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Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/bax pathway

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World Journal of Gastroenterology 2009年第14期15卷 1751-1758页

作者： Yu Yao Chen Huang Zong-Fang Li Ai-Ying Wang Li-Ying Liu xiao-ge zhao Yu Luo Lei Ni Wang-Gang Zhang Tu-Sheng Song Department of Oncology First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Department of genetics and Molecular Biology Medical School Xi'an Jiaotong University/Key Laboratory of Environment and Genes Related to Diseases Ministry of Education Xi'an 710061 Shaanxi Province China Second Affiliated Hospital of Xi'an Jiaotong University/Key Laboratory of Environment and genes Related to Diseases Ministry of Education Xi'an 710004 Shaanxi Province China

AIM: To investigate the signaling pathways implicated in phosphatidylethanolamine (PE)-induced apoptosis of human hepatoma HepG2 cells. METHODS: Inhibitory effects of PE on human hepatoma HepG2 cells were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle, apoptosis and mitochondrial transmembrane potential (ΔΨm) were analyzed by flow cytometry. Immunocytochemical assay and Western blotting were used to examine Bcl-2, Bax and caspase-3 protein levels in HepG2 cells treated with PE. RESULTS: PE inhibited the growth of HepG2 cells in a doseand timedependent manner. It did notaffect the cell cycle, but induced apoptosis. PE significantly decreased ΔΨm at 0.25, 0.5 and 1 mmol/L, respectively, suggesting that PE induces cell apoptosis by decreasing the mitochondrial transmembrane potential. The Bcl-2 expression level induced by different concentrations of PE was lower than that in control groups. However, the Bax expression level induced by PE was higher than that in the control group. Meanwhile, PE increased the caspase-3 expression in a doseand time-dependent manner. CONCLUSION: Exogenous PE induces apoptosis of human hepatoma HepG2 cells via the bcl-2/bax pathway.

关键词： Apoptosis Bcl-2 Bax Caspase-3 Phosphatidylethanolamine Human hepatoma HepG2 cell

Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： Xin Lin Xin Lu Yun-He zhao Yi-Bei Wang Ru-ge Niu xiao-Hu Chen Department of Cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CIN).Methods:CIN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CIN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CIN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CIN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP

Carbon efficiency modeling and optimization of solar-powered cellular networks

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Science China(Information Sciences) 2024年第5期67卷 228-243页

作者： Yuxi zhao xiaohu ge Wen YAN Tao HAN Yi ZHONG School of Electronic Information and Communications Huazhong University of Science and Technology Huawei Technology Co. Ltd.

As wireless communication traffic experiences rapid growth, the carbon emissions caused by the communication industry are also on the rise. To achieve “carbon neutrality”, researchers are considering the use of renewable energy sources to power cellular networks, thereby reducing carbon emissions. However, a challenge arises when using renewable energy, specifically owing to the unpredictable nature of both the energy consumption of the cellular network and the power generation from renewable sources. This inconsistency results in low renewable energy utilization and reduced carbon efficiency. Herein, we construct a carbon efficiency model of solar-powered cellular networks using practical data from solar radiation. We propose a mechanism that alternately optimizes the performance of the renewable energy network and the cellular network. This approach is based on convex optimization theory and the Dinkelback algorithm, and it leads to the design of a carbon efficiency optimization algorithm. This algorithm aims to improve the carbon efficiency of cellular networks and reduce their carbon emissions. Simulation results demonstrate that our optimization scheme yields a maximum improvement of 2.56 × 108bps/g in the carbon efficiency of the cellular network as compared to conventional power allocation schemes such as the traditional water filling method and heuristic energy sharing and charge/discharge algorithms.

关键词： cellular networks renewable energy carbon efficiency convex optimization theory dinkelbach

Along-track Calibration of the Zhurong Rover Magnetometer

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Science China Earth Sciences 2024年第2期67卷 552-565页

作者： Hao LUO Aimin DU Yasong ge Ying ZHANG Haiying LI Lin TIAN Kuixiang ZHANG Shuquan SUN Lin zhao Zhi LI xiao FENG CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth Science University of Chinese Academy of SciencesBeijing100049China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China

As part of the Chinese Tianwen-1 mission,the Zhurong Rover began its scientific investigation in the southern Utopia Planitia after its successful landing in 15 May,*** Zhurong Rover magnetometer(RoMAG),one of the six payloads onboard the rover,includes two identical high-sensitivity triaxial fluxgate magnetometers and can implement mobile magnetic measurements on the surface of *** a rover magnetic compensation procedure was conducted to remove the magnetic interferences pre-launch,due to the different state of the payloads and electric power system such as the solar panel,an along-track calibration of the magnetometer is necessary to obtain a more accurate Martian magnetic *** methods,mast yaw rotations and Rover yaw rotations were utilized separately to determine the Martian horizontal magnetic *** show that the Martian horizontal magnetic components determined by the two methods are in good agreement,with the root mean square deviation less than 2.0 *** vertical component was also constrained through the pitch movements of the mast by assuming the interferences field distributes like a dipole field.A linear correlation between magnetic field measurements and the solar array currents was derived to calibrate the body field during the regular *** conclude that more accurate measurements could be made when applying the calibration results in the magnetic survey on the surface of Mars.

关键词： The Zhurong Rover Magnetometer Along-track calibration Remnant magnetization

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Current understanding of ELF4 deficiency:a novel inborn error of immunity

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World Journal of Pediatrics 2024年第5期20卷 444-450页

作者： Hong-Qiang Du xiao-Dong zhao Department of Rheumatology&Immunology National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Rare Diseases in Infection and ImmunityChildren’s Hospital of Chongqing Medical UniversityZhongshan Er Road 136Yuzhong DistrictChongqingChina

Background ELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity(IEIs),specifically categorized as a“disease of immune dysregulation.”Cases of this condition,reported by our team and others,are very limited *** such,our current knowledge of this new disease remains *** review aims to provide a brief overview of the clinical manifestations,pathogenesis,and treatment strategies for this novel *** sources A comprehensive review was conducted after an extensive literature search in the PubMed/Medline database and websites concerning transcriptional factor ELF4 and reports concerning patients with ELF4 *** search strategy was“ELF4 OR ETS-related transcription factor Elf-4 OR EL4-like factor 4 OR myeloid Elf-1-like factor”as of the time of manuscript *** The current signature manifestations of ELF4 deficiency disorder are recurrent and prolonged oral ulcer,abdominal pain,and diarrhea in pediatric *** some cases,immunodeficiency and autoimmunity can also be *** Sanger sequencing or whole exome sequencing can be used to detect variation in ELF4 *** blotting for ELF4 expression of the patient’s cells can confirm the pathogenic effect of the *** fully confirm the pathogenicity of the variant,further functional test is strongly *** and biologics are the mainstream management of ELF4 deficiency *** Pediatric males presenting with recurring ulcerations in digestive tract epithelium with or without recurrent fever should be suspected of *** atypical presentations are prominent,variations in ELF4 gene should be carefully evaluated functionally due to the complex nature of ELF4 *** of treating DEX includes use of glucocorticoid and biologics and more precise treatment needs more patients to identify and further mechanistic study.

关键词： ELF4 transcription factor Immune dysregulation Inborn errors of immunity Mechanism Recurrent infections

Observation and Analysis of VLF Nocturnal Multimode Interference Phenomenon based on Waveguide Mode Theory

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Research in Astronomy and Astrophysics 2024年第1期24卷 78-86页

作者： Sai Yang You-Tian Niu Zhe Wang Xiu-Kun zhao Bei Li Yu-Ling Ding ge-ge zhao An-Qi Zhang College of Electronic and Electrical Engineering Henan Normal UniversityXinxiang 453007China Academician Workstation of Electromagnetic Wave Engineering of Henan Province Xinxiang 453007China Key Laboratory of Optoelectronic Sensing Integrated Application of Henan Province Xinxiang 453007China Engineering Laboratory of Intelligent Additive Manufacturing of Henan Province Xinxiang 453007China

Very low frequency(VLF)signals are propagated between the *** interference will cause the phase to show oscillatory changes with distance while propagating at night,leading to abnormalities in the received VLF *** study uses the VLF signal received in Qingdao City,Shandong Province,from the Russian Alpha navigation system to explore the multimode interference problem of VLF signal *** characteristics of the effect of multimode interference phenomena on the phase are analyzed according to the variation of the phase of the VLF ***,the phase of VLF signals will also be affected by the X-ray and energetic particles that are released during the eruption of solar flares,therefore the two phenomena are studied in this *** is concluded that the X-ray will not affect the phase of VLF signals at night,but the energetic particles will affect the phase change,and the influence of energetic particles should be excluded in the study of multimode interference *** VLF signals for navigation positioning in degraded or unavailable GPS conditions is of great practical significance for VLF navigation systems as it can avoid the influence of multimode interference and improve positioning accuracy.

关键词： waves methods:data analysis Sun:flares Sun:X-rays gamma-rays

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Microbiome in Female Reproductive Health:Implications for Fertility and Assisted Reproductive Technologies

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genomics, Proteomics & Bioinformatics 2024年第1期22卷 5-18页

作者： Liwen xiao Zhenqiang Zuo Fangqing zhao CAS Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Beijing Institutes of Life Science/Institute of Zoology Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The microbiome plays a critical role in the process of conception and the outcomes of *** in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which significantly impact maternal and fetal *** studies have associated the microbiome in the female reproductive tract(FRT)with assisted reproductive technology(ART)outcomes,and restoring microbiome balance has been shown to improve fertility in infertile *** review provides an overview of the role of the microbiome in female reproductive health,including its implications for pregnancy outcomes and ***,recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized.A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal *** knowledge can also contribute to the development of ARTs and microbiome-based interventions.

关键词： Microbiome Pregnancy Female reproductive health Assisted reproductive technology Microbial biomarker

Multi-blade rubbing characteristics of the shaft-disk-blade-casing system with large rotation

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 111-136页

作者： Zhiyuan WU Linchuan zhao Han YAN ge YAN Ao CHEN Wenming ZHANG State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Aerospace Systems Engineering Shanghai 201108China

Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.

关键词： shaft-disk-blade-casing(SDBC) large rotation spin and whirl multi-blade rubbing rotational effect

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Influence and optimization of swirler parameters on elbow wear of deep coal fluidization pipeline transportation system

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Friction 2024年第7期12卷 1408-1433页

作者： Shaodi zhao Jiusheng BAO Shirong ge Zhongbin WANG Yan YIN Congguang HUANG School of Mechanical and Electrical Engineering China University of Mining and TechnologyXuzhou 221116China School of Mechanical Electronic and Information Engineering China University of Mining and Technology-BeijingBeijing 100083China Frontier Scientific Research Center for Fluided Mining of Deep Underground Resources China University of Mining and TechnologyXuzhou 221008China

Elbow wear is a major threat to the multiphase pipeline transportation industry,which has a negative impact on the stable operation of the transportation *** order to find the wear reduction methods of elbows in the fluidization pipeline transportation system for 2000-meter-deep coal resources,the swirler was installed upstream of the elbows,and wear simulations and tests of three kinds of elbows were carried *** results showed that the maximum wear rate(MWR)of elbows increased and then decreased along the elbow *** to the different directions of gravity,the heavy wear position(HWP)of the horizontal-vertical(H-V)elbow was in front of the vertical-horizontal(V-H)*** the downstream portion of the horizontal-horizontal(H-H)elbow was still a horizontal pipe,the HWP of the H-H elbow almost covered the whole *** swirler placed upstream of the elbows could make the particles at the elbow move to the intrados of the elbows,resulting in less collision between the particles and the extrados of the elbows,thus reducing the wear of the *** wear reduction effects of swirlers on three different elbows were favorably connected with the guide vane angle(GVA)and negatively correlated with the guide vane length(GVL),decreased first and then increased as the guide vane height(GVH)increased,and were little affected by the guide vane number(GVN)and the guide vane thickness(GVT).The mathematical models between the MWR of the elbows and guide vane parameters were *** bench tests,the wear reduction effect of three kinds of elbows under the optimal guide vane parameters was 58.4%,76.9%,and 78.6%,*** errors between the bench test results and the simulation results were around 10%.

关键词： pipe elbow erosion wear spiral flow swirler guide vane parameters particle collision