charge transfer during charge/*** side reactions at the interface between the cathode and the electrolyte are suppressed,and thereby,the cycling performance and rate capability are considerably ***-NCM delivers an initial capacity of 157.2 mAh·g^(-1)as well as excellent cyclability(capacity retention of 88%after 500 cycles at 2C),whereas the capacity of the bare NCM811 has dropped to 31.3 mAh·g^(-1).In addition,polypyrrole and polythiophene also can be formed through electrolytic electrochemical polymerization process,which provides a practicable tactic to modify the interfacial stability of cathodes for high-energy Li-ion batteries.

关键词： Lithium-ion battery Ni-rich cathode In-situ polymerization Conductive polymer Electrochemical performance

维普期刊数据库