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Research on Object Detection and Combination Clustering for Railway switch Machine Gap Detection

Chinese Journal of Electronics 2024年

作者： Qingsheng feng shuai xiao Wangyang LIU Hong LI school of Automation and Electrical Engineering Dalian Jiaotong University school of software Dalian Jiaotong University

Turnouts and switch machines play a crucial role in facilitating train line operations and establishing routes, making them vital for ensuring the safety and efficiency of railway transportation. Through the gap detection system of switch machines, the real-time working status of turnouts and switch machines on railway sites can be quickly known. However, due to the challenging working environment and demanding conversion tasks of switch machines, the current gap detection system has often experienced the issues of fault detection. To address this, this study proposes an automatic gap detection method for railway switch machines based on object detection and combination clustering. Firstly, a lightweight object detection network, specifically the MobilenetV3-YOLOv5s model, is used to accurately locate and extract the focal area. subsequently, the extracted image undergoes preprocess.ng and is then fed into a combination clustering algorithm to achieve precise segmentation of the gap area and background,the algorithm consists of simple linear iterative clustering(sLIC), Canopy and kernel fuzzy c-means clustering(KFCM). Finally, the Fisher optimal segmentation criterion is utilized to divide the data sequence of pixel values, determine the classification nodes and calculate the gap size. The experimental results obtained from switch machine gap images captured in various scenes demonstrate that the proposed method is capable of accurately locating focal areas, efficiently completing gap image segmentation with a segmentation accuracy of 93.55%, and swiftly calculating the gap size with a correct rate of 98.57%. notably, the method achieves precise detection of gap sizes even after slight deflection of the acquisition camera, aligning it more closely with the actual conditions encountered on railway sites.

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Targeting nRP1 axis as a strategy for treating energy metabolism impairment induced by sARs-CoV-2 spike

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science China(Life sciences) 2024年第10期67卷 2277-2279页

作者： Lihui Zhang Wanting Hu Jingxuan Li Yuehan Li feng Liu Wenyi xiao ning Jiang Zhiyong xiao Lu Han Wenxia Zhou Beijing Institute of Pharmacology&Toxicology Beijing 100850China state Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China school of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China

Dear Editor,Free spike protein of sARs-CoV-2 alone can cause abnormal energy metabolism(Table s1 in supporting Information),and limited research suggested a potential correlation between spike-induced mitochondrial da... 详细信息

关键词： metabolism ACE2

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subsoil tillage enhances wheat productivity,soil organic carbon and available nutrient status in dryland fields

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Journal of Integrative Agriculture 2024年第1期23卷 251-266页

作者： Qiuyan Yan Linjia Wu Fei Dong shuangdui Yan feng Li Yaqin Jia Jiancheng Zhang Ruifu Zhang xiao Huang Institute of Wheat Research Shanxi Agricultural UniversityLinfen 041000China state Key Laboratory of sustainable Dryland Agriculture(in preparation) Shanxi Agricultural UniversityTaiyuan 030031China College of Resources and Environment Shanxi Agricultural UniversityTaigu 030801China Jiangsu Key Lab and Engineering Center for solid Organic Waste Utilization National Engineering Research Center for Organicbased FertilizersNanjing Agricultural UniversityNanjing 210095China

Tillage practices during the fallow period benefit water storage and yield in dryland wheat ***,there is currently no clarity on the responses of soil organic carbon(sOC),total nitrogen(Tn),and available nutrients to tillage practices within the growing *** study evaluated the effects of three tillage practices.nT,no tillage;ss,subsoil tillage;DT,deep tillage)over five years on soil physicochemical *** samples at harvest stage from the fifth year were analyzed to determine the soil aggregate and aggregate-associated C and n *** results indicated that ss and DT improved grain yield,straw biomass and straw carbon return of wheat compared with *** contrast to DT and nT,ss favored sOC and Tn concentrations and stocks by increas.ng the soil organic carbon sequestration rate(sOCsR)and soil nitrogen sequestration rate(TnsR)in the 0-40 cm *** sOC levels under ss and nT were associated with greater aggregate-associated C fractions,while Tn was positively associated with soluble organic nitrogen(s.n).Compared with DT,the nT and ss treatments improved soil available nutrients in the 0-20 cm *** findings suggest that ss is an excellent practice for increas.ng soil carbon,nitrogen and nutrient availability in dryland wheat fields in north China.

关键词： tillage dryland wheat fields soil aggregate size soil nutrients soil carbon and nitrogen fractions

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Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-feng Yuan xiao-Yan Ren xiao-Tong Guo Yi Hua Lu Xu Cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia sheng Pei-Fang Jiang Zheng-Yan Zhao feng Gao Department of neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CsF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics.next-generation sequencing-negative inflammatory neurological diseases(InD group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLs-DA)and orthogonal PLs-DA(O-PLs-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed us.ng Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Us.ng the O-PLs-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,catheps.n F,interalpha-tryps.n inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLs-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid bios.nthesis compared to the HC *** The proteomic alterations in CsF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

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Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

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Genes & Diseases 2024年第2期11卷 1066-1081页

作者： Junyan Yan Lu xiao Di feng Baolin Chen Ting Yang Bei Tong Ruifang Luo Yuting Wang Jie Chen Children nutrition Research Center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an ess.ntial role in modulating both the gut microbiota and gut barrier ***-chain fatty acids (sCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is ***,there is an urgent need to understand how and which sCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAn),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of sCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAn groups were enriched by RnA *** the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were ***,the above changes in the VAD groups were rescued by VA supplementation in the early pos.natal *** study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its *** findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely pos.natal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 short-chain fatty acids Vitamin A deficiency

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Casual associations between blood metabolites and colon cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue Hu Yi-Quan Cheng Zhi-Long shi Fu-Peng Ren Gang-feng xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUnD Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several s.nsitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robus.ness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],n-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyros.ne[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],n-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of s.nsitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen feng-Lin Chen Ying-Jie Zhang xiao-Cong Liu xiao-Yan Yang shan-shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate school Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUnD The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General surgery Department of Chengdu second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as.normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Fast X-ray imaging beamline at ssRF

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nuclear science and Techniques 2024年第9期35卷 68-81页

作者： Ke Li Hong-Lan Xie Ya-nan Fu Fei-Xiang Wang Guo-Hao Du Jian-feng ji Biao Deng Ti-Qiao xiao shanghai s.nchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

The fast X-ray imaging beamline(BL16U2)at shanghai s.nchrotron Radiation Facility(ssRF)is a new beamline that provides X-ray micro-imaging capabilities across a wide range of time scales,spanning from 100 ps toμs and *** beamline has been specifically designed to facilitate the investigation of a wide range of rapid phenomena,such as the deformation and failure of materials subjected to intense dynamic *** addition,it enables the study of high-pressure and high-speed fuel spray processes in automotive *** light source of this beamline is a cryogenic permanent magnet undulator(CPMU)that is cooled by liquid *** CPMU can generate X-ray photons within an energy range of 8.7-30 *** beamline offers two modes of operation:monochromatic beam mode with a liquid nitrogen-cooled double-crystal monochromator(DCM)and pink beam mode with the first crystal of the DCM out of the beam *** X-ray imaging methods were implemented in BL16U2:s.ngle-pulse ultrafast X-ray imaging,microsecond-resolved X-ray dynamic imaging,millisecond-resolved X-ray dynamic micro-CT,and high-resolution quantitative ***,BL16U2 is equipped with various in situ impact loading systems,such as a split Hopkins.n bar system,light gas gun,and fuel spray *** the completion of the final commissioning in 2021 and subsequent trial operations in 2022,the beamline has been officially available to users from 2023.

关键词： Multiple time-scale X ray imaging s.ngle-pulse X ray imaging Dynamic 2D imaging Dynamic micro-CT

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Remote s.ns.ng of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang Yong Chen Chun-li Chen Yong-ke Zhang Ji-hui Dong Tao Peng xiao-feng Li Ding-fu Zhou school of Physics Beijing Institute of TechnologyBeijing 100081China southwest Institute of Technical Physics Chengdu 610041SichuanChina school of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote s.ns.ng of atmospheric pollution is proposed and *** system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques us.ng a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber *** combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote s.ns.ng of atmospheric *** static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 *** experiments is conducted with the *** of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 *** test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting s.ns.ng Atmospheric pollution

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Interfacial Electronic Modulation of Dual-Monodispersed Pt–ni_(3)s_(2) as Efficacious Bi-Functional Electrocatalysts for Concurrent H_(2) Evolution and Methanol selective Oxidation

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nano-Micro Letters 2024年第4期16卷 415-431页

作者： Qianqian Zhao Bin Zhao Xin Long Renfei feng Mohs.n shakouri Alisa Paters.n Qunfeng xiao Yu Zhang Xian‑Zhu Fu Jing‑Li Luo shenzhen Key Laboratory of Energy Electrocatalytic Materials Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Canadian Light source Inc. SaskatoonSK S7N 0X4Canada Instrumental Analysis Center of shenzhen University(Lihu Campus) Shenzhen UniversityShenzhen 518055People’s Republic of China

Constructing the efficacious and applicable bifunctional electrocatalysts and establishing out the mechanisms of organic electro-oxidation by replacing anodic oxygen evolution reaction(OER) are critical to the development of electrochemicallydriven technologies for efficient hydrogen production and avoid CO_(2) emission. Herein, the hetero-nanocrystals between monodispersed Pt(~ 2 nm) and ni_(3)s_(2)(~ 9.6 nm) are constructed as active electrocatalysts through interfacial electronic modulation, which exhibit superior bi-functional activities for methanol selective oxidation and H_(2) generation. The experimental and theoretical studies reveal that the asymmetrical charge distribution at Pt–ni_(3)s_(2) could be modulated by the electronic interaction at the interface of dual-monodispersed heterojunctions, which thus promote the adsorption/desorption of the chemical intermediates at the interface. As a result, the selective conversion from CH_(3)OH to formate is accomplished at very low potentials(1.45 V) to attain 100 m A cm^(-2) with high electronic utilization rate(~ 98%) and without CO_(2) emission. Meanwhile, the Pt–ni_(3)s_(2) can simultaneously exhibit a broad potential window with outstanding stability and large current densities for hydrogen evolution reaction(HER) at the cathode. Further, the excellent bi-functional performance is also indicated in the coupled methanol oxidation reaction(MOR)//HER reactor by only requiring a cell voltage of 1.60 V to achieve a current density of 50 m A cm^(-2) with good reusability.

关键词： Dual-monodispersed heterostructure Electronic interactive modulation Reaction mechanism Methanol oxidation reaction Hydrogen generation

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