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Two Structure-Preserving-Doubling Like Algorithms to Solve the Positive Definite Solution of the Equation X-A^(H)X^(-1)A=Q

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Communications on Applied Mathematics and Computation 2021年第1期3卷 123-135页

作者： xiao-Xia Guo hong-xiao wu School of Mathematical Science Ocean University of ChinaQingdao 266100Shandong ProvinceChina

In this paper,we study the nonlinear matrix equation X-A^(H)X^(-1)A=Q,where A,Q∈C^(n×n),Q is a Hermitian positive definite matrix and X∈C^(n×n)is an unknown *** prove that the equation always has a unique Hermitian positive definite *** present two structure-preserving-doubling like algorithms to find the Hermitian positive definite solution of the equation,and the convergence theories are ***,we show the effectiveness of the algorithms by numerical experiments.

关键词： Positive definite solution Structure-preserving-doubling like algorithm Convergence Numerical experiment

On the Origin and Numerical Range of Bounded Operators

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Acta Mathematica Sinica,English Series 2019年第10期35卷 1715-1722页

作者： xiao hong wu Jun Jie HUANG ALATANCANG School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021P.R.China Department of Mathematics Hohhot Minzu CollegeHohhot 010051P.R.China

Numerical range has an important applications on spectrum distribution of operators. In this paper, we devoted to characterizing operators whose numerical range contains the origin. Some necessary and sufficient conditions are given by operator decomposition technique and constructive methods. Furthermore, the closeness of the numerical range of a given operator is also investigated.

关键词： Bounded linear operator numerical range origin

Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： hong-xiao wu xiao-Yan Ding Ya-Wen Xu Ming-Hua Yu xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Current Status and Prospect of Stent Placement for May-Thurner Syndrome

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Current Medical Science 2021年第6期41卷 1178-1186页

作者： Qin LIU Fang LIU Ping LÜ hong-xiao wu Pin YE Yun YOU Zhong YAO Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Donnelly Centre for Cellular and Biomolecular Research University of TorontoTorontoOntario M5S 2E8Canada

Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical *** research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent ***,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial ***,relatively common corresponding complications may come along later,which include stent displacement,deformation,and *** measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these *** ideal venous stent is presently being evaluated and will be introduced in detail in this review.

关键词： May-Thumer syndrome deep vein thrombosis post-thrombotic syndromes stent stent placement

Nkx2-1:a novel tumor biomarker of lung cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 855-866页

作者： LiYANG Min LIN Wen-jing RUAN Liang-liang DONG En-guo CHEN xiao-hong wu Ke-jing YING Department of Respiratory Medicine the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006 China Department of Radiology the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 China Key Laboratory of Biotherapy of Zhejiang Province Department of Respiratory Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

关键词： Nkx2-1 TTF-1 Lung cancer Biomarker Diagnosis Prognosis Therapy

Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells

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World Journal of Gastroenterology 2007年第24期13卷 3342-3349页

作者： xiao-hong wu Cui-Ping Liu Kuan-Feng Xu xiao-Dong Mao Jian Zhu Jing-Jing Jiang Dai Cui Mei Zhang Yu Xu Chao Liu Department of Endocrinology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM: To study the capacity of bone marrow mesenchymal stem cells (BM-MSCs) trans-differentiating into islet-like cells and to observe the effect of portal vein transplantation of islet-like cells in the treatment of streptozotocin-induced diabetic rat. METHODS: BM-MSCs were isolated from SD rats and induced to differentiate into islet-like cells under defined conditions. Differentiation was evaluated with electron microscopy, RT-PCR, immunofluorescence and flow cytometry. insulin release after glucose challenge was tested with ELiSA. Then allogeneic islet-like cells were transplanted into diabetic rats via portal vein. Blood glucose levels were monitored and islet hormones were detected in the liver and pancreas of the recipient by immunohistochemistry. RESULTS: BM-MSCs were spheroid adherent monolayers with high CD90, CD29 and very low CD45 expression. Typical islet-like cells clusters were formed after induction. Electron microscopy revealed that secretory granules were densely packed within the cytoplasm of the differentiated cells. The spheroid cells expressed islet related genes and hormones. The insulin-positive cells accounted for 19.8% and mean fluorescence intensity increased by 2.6 fold after induction. The cells secreted a small amount of insulin that was increased 1.5 fold after glucose challenge. After transplantation, islet-like cells could locate in the liver expressing islet hormones and lower the glucose levels of diabetic rats during d 6 to d ***: Rat BM-MSCs could be transdifferentiated into islet-like cells in vitro . Portal vein transplantation of islet-like cells could alleviate the hyperglycemia of diabetic rats.

关键词： Bone marrow mesenchymal stem cells Trans-differentiation Islet Insulin Transplantation

NUMERICAL STUDY OF HYDRODYNAMICS OF MULTIPLE TANDEM JETS IN CROSS FLOW

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Journal of Hydrodynamics 2011年第6期23卷 806-813页

作者： xiao Yang TANG hong-wu LIANG Dong-fang ZHANG Jiu-ding State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing 210098 China College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China Department of Engineering University of Cambridge Cambridge UK

The hydrodynamics of a single jet and four tandem jets in a cross flow are simulated by using the Computational Fluid Dynamics （CFD） software Fluent. The realizable model is used to close the Reynolds-Averaged equations. The flow characteristics of the jets, including the jet trajectory, the velocity field and the turbulent kinetic energy are obtained with various jet-to-cross flow velocity ratios in the range of 2.38-17.88. It is shown that a single jet penetrates slightly deeper than the first jet in a jet group at the same , although the difference decreases with the decrease of . It is also found that the way in which the velo-city decays along the centerline of the jet is similar for both a single jet and the first jet in a group, and the speed of the decay increases with the decrease of . The downstream jets in a group are found to behave differently due to the sheltering effect of the first jet in the group. Compared with the first jet, the downstream jets penetrate deeper into the cross flow, and the velocity decays more slowly. The circulation zone between the two upstream jets in the front is stronger than those formed between the downstream jets. The Turbulent Kinetic Energy （TKE） sees a distinct double-peak across the cross-sections close to each nozzle, with low values in the jet core and high values in the shear layers. The double-peak gradually vanishes, as the shear layers of the jet merge further away from the nozzle, where the TKE assumes peaks at the jet centerline.

关键词： multiple tandem jets jet in cross flow realizable model flow dynamics

Endometrial Mucin-1 and Pinopode in Peri-implantation Phase in Ovarian High Responders during Controlled Ovarian Hyperstimulation Cycles

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Journal of Reproduction and Contraception 2007年第3期18卷 187-196页

作者： Qiu-ju CHEN xiao-xi SUN Lu LI xiao-hong GAO Yu wu Li-nan CHENG Department of Reproductive Medicine International Peace Maternity and Child Health Hospital Shanghai200030 China

Objective To investigate effects of ovarian high response on endometrial mucin-1 （MUC1） and pinopode in peri-implantation phase in controlled ovarian hyperstimulation （COH） cycles. Methods Ovarian high response was defined as serum E2 〉 15 000 pmol/L on the day of hCG administration in COH cycle using GnRH agonist and recombinant FSH （n=8）. Healthy and fertile women were used as the natural control （n=10）. Endometrial biopsies were performed on the day of LH＋ 7/hCG＋ 7. Pinopode formation was observed by scanning electron microscope. Expression of MUC1 was detected with quantitative Real-time PCR and immunohistochemistry. Results In high response group, the lumen surface was covered with variant pinopodes and microvillous. The expression of MUC1 mRNA in high response group was lower than that in the natural control （P〈0.05）. Immunostaining for MUC1 protein in glandular and luminal epithelium in high response group was lower than that in the natural control （P〈0. 05）. Conclusion Asynchronized pinopode appearance and lower expression of MUC1 during peri-implantation period were the characteristics of endometrium in high response group, Which may provide a clue of decreased endometrial receptivity in the supraphysiological hormone milieu.

关键词： endometrium controlled ovarian hyperstimulation high response mucin-1 pinopode

Synthesis and Microstructure of Doped Alumina Composite Membrane by Sol-Gel Process

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Journal of wuhan University of Technology(Materials Science) 2003年第3期18卷 15-19页

作者：徐晓虹 School of Materials Science and Engineering Wuhan University of Technology

The supported membranes of Al 2O 3 and its modification membranes were *** 2O 3,Al 2O 3 SiO 2 TiO 2 and Al 2O 3 SiO 2 TiO 2 ZrO 2 membranes were mamufatured by the slip casting process using mixing boehmite,silicate,titania and zirconia sols under proper conditions,then the composite membrane was *** structure and characteristics of the membrane were determined by XRD,SEM and AFM *** conditions of preparation of the membrane are *** thickness of the layer is about 1-2μm,the diameter of an average pore is 200-300nm and has a narrow pore distribution without crack *** changing the ratios of Al∶Si∶Ti∶Zr(mol),variations of surface pore size of Al 2O 3 SiO 2 TiO 2 ZrO 2 membrane can be gained.

关键词： doped alumina composite membrane sol gel process