检索结果-南通市图书馆

维普期刊数据库

Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation,invasion,and migration of gastric cancer cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 991-1005页

作者： jing-Wen Zhang Ling-Yan Huang Ya-Ning Li Ying Tian Jia Yu xiao-Fei wang School of Basic Medical Science NHC Key Laboratory of Metabolic Cardiovascular Diseases ResearchNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChin

BACKGROUND The precise role of mitochondrial carrier homolog 2(MTCH2)in promoting malignancy in gastric mucosal cells and its involvement in gastric cancer cell metastasis have not been fully *** To determine the role of MTCH2 in gastric *** We collected 65 samples of poorly differentiated gastric cancer tissue and adjacent tissues,constructed MTCH2-overexpressing and MTCH2-knockdown cell models,and evaluated the proliferation,migration,and invasion of human gastric epithelial cells(GES-1)and human gastric cancer cells(AGS)*** mito-chondrial membrane potential(MMP),mitochondrial permeability transformation pore(mPTP)and ATP fluorescence probe were used to detect mitochondrial *** function and ATP synthase protein levels were detected via Western *** The expression of MTCH2 and ATP2A2 in gastric cancer tissues was significantly greater than that in adjacent *** of MTCH2 promoted colony formation,invasion,migration,MMP expression and ATP production in GES-1 and AGS cells while upregulating ATP2A2 expression and inhibiting cell apoptosis;knockdown of MTCH2 had the opposite effect,promoting overactivation of the mPTP and promoting *** MTCH2 can increase the malignant phenotype of GES-1 cells and promote the proliferation,invasion,and migration of gastric cancer cells by regulating mitochondrial function,providing a basis for targeted therapy for gastric cancer cells.

关键词： Gastric cancer Mitochondrial carrier homolog 2 ATP synthase ATP2A2 Mitochondrial permeability transformation pore

Exhaust hood performance and its improvement technologies in industrial buildings:A literatu rereview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第1期17卷 23-40页

作者： jing Zhang Jian wang Jun Gao Weimin Zhang Architectural Engineering Institute Jinhua PolytechnicJinhua 321017China Institute of HVAC Engineering Schoolof Mechanical EngineeringTongji UniversityShanghai 200092China Tongji Architectural Design(Group)Co .LtdShanghai 200092China

The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial *** better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement *** create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental *** to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood *** most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio *** use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust *** more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.

关键词： industrial ventilation exhaust hood capture efficiency exhaust rate performance improvement

Energy modeling and optimization of building condenser water systems with all-variable speed pumps and tower fans:A case study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第7期17卷 1085-1111页

作者： Yong Cao Chuang wang Sheng wang xiao Fu Xinguo Ming School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Air-Conditioning Equipment and System Energy Conservation Zhuhai 519070China GREE Electric Appliances Inc.of ZhuhaiZhuhai 519070China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Beijing Advanced Innovation Centerfor Future Urban Design Beijing University of Civil Engineering and ArchitectureBeijing 100044China

The emergence of building condenser water systems with all-variable speed pumps and tower fans allows for increased efficiency and flexibility of chiller plants in partial load operation but also increases the control complexity of condenser water *** study aims to develop an integrated modeling technique for evaluating and optimizing the energy performance of such a condenser water *** proposed system model is based on the semi-physical semi-empirical chiller,pump,and cooling tower models,with capabilities of fully considering the hydraulic and thermal interactions in the condenser water loop,being solved analytically and much faster than iterative solvers and supporting the explicit optimization of the pump and tower fan frequency.A mathematical approach,based on the system model and constrained optimization technique,is subsequently established to evaluate the energy performance of a typical dual setpoint-based variable speed strategy and find its energy-saving potential and most efficient operation by jointly optimizing pumps and tower *** all-variable speed chiller plant from Wuhan,China,is used for a case study to validate the system model’s accuracy and explore its *** results showed that the system model can accurately simulate the condenser water system’s performance under various operating *** optimizing the frequencies of pumps and tower fans,the total system energy consumption can be reduced by 12%–13%compared to the fixed dual setpoint-based strategy with range and approach setpoints of 4℃and 2℃.In contrast,the energy-saving potential of optimizing the cooling tower sequencing is insignificant.A simple joint speed control method for optimizing the pumps and tower fans emerged,i.e.,the optimal pump and fan frequency are linearly correlated(if both are non-extremes)and depend on the chiller part load ratio only,irrespective of the ambient wet-bulb temperature and chilled water supply *** was also foun

关键词： all-variable speed chiller plant model-based optimization hydraulic and thermal coupling analytical solution dual setpoint-based variable speed control optimal joint speed control

Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 572-595页

作者： Yue wang Fuping Sun Xian wang Jinming Hao Kai xiao School of Geospatial Information The PLA Information Engineering UniversityZhengzhou 450001HenanChina

This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation *** evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment *** principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively ***,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to *** evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.

关键词： Jamming effect Multiple interference sources Collaborative deployment Effect evaluation Defense capability

维普期刊数据库

Effect of rare earth on primary carbides in H13 die steel and their addition method:a review

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第3期31卷 531-551页

作者： jing-feng wang Lin-zhu wang Chao-yi Chen Xiang wang Fei Zhao School of Materials and Metallurgy Guizhou UniversityGuiyang 550025GuizhouChina Zhengzhou Railway Vocational and Technical College Zhengzhou 450000HenanChina Guizhou Provincial University Key Laboratory of High Performance Battery Materials Guizhou UniversityGuiyang 550025GuizhouChina Shougang Guiyang Special Steel Co. Guiyang 550005GuizhouChina

Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue *** earth was usually added to modify the carbides and *** existing literature is reviewed on the effect of rare earth on primary carbides in H13 steel.A comprehensive review on the effect of rare earth on the characteristics of primary carbides,i.e.,number,size,morphology,and thermal stability in H13 steel,was *** precipitation mechanism and nucleation of primary carbides with rare earth were *** position and form of rare earth in steel and their effects on alloying elements segregation were *** addition techniques of rare earth in H13 steel were compared,and the prospects for other uncommon rare earth and emerging technology were *** on the current references,it can be known that adding rare earth facilitated refined and dispersed primary *** size of primary carbides would be reduced,and their morphology would be improved because the rare earth inclusions formed in H13 steel can act as nucleation cores forγ-Fe orδ-Fe,refining the dendritic ***,the number of primary carbides at grain boundaries would be significantly ***,rare earth had little impact on thermal *** nucleation of primary carbides tended to be inhibited due to the modification of inclusions by rare earth which were likely to be nucleation cores for primary *** earth had been reported to affect the mechanism and process of primary carbide ***,the addition of rare earth can inhibit the segregation of alloying elements and carbon diffusion by ***,laboratory experiments and theoretical calcu-lations need to be conducted to study the states and evolution of rare earth steels.

关键词： Rare earth H13 die steel Primary carbide Nucleation Dendritic structure

Computational neuroscience:a frontier of the 21st century

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2020年第9期7卷 1418-1422页

作者： xiao-jing wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou Center for Neural Science New York University Center for Neuroscience Key Laboratory of Medical Neurobiology of the Ministry of Health of China School of Medicine Zhejiang University Department of Neuroscience and Department of Mathematics Center for the Neural Basis of Cognition University of Pittsburgh Université Claude Bernard Lyon 1 Inserm Stem Cell and Brain Research Institute U1208 Institute of Neuroscience State Key Laboratory of Neuroscience Chinese Academy of SciencesCAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Center for Brain Science and Brain-Inspired Technology Division of Arts and Sciences and NYU-ECNU Institute of Cognitive Neuroscience NYU Shanghai School of Biomedical Engineering Hainan University Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics Division of Biology and Biological Engineering California Institute of Technology Howard Hughes Medical Institute School of Electronics Engineering and Computer Science IDG/Mc Govern Institute for Brain Research PKU-Tsinghua Center for Life SciencesPeking University College of Computer Science and Technology Zhejiang University Institute of Brain-Intelligence Science and Technology Zhangjiang Lab School of Mathematical Sciences MOE-LSCand Institute of Natural Sciences Shanghai Jiao Tong University

THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors, thoughts,emotions and consciousness. Although comprising only 2%of the total body weigh... 详细信息

关键词： NETWORKS

Control of fine particulate nitrate during severe winter haze in“2+26”cities

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 261-269页

作者： Chuang Qin xiao Fu Tao wang Jian Gao Jiaqi wang Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Civil and Environmental Engineering Hong Kong Polytechnic UniversityHong Kong 99907China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 10084China

The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in *** prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control ***,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”*** on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term *** synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate *** extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities.

关键词： Nitrate Winter haze pollution Emission reduction “2+26”cities

维普期刊数据库

Effect of magnetic resonance imaging in liver metastases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第1期30卷 112-114页

作者： Xing-Liang Huang xiao-Dong wang Zhao-Miao Gong Yan-Feng Zheng jing-Xin Mao Department of Science and Education Dianjiang People's Hospital of ChongqingChongqing 408399China Department of Science and Industry Chongqing Medical and Pharmaceutical CollegeChongqing 400030China

This letter to the editor is a commentary on a study titled"Liver metastases:The role of magnetic resonance imaging."Exploring a noninvasive imaging evaluation system for the biological behavior of hepatocellular carcinoma(HCC)is the key to achieving precise diagnosis and treatment and improving *** review summarizes the role of magnetic resonance imaging in the detection and evaluation of liver metastases,describes its main imaging features,and focuses on the added value of the latest imaging tools(such as T1 weighted in phase imaging,T1 weighted out of phase imaging;diffusion-weighted imaging,T2 weighted imaging).In this study,I investigated the necessity and benefits of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid for HCC diagnostic testing and prognostic evaluation.

关键词： Liver metastases Magnetic resonance imaging Liver-specific contrast agents Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Hepatocellular carcinoma Hepatobiliary contrast agents

Reducibility of Three Dimensional Skew Symmetric System with High Dimensional Weak Liouvillean Frequencies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第10期40卷 2388-2410页

作者： Jie LIU Yuan SHAN jing wang School of Mathematics and Statistics Nanjing University of Science and Technology School of Statistics and Data Science Nanjing Audit University

In this paper, we consider the reducibility of three-dimensional skew symmetric *** obtain a reducibility result if the base frequency is high-dimensional weak Liouvillean and the parameter is sufficiently small. The ... 详细信息

关键词： 34C20 37J40 high-dimensional weak Liouvillean KAM theory three dimensional skew-symmetric system