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Atmospheric and Oceanic Science Letters 2017年第3期10卷 252-260页

作者： ZHOU Li-Hua ZHANG Xing-Ying ZHANG jing ZHU Si-Guang MENG xiao-Yang College of Global Change and Earth System Sciences Beijing Normal University National Satellite Meteorological Center China Meteorological Administration

Based on satellite observations, the effects of emission reduction measures on air pollutants （NO2 （nitrogen dioxide）, SO2 （sulfur dioxide）, and aerosols） were estimated in Beijing and its surroundings during the 2015 World Championships and Parade （WCP） held in Beijing. Compared with the same period in the previous three years （2012-2014）, the tropospheric vertical column densities of NO2 and SO2 in 2015 were significantly reduced in Beijing and its surroundings. During the WCP, aerosol optical depth was reduced most significantly in Beijing, while NO2 and SO2 were reduced most significantly in Hebei and Tianjin, respectively. The meteorological conditions were also favorable during this period. During the WCP, the North China Plain was located under high pressure from the north of China. A southward pressure gradient force and weak northerly and northeasterly winds blocked the transport of pollution from southern and western parts of the industrial area （Hebei, Shanxi and Shandong provinces）. Cold air masses pushed southwards weakly. These conditions were beneficial to the removal of air pollutants in Beijing.

关键词： Parade air quality satellite observation emission control meteorological factor

A New Method for Ultra-sensitive P24 Antigen Assay Based on Near-infrared Fluorescent Microsphere Immunochromatography

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Biomedical and Environmental Sciences 2020年第3期33卷 174-182页

作者： WANG Qi HOU Mei Ling LIU Li Peng MA jing ZHANG xiao Guang ZHOU Zhi Xiang CAO Yu Xi Beijing University of Technology College of Life Science and BioengineeringBeijing 100124China Beijing Runbio Biotechnology Development Co. LtdBeijing 100106China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective To develop a rapid,highly sensitive quantitative method for detecting P24 antigen based on near-infrared fluorescent microsphere *** First,we prepared a lateral flow assay test strip,and labeled the detection antibody using a fluorescent ***,we optimized the antibody labeling ***,we optimized the detection ***,we created a working ***,we conducted a methodological assessment of the established fluorescent microsphere immunochromatography ***-six clinical samples were tested,and we compared the established fluorescent microsphere immunochromatography with the quantitative ELISA *** According to the working curve,the detection limit of the method is 3.4 pg/mL,and the detection range is 3.4 pg/mL to 10 ng/*** average intra-assay recovery was 99.6%,and the Coefficient of Variation(CV)was 5.4%–8.6%;the average inter-assay recovery was 97.3%,and the CV was 8.5%–11%.The detection rate of fluorescent microsphere immunochromatography was higher than ELISA method,and had a good correlation with *** The P24 antigen quantitative detection method based on near-infrared fluorescent microsphere immunochromatography has the advantages of rapid detection,high sensitivity,and wide detection range;thus,it is suitable for early clinical diagnosis and continuous monitoring of AIDS.

关键词： Fluorescent microsphere immunochromatography HIV P24 antigen POCT

Gold Self-Relay Catalysis Enabling[3,3]-Sigmatropic Rearrange-ment/Nazarov Cyclization and Allylic Alkylation Cascade for Constructing All-Carbon Quaternary Stereocenters

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Chinese Journal of Chemistry 2022年第6期40卷 687-692页

作者： Fan-Tao Meng xiao-Yan Qin jing Li Tian-Shu Zhang Shu-Jiang Tu Bo Jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhouJiangsu 221116China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsu 221018China

Molecular scaffolds endowed with all-carbon quaternary stereocenter are ubiquitous in natural products and significant bioactive ***,efficient construction of this type of structure units is full of challenge due to their congested chemical ***,we report a new gold(Ⅰ)self-relay catalysis merging[3,3]-sigmatropic rearrangement/Nazarov cyclization with al-lylic alkylation starting from 1,3-enyne acetates and allylic alcohols,producing a wide range of synthetically important allyl cyclo-pentenones with an all-carbon quaternary stereocenter in good yields under mild *** protocol demonstrates the precise control of regioselectivity,high functional group tolerance of substrates and the low loading of gold catalyst without inert atmos-phere protection,providing a catalytic and efficient entry to all-carbon quaternary stereocenters.

关键词： Allylation Domino reactions Carbocycles Gold self-relay catalysis 1,3-Enynes

Research on thermoforming process of JUNO large acrylic spherical panel

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Radiation Detection Technology and Methods 2022年第1期6卷 122-128页

作者： xiao-Hui Qian xiao-Yan Ma Yue-Kun Heng Jian-Xia xiao Yue-Sheng Tang Gao-Feng Zhang Wei Cheng xiao-Long Wang Wei He Ya-Tian Pei xiao-Yu Yang Shao-jing Hou Institute of High Energy Physics Chinese Academy of ScienceBeijing 100049China University of Chinese Academy of Science Beijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China Jiangsu Domchamp New Material Technology Co. LtdTaixing City 225400China

Introduction Jiangmen Underground Neutrino Observation(JUNO)focuses on determining neutrino mass hierarchy and other physical *** central detector is one of the keys to the *** main structure of the central detector is an acrylic spherical container with a diameter of 35.4 m,which will be the largest acrylic spherical vessel in the *** construction will inevitably face many great challenges and *** The thermoforming process of large acrylic spherical panel is introduced,which is a very important step in panel *** effect of temperature on the curvature of panel during thermoforming is *** thermal deformation of panel in thermoforming process is analyzed by finite element *** bending experiment and curvature measurement are carried out,and the influence of deformation of the panel under gravity on the curvature of the panel is *** The current thermoforming process makes the curvature of panel smaller than that of *** measurement results show that the curvatures are different due to the influence of gravity when the panel is placed on the mold or *** suggestions for improving the shape of spherical panels are put *** the thermoforming process,the temperature of the concave-convex surfaces of the panel should be controlled at the same level as far as *** feasible method is to increase the radius of the forming mold to obtain a spherical panel with designed radius.

关键词： JUNO Acrylic spherical vessel Thermoforming process Measurement of spherical panel Panel curvature

强直性脊柱炎椎骨去松质骨化截骨术后钛棒有限元分析

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解剖学报 2024年第3期55卷 339-344页

作者：苏宝科王永清康志杰王海燕金凤李筱贺曹振华霍佳萱祝勇李峰内蒙古自治区中医医院(内蒙古医科大学中医附属医院)急诊科呼和浩特010000 内蒙古医科大学研究生院呼和浩特010000 内蒙古医科大学基础医学院人体解剖学教研室呼和浩特010000 内蒙古医科大学附属医院影像科呼和浩特010000 锦州医科大学第三附属院骨科辽宁锦州121000 内蒙古医科大学第二附属医院脊柱外科呼和浩特010000 中国人民解放军总医院脊柱外科北京100000 内蒙古医科大学第一临床医学院呼和浩特010000 北京大学肿瘤医院内蒙古医院(内蒙古医科大学附属肿瘤医院) 内蒙古癌症中心呼和浩特010000

目的通过对去松质骨化(VCD)截骨术后强直性脊柱炎患者胸椎(T)_(11)~骶骨(S)节段钛棒应力变化分析,为术前钛棒选择、改进提供参考。方法将VCD截骨术后强直性脊柱炎患者连续扫描的断层影像原始数据以DICOM格式导入Mimics 21.0软件,分别重... 详细信息

目的通过对去松质骨化(VCD)截骨术后强直性脊柱炎患者胸椎(T)_(11)~骶骨(S)节段钛棒应力变化分析,为术前钛棒选择、改进提供参考。方法将VCD截骨术后强直性脊柱炎患者连续扫描的断层影像原始数据以DICOM格式导入Mimics 21.0软件,分别重建T_(11)~S、螺钉和钛棒,导入到3-Matic建立初步几何模型,进行去噪、铺面、平滑等处理,完善后的模型导入Hypermesh10软件进行网格划分,对材料进行属性赋值后导入ANSYS 19.2中显示有限元模型,设定边界和载荷条件,测量螺钉与钛棒连接处应力值。结果在中立位、前屈、侧向弯曲、轴向旋转工况下,钛棒在上端椎(T_(11))应力最大,顶椎(L_(3))应力最小;在后伸工况下,钛棒在下端椎(L_(5))应力最大。结论在上、下端椎可考虑增粗钛棒直径,增强钛棒硬度,或改为双棒。

关键词：强直性脊柱炎螺钉钛棒矫形后有限元分析人

术中获得性压力性损伤风险预测模型的系统评价

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医学信息 2024年第9期37卷 36-40+53页

作者：陈雯景新华张成欢温晓萌江竹月常州市第一人民医院急诊医学科常州市第一人民医院护理部常州市第一人民医院手术室

目的系统评价术中获得性压力性损伤风险预测模型，为模型构建、应用及优化提供建议。方法计算机检索PubMed、Web of Science、Cochrane Library、Medline、CINAHL、中国知网、中国生物医学文献数据库、万方数据库及维普全文数据库中... 详细信息

目的系统评价术中获得性压力性损伤风险预测模型，为模型构建、应用及优化提供建议。方法计算机检索PubMed、Web of Science、Cochrane Library、Medline、CINAHL、中国知网、中国生物医学文献数据库、万方数据库及维普全文数据库中有关构建术中获得性压力性损伤风险预测模型的文献，检索时限为建库至2022年7月。由两名研究者独立筛选文献并提取资料，采用预测模型构建研究数据提取和质量评价清单对纳入的研究进行质量评价。结果共纳入13篇文献，包含17个术中获得性压力性损伤风险预测模型，其中13个模型在验证模型过程中的受试者工作特征曲线下面积均大于0.7，进入模型频次最高的预测因子主要为手术时间、年龄、糖尿病、低蛋白血症和BMI。结论术中获得性压力性损伤风险预测模型的研究质量较高，模型性能较好，手术患者发生压力性损伤的高危因素为手术时间、年龄、糖尿病、低蛋白血症和BMI，医务人员应尽早识别并实施针对性的措施。

关键词：术中获得性压力性损伤预测模型预测因子

Identification of γ-aminobutyric acid transporter (GAT1)on the rat sperm

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Cell Research 2000年第1期10卷 51-58页

作者： HU jing HUA xiao BING HE YUAN CHANG YAN (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031) Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai

Some recent studies indicated that GABAergic system is involved in mammalian sperm acrosome reaction (AR), but direct evidence pertaining to the expression of gat1 in mammalian sperm is not yet demonstrated. In this study, we evaluated the presence of 67kDa GAT1 protein and mRNA in rat testis by Western blotting and reverse transcription-polymerase chain reaction. Meanwhile, immunohistochemical and immunofluorescent analyses also identified GAT1 protein on the elongated spermatid and sperm. These results indicated that rat testis is a novel site of gat1 expression. Further studies should be taken to explore the role of GAT1 protein on sperm acrosome reaction.

关键词： Gat1 rat testis sperm expression.

小豆蔻明通过调节Notch/NF-κB信号通路介导的细胞焦亡减轻蒽环类药物所致大鼠的心脏毒性

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中国临床药理学杂志 2024年第9期40卷 1277-1281页

作者：于晓磊李文鑫陈盼盼梁云飞崔艳荣焦海静徐繁承德医学院附属医院肿瘤科河北承德067000

目的研究小豆蔻明(CAR)通过调节Notch/核转录因子κB(NF-κB)信号通路介导的细胞焦亡对蒽环类药物所致大鼠心脏毒性的保护作用。方法腹腔注射阿霉素(DOX)建立大鼠心脏毒性模型,将模型大鼠随机分为DOX组、CAR低剂量组、CAR高剂量组、Jagg... 详细信息

目的研究小豆蔻明(CAR)通过调节Notch/核转录因子κB(NF-κB)信号通路介导的细胞焦亡对蒽环类药物所致大鼠心脏毒性的保护作用。方法腹腔注射阿霉素(DOX)建立大鼠心脏毒性模型,将模型大鼠随机分为DOX组、CAR低剂量组、CAR高剂量组、Jagged1组。另取10只大鼠作为对照组。对照组和DOX组给予等量0.9%NaCl,CAR低、高剂量组分别给予大鼠40、80 mg·kg^(-1)CAR灌胃,Jagged1组灌胃80 mg·kg^(-1)CAR+和25 ng·kg^(-1)Jagged1,每天1次,连续4周。用试剂盒检测心肌损伤标志物肌酸激酶同工酶(CK-MB)、肌钙蛋白Ⅰ(cTnⅠ);用免疫组化法观察焦亡蛋白Nod样受体蛋白3(NLRP3)、消皮素D(GSDM-D)表达;用蛋白质印迹法检测检测心肌组织Notch1、磷酸化NF-κB p65(p-NF-κB p65)蛋白表达。结果对照组、DOX组、CAR低剂量组、CAR高剂量组和Jagged1组的CK-MB水平分别为(48.51±5.39)、(175.93±13.27)、(106.83±9.73)、(83.71±8.39)和(126.08±9.74)U·L^(-1),cTnⅠ水平分别为(1.95±0.18)、(12.46±1.83)、(7.15±0.64)、(4.13±0.38)和(8.01±0.78)ng·mL^(-1),NLRP3蛋白的平均光密度值分别为0.19±0.07、0.36±0.05、0.25±0.05、0.21±0.03和0.31±0.06,GSDM-D的平均光密度值分别为0.18±0.04、0.43±0.06、0.24±0.03、0.19±0.04和0.32±0.05。DOX组上述指标与对照组比较,在统计学上差异均有统计学意义(均P<0.05);CAR低、高剂量组上述指标与DOX组比较,在统计学上差异均有统计学意义(均P<0.05),且CAR低、高剂量组上述指标比较,在统计学上差异均有统计学意义(均P<0.05);Jagged1组上述指标与CAR高剂量比较,在统计学上差异均有统计学意义(均P<0.05)。结论CAR能改善DOX心脏毒性大鼠心肌损伤,降低氧化应激、炎症反应和细胞焦亡,其作用机制可能与抑制Notch/NF-κB通路有关。

关键词：小豆蔻明心脏毒性蒽环类药物细胞焦亡 Notch/核转录因子κB信号通路

基于血液自噬相关基因构建的静脉血栓栓塞机器学习模型研究

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中国血管外科杂志（电子版） 2024年第2期16卷 162-171页

作者：覃忠陈泉志陈靖张江锋卢海林覃晓广西医科大学第一附属医院血管外科广西南宁530021 广西医科大学生物技术教研室广西南宁530021

目的利用生物信息学构建自噬相关基因(autophagy related genes,ATGs)的静脉血栓栓塞(venous thromboembolism,VTE)诊断预测模型。方法根据GSE19151数据集分析VTE人群的差异性ATGs(differentially expressed autophagy-related genes,DE-ATGs)和免疫细胞浸润,建立最优机器学习模型并通过诺谟图、校准曲线、决策曲线分析和外部数据集验证模型的预测效率。结果VTE患者中发现18个差异性表达的ATGs和差异的免疫细胞浸润。诺谟图、校准曲线和决策曲线分析证明机器学习模型对预测VTE具有一定的准确性,其中支持向量机器(support vector machine,SVM)机器学习模型对VTE的预测准确性最高。以SVM模型最重要的5个基因PRKCD、ULK1、CD46、PRKAR1A和FOS作为预测基因,在外部验证数据集表现出令人满意的性能,且与VTE患者的风险有关。结论研究首次揭示自噬与VTE之间的关系,并建立最优的机器学习模型来评估VTE患者的风险。

关键词：静脉血栓栓塞自噬免疫细胞机器学习模型基因

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福建龙岩烟区烤烟施肥关键参数研究

中国土壤与肥料 2024年第7期 123-128页

作者：荆晓雯曾文龙蒋鸿月钟小丽边立丽李志宏兰其骏张云贵吴树松蒋代兵郭学清刘青丽中国农业科学院农业资源与农业区划研究所北京100081 福建省烟草公司龙岩市公司福建龙岩364000 云南农业大学烟草学院云南昆明650201

为了研究福建省龙岩市烟区不同肥料用量下烤烟的肥料效应,确定适宜的肥料施用量,在福建省龙岩市,以当地主栽品种云烟87为材料,开展了氮肥6水平、磷钾肥2水平的肥料田间试验。研究了氮、磷、钾肥料配合施用对烤烟养分吸收量、相对产量及... 详细信息

为了研究福建省龙岩市烟区不同肥料用量下烤烟的肥料效应,确定适宜的肥料施用量,在福建省龙岩市,以当地主栽品种云烟87为材料,开展了氮肥6水平、磷钾肥2水平的肥料田间试验。研究了氮、磷、钾肥料配合施用对烤烟养分吸收量、相对产量及限制产量的养分因素、经济性状及肥料利用率的影响。结果表明:在烤烟生育期内,氮、磷、钾的养分积累量表现为钾>氮>磷,养分积累主要集中在旺长期。缺素会使龙岩烟区烤烟产量和经济性状降低,缺氮、缺磷、缺钾对烤烟产量和经济性状的影响大小表现为缺氮>缺磷>缺钾。不同施氮处理中,N3处理(N:135kg/hm^(2),P_(2)O_(5):105kg/hm^(2),K_(2)O:375kg/hm^(2))的各项指标最优,分别为产量2053.17kg/hm^(2)、上等烟比例79.64%、中上等烟比例95.64%、产值61850.36元/hm^(2)、均价30.12元/kg、氮肥利用率31.27%农学利用率11.28kg/kg、偏生产力15.21kg/kg。用肥料效应方程对施氮量和烟叶产量进行拟合,方程为y=511.488+1.3614x+0.116x^(2)-0.0004x^(3)(R^(2)=0.9812)。综合烟叶产量、肥料利用率和经济效益,龙岩地区推荐施氮量为135.0~177.2kg/hm^(2)。

关键词：烤烟氮磷钾推荐施肥肥料效应方程