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A novel synthetic route for 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanamine

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Chinese Chemical Letters 2008年第1期19卷 59-60页

作者： xiao Chuan Luo Guo Hua Chen hui Bin Zhang Wen Long huang epartment of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Center of Drug Discovery China Pharmaceutical University Nanjing 210009 China

2-[2-（2,2,2-Trifluoroethoxy）phenoxy]ethanamine is the key intermediate of Silodosin, the α1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia. In order to obtain this intermediate, we developed a novel synthetic route by utilizing 2- nitrochlorobenzene as the starting material via O-alkylation, reduction, diazotization, acidolysis, etherification, condensation and hydrazinolysis. The highlight of this method lies on its convenience and economy in accessing this intermediate. 2007 Guo Hua Chert. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Silodosin 2-[2-(2,2,2-Trifluoroethoxy)phe'noxy]ethanamine Synthesis

Prostate artery embolization on lower urinary tract symptoms related to benign prostatic hyperplasia: A systematic review and metaanalysis

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World Journal of Clinical Cases 2022年第32期10卷 11812-11826页

作者： xiao-Yan Wang Yu-Meng Chai Wen-hui huang Yong Zhang Department of Urology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China School of Information Science and Engineering Shandong Normal UniversityJinan 250014Shandong ProvinceChina

BACKGROUND Prostate artery embolization(PAE)is a promising minimally invasive therapy that improves lower urinary tract symptoms(LUTS)related to benign prostatic hyperplasia(BPH).Transurethral resection of the prostate(TURP)is the gold standard therapy for LUTS/*** To evaluate the efficacy and safety of PAE vs TURP on LUTS related to *** A literature review was performed to identify all published articles on PAE vs TURP for LUTS/*** included PubMed,Embase,Cochrane library databases,and Chinese databases before June 2022.A systematic review and meta-analysis were *** measurements were combined by calculating the mean difference with a 95%confidence *** analysis was carried out using Review Manager *** Eleven studies involving 1070 participants were *** with the TURP group,the PAE group had a similar effect on the International Index of Erectile Function(IPSS)score,Peak urinary flow rate(Qmax),postvoid residual volume(PVR),Prostate volume(PV),prostatic specific antigen(PSA),The International Index of Erectile Function short form(IIEF-5)scores,and erectile dysfunction during 24 mo *** quality of life(QoL)score,lower rate of retrograde ejaculation and shorter hospital stay in the PAE *** was no participant death in either group.A higher proportion of haematuria,urinary incontinence and urinary stricture was identified in the TURP *** PAE may be an appropriate option for elderly patients,patients who are not candidates for surgery,and patients who do not want to risk the potential adverse effects of *** with large cases and long follow-up time are needed to validate results.

关键词： Lower urinary tract symptoms Benign prostatic hyperplasia Meta-analysis Prostate artery embolization Transurethral resection of the prostate

Formability of AA 2219-O sheet under quasi-static,electromagnetic dynamic,and mechanical dynamic tensile loadings

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Journal of Materials Science & Technology 2021年第11期70卷 125-135页

作者： Hongliang Su Liang huang Jianjun Li Wang xiao hui Zhu Fei Feng Hongwei Li Siliang Yan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China

The mechanism by which electromagnetic forming(EMF)enhances the formability of metals is unclear owing to the coupling effect of multi-physics *** the present work,the associated formability improvement mechanisms were qualitatively categorized and *** was realized by comparing the formability of fully annealed 2219 aluminum alloy(AA 2219-O)sheet under quasi-static(QS),electromagnetic dynamic(EM),and mechanical dynamic(MD)tensile *** was found that the forming limit of AA 2219-O sheet under EM tensile loading was significantly(45.4%)higher than that under QS tensile loading,and was marginally(3.7%–4.3%)higher than that under MD tensile *** addition,the forming limit of AA 2219-O sheet demonstrated a negative dependency on the strain rate within the range of the dynamic tensile tests *** deformation conditions common to EM and MD tensile loadings were responsible for the significant formability improvement compared with QS tensile *** particular,the inertial effect was *** different deformation conditions that distinguish EM tensile loading from MD tensile loading resulted in the marginal improvement in *** was caused by the absence of a sustaining contact force at the later deformation stage and the lower strain *** body force exerted little influence on the formability improvement,and the thermal effect under the two dynamic tensile loadings was negligible.

关键词： Formability Aluminum alloy sheet Quasi-static Electromagnetic dynamic Mechanical dynamic Tensile loading

基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法

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光电子·激光 2025年第1期36卷 46-52页

作者：赵辉黄镖王红君岳有军天津理工大学电气工程与自动化学院天津市复杂系统控制理论与应用重点实验室

为对巡检机器人在巡检过程中产生的运动模糊图像进行高效精准识别，提出了一种基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法。为有效提取图像重要特征，该方法将通道注意力(channel attention, CA)机制集成到DeblurGAN-v2主... 详细信息

为对巡检机器人在巡检过程中产生的运动模糊图像进行高效精准识别，提出了一种基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法。为有效提取图像重要特征，该方法将通道注意力(channel attention, CA)机制集成到DeblurGAN-v2主干网格中，使模型更加关注细节特征，提高对运动模糊图像的复原能力；此外，在原模型特征提取网络顶层引入空间金字塔池化(spatial pryamid pooling, SPP)缓解图像多尺度变化造成对图像复原的负面影响，提高模型对图像复原的性能。基于实际农田环境建立的数据集所做的实验结果表明，改进后算法的PSNR、SSIM指标分别为26.281 8 dB、0.947 3,较原模型提升了8、7.2个百分点。与其他主流模型的对比实验结果表明，本文方法对模糊图像的实际复原效果更优，对解决运动模糊农作物害虫的图像复原问题具有实际应用价值。

关键词：运动模糊深度学习图像复原 DeblurGAN-v2 通道注意力(CA)机制空间金字塔池化(SPP)模块

Geometric effects of cross sections on equilibrium of helical and twisted ribbon

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 495-504页

作者： Ye xiao Zaixing huang State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In the framework of elastic rod model, the Euler-Lagrange equations characterizing the equilibrium configuration of the polymer chain are derived from a free energy functional associated with the curvature, torsion, twisting angle, and its derivative with respect to the arc-length. The configurations of the helical ribbons with different cross-sectional shapes are given. The effects of the elastic properties, the cross-sectional shapes, and the intrinsic twisting on the helical ribbons are discussed. The results show that the pitch angle of the helical ribbon decreases with the increase in the ratio of the twisting rigidity to the bending rigidity and approaches the intrinsic twisting. If the bending rigidity is much greater than the twisting rigidity, the bending and twisting of the helical ribbon always appear simultaneously.

关键词： Euler-Lagrange equation twisting angle pitch angle elastic rod model helical and twisted ribbon

All-parameters Rayleigh wave inversion

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 517-534页

作者： xiao-hui Yang Ka-Veng Yuen State Key Laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China

Since S-wave velocity of the subsurface is an important parameter in near surface applications,many studies have been conducted for its *** the various methods that use surface waves or body waves,Rayleigh wave inversion is the most *** practice,the densities and P-wave velocities of different layers are usually assumed to be known to avoid ill-posed problems,as they have less influence on the dispersion ***,improper assignment of these two groups of parameters leads to inaccurate estimation of the S-wave velocity *** order to address this problem,the all-parameters Rayleigh wave inversion strategy is proposed in which the S-wave velocities,layer thicknesses,densities and P-wave velocities of different layers are included as the unknown parameters for ***,the transitional Markov Chain Monte Carlo(TMCMC)algorithm is applied for the implementation of all-parameters Rayleigh wave *** simulated example and two real-test applications are demonstrated to verify the capability of the proposed method in the estimation of the S-wave velocity profile,the densities and the P-wave ***,it is verified that the proposed method achieved more accurate S-wave velocity profile estimation than the traditional approach.

关键词： all-parameters Rayleigh wave inversion Bayesian S-wave velocity profile TMCMC algorithm uncertainty quantification

Phase evolution of binary immiscible Al-Sn film

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Rare Metals 2022年第12期41卷 4241-4247页

作者： xiao-Meng Pan hui-Ping Duan School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Binary immiscible Al-Sn alloy is a very important potential anode material for lithium ion *** phase stability and separation process of Al-Sn film,fabricated by magnetron co-sputtering method,was investigated by X-ray diffractometer(XRD),differential scanning calorimetry(DSC) and in situ transmission electron microscopy(TEM) and explained by Miedema theoretical *** analysis reveals that the asdeposited Al-Sn film will decompose spontaneously into Al-riched areas and Sn-riched areas because of the positive mixing *** crystallization process takes place when the Al content in the Al-riched area or Sn content in the Sn-riched area *** results show that Al-Sn thin film is composed of an amorphous matrix and well-dispersed composite *** particle contains an Al-riched area and a Sn-riched *** Snriched area crystallizes and swallows up the Al-riched area gradually during heating through uphill diffusion of the Sn *** on the theoretical analysis and experimental results,an empirical model to explain the phase evolution process in the Al-Sn film was proposed.

关键词： Immiscible alloy Uphill diffusion Phase evolution Miedema theory

四川盆地天然气资源状况与可持续发展问题思考

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天然气地球科学 2005年第1期16卷 44-47页

作者：张廷山王顺玉陈晓慧黄世伟西南石油学院四川南充617001

通过论述四川盆地天然气的地层分布、勘探区块分布、资源品质分布和煤层气资源分布特征,综合分析了四川盆地天然气资源状况并讨论了对其勘探状况,指出四川盆地是我国的天然气资源大区,但是,其勘探程度还相对较低,各个层系和各区块均还... 详细信息

通过论述四川盆地天然气的地层分布、勘探区块分布、资源品质分布和煤层气资源分布特征,综合分析了四川盆地天然气资源状况并讨论了对其勘探状况,指出四川盆地是我国的天然气资源大区,但是,其勘探程度还相对较低,各个层系和各区块均还有相当大的勘探潜力,特别是在煤层气的勘探开发方面潜力更大。在四川经济快速发展的关键时期,天然气资源能否满足、支撑经济的高速增长,同时保证四川自然环境状况的不断改善十分重要,据此,提出了四川天然气工业可持续发展应考虑的问题。

关键词：天然气资源分布特征勘探状况可持续发展思考四川盆地

Effect of Zinc Oxide Nanoparticles on Denitrification and Denitrifying Bacteria Communities in Typical Estuarine Sediments

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Journal of Ocean University of China 2021年第3期20卷 599-607页

作者： CHEN Xi XIANG Zhuangzhuang REN Zhaomeng huang xiao LI hui SUN Pengfei BAI Jie College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlSchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Marine Environmental Science and Ecology Ministry of EducationOcean University of ChinaQingdao 266100China

For revealing the effects of increasing of zinc oxide nanoparticles(ZnO NPs)on denitrification and denitrifying bacteria communities in estuarine sediments,the surface sediments of two typical estuaries(the Yangtze River Estuary and the Yellow River Estuary)were added with medium concentration(170mgL−1)and high concentration(1700mgL−1)of ZnO NPs for anaerobic cul-ture in *** concentration of NO_(3)^(−)and NO_(2)^(−),the reductase activity and denitrification rate were measured by physico-chemical analysis,nirS gene abundance and denitrifying bacteria communities by molecular biological *** results showed that ZnO NPs inhibited NO_(3)^(−), NO_(2)^(−)reduction process and NO_(3)^(−), NO_(2)^(−)reductase activity,and a stronger inhibition effect resulting from the higher ZnO NPs *** NPs decreased nirS gene abundance and community diversity of denitrifying *** addition,the inhibition degree of ZnO NPs on the denitrification process of sediments in different estuaries was *** results were of great significance for evaluating the potential ecological toxicity and risks of nanomaterials in estuaries.

关键词： zinc oxide nanoparticles denitrification denitrifying bacteria community estuarine sediments