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An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： Ying Li Long-jie Wang Yong-Kang Zhou Jun Liang Bin xiao Ji-Shen Zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

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Radiation construction and excellent performances of Ag NPs/TiO_(2)/PEG/PVP multifunctional aerogel:Adsorption-photocatalytic degradation,photosensitive antibacterial and cytotoxicity

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Journal of Materiomics 2024年第3期10卷 585-593页

作者： Jin-Yu Yang Dong-Liang Liu Yue-Sheng Li xiao-jie Yang Yi Liu School of Nuclear Technology and Chemistry&Biology/Hubei Key Laboratory of Radiation Chemistry and Functional Materials Hubei University of Science and TechnologyXianning437100HubeiChina Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province School of Chemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhan437100HubeiChina College of Chemistry and Chemical Engineering Tiangong UniversityTianjin300387China

A cutting-edge method known as photocatalytic antibacterial technology can effectively eliminate drug-resistant bacterial strains and boast a wide-ranging antimicrobial *** the study,a novel Ag NPs/TiO_(2)/PEG/PVP(ATPP)aerogel photocatalyst was synthesized by an electron beam in-situ radiation method using polyethylene glycol(PEG),polyvinylpyrrolidone(PVP),AgNO_(3),and TiO_(2)as raw *** was characterized by X-ray diffraction spectroscopy(XRD),X-ray photoelectron spectroscopy(XPS)and solid ultraviolet diffuse reflectance spectroscopy(UV-Vis DRS).The results demonstrated that silver ions were reduced to silver nanoparticles by electron beam radiation *** the same time,the doping of silver nanoparticles(Ag NPs)enhanced visible-light *** degradation rate of methylene blue(MB)on 5%(in mass)ATPP could reach 81%under visible light for 180 *** coli(***)and Staphylococcus aureus(***)were used as model bacteria to explore the antimi-crobial properties of ATPP by zone of the inhibition method,plate counting method and live/dead bacterial *** antibacterial experiments showed that the antibacterial effect of ATPP was ***,MTT assay and Hoechst33342/PI double staining were used to prove that the composite had good *** aerogel photocatalytic material has the potential to decrease microbial presence in both medical and environmental settings,making it a valuable tool for such applications.

关键词： Ag NPs/TiO_(2)/PEG/PVP aerogel Electron beam radiation Adsorption-photocatalytic Photosensitive antibacterial Cytotoxicity

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A long-term daily gridded snow depth dataset for the Northern Hemisphere from 1980 to 2019 based on machine learning

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Big Earth Data 2024年第2期8卷 274-301页

作者： Yanxing Hu Tao Che Liyun Dai Yu Zhu Lin xiao jie Deng Xin Li Key Laboratory of Remote Sensing of Gansu Province Heihe Remote Sensing Experimental Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina College of Resources and Environment University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijingChina Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Institute of International Rivers and Eco-SecurityYunnan UniversityKunmingChina National Forestry and Grassland Administration Key Laboratory of Forest Resource Conservation and Ecological Safety on the Upper Reaches of the Yangtze River Sichuan Province Key Laboratory of Ecological Forestry Engineering on the Upper Reaches of the Yangtze RiverCollege of ForestrySichuan Agricultural UniversityChengduChina

A high-quality snow depth product is very import for cryospheric science and its related *** long time-series snow depth products covering the Northern Hemisphere can be divided into two categories:remote sensing snow depth products and reana-lysis snow depth ***,existing gridded snow depth products have some *** sensing-derived snow depth products are temporally and spatially discontinuous and tend to underestimate snow depth,while reanalysis snow depth products have coarse spatial resolutions and great *** overcome these problems,in our previous work we proposed a novel data fusion framework based on Random Forest Regression of snow products from Advanced Microwave Scanning Radiometer for the Earth Observing System(AMSR-E),Advanced Microwave Scanning Radiometer-2(AMSR2),Global Snow Monitoring for Climate Research(GlobSnow),the Northern Hemisphere Snow Depth(NHSD),ERA-Interim,and Modern-Era Retrospective Analysis for Research and Applications,ver-sion 2(MERRA-2),incorporating geolocation(latitude and longitude),and topographic data(elevation),which were used as input indepen-dent *** than 30,000 ground observation sites were used as the dependent variable to train and validate the model in different time *** fusion framework resulted in a long time series of continuous daily snow depth product over the Northern Hemisphere with a spatial resolution of 0.25°.Here,we compared the fused snow depth and the original gridded snow depth products with 13,272 observation sites,showing an improved precision of our *** evaluation indices of the fused(best original)dataset yielded a coeffi-cient of determination R2 of 0.81(0.23),Root Mean Squared Error(RMSE)of 7.69(15.86)cm,and Mean Absolute Error(MAE)of 2.74(6.14)*** of the bias(88.31%)between the fused snow depth and in situ observations was in the range of−5 cm to 5 *** accuracy assessment of independent snow observation sites-Sodank

关键词： Snow depth datasets machine learning data fusion Northern Hemisphere

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V0405 Dra:A New Deep and Low Mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

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Research in Astronomy and Astrophysics 2024年第6期24卷 287-293页

作者： Chao-Yue Li Lin-Qiao Jiang jie Zheng Yi-Man Liu xiao-Yu Long Min Sun Han-Lu Zhang xiao-Man Tian School of Science Leshan Normal UniversityLeshan 614000China Center for Applied Optics Research Leshan Normal UniversityLeshan 614000China Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan Leshan 614000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Aeronautics Shandong Jiaotong UniversityJinan 250000China

V0405 Dra is a W UMa-type binary *** on the TESS data,we have conducted an orbital period study and performed a light curve analysis for the *** orbital period study reveals that the O-C curve for V0405 Dra exhibits secular decrease at an extremely high rate of d P/dt=-2.71×10^(-6)day year^(-1),along with periodic variations characterized by an amplitude of A_(3)=0.0032 day and a period of P_(3)=1.413 *** orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system,for which we estimate a minimum mass of M_(3)=0.77M_(⊙).By employing the 2013 version of the Wilson-Devinney(W-D)method to synthesize a light curve,we derived photometric solutions indicating that V0405 Dra is a new deep(f=68.7%)and low-mass ratio(q=0.175)contact *** fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star,or due to angular momentum *** further mass transfer and loss of angular momentum,the binary will gradually evolve into a tighter contact configuration,eventually leading to a merger into a single star,following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

关键词： (stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:individual(V0405 Dra)

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Rare esophageal carcinoma-primary adenoid cystic carcinoma of the esophagus: A case report

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World Journal of Clinical Cases 2024年第3期12卷 630-636页

作者： Li-Dan Geng jie Li Li Yuan xiao-Bo Du Department of Oncology Mianyang Central HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Esophageal adenoid cystic carcinoma(EACC)is an exceedingly rare malignant tumor of the esophagus,posing significant challenges in the *** SUMMARY This report detailed the case of a 72-year-old male whose diagnosis of EACC was confirmed through postoperative histopathological *** patient underwent thoracoscopy-assisted radical resection of the esophageal tumor,coupled with lymph node *** findings revealed an adenoid cystic carcinoma infiltrating the entire layer of the muscularis propria,locally extending into the outer membrane of the esophageal fiber,involving the cardia and exhibiting no lymph node *** patient’s condition was classified as primary EACC,T3N0M0,per the American Joint Committee on Cancer(2017;8th edition).One month after surgery,the patient received postoperative adjuvant radiation *** In addressing the rarity and high potential for biopsy misdiagnosis of EACC,this study delved into its diagnostic methods and treatment.

关键词： Esophageal adenoid cystic carcinoma Malignant tumor Lymph node dissection Adjuvant radiation therapy Misdiagnosis Case report

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Effect of Artificial Electric Field Surface by Wave-Driven Triboelectricity on Anti-Bioadhesion for Riser Protection

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China Ocean Engineering 2024年第3期38卷 483-490页

作者： YI Peng QIU Hong-yuan LI Yong CAI Bao-ping Javad MOSTAGHIMI ZHANGWen-jie xiao Wen-sheng College of Mechanical and Electrical Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Equipment Technology Co. Ltd.Tianjin 300450China Department of Mechanical&Industrial Engineering University of TorontoToronto ONM5S3G8Canada

Biofouling has been a persistent problem in marine riser system, resulting in energy waste and equipment damage. Inthis study, a kind of water wave-driven contact-mode flexible triboelectric nanogeneration has been prepared byusing graphene-doped PDMS as dielectric friction material. When the graphene content is 2%, the average outputvoltage can reach 46 V under the contact frequency 10 Hz. The flexible triboelectric nanogeneration encapsulationmodule is impinged by water waves to generate alternating microelectric field on the riser surface and destroy theadhesion conditions of microorganisms during the biofilm stage. In the biofouling experiments at different stages, thebiofouling area of the platymonas subcordiformis has been reduced by 53%, 62% and 61%. It provides a new ideafor effective treatment of biofouling of mussels, oysters and barnacles attached to risers.

关键词： wave-drive triboelectric nanogeneration alternating microelectric field anti-biofouling

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： jie Pang Lin-Yan Qian Ping Lv xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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A simple model for two-proton radioactivity

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Chinese Physics C 2024年第10期48卷 247-255页

作者： jie-Dong Jiang xiao Liu Dong-Meng Zhang Ming Li Xi-Jun Wu xiao-Hua Li School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Math and Physics University of South ChinaHengyang 421001China National Exemplary Base for International Sci&Tech.Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In this work,considering the preformation factor of the emitted two protons in parent nucleus S_(2p) and the effect of the parent nucleus deformation,based on the Wentzel-Kramers-Brillouin approximation and Bohr-Sommerfeld quantization condition,we improve a simple phenomenological model proposed by Bayrak[***.G:47,025102(2020)]to systematically study 2p radioactivity *** model contains two adjustable parameters V_(0) and a_(β),which are related to the depth of nuclear potential and effect of *** calculated results show that this model can effectively reproduce the experimental data with a corresponding root-mean-square(RMS)standard deviation of σ=*** comparison,we include the Gamow-like model(GLM)proposed by Liu et al.[***.C 45,044110(2021)],generalized liquid drop model(GLDM)proposed by Cui et al.[***.C 101,014301(2020)],effective liquid drop model(ELDM)proposed by *** et al.[***.B 774,14(2017)],two-potential approach with Skyrme-Hartree-Fock(TPASHF)proposed by Pan et al.[***.C 45,124104(2021)],phenomenological model with a screened electrostatic barrier(SEB)propoesed by Zou et al.[***.C 45,104101(2021)],unified fission model(UFM)proposed by Xing et al.[***.C 45,124105(2021)],Coulomb and proximity potential model for deformed nuclei(CPPMDN)proposed by Santhosh[***.C 104,064613(2021)],two-parameter empirical formula proposed by Liu et al.[***.C 45,024108(2021)],and four-parameter empirical formula proposed by Sreeja et al.[***.J.A 55,33(2019)].In addition,we use this model to 2p predict the radioactive half-lives of some possible potential nuclei whose 2p radioactivity are energetically allowed or observed but not yet quantified in NUBASE2020.

关键词： two-proton radioactivity half-lives Wentzel-Kramers-Brillouin approximation

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Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

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Nuclear Science and Techniques 2024年第2期35卷 123-130页

作者： Da-Wei Si Yan Zhou Sheng xiao Zhi Qin Dong Guo Yu-Hao Qin Yi-jie Wang Bo-Yuan Zhang Bai-Ting Tian Zhi-Gang xiao Department of Physics Tsinghua UniversityBeijing 100084China

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

关键词： Bremsstrahlungγ-rays Čerenkov Geant4 Energy resolution Direction reconstruction Hough transform

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A topology approach to overcome the pore size/volume trade-offs for autonomous indoor humidity control

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Science China Chemistry 2024年第9期67卷 2968-2974页

作者： Zhi-Shuo Wang Xue-Wen Zhang Kai Zheng xiao-Xian Chen Dong-Dong Zhou jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-Sen UniversityGuangzhou 510275China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515021China

Autonomous indoor humidity control is gaining more and more attention but is limited by the trade-offs among pore volume,pore size and water stability of water *** solve this problem by using a unique coordination network topology combined with hydrolytically stable M(Ⅲ)carboxylate *** extending the ligand length from 9.0 to 11.2 and 13.7?,the pore volume significantly increases from 0.99 to 1.40 and 1.78 cm^(3)g^(-1),which proportionally increases the saturated water adsorption ***,the pore size slightly increases from 10.4 to 11.0 and 13.5A,which restricts the isotherm inflection pressure and hysteresis width to meet the requirement of indoor humidity *** single-crystals suitable for Xray diffraction studies were obtained by using Fe(Ⅲ)salts,while isostructural frameworks with sufficiently high water stabilities were synthesized by using Cr(Ⅲ)salts,which offer record working capacity of 0.90 and 1.10 g g^(-1)for indoor humidity control.

关键词： metal-organic frameworks water adsorption indoor humidity control water stability pore engineering

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