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Feasibility of MRI Radiomics for Predicting KRAS Mutation in Rectal Cancer

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Current Medical Science 2020年第6期40卷 1156-1160页

作者： xiao-fang GUO Wen-qian YANG Qian YANG Zi-long YUAN Yu-lin LIU xiao-hui niu Hai-bo XU Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China College of Informatics Huazhong Agricultural UniversityWuhan 430070China

The mutation status of KRAS is a significant biomarker in the prognosis of rectal *** study investigated the feasibility of MRI-based radiomics in predicting the mutation status of KRAS with a composite index which could be an important criterion for KRAS mutation in clinical *** this retrospective study,a total of 127 patients with rectal cancer were *** 3D Slicer was used to extract the radiomics features from the MRI images,and sparse support vector machine(SVM)with linear kernel was applied for feature *** radiomics classifier for predicting the KRAS status was then constructed by Linear Discriminant Analysis(LDA)and its performance was *** composite index was determined with LDA *** of 127 rectal cancer subjects,there were 44 KRAS mutation cases and 83 wild cases.A total of 104 radiomics features were extracted,54 features were filtered by linear SVM with L1-norm regularization and 6 features that had no significant correlations within them were finally *** radiomics classifier constructed using the 6 features featured an AUC value of 0.669(specificity:0.506;sensitivity:0.773)with ***,the composite index(Radscore)had statistically significant difference between the KRAS mutation and wild *** is suggested that the MRI-based radiomics has the potential in predicting the KRAS status in patients with rectal cancer,which may enhance the diagnostic value of MRI in rectal cancer.

关键词： rectal cancer KRAS mutation MRI radiomics

Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4104-4114页

作者： Zhe-Xing Hu Yin Li Xuan Yang Yu-Xia Li Yao-Yao He xiao-hui niu Ting-Ting Nie xiao-Fang Guo Zi-Long Yuan Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Department of Radiology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina College of Informatics Huazhong Agriculture UniversityWuhan 430070Hubei ProvinceChina

BACKGROUND The colon cancer prognosis is influenced by multiple factors,including clinical,pathological,and non-biological ***,only a few studies have focused on computed tomography(CT)imaging ***,this study aims to predict the prognosis of patients with colon cancer by combining CT imaging features with clinical and pathological characteristics,and establishes a nomogram to provide critical guidance for the individualized *** To establish and validate a nomogram to predict the overall survival(OS)of patients with colon *** A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December *** patients were randomly divided into training and testing groups at a 1:1 *** and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS,and a nomogram model was constructed for the training *** curves were calculated using the Kaplan–Meier *** concordance index(C-index)and calibration curve were used to evaluate the nomogram model in the training and testing *** Multivariate logistic regression analysis revealed that lymph node metastasis on CT,perineural invasion,and tumor classification were independent prognostic factors.A nomogram incorporating these variables was constructed,and the C-index of the training and testing groups was 0.804 and 0.692,*** calibration curves demonstrated good consistency between the actual values and predicted probabilities of *** A nomogram combining CT imaging characteristics and clinicopathological factors exhibited good discrimination and *** can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.

关键词： Colon cancer Nomogram Prognosis Overall survival Computed tomography Clinicopathology

Computer navigation-aided joint-preserving resection and custom-made endoprosthesis reconstruction for bone sarcomas:long-term outcomes

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Chinese Medical Journal 2021年第21期134卷 2597-2602页

作者： Li-hui Xu Qing Zhang Hai-Tao Zhao Feng Yu xiao-hui niu Department of Orthopedic Oncology Surgery Beijing Ji Shui Tan HospitalPeking UniversityBeijing 100035China

Background:Computed tomography(CT)and magnetic resonance imaging(MRI)data can be fused to identify the tumor *** enables surgeons to set close but tumor-free surgical margins and excise the tumor more *** study aimed to report our experience in performing computer navigation-aided joint-preserving resection and custom-made endoprosthesis reconstruction to treat bone sarcoma in the diaphysis and metaphysis of the femur and ***:Between September 2008 and December 2015,24 patients with bone sarcomas underwent surgical resection and joint-sparing reconstruction under image-guided computer *** cohort comprised 16 males and eight females with a median age of 19.5 years(range:12-48 years).The tumor location was the femoral diaphysis in three patients,distal femur in 19,and proximal tibia in *** tumors were osteosarcoma(n=15),chondrosarcoma(n=3),Ewing sarcoma(n=3),and other sarcomas(n=3).We created a pre-operative plan for each patient using navigation system software and performed navigation-aided resection before reconstructing the defect with a custom-made prosthesis with extracortical plate ***:Pathological examination verified that all resected specimens had appropriate surgical *** median distance from the tumor resection margin to the joint was 30 mm(range:13-80 mm).The median follow-up duration was 62.5 months(range:24-134 months).Of the 24 patients,21 remain disease free,one is alive with disease,and two died of the *** patient developed local *** requiring additional surgical procedures occurred in six patients,including one with wound hematoma,one with delayed wound healing,one with superficial infection,one with deep infection,and two with mechanical failure of the *** mean Musculoskeletal Tumor Society score at the final follow-up was 91%(range:80%-100%).The 5-and 10-year implant survival rates were 91.3%and 79.9%,***:Computer naviga

关键词： Bone sarcoma Computer-assisted navigation Joint-preserving resection Custom-made endoprosthesis

Is There a Reliable Method to Predict the Limb Length Discrepancy after Chemotherapy and Limb Salvage Surgery in Children with Osteosarcoma？

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Chinese Medical Journal 2016年第16期129卷 1912-1916页

作者： Yuan Li Feng Liao Hai-Rong Xu xiao-hui niu Department of Orthopedic Oncology Surgery Beijing Jishuitan Hospital The Fourth Clinical Medical College of Peking University Beijing 100035 China

Background： For a child with osteosarcoma, prediction of the limb length discrepancy at maturity is important when planning for limb salvage surgery. The purpose of this study was to provide a reliable prediction method. Methods： A retrospective review of Chinese children receiving chemotherapy for osteosarcoma before skeletal maturity was conducted. Standing full-length radiographs of the lower extremity were used for length measurements. Length-for-age curves were constructed using the LMS method. The lower limb multiplier for a specific age and gender was calculated using the formula M =Lm/L, where M was the gender- and age-specific multiplier, Lm was the bone length at maturity, and L was the age-specific bone length. Prematurity and postmaturity radiographs were used to assess the accuracy of the prediction methods. Results： A total of 513 radiographs of 131 boys and 314 radiographs of 86 girls were used to calculate the coefficients of the multiplier. The multipliers of 8-, 9-, 10-, 11-, 12-, 13-, 14-, 15-, 16-, 17-, and 18-year-old boys after chemotherapy for osteosarcoma were 1.394, 1.306, 1.231, 1.170, 1.119, 1.071, 1.032, 1.010, 1.004, 1.001, and 1.000, respectively; while for girls at the same ages, the multipliers were 1.311, 1.221, 1.146, 1.092, 1.049, 1.021, 1.006, 1.001, 1.000, 1.000, and 1.000, respectively. Prematurity and postmaturity femoral and tibial lengths of 21 patients were used to assess the prediction accuracy. The mean prediction error was 0 cm, 0.8 cm, and 1.6 cm fbr the multiplier method using our coefficients, Paley＇s coefficients, and Anderson＇s method, respectively. Conclusions： Our coefficients for the multiplier method are reliable in predicting lower limb length growth of Chinese children with osteosarcoma.

关键词： Chemotherapy Chinese Children Lower Limb Length Multiplier Method Osteosarcoma

Computer Navigation-aided Resection of Sacral Chordomas

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Chinese Medical Journal 2016年第2期129卷 162-168页

作者： Yong-Kun Yang Chung-Ming Chan Qing Zhang Hai-Rong Xu xiao-hui niu Department of Orthopedic Oncology Surgery Beijing Ji Shui Tan Hospital Peking University Beijing 100035 China Department of Orthopaedics and Rehabilitation Division of Musculoskeletal Oncology University of Florida Gainesville Florida 32611 USA

Background： Resection of sacral chordomas is challenging. The anatomy is complex, and there are often no bony landmarks to guide the resection. Achieving adequate surgical margins is, therefore, difficult, and the recurrence rate is high. Use of computer navigation may allow optimal preoperative planning and improve precision in tumor resection. The purpose of this study was to evaluate the safety and feasibility of computer navigation-aided resection of sacral chordomas. Methods： Between 2007 and 2013, a total of 26 patients with sacral chordoma underwent computer navigation-aided surgery were included and followed for a minimum of 18 months. There were 21 primary cases and 5 recurrent cases, with a mean age of 55.8 years old （range： 35 84 years old）. Tumors were located above the level of the $3 neural foramen in 23 patients and below the level of the $3 neural foramen in 3 patients. Three-dimensional images were reconstructed with a computed tomography-based navigation system combined with the magnetic resonance images using the navigation software. Tumors were resected via a posterior approach assisted by the computer navigation. Mean follow-up was 38.6 months （range： 18-84 months）. Results： Mean operative time was 307 min. Mean intraoperative blood loss was 3065 ml. For computer navigation, the mean registration deviation during surgery was 1.7 ram. There were 18 wide resections, 4 marginal resections, and 4 intralesional resections. All patients were alive at the final follow-up, with 2 （7.7%） exhibiting tumor recurrence. The other 24 patients were tumor-free. The mean Musculoskeletal Tumor Society Score was 27.3 （range： 19-30）. Conclusions： Computer-assisted navigation can be safely applied to the resection of the sacral chordomas, allowing execution of preoperative plans, and achieving good oncological outcomes. Nevertheless, this needs to be accomplished by surgeons with adequate experience and skill.

关键词： Chordoma Computer-assisted Navigation Resection Sacral

Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients

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Chinese Medical Journal 2016年第21期129卷 2530-2534页

作者： Wei Zhang Qing Zhang Ting-Ting Zheng Jian-Cun Zhen xiao-hui niu Department of Clinical Pharmacology Beijing Jishuitan Hospital Beijing 100035 China Department of Orthopaedic Oncology Beijing Jishuitan Hospital Beijing 100035 China

Background：High-dose methotrexate （HD-MTX） with folinic acid （leucovorin） rescue is ＆quot;gold standard＆quot; therapy for *** concentrations of methotrexate （MTX） are closely related to its efficacy and *** excretion of MTX can lead to serious adverse reactions that may result in treatment cessation,irreversible organ damage,and *** study focused on the incidence of delayed excretion of MTX in Chinese osteosarcoma ***：A total of 1277 osteosarcoma patients were treated with HD-MTX chemotherapy （4291 cycles） from 2010 to *** that could influence delayed excretion of MTX （gender,age,number of chemotherapy cycles,and serum concentration of MTX） were ***：The incidence of delayed excretion of MTX （serum concentrations at 24 h [C24 h] 〉5 μmol/L） and severe delayed excretion of MTX （C24 h 〉20 μmol/L） were 6.19% and 0.86% per patient,and 2.31% and 0.26% per cycle of treatment,*** incidence of severe delayed excretion of MTX was associated with gender,age,and C24 ***：Precaution of delayed excretion of MTX is needed during osteosarcoma treatment using *** optimal individualized rescue strategy can be created with consideration of gender,age,and C24 h.

关键词： Delayed Excretion Methotrexate, Osteosarcoma Therapeutic Drug Monitoring

Biomechanical Properties of Synthetic Mesh Reconstructed Glenohumeral Joint Capsule

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Chinese Medical Journal 2017年第14期130卷 1743-1744页

作者： Tao Jin Wei-Feng Liu Hai-Rong Xu Yuan Li xiao-hui niu Department of Orthopaedic Oncology Surgery Beijing Jishuitan Hospital Peking University Beijing 100035 China

Synthetic mesh is often used in soft tissue reconstruction after artificial prosthesis replacement for patients with proximal humeral bone *** carried out biomechanical and histological tests on two amputated extremit... 详细信息

关键词： Biomechanical Shoulder Joint Stability Synthetic Mesh Tumors

Magnetic Resonance Imaging for the Assessment of Long Bone Tumors

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Chinese Medical Journal 2017年第21期130卷 2547-2550页

作者： Tao Jin Zhi-Ping Deng Wei-Feng Liu Hai-Rong Xu Yuan Li xiao-hui niu Department of Orthopaedic Oncology Surgery Beijing Jishuitan Hospital Peking University Beijing 100035 China

Background： Wide resection margins of osseous tumors are associated with a low incidence of local recurrence, making accurate measurement of the intraosseous extent of primary malignant long bone tumors is crucial. We compared the intraosseous tumor extent assessed by magnetic resonance imaging （MRI） with the gross specimen to evaluate the accuracy of MRI. Methods： A total of 255 patients with primary malignant tumors in the long bones were included. Using MRI, we defined the length of tumor as the distance from the articular surface to the boundary between abnormal and normal marrow signal. The extent of the abnormal intraosseous signal was measured on unenhanced T1-weighted （T1WI） magnetic resonance images after chemotherapy. All gross surgical specimens were sectioned, and tumor extent was measured. Wilcoxon signed-rank test was used to test the differences between MRI and gross specimen findings. Spearman＇s correlation analysis was used to test the correlation between groups. Results： Median tumor length by gross specimen （112 mm; range, 45–300 mm） was longer than that by MRI （108 mm; range, 45–304 mm;Z = -6.916, P 〈 0.001）. Of 255 images, tumor length was accurately represented on 27 T1WI magnetic resonance images, overestimated on 79 images, and underestimated on 149 images. The median difference between imaging and gross specimen measurements was 2.0 mm （range： 1.0–15.0 mm） for the 79 cases where tumor length was overestimated, and 5.0 mm （range： 1.0–18.0 mm） for the 149 cases where tumor length was underestimated. The Spearman correlation demonstrated a high correlation of tumor length on gross specimen with the tumor length on MRI （R = 0.99, P 〈 0.01）. Conclusions： We conclude that preoperative MRI could be a useful method in determining intramedullary malignant bone tumor boundaries and may serve as an accepted assessment method of long bone tumors before limb-sparing surgery.

关键词： Bone Tumor Gross Specimen Long Bone Magnetic Resonance Imaging Tumor Length

A novel method to reconstruct phylogeny tree based on thechaos game representation

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Journal of Biomedical Science and Engineering 2009年第8期2卷 582-586页

作者： Na-Na Li Feng Shi xiao-hui niu Jing-Bo Xia 不详

We developed a new approach for the reconstruction of phylogeny trees based on the chaos game representation (CGR) of biological sequences. The chaos game representation (CGR) method generates a picture from a biological sequence, which displays both local and global patterns. The quantitative index of the biological sequence is extracted from the picture. The Kullback-Leibler discrimination information is used as a diversity indicator to measure the dissimilarity of each pair of biological sequences. The new method is inspected by two data sets: the Eutherian orders using concatenated H-stranded amino acid sequences and the genome sequence of the SARS and coronavirus. The phylogeny trees constructed by the new method are consistent with the commonly accepted ones. These results are very promising and suggest more efforts for further developments.

关键词： CGR (Chaos Game Representation) Discrimination Information Phylogeny Tree