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Construction of Chiroptical Switch on Silica Nanopartide Surface via Chiral Self-assembly of Side-chain Azobenzene-containing Polymer

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Chinese Journal of Polymer Science 2021年第12期39卷 1528-1537页

作者： Guang-Xing Song Teng-Fei Miao xiao-xiao Cheng Hao-Tian Ma Zi-Xiang he Wei Zhang zheng-Biao Zhang Xiu-Lin Zhu Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou Industrial ParkSuzhou 215123China

In this contribution,we utilized surface initiated atom transfer radical polymerization(SI-ATRP)to prepare organicinorganic hybrid core/shell silila nanoparticles(NPs),where silia particles acted as cores and polymeric shells(PAzoMA*)were attached to silica particles via covalent ***,chiroptical switch was sccessfully constructed on silica NPs surface taking advantage of supramolecular chiral self-assembly of the grafted side chain Azo-containing polymer(PAzoMA*).We found that the supramolecular chirality was highly dependent on the molecular weight of grafted PAzoMA*.Meanwhile,the supramolecular chirality could be regulated using 365 nm UV light iradiation and heating cooling treatment,and a reversible supramolecular chiroptical switch could be repeated for over five cycles on silia NPs ***,when heated above the glass transition temperature(T_(g))of PAzoMA",the organic-inorganic hybrid nanoparticles(SiO_(2)@PAzoMA*NPs)still exhibited intense DRCD ***,the supramolecular chirality could be retained in solid film for more than 3 *** conclude,we have prepared an organic inorganic hybrid core/shell chiral slia nanomaterial with dynamic reversible chirality,thermal stability and chiral storage functions,providing potential applications in dynamic asymmetric catalysis,chiral separation and so on.

关键词： Silia nanopartides Chiroptical switch Supramolecular chiral assembly Azo containing polymer

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

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Chinese Chemical Letters 2024年第5期35卷 314-319页

作者： Wen xiao Fazhan Wang Yangzhuo Gu Xi he Na Fan Qian zheng Shugang Qin Zhongshan he Yuquan Wei Xiangrong Song Department of Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450000China

Dendritic cell(DC)-targeted delivery of mRNA is a prominent method to boost the efficacy of mRNA tumor *** targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRNA delivery *** the PEG linker length influences the targeting delivery efficiency of mRNA nanocarrier in vivo remains ***,we designed and constructed DC-targeted mRNA delivery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP_(400)-LPX(the linker was PEG400)showed the optimal mRNA expression and antigen presentation owing to the highly efficient uptake by ***,MP_(400)-LPX could better inhibited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse ***,these results demonstrated that PEG400 was the optimal linker for the PEGylated DC-targeted mRNA *** findings provided a new platform for the rational design of targeted mRNA nanovaccines with shorter-length PEG.

关键词： Cancer immunotherapy mRNA vaccines DC-targeted delivery PEGylated liposomes Cellular uptake

Bright InP quantum dots by Ga-doping for red emitters

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Nano Research 2024年第7期17卷 6721-6733页

作者： Kai-zheng Song xiao-Hang he Zhe-Yong Chen Ge Tang Jin-Zhao Huang Feng-Lei Jiang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

Environment-friendly indium phosphide(InP)-based quantum dots(QDs)with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting ***,the syntheses of InP QDs using tris(trimethylsilyl)phosphine as the precursor are highly toxic and ***,we successfully introduced gallium(Ga)ions into tris(dimethylamino)phosphine-based red InP cores through thermally-promoted cation exchange,and the obtained Ga-doped InP cores exhibited significantly increased photoluminescence quantum yields(PLQY)of up to 26%.The existence of Ga was directly confirmed by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy,and the functions of Ga were systematically *** subsequent coating of Ga-doped InP cores with ZnSeS and ZnS shells,the resulting Ga-InP/ZnSeS/ZnS QDs achieved a high PLQY of 62%with an emission maximum at 640 *** contrast,without Ga-doping,the PLQY only attained 36%using the same synthetic *** indicated an approximate 1.7-fold increase in *** enhancement of photoluminescence was related to the Ga^(3+),as it not only passivated surface defects of InP cores but also reduced core–shell interface *** Ga-InP/ZnSeS/ZnS QDs exhibited good stability towards heat treatment and ultraviolet(UV)***,the red light-emitting diode(LED)based on Ga-InP/ZnSeS/ZnS QDs performed well in a wide injected current range of 2 to 200 mA,with a maximum power efficiency of 0.68 lm/*** work showcases Ga-doping through cation exchange as a promising strategy for enhancing the efficiency of InP-based red emitters.

关键词： indium phosphide gallium doping optical properties light emitting diode

A Survey on Graph Processing Accelerators:Challenges and Opportunities

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Journal of Computer Science & Technology 2019年第2期34卷 339-371页

作者： Chuang-Yi Gui Long zheng Bingsheng he Cheng Liu Xin-Yu Chen xiao-Fei Liao Hai Jin National Engineering Research Center for Big Data Technology and System School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Services Computing Technology and System Laboratory School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Cluster and Grid Computing Laboratory School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China School of Computing National University of Singapore Singapore 117418 Singapore Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China

Graph is a well known data structure to represent the associated relationships in a variety of applications,e.g.,data science and machine *** a wealth of existing efforts on developing graph processing systems for improving the performance and/or energy efficiency on traditional architectures,dedicated hardware solutions,also referred to as graph processing accelerators,are essential and emerging to provide the benefits significantly beyond what those pure software solutions can *** this paper,we conduct a systematical survey regarding the design and implementation of graph processing ***,we review the relevant techniques in three core components toward a graph processing accelerator:preprocessing,parallel graph computation,and runtime *** also examine the benchmarks and results in existing studies for evaluating a graph processing ***,we find that there is not an absolute winner for all three aspects in graph acceleration due to the diverse characteristics of graph processing and the complexity of hardware *** finally present and discuss several challenges in details,and further explore the opportunities for the future research.

关键词： graph processing accelerator domain-specific architecture performance energy efficiency

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江门地区儿童变应性鼻炎变应原临床分析

中国眼耳鼻喉科杂志 2012年第2期12卷 98-100页

作者：何晓峥吴树浓卢坚高鸿明何婷婷黄纪逸邹建华欧华雄广东省江门市人民医院耳鼻咽喉科江门529020

目的了解江门地区变应性鼻炎患儿的变应原种类,为儿童变应性鼻炎的防治提供科学依据。方法应用18种变应原点刺液对332例变应性鼻炎患儿进行皮肤点刺试验。结果 332例变应性鼻炎患儿中,变应原阳性率86.7%,2种或2种以上变应原阳性率56.6%... 详细信息

目的了解江门地区变应性鼻炎患儿的变应原种类,为儿童变应性鼻炎的防治提供科学依据。方法应用18种变应原点刺液对332例变应性鼻炎患儿进行皮肤点刺试验。结果 332例变应性鼻炎患儿中,变应原阳性率86.7%,2种或2种以上变应原阳性率56.6%;变应原阳性率前5位的是粉尘螨、蟑螂、海蟹、海虾、狗毛,分别为80.1%、34.6%、24.4%、18.7%、16.6%。随年龄增长,男女变应原阳性率及粉尘螨强阳性率均出现差异。结论粉尘螨是江门地区变应性鼻炎患儿的首要变应原,明确变应原后对变应性鼻炎的预防及特异性免疫治疗具有重要指导意义。

关键词：变应性鼻炎变应原粉尘螨皮肤点刺试验

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贝复舒在鼻腔射频止血后的临床应用

国际医药卫生导报 2011年第19期17卷 2389-2390页

作者：何晓峥吴树浓卢坚高鸿明欧华雄黄纪逸邹建华何婷婷江门市人民医院耳鼻咽喉科 529020

目的探讨鼻腔射频后局部应用贝复舒对鼻腔粘膜恢复的影响。方法93例鼻中隔Little区鼻出血患者中，35例对照组射频后创面局部使用金霉素眼膏，58例治疗组射频后创面局部使用贝复舒凝胶，对比观察其疗效。结果10天后贝复舒治疗组治愈率为9... 详细信息

目的探讨鼻腔射频后局部应用贝复舒对鼻腔粘膜恢复的影响。方法93例鼻中隔Little区鼻出血患者中，35例对照组射频后创面局部使用金霉素眼膏，58例治疗组射频后创面局部使用贝复舒凝胶，对比观察其疗效。结果10天后贝复舒治疗组治愈率为91．4％，对照组为65．7％，两组差异有统计学意义（P〈0．05）。结论贝复舒对鼻腔射频后粘膜的修复有促进作用。

关键词：贝复舒碱性成纤维细胞生长因子射频鼻出血

Significantly improved interfacial properties of silicon dioxide nanowire functionalized poly(p-phenylene-2,6-benzobisoxazole)(PBO)fibers/polytetrafluoroethylene(PTFE)wave-transparent laminated composites

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Journal of Materials Science & Technology 2024年第16期183卷 232-240页

作者： Xusheng he Chao xiao Huichao Du Yanyan Wang Xin Ding Kang zheng Meng Xue Xingyou Tian Xian Zhang Key Laboratory of Photovoltaic and Energy Conservation Materials Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Anhui UniversityHefei 230601China Lu’an Branch Anhui Institute of Innovation for Industrial TechnologyLu’an 237000China Guangdong Banggu Film Coatings Innovation Academy Co. Ltd.Nanxiong 512400China

Poly(p-phenylene-2,6-benzobisoxazole)(PBO)fiber and polytetrafluoroethylene(PTFE)resin have been widely acknowledged as excellent wave-transparent materials for future high-frequency applications due to their exceptional dielectric ***,the weak interfacial bonding between these two materials hampers their full *** this study,we successfully addressed this limitation by enhancing the surface roughness of PBO fibers and introducing active sites through the insitu grafting of silica *** added silica acted as an interfacial anchor on the PBO fiber surface,significantly improving the bonding force between PBO and ***/PTFE wave-transparent laminated composites were fabricated using hot compression *** results demonstrate that the PBO(treated with insitu grown silica)/PTFE laminated composites exhibit superior interlaminar shear strength(ILSS),flexural strength,flexural modulus,and tensile modulus compared to the pristine PBO/PTFE laminated ***,these properties are found to be 58.6%,32.9%,138.1%,and 25.35%higher,***,these composites demonstrate low dielectric constant and dielectric *** notably,they achieve a wave transmittance of 91.45%at 10 GHz,indicating significant potential for wide-range applications in next-generation advanced military weapons,such as“lightweight/high-strength/wavetransparent”electromagnetic window materials,as well as civilian communication base stations.

关键词： PBO fibers PTFE Silicon dioxide nanowires Wave-transparent laminated composites

Activator protein-1 involved in growth inhibition by RASSF1A gene in the human gastric carcinoma cell line SGC7901

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World Journal of Gastroenterology 2008年第9期14卷 1437-1443页

作者： zheng-Hao Deng Ji-Fang Wen Jing-he Li De-Sheng xiao Jian-Hua Zhou Department of Pathology Xiangya School of Medicine Central South University Changsha 410078 Hunan Province China

AIM:To investigate the role of Ras association domain family protein 1 isoform A (RASSF1A) in gastric tumorigenesis. METHODS:Through over-expression of RASSF1A gene in the SGC7901 cell line which was induced by a lipofectamine-mediated gene transfer approach. Activator protein-1 (AP-1) DNA binding activity was measured by electrophoretic mobility shift assay (EMSA). RESULTS:Compared with the control clones, cells over- expressing RASSF1A exhibited significant inhibition of cell growth with G1 cell cycle arrest in vitro and in vivo. The over-expression of RASSF1A significantly inhibited AP-1 activity in SGC7901 cells (0.981±0.011 vs 0.354±0.053, Phemistry demonstrated that RASSF1A down-regulated the expression of c-Fos (0.975± 0.02 vs 0.095±0.024, Phe growth of SGC7901 cells by negatively regulating the AP-1 activity, the latter in turn negatively signals cell proliferation.

关键词： RASSFIA Gastric adenocarcinoma SGC7901, Activator protein-1

Blow up of Solutions for a Nonlinear Petrovsky Type Equation with Time-dependent Coefficients

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 836-846页

作者： xiao-xiao zheng Ya-dong SHANG xiao-ming PENG School of Mathematical Sciences Qufu Normal UniversityQufu 273155China School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006China School of Statistics and Mathematics Guangdong University of Finance and EconomicsGuangzhou 510320China

4In this paper,we study a nonlinear Petrovsky type equation with nonlinear weak damping,a superlinear source and time-dependent coefficients utt+△^2u-ki(t)|ut|m^2ut=k2(t)|u|^p-2u,x∈Ω,t>0,whereΩis a bounded domain in R^*** certain conditions on k1(t),k2(t)and the initial-boundary data,the upper bound for blow-up time of the solution with negative initial energy function is given by means of an auxiliary functional and an energy estimate met hod if p>***,a lower bound of blow-up time are obtained by using a Sobolev-type inequality and a first order differential inequality technique for n=2,3 and n>4.

关键词： nonlinear Petrovsky type equation time-dependent coefficients blow-up upper bound lower bound