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具有免疫反应和细胞内时滞的病毒动态模型（英文）

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生物数学学报 2016年第4期31卷 409-418页

作者：王晓静王丹崔景安李泽妤北京建筑大学理学院北京100044 北京工商大学嘉华学院北京101118

本文研究了一类具有免疫反应和细胞内时滞的病毒动态学模型.通过构造李雅普诺夫函数和应用Lasalle不变原理,得到:模型的全局动力学行为是完全由基本的再生数决定的,并在一定条件下,无病平衡点和地方病平衡点是全局稳定的.我们的结果可... 详细信息

本文研究了一类具有免疫反应和细胞内时滞的病毒动态学模型.通过构造李雅普诺夫函数和应用Lasalle不变原理,得到:模型的全局动力学行为是完全由基本的再生数决定的,并在一定条件下,无病平衡点和地方病平衡点是全局稳定的.我们的结果可以应用到许多发生率函数,如线性发生率函数、标准发生率函数,等等.最后,我们做了数值模拟来验证我们的理论分析并提出了控制病毒感染的方法.

关键词：病毒动态行为免疫反应细胞内时滞全局稳定李雅普诺夫函数

Identification and Characterization of Two Putative SAC Genes Involved in Fungal Development and Benzimidazole Resistance in Gibberella zeae

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Identification and Characterization of Two Putative SAC Gene...

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

中国植物病理学会2012年学术年会

作者： ZHANG Lei-Gang YU Xin-Yan JIA xiao-jing wang Jian-Xin CHEN Chang-Jun ZHOU Ming-Guo~* (College of Plant Protection,Nanjing Agricultural University,Nanjing,China)

Resistance to carbendazim and other benzimidazole fungicides in Gibberella zeae is conferred by point mutations in theβ-tubulin gene,a gene that plays an important role in spindle assembly. The spindle assembly checkpoint is a cellular surveillance system that ensures the fidelity of chromosome segregation,which is critical for maintaining genomic *** this study,we isolated and characterized two predicted checkpoint protein-encoding genes(Mad2 and Bub1 ) in *** and designated them as FgMad2 and FgBub1,*** sequenced the two genes in two parental strains(one was sensitive to carbendazim while the other was highly resistant) and found no mutation,indicating that the resistance did not result from mutation of the two checkpoint *** FgMad2 deletion mutants grew slowlier and produced fewer conidia,both hyphae and conidia ***,the deletion of FgBub1 had no effect on fungal development other than a 47.7%～48.2%reduction in conidia ***2 deletion mutants exhibited a severe decrease(from 89.6%-90.4%) in perithecia production and pathogenicity along with a 39.5%～47.2%down-regulation of deoxynivalenol synthesis, whereas FgBub1 deletion mutants exhibited only a slight reduction in perithecia production but their pathogenicity was decreased by 51.1%～54.8%;these results suggested that asexual development,sexual development,and pathogenicity depend more on FgMad2 than on ***,the decrease in the pathogenicity of FgBub1 deletion mutants was accompanied by a two-fold increase in deoxynivalenol *** sensitivity of FgMad2 and FgBub1 deletion mutants to benzimidazole fungicides were both enhanced,especially for mutants original from MBC-high-resistant strain ***,parental strains and theirβ orβ -tubulin deletion mutants displayed high Mad2 expression when treated with MBC,which was not observed for Bub1,suggesting that FgMad2 responsed to spindle damage resulted from *** can

关键词： Gibberella zeae spindle assembly checkpoint Mad2 Bub1 benzimidazole resistance

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He jing Jin Hong-Lian wang Yun-Feng wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing wang Bing Zhang Lanfang Li xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-jing Jiang Lu Wu xiao Yang Yu Pu Bing-Jie Ning Na Peng xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long xiao Gao Zhengwei wang Zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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埃克森美孚投资分析及借鉴

石油科技论坛 2011年第2期30卷 48-51,71页

作者：刘孝成王婧北京石油管理干部学院

文章分析了近年来全球最大的石油公司——埃克森美孚公司的投资策略,总结了该公司在投资决策中所遵循的一些基本原则;分析认为,该公司坚持非机会驱使型投资理念,始终保持投资不断增长、坚持向上游倾斜、向研究开发倾斜的策略和慎重决策... 详细信息

文章分析了近年来全球最大的石油公司——埃克森美孚公司的投资策略,总结了该公司在投资决策中所遵循的一些基本原则;分析认为,该公司坚持非机会驱使型投资理念,始终保持投资不断增长、坚持向上游倾斜、向研究开发倾斜的策略和慎重决策的一些原则,对我国的石油公司具有借鉴意义。

关键词：埃克森美孚公司投资策略上游投资

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海口市老年人口腔健康KAP调查分析

中国健康教育 2017年第3期33卷 269-271页

作者：刘晓晶王小丹薄丹丹高允锁中南大学湘雅医学院附属海口医院口腔中心.海南省口腔医学中心海南海口570102 海南医学院海南海口571101 海南省人民医院海南海口570311

目的探讨老年人口腔健康知识、态度、行为(KAP)的影响因素,为深入开展老年人群社区口腔健康教育工作提供参考依据。方法采用自制的老年人口腔健康知识、态度、行为调查表对海口市4个城区的800名65~74岁的老年人进行问卷调查。结果海口... 详细信息

目的探讨老年人口腔健康知识、态度、行为(KAP)的影响因素,为深入开展老年人群社区口腔健康教育工作提供参考依据。方法采用自制的老年人口腔健康知识、态度、行为调查表对海口市4个城区的800名65~74岁的老年人进行问卷调查。结果海口市老年人口腔健康知识调查显示,"保持口腔卫生是防治牙病的关键"的认知度最高,有83.2%;"爱牙日是哪一天"的知晓率最低,仅5.5%;态度调查显示,78.2%的老年人认为老年掉牙是必然的。32.3%的老年人认为牙好坏是天生的,与自身保护关系不大;行为调查显示,73.8%的老年人有饭后漱口的习惯,66.4%的老年人会早晚刷牙,28%的老年人过去1年内有没有看过牙;KAP总平均分为(16.23(4.94)分,不同性别间KAP总平均分差异无统计学意义(F=1.18,P=0.277),不同文化程度和城乡间均有统计学意义(P<0.05)。结论应采取有针对性的措施,建立以社区为基础的老年人口腔健康KAP保健模式,改变口腔不良习惯,提高老年人的生活质量。

关键词：口腔健康知识口腔健康态度口腔健康行为老年人

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling wang jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation