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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao feng Hua zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

miR-93 suppresses proliferation and colony formation of human colon cancer stem cells

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World Journal of Gastroenterology 2011年第42期17卷 4711-4717页

作者： xiao-feng Yu Jian zou Zhi-Jun Bao Jie Dong Department of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

AIM： TO identify differentially expressed microRNAs （miRNAs） in human colon cancer stem cells （SW1116csc） and study their function in SW1116csc proliferation. METHODS： SW1116csc were isolated from the human colon cancer cell line, SW1116 and cultured in serum- free medium. A miRNA microarray was used to detect differential expression profiles of rniRNAs in SW1116csc and SW1116 cells. Real-time quantitative polymerase chain reaction （PCR） was performed to verify the dif- ferential expression of candidate miRNAs obtained from the microarray. Target mRNAs of differentially expressed miRNAs were predicted with target predic- tion tools, miRNA expression plasmids were transfected into SW1116csc using Lipofectamine 2000 reagent. Cell proliferation curves were generated with trypan blue staining, and the colony formation rate of transfected cells was measured with the soft agar colony formation assay. Expression of target mRNAs and proteins from differentially expressed miRNAs were detected using reverse transcription （RT）-PCR and western ***： Compared with expression in SW1116 cells, 35 miRNAs （including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa- miR-32） were upregulated more than 1.5-fold, and 11 miRNAs （including hsa-miR-93, hsa-miR-1231, hsa- miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561） were downregulated in SW1116csc. The miRNA microarray results were further validated with quantitative RT-PCR. miR-93 was downregulated, and its predicted mRNA targets included BAMBI, CCND2, CDKNIA, HDACS, KIF23, MAP3K9, MAP3K11, MYCN, PPARD, TLE4 and ZDHHCl. Overexpressed miR-93 sig- nificantly inhibited cell proliferation and colony forma- tion by SW1116csc. Furthermore, miR-93 negatively regulated the mRNA and protein levels of HDAC8 and TLE4. CONCLUSION： Some miRNAs were differentially ex- pressed during differentiation of SW1116csc into SW1116 cells, miR-93 may inhibit SW1116csc proliferation and colony formation.

关键词： miR-93 Stem cell Colon cancer Expres-sion profile

Fast nuclear-spin gates and electrons−nuclei entanglement of neutral atoms in weak magnetic fields

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Frontiers of physics 2024年第2期19卷 179-203页

作者： xiao-feng Shi School of Physics Xidian UniversityXi’an 710071China

We present a novel class of Rydberg-mediated nuclear-spin entanglement in divalent atoms with global laser ***,we show a fast nuclear-spin controlled phase gate of an arbitrary phase realizable either with two laser pulses when assisted by Stark shifts,or with three ***,we propose to create an electrons−nuclei-entangled state,which is named a super bell state(SBS)for it mimics a large Bell state incorporating three small Bell ***,we show a protocol to create a three-atom electrons-nuclei entangled state which contains the three-body W and Greenberger−Horne−Zeilinger(GHZ)states *** protocols possess high intrinsic fidelities,do not require single-site Rydberg addressing,and can be executed with large Rydberg Rabi frequencies in a weak,Gauss-scale magnetic *** latter two protocols can enable measurement-based preparation of Bell,hyperentangled,and GHZ states,and,specifically,SBS can enable quantum dense coding where one can share three classical bits of information by sending one particle.

关键词： nuclear-spin qubit electrons−nuclei entanglement super Bell state Greenberger−Horne−Zeilinger state Rydberg-mediated entanglement quantum dense coding

Covariate-Assisted Matrix Completion with Multiple Structural Breaks

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Journal of Systems Science & Complexity 2024年第2期37卷 692-728页

作者： MENG Jing feng Long zou Changliang WANG Zhaojun School of Statistics and Data Science KLMDASRLEBPSand LPMCNankai UniversityTianjin 300071China

In matrix completion,additional covariates often provide valuable information for completing the unobserved entries of a high-dimensional low-rank matrix *** this paper,the authors consider the matrix recovery problem when there are multiple structural breaks in the coefficient matrix β under the column-space-decomposition model A=Xβ+B.A cumulative sum(CUSUM)statistic is constructed based on the penalized estimation of β.Then the CUSUM is incorporated into the Wild Binary Segmentation(WBS)algorithm to consistently estimate the location of ***,a nearly-optimal recovery of A is *** findings are further corroborated via numerical experiments and a real-data application.

关键词： Additional covariates matrix completion multiple structural breaks wild Binary Segmentation

Nonlinear constitutive models of rock structural plane and their applications

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 790-806页

作者： Wenlin feng Shuangjian Niu Chunsheng Qiao Dujian zou School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhenChina Shenzhen Municipal Engineering Corporation Shenzhen518000China School of Civil Engineering Beijing Jiaotong UniversityBeijing100044China

Structural planes play an important role in controlling the stability of rock engineering,and the influence of structural planes should be considered in the design and construction process of rock *** this paper,mechanical properties,constitutive theory,and numerical application of structural plane are studied by a combination method of laboratory tests,theoretical derivation,and program *** test results reveal the change laws of various mechanical parameters under different roughness and normal *** the pre-peak stage,a non-stationary model of shear stiffness is established,and threedimensional empirical prediction models for initial shear stiffness and residual stage roughness are *** nonlinear constitutive models are established based on elasto-plastic mechanics,and the algorithms of the models are developed based on the return mapping *** to a large number of statistical analysis results,empirical prediction models are proposed for model parameters expressed by structural plane characteristic ***,the discrete element method(DEM)is chosen to embed the constitutive models for practical *** running programs of the constitutive models have been compiled into the discrete element model *** comparison results between the proposed model and the Mohr-Coulomb slip model show that the proposed model can better describe nonlinear changes at different stages,and the predicted shear strength,peak strain and shear stiffness are closer to the test *** research results of the paper are conducive to the accurate evaluation of structural plane in rock engineering.

关键词： Structural plane Engineering stability Roughness Normal stress Elasto-plastic constitutive model Discrete element method

A Trust Evaluation Mechanism Based on Autoencoder Clustering Algorithm for Edge Device Access of IoT

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Computers, Materials & Continua 2024年第2期78卷 1881-1895页

作者： xiao feng Zheng Yuan Cyber Security Academy Beijing University of Posts and TelecommunicationsBeijing100876China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China State Grid Info-Telecom Great Power Science and Technology Co. Ltd.Beijing102211China

First,we propose a cross-domain authentication architecture based on trust evaluation mechanism,including registration,certificate issuance,and cross-domain authentication processes.A direct trust evaluation mechanism based on the time decay factor is proposed,taking into account the influence of historical interaction *** weight the time attenuation factor to each historical interaction record for updating and got the new historical record *** refer to the beta distribution to enhance the flexibility and adaptability of the direct trust assessment model to better capture time trends in the historical *** we propose an autoencoder-based trust clustering *** perform feature extraction based on *** leibler(KL)divergence is used to calculate the reconstruction *** constructing a convolutional autoencoder,we introduce convolutional neural networks to improve training efficiency and introduce sparse constraints into the hidden layer of the *** sparse penalty term in the loss function measures the difference through the KL *** clustering is performed based on the density based spatial clustering of applications with noise(DBSCAN)clustering *** the clustering process,edge nodes have a variety of trustworthy attribute *** assign different attribute weights according to the relative importance of each attribute in the clustering process,and a larger weight means that the attribute occupies a greater weight in the calculation of ***,we introduced adaptive weights to calculate comprehensive trust *** experiments prove that our trust evaluation mechanism has excellent reliability and accuracy.

关键词： Cross-domain authentication trust evaluation autoencoder

Artificial Intelligence Meets Flexible Sensors:Emerging Smart Flexible Sensing Systems Driven by Machine Learning and Artificial Synapses

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Nano-Micro Letters 2024年第1期16卷 235-273页

作者： Tianming Sun Bin feng Jinpeng Huo Yu xiao Wengan Wang Jin Peng Zehua Li Chengjie Du Wenxian Wang Guisheng zou Lei Liu Department of Mechanical Engineering State Key Laboratory of Tribology in Advanced EquipmentKey Laboratory for Advanced Manufacturing by Materials Processing TechnologyMinistry of Education of PR ChinaTsinghua UniversityBeijing 100084People’s Republic of China College of Materials Science and Engineering Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024People’s Republic of China

The recent wave of the artificial intelligence(AI)revolution has aroused unprecedented interest in the intelligentialize of human *** an essential component that bridges the physical world and digital signals,flexible sensors are evolving from a single sensing element to a smarter system,which is capable of highly efficient acquisition,analysis,and even perception of vast,multifaceted *** challenging from a manual perspective,the development of intelligent flexible sensing has been remarkably facilitated owing to the rapid advances of brain-inspired AI innovations from both the algorithm(machine learning)and the framework(artificial synapses)*** review presents the recent progress of the emerging AI-driven,intelligent flexible sensing *** basic concept of machine learning and artificial synapses are *** new enabling features induced by the fusion of AI and flexible sensing are comprehensively reviewed,which significantly advances the applications such as flexible sensory systems,soft/humanoid robotics,and human activity *** two of the most profound innovations in the twenty-first century,the deep incorporation of flexible sensing and AI technology holds tremendous potential for creating a smarter world for human beings.

关键词： Flexible electronics Wearable electronics Neuromorphic Memristor Deep learning

A novel polyionic liquid with lubricity and viscosity-increasing dual functionalities as the additive in aqueous lubrication system

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Friction 2024年第4期12卷 698-710页

作者： Bo YU Kun zou Rui WANG Qiang CHEN Rui DONG xiao LIU Jiaying ZHANG Wenquan LV Qiangliang YU Meirong CAI feng ZHOU College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China Institute of Polymer Materials Nanjing Forestry UniversityNanjing 210037China

The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating *** rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity *** tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing *** was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing *** obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.

关键词： polyionic liquid lubricant additives viscosity modifier lubrication regime

Recovery of cyanophycin granule polypeptide from activated sludge: carbon source dependence and aggregation-induced luminescence characteristics

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 25-34页

作者： Kui zou Hongyuan Liu Bo feng Taiping Qing Peng Zhang College of Environment and Resources Xiangtan UniversityXiangtan 411105China

In the sewage treatment process,facilitating the conversion of pollutants into value-added resources holds great potential for reducing the amount of greenhouse gas emissions and promoting economic *** granule polypeptide(CGP),a recently discovered high value-added biopolymer present in activated sludge,has provided new avenues for the recovery of ***,the mechanisms that regulate CGP synthesis and the characteristics of this biopolymer in activated sludge remain unclear thus *** study investigated the synthesis of CGP,polyhydroxyalkanoates(PHA),and alginate-like exopolysaccharides(ALE)in various microbial aggregates under different carbon sources feeding *** results showed that the CGP yields was superior that of PHA and ALE when subjected to identical carbon source feeding ***,biofilm was more conducive to CGP accumulation than floc *** with glucose and methanol,sodium acetate significantly enriched the CGP synthetase-encoding gene(cphAabundance=~17419),resulting in the highest CGP yield(average 107.1 mg/g MLSS)in both biofilm and floc *** study is the first to reported the characteristic fluorescence of CGP(Ex/Em=~360/450 nm)caused by the aggregated luminescence of arginine on the side ***,this study highlights the potential application of CGP as a fluorescent material and offers insights into CGP recovery from activated sludge in wastewater treatment plants.

关键词： Cyanophycin Polyhydroxyalkanoate Alginate-like exopolysaccharides Bioresource recovery Aggregation-induced luminescence