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Hierarchically Porous Polypyrrole Foams Contained Ordered Polypyrrole Nanowire Arrays for Multifunctional Electromagnetic Interference Shielding and Dynamic Infrared Stealth

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Nano-Micro Letters 2025年第4期17卷 399-418页

作者： Yu-long Liu Ting-yu Zhu Qin Wang Zi-jie huang De-xiang Sun Jing-hui Yang xiao-dong Qi Yong Wang School of Chemistry Key Laboratory of Advanced Technologies of Materials(Ministry of Education)Southwest Jiaotong UniversityChengdu 610031People’s Republic of China

As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal conversion ability have received extensive *** the aforesaid requirements simultaneously remains a huge *** this research,the melamine foam(MF)/polypyrrole(PPy)nanowire arrays(MF@PPy)were fabricated via one-step electrochemical *** hierarchical MF@PPy foam was composed of three-dimensional PPy micro-skeleton and ordered PPy nanowire *** to the upwardly grown PPy nanowire arrays,the MF@PPy foam possessed good hydrophobicity ability with a water contact angle of 142.00°and outstanding stability under various harsh ***,the MF@PPy foam showed excellent thermal insulation property on account of the low thermal conductivity and elongated ligament characteristic of PPy nanowire ***,taking advantage of the high conductivity(128.2 S m^(-1)),the MF@PPy foam exhibited rapid Joule heating under 3 V,resulting in dynamic infrared stealth and thermal camouflage *** importantly,the MF@PPy foam exhibited remarkable EMI shielding effectiveness values of 55.77 dB and 19,928.57 dB cm^(2)g^(-1).Strong EMI shielding was put down to the hierarchically porous PPy structure,which offered outstanding impedance matching,conduction loss,and multiple *** innovative approach provides significant insights to the development of advanced multifunctional EMI shielding foams by constructing PPy nanowire arrays,showing great applications in both military and civilian fields.

关键词： Polypyrrole nanowire arrays Hierarchical foam Hydrophobicity Infrared stealth Electromagnetic interference shielding

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Advances and applications of genome-edited animal models for severe combined immunodeficiency

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Zoological Research 2025年第01期 249-260页

作者： xiao Zheng Chun-hui huang Sen Yan Ming-Deng Rong Stomatological Hospital School of Stomatology Southern Medical University Guangdong Key Laboratory of Non-Human Primate Models Guangdong-Hongkong-Macau Institute of CNS Regeneration Jinan University School of medicine Jinan University Department of Neurology Guangzhou Red Cross Hospital Faculty of Medical Science Jinan University

Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death. Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies. Recent advances in gene-editing technologies, including zincfinger nucleases(ZFNs), transcription activator-like effector nucleases(TALENs), CRISPR/Cas9, and base editing, have significantly enhanced the generation of SCID models. These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy, stem cell transplantation, organ transplantation, and infectious *** comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.

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Rab23 is a potential biological target for treating hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第7期13卷 1010-1017页

作者： Yun-Jian Liu Qian wang Wen Li xiao-hui huang Shu-Hong huang Lian-Zhou Chen Ling Xue Hong-Wei Zhang Department of HepatobiliarySurgery First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080 Guangdong Province China Depatment of Pathology First Affiliated Hospitalof Sun Yat-Sen University Guangzhou 510080 GuangdongProvince China Institute of DevelopmentalBiology School of Life Sciences Shandong University Jinan250100 Shandong Province China

AIM： To elucidate the role of Rab23 in hepatocellular carcinoma （HCC） by assessing the expression of Rab23 in HCC tissue and in HCC cell lines. METHODS： Primary tumors （n = 100） were stained with Rab23 antibodies using immunohistochemistry and in situ hybridization in tissue microarrays. Relationships between gene expression and pathology parameters were analysed. The biological significance of Rab23 in Hep-3B cells was examined by knocking down Rab23 gene expression. We designed a pair of doublestranded RNAs against human rab23 and transfected siRNA into Hep-3B cells. Rab23 expression in these cells was examined using RT-PCR and Western blots. We investigated cell growth by MTT assays and fluorescenceactivated cell sorting. RESULTS： High cytoplasmic and nuclear expression of Rab23 was found in 38 of 71 （53.5%） and in 49 of 68 HCC patients （72%） respectively, which correlated with tumor size. HCC cell lines expressed Rab23. In Hep3B cells, siRNA for Rab23 decreased Rab23 mRNA by 4.5-fold and protein expression by 2-fold. Survival rates at 24 and 48 h for Hep-3B cells tTansfected with siRNA were lower and about 30% Hep-3B cells were apoptotic. Knocking down rab23 suppressed Hep3B cell growth, suggesting that rab23 could play an important role in Hep3B cell growth. CONCLUSION： Rab23 is overexpressed and/or activatedin HCC. Rab23 may be both a HCC predictor and a target for treating HCC.

关键词： Rab23 Sonic hedgehog Hepatocellularcarcinoma Tissue microarray siRNA

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Scheduling in a Meta Search Engine by Genetic Algorithm

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 541-546页

作者： Zhang Wei feng, Xu Bao wen, Zhou xiao yu, huang hui Department of Computer Science and Engineering, Southeast University, Nanjing 210096,China State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072,China Department of Computer Science and Engineering Southeast University Nanjing 210096 China

The meta search engines provide service to the users by dispensing the users' requests to the existing search engines. The existing search engines selected by meta search engine determine the searching quality. Because the performance of the existing search engines and the users' requests are changed dynamically, it is not favorable for the fixed search engines to optimize the holistic performance of the meta search engine. This paper applies the genetic algorithm (GA) to realize the scheduling strategy of agent manager in our meta search engine, GSE(general search engine), which can simulate the evolution process of living things more lively and more efficiently. By using GA, the combination of search engines can be optimized and hence the holistic performance of GSE can be improved dramatically.

关键词： WWW internet search engine meta search engine genetic algorithm agent

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Effects of supplying silicon nutrient on utilization rate of nitrogen and phosphorus nutrients by rice and its soil ecological mechanism in a hybrid rice double-cropping system

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第6期21卷 474-484页

作者： Min LIAO Zhi-ping FANG Yu-qi LIANG xiao-hui huang Xu YANG Shu-sen CHEN xiao-mei XIE Chang-xu XU Jia-wen GUO College of Environmental and Resource Science Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition Hangzhou 310058China Experimental Teaching Center College of Environment and ResourcesZhejiang UniversityHangzhou 310058China Institute of Soil&Fertilizer and Resource&Environment Jiangxi Academy of Agricultural SciencesNanchang 330200China

This study was conducted to reveal the effects of silicon(Si) application on nutrient utilization efficiency by rice and on soil nutrient availability and soil microorganisms in a hybrid rice double-cropping planting system. A series of field experiments were conducted during 2017 and 2018. The results showed that Si nutrient supply improved grain yield and the utilization rates of nitrogen(N) and phosphorus(P) to an appropriate level for both early and late plantings, reaching a maximum at 23.4 kg/ha Si. The same trends were found for the ratios of available N(AN) to total N(TN) and available P(AP) to total P(TP), the soil microbial biomass carbon(MBC), microbial biomass nitrogen(MBN), microbial biomass phosphorus(MBP), and the ratios of MBN to TN and MBP to TP, at different levels of Si. Statistical analysis further revealed that Si application enhanced rice growth and increased the utilization rate of fertilizer due to an ecological mechanism, i.e., Si supply significantly increased the total amount of soil microorganisms in paddy soil compared to the control. This promoted the mineralization of soil nutrients and improved the availability and reserves of easily mineralized organic nutrients.

关键词： Silicon nutrient Utilization rate of fertilizer Ecological mechanism Rice double-cropping system

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Sequence-controlled dynamic covalent units enable decoupling of mechanical and self-healing performance of polymers

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Science China Chemistry 2025年第2期68卷 745-753页

作者： Luzhi Zhang Hongfei huang Lijie Sun xiaopeng Ma hui Tan Zhengwei You Respiratory Department Shenzhen Children’s Hospital Affiliated to Shantou University Medical CollegeShenzhen 518038China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua UniversityShanghai 201620China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China

Sequence regulation provides an effective approach to controlling the properties of polymer ***,this approach remains an open question in the field of dynamic polymers,which emerge as more and more important new generation ***,we systematically investigate the effect of sequence control of dynamic covalent units in tuning the properties of *** sequence-controlled poly(oxime-urethanes)are *** dynamic oxime-urethane groups are relatively dispersed(SCP-1)or concentrated(SCP-2)distributed in their molecular *** sequence control strategy provides an efficient way to decouple the mechanical and self-healing performance of polymers,which is one of the most pressing challenges in the *** relatively dispersed oxime-urethane groups in SCP-1 not only facilitate the reorganization of the dynamic covalent bonds but also increase the probability of the reformation of hydrogen *** reversible dissociation/reassociation of dynamic bonds is conducive to dissipating energy to enhance mechanical performance and promote self-healing *** a result,SCP-1 exhibits much faster self-healing than SCP-2,and its tensile strength is nearly twice that of *** addition,energy dissipation capacity and degradation behavior also show significant sequence ***,this work reveals a new molecular structure-property relationship and provides a powerful strategy to construct high-performance polymers.

关键词： sequence control dynamic polymer poly(oxime-urethane) strength polyurethane

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The Damage Patterns of Retinal Nerve Fiber Layer in Acute and Chronic Intraocular Pressure Elevation in Primary Angle Closure Glaucoma

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Eye Science 2011年第3期26卷 154-160页

作者： Xing Liu Mei Li Yimin Zhong hui xiao Jingjing huang Zhen Mao Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose:To observe the differences of damage patterns of retinal nerve fiber layer(RNFL) between acute and chronic intraocular pressure(IOP) elevation in primary angle closure glaucoma.(PACG).using optical coherence tomography(OCT).Methods:Twenty four patients(48 eyes) with unilateral acute PACG(APACG) attack in the 6 months after remission and 36 patients(64 eyes) with chronic PACG(CPACG) were included in this prospective *** all cases,IOP has been controlled less than 21 mmHg after *** stratus OCT,the RNFL thickness was assessed in eyes with PACG within 3 days,2 weeks,1,3 and 6 months after IOP *** measures ANOVA was used to examine the time course of changes after IOP controlled in RNFL thickness in both acute attack and unaffected fellow eyes of APACG and eyes with ***:The mean RNFL thickness(μm) for the APACG-attacked eyes increased significantly within 3 days.(121.49±23.84).after acute strike and then became thinner along with time.(107.22±24.72 at 2 week,93.58±18.37 at 1 month,84.10±19.89 at 3 months and 78.98±19.17 at 6 months).In APACG-attacked eyes,there were significant differences of average RNFL thickness among 5 different times after IOP was controlled(P<0.001).In the APACG unaffected fellow eyes and CPACG eyes,there were no significant differences in mean RNFL thickness among 5 different times(F=0.450,P=0.104 in APACG unaffected fellow eyes and F=1.558,P=0.200 in CPACG eyes).There was significant difference for interaction between time periods and groups(F=1.912,P= 0.003).Conclusion:RNFL damage patterns are different under different IOP elevated *** APACG,RNFL was found to be swollen and thickening right after acute attack and then becomes thinning and atrophy along with the time,while RNFL was found to be diffused thinness in CPACG.

关键词：神经纤维破坏模式视网膜纤维层青光眼原发性眼压急性

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Bioinspired smart dual-layer hydrogels system with synchronous solar and thermal radiation modulation for energy-saving all-season temperature regulation

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Journal of Energy Chemistry 2025年第2期101卷 175-190页

作者： Meng-Chen huang Chao-Hua Xue Zhongxue Bai Jun Cheng Yong-Gang Wu Chao-Qun Ma Li Wan Long Xie hui-Di Wang Bing-Ying Liu xiao-Jing Guo College of Bioresources Chemical and Materials Engineering Shaanxi University of Science & Technology School of Manufacture Science and Engineering Key Laboratory of Testing Technology for Manufacturing Process Ministry of Education Southwest University of Science and Technology School of Life Science and Engineering Southwest University of Science and Technology Northwest Institute for Nonferrous Metal Research Shaanxi Key Laboratory of Biomedical Metal Materials

All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating ***,the static single thermal management for cooling or heating fails to self-regulate the temperature in dynamic seasonal temperature ***,inspired by the dual-temperature regulation function of the fur color changes on the backs and abdomens of penguins,a smart thermal management composite hydrogel(PNA@H-PM Gel) system was subtly created though an "on-demand" dual-layer structure design *** PNA@H-PM Gel system features synchronous solar and thermal radiation modulation as well as tunable phase transition temperatures to meet the variable seasonal thermal requirements and energy-saving demands via self-adaptive radiative cooling and solar heating ***,this system demonstrates superb modulations of both the solar reflectance(ΔR=0.74) and thermal emissivity(ΔE=0.52) in response to ambient temperature changes,highlighting efficient temperature regulation with average radiative cooling and solar heating effects of 9.6℃ in summer and 6.1℃ in winter,***,compared to standard building baselines,the PNA@H-PM Gel presents a more substantial energy-saving cooling/heating potentials for energy-efficient buildings across various regions and *** novel solution,inspired by penguins in the real world,will offer a fresh approach for producing intelligent,energy-saving thermal management materials,and serve for temperature regulation under dynamic climate conditions and even throughout all seasons.

关键词： Energy-saving Radiative cooling Self-adaptive thermal management Spectral modulation Thermochromic hydrogel

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Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells

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Acta Pharmacologica Sinica 2007年第6期28卷 879-887页

作者： Liang-qi CAO~2,Xi-lin CHEN~2,Qian WANG~3,xiao-hui huang,Mao-chuan ZHEN,Long-juan ZHANG,Wen LI,Jiong BIDepartment of Hepatobiliary Surgery the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China Department of Hepatobiliary Surgery the First Affiliated Hospital of Sun Yat-Sen University Guangzhou China

Aim:To investigate the effects of rosiglitazone,a peroxisome proliferator-ac-tivated receptor gamma (PPART) agonist,on the expression of the phosphataseand tensin homologue deleted on chromosome 10 gene (PTEN) and cell growthin hepatocellular carcinoma cells,as well as the underlying mechanisms of ***:RT-PCR and Western blotting analyses were performed to de-tect transcription and the expression of PTEN in Hep3B cells treated withrosiglitazone.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide as-say was used to evaluate cell *** cytometry,DNA fragmentation analysis,caspase enzymatic assay,and Hoechst 33258 staining were used to determine ***,small interfering RNA was used to suppress ***:Rosiglitazone increased the expression of PTEN in a dose-and time-dependent manner through the PPARγ-dependent signal *** upregulation was concomitant with a decreased level of Aktphosphorylation,subsequently resulting in cell growth inhibition and apoptosisin Hep3B *** knockdown dramatically blocked these effects ***,the exposure of cells to rosiglitazone activated caspases-9and-3 during apoptotic ***:Thus,upregulation of PTENis involved in the inhibition of cell growth and the induction of cell apoptosis byrosiglitazone,suggesting that rosiglitazone may be useful in liver cancer therapyvia apoptosis.

关键词： rosiglitazone PTEN apoptosis hepato cellular carcinoma PPARγ

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Tetraphenylethylene-derived organic cages with persistent photogenic radicaloids and efficient photothermal conversion

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Science China Chemistry 2025年第2期68卷 661-669页

作者： Suqiong Yan Bo Yang Fanda Feng Yuan Zhang Shirong Ban hui Ma Wei huang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen Research Institute of Nanjing University Shenzhen 518057China

Transformation of the electronic spin states has received significant interest in recent years because of its applications in the magnetic information storage materials and optical response ***,it can be formidably challenging to use ultraviolet(UV)light as a contactless stimulus to alter the electronic spin states of the supramolecular *** by the approach on the radical cation mechanism of the Scholl reaction and the photocyclization reactivity of tetraphenylethylene(TPE)derivatives,we report two photochromic cages(cage-TPE-1 and cage-TPE-2)that can be photochemically transformed from electron paramagnetic resonance(EPR)-silent to EPR-active form via UV irradiation due to the photo-induced electron transfer process at the TPE *** provided a strong single-electron signal with a g value of 2.003 in cage-TPE-1 and cage-TPE-2 but no signal was detected for the pristine samples without the *** transformation can be monitored by ultraviolet–visible–near-infrared(UV–vis–NIR)and photoluminescence(PL)*** photogenic radical cage intermediate was unstable in solution resulting in the degradation and intramolecular cyclization of the reactive species,while the radicals were found to be stable and persistent in the solid state due to the spin delocalization,the steric protection of confined cavities,and the oxygen *** theoretical calculations and spectral measurements suggest that the photogenic radical cage-TPE-2(•+)experiences photocyclization on the TPE *** with the close-shell cage,the radical cage-TPE-1(•+)and cage-TPE-2(•+)exhibit better photothermal conversion performance due to the incubated infrared absorption from open-shell electron feature and reduced band gap.

关键词： supramolecular cage photogenic radical photocyclization photothermal conversion

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