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Comparison of clinical features and outcomes in peritoneal dialysisassociated peritonitis patients with and without diabetes:A multicenter retrospective cohort study

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World Journal of Diabetes 2020年第10期11卷 435-446页

作者： Ling-Fei Meng Li-Ming Yang Xue-Yan Zhu xiao-Xuan Zhang Xin-Yang Li Jing Zhao Shi-Chen Liu xiao-hua zhuang Ping Luo Wen-Peng Cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Nephrology The First Hospital of Jilin University-the Eastern DivisionChangchun 130041Jilin ProvinceChina Department of Nephrology Jilin Central HospitalJilin 132011Jilin ProvinceChina Department of Nephrology Jilin FAW General HospitalChangchun 130041Jilin ProvinceChina

BACKGROUND The number of end-stage renal disease patients with diabetes mellitus(DM)who are undergoing peritoneal dialysis is *** dialysis-associated peritonitis(PDAP)is a serious complication of peritoneal dialysis leading to technical failure and increased mortality in patients undergoing peritoneal *** profile of clinical symptoms,distribution of pathogenic organisms,and response of PDAP to medical management in the subset of end-stage renal disease patients with DM have not been reported *** results have been found in long-term prognostic outcomes of PDAP in patients with *** inferred that DM is associated with bad outcomes in PDAP *** To compare the clinical features and outcomes of PDAP between patients with DM and those *** In this multicenter retrospective cohort study,we enrolled patients who had at least one episode of PDAP during the study *** patients were followed for a median of 31.1 *** were divided into a DM group and a non-DM *** features,therapeutic outcomes,and long-term prognostic outcomes were compared between the two *** factors associated with therapeutic outcomes of PDAP were analyzed using multivariable logistic regression.A Cox proportional hazards model was constructed to examine the influence of DM on patient survival and incidence of technical *** Overall,373 episodes occurred in the DM group(n=214)and 692 episodes occurred in the non-DM group(n=395).The rates of abdominal pain and fever were similar in the two groups(P>0.05).The DM group had more infections with coagulase-negative Staphylococcus and less infections with Escherichia coli(***)as compared to the non-DM group(P0.05).Patients in the DM group were older and had a higher burden o

关键词： Diabetes mellitus Mortality Peritoneal dialysis Peritoneal dialysis-associated peritonitis Technical failure

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Risk factors for mortality within 6 mo in patients with diabetes undergoing urgent-start peritoneal dialysis:A multicenter retrospective cohort study

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World Journal of Diabetes 2022年第4期13卷 376-386页

作者： Si-Yu Cheng Li-Ming Yang Zhan-Shan Sun xiao-Xuan Zhang Xue-Yan Zhu Ling-Fei Meng Shi-Zheng Guo xiao-hua zhuang Ping Luo Wen-Peng Cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Nephrology The First Hospital of Jilin University-the Eastern DivisionChangchun 130041Jilin ProvinceChina Department of Nephrology Xing’anmeng People’s HospitalUlan Hot 137400Inner Mongolia Autonomous Region China Department of Nephrology Jilin FAW General HospitalChangchun 130041Jilin ProvinceChina Department of Nephrology Jilin Central HospitalJilin 132011Jilin ProvinceChina

BACKGROUND The risk of early mortality of patients who start dialysis urgently is high;however,in patients with diabetes undergoing urgent-start peritoneal dialysis(USPD),the risk of,and risk factors for,early mortality are *** To identify risk factors for mortality during high-risk periods in patients with diabetes undergoing *** This retrospective cohort study enrolled 568 patients with diabetes,aged≥18 years,who underwent USPD at one of five Chinese centers between 2013 and *** divided the follow-up period into two survival phases:The first 6 mo of USPD therapy and the months *** compared demographic and baseline clinical data of living and deceased patients during each ***-Meier survival curves were generated for all-cause mortality according to the New York Heart Association(NYHA)classification.A multivariate Cox proportional hazard regression model was used to identify risk factors for mortality within the first 6 mo and after 6 mo of *** Forty-one patients died within the first 6 mo,accounting for the highest proportion of mortalities(26.62%)during the entire follow-up *** disease was the leading cause of mortality within 6 mo(26.83%)and after 6 mo(31.86%).The risk of mortality not only within the first 6 mo but also after the first 6 mo was higher for patients with obvious baseline heart failure symptoms than for those with mild or no heart failure *** risk factors for mortality within the first 6 mo were advanced age hazard ratio(HR:1.908;95%CI:1.400-2.600;P<0.001),lower baseline serum creatinine level(HR:0.727;95%CI:0.614-0.860;P<0.001),higher baseline serum phosphorus level(HR:3.162;95%CI:1.848-5.409;P<0.001),and baseline NYHA class III-IV(HR:2.148;95%CI:1.063-4.340;P=0.033).Independent risk factors for mortality after 6 mo were advanced age(HR:1.246;95%CI:1.033-1.504;P=0.022)and baseline NYHA class III-IV(HR:2.015;95%CI:1.298-3.130;P=0.002).CONCLUSION To reduce the risk

关键词： Peritoneal dialysis Urgent start Diabetes mellitus,Mortality within the first 6 mo Risk factor End-stage renal disease

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亚太区域经济一体化与两岸共同参与策略选择

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宁夏社会科学 2017年第2期 122-126页

作者：郑学党华晓红庄芮工业和信息化部国际经济技术合作中心北京100846 中国国际贸易促进委员会电子信息行业分会北京100846 对外经济贸易大学国际经济研究院北京100029

亚太区域经济合作是世界经济全球化的重要组成部分,以FTA为代表的经济一体化是未来亚太区域经济合作发展的主流和方向。中国大陆与台湾同处亚太生产网络的关键环节,但相比中国大陆,台湾FTA进展缓慢,基本被排除在亚太主要FTA之外。运用G... 详细信息

亚太区域经济合作是世界经济全球化的重要组成部分,以FTA为代表的经济一体化是未来亚太区域经济合作发展的主流和方向。中国大陆与台湾同处亚太生产网络的关键环节,但相比中国大陆,台湾FTA进展缓慢,基本被排除在亚太主要FTA之外。运用GTAP模型,以RCEP和中日韩FTA为例,模拟分析了亚太两大FTA贸易自由化对两岸经济的影响。研究发现,包括台湾在内的非成员,无论GDP增长、社会福利还是贸易条件等,均受到两大FTA不同程度的负面影响,尤其是两大FTA同时实现贸易自由化,台湾受损程度更为严重。在当前两岸互信不足情况下,只有联合中国大陆共同参与亚太区域经济合作,才是台湾拓展"国际经济空间"和避免被"边缘化"的根本出路。

关键词：两岸 RCEP 中日韩FTA 经济效应共同参与

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Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： hua Bai xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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地方高校实验教学学分制改革实践

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实验技术与管理 2010年第3期27卷 132-135,148页

作者：肖毅潘华庄发文宗莲松西华大学教务处

实验教学学分制的改革与实施,为地方高校实验教学提供了一种新的教学与管理模式,不仅较好地解决了实验教学与理论教学的冲突,提高了实验教学资源的利用率,而且为学生个性化发展与培养提供了平台,提高了实验教学对人才培养的质量和作用。

关键词：地方高校实验教学学分制改革实践

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-Zhao xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： xiao-Yu Zhao Juan-Han Yu Yi-hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Beneficial Effects and Potential Mechanisms of Tai Chi on Lower Limb Osteoarthritis:A Biopsychosocial Perspective

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Chinese Journal of Integrative Medicine 2023年第4期29卷 368-376页

作者： zhuang Shu-zhao CHEN Pei-jie HAN Jia xiao Wei-hua Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Lower limb osteoarthritis(OA)is a chronic,multifactorial disease characterized by impaired physical function,chronic pain,compromised psychological health and decreased social *** inflammation plays a critical role in the pathophysiology of *** Chi is a type of classical mind-body exercise derived from ancient Chinese martial *** supports that Tai Chi has significant benefits for relieving lower limb OA *** a biopsychosocial framework,this review aims to elucidate the beneficial effects of Tai Chi in lower limb OA and disentangle its potential mechanisms from the perspective of biology,psychology,and social *** biomechanical,biochemical,neurological,psychological,and social mechanisms,including strengthening of muscles,proprioception improvement,joint mechanical stress reduction,change of brain activation and sensitization,attenuation of inflammation,emotion modulation and social support,are discussed.

关键词： Tai Chi osteoarthritis mechanism biopsychosocialmodel

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-hua Wan Hong-Wei Zhang xiao Guo hua Guo Shou-Feng Jia xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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