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Galectin 2 regulates JAK/sTAT3 signaling activity to modulate oral squamous cell carcinoma proliferation and migration in vitro

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BIOCELL 2024年第5期48卷 793-801页

作者： XInRU feng LI xiao Medical school University of Electronic Science and Technology of ChinaChengdu610072China Department of stomatology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Galectin 2(LGALs2)is a protein previously reported to serve as a mediator of disease progression in a range of *** function of LGALs2 in oral squamous cell carcinoma(OsCC),however,has yet to be explored,prompting the pres.nt study to address this literature ***:Overall,144 paired malignant tumor tissues and paracancerous OsCC patient samples were harvested and the LGALs2 expression levels were examined through qPCR and western *** LGALs2 coding sequence was introduced into the pcDnA3.0 vector,to enable the overexpression of this gene,while an LGALs2-specific shRnA and corresponding controls were also *** functionality of LGALs2 as a regulator of the ability of OsCC cells to grow and undergo apoptotic death in vitro was assessed through EdU uptake and CCK-8 assays,and flow cytometer,whereas a Transwell system was used to assess migratory activity and *** agonist of the Janus Kinase 2(JAK2)/signal Transducer and Activator of Transcription 3(sTAT3)pathway was also used to assess the role of this pathway in the context of LGALs2 ***:Here,we found that lower LGALs2 protein and mRnA expression were evident in OsCC tumor tissue samples,and these expression levels were associated with clinicopathological characteristics and patient survival *** LGALs2 enhanced proliferation in OsCC cells while rendering these cells better able to resist *** opposite was instead observed after LGALs2 was ***,the ability of LGALs2 to suppress the progression of OsCC was related to its ability to activate the JAK/sTAT3 signaling ***:Those results suggest a role for LGALs2 as a suppressor of OsCC progression through its ability to modulate JAK/sTAT3 signaling,supporting the potential utility of LGALs2 as a target for efforts aimed at treating OsCC patients.

关键词： LGALs2 Oral squamous cell carcinoma(OsCC) Janus Kinase 2/signal Transducer and Activator of Transcription 3(JAK2-sTAT3) Progression

Effect of oxide inclusions on Mns precipitates and tensile mechanical property of high-strength low-alloy steel

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Journal of Iron and steel Research International 2024年第5期31卷 1210-1220页

作者： xiao-yong Gao Hong Wei Li-feng Zhang school of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina school of Materials science and Engineering Yanshan UniversityQinhuangdao066004HebeiChina school of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

The key role of oxide inclusions on the microstructure and mechanical property of a high-strength low-alloy steel was *** field emission scanning electron microscope equipped with energy-dispersive spectrometry was used to characterize Mns *** inclusions play an important role in the shape control of Mns *** oxides fovored to decrease the size and the aspect ratio of Mns *** less oxide inclusions in the steel,approximately over 16.7%Mns precipitates were with aspect ratio a>5 and pure Mns precipitates accounted for 75.9%in ***,with more oxide inclusions in the steel,only 7.4%Mns precipitates were with a>5 and pure Mns precipitates accounted for 60.1%in *** of Mns by oxide inclusions improved the strength and inhibited the *** oxide inclusions in the steel increased the yield strength and tensile strength of the steel in both longitudinal and transverse directions,and lowered the anisotropy of the mechanical property.

关键词： High-strength low-alloy steel Mns Oxide inclusion Mechanical property Anisotropy

severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-n,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao feng Hua Zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-n,3-dimethylbenzamide is a key intermediate in the s.nthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-n,3-dimethylbenzamide pois.ning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-n,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-n,3-dimethylbenzamide pois.ning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-n,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eos.n staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-n,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor pers.nal protective *** typical course of 2-amino-5-chloro-n,3-dimethylbenzamide pois.ning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-n,

关键词： 2-amino-5-chloro-n,3-dimethylbenzamide Pois.ning Clinical characteristics Liver injury

Peer-to-Peer Trading in Distribution systems with the Utility's Operation

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CsEE Journal of Power and Energy systems 2024年第2期10卷 629-638页

作者： Xuanyi xiao feng Wang Mohammad shahidehpour Yujia Zhai Quan Zhou Department of Electrical and Information Engineering Hunan UniversityChangshaChina Robert W.Galvin Center for Electricity Innovation Ilinois Institute of TechnologyChicagoIL60616USA

To realize a liberalized peer-to-peer (P2P) electricity market in distribution systems with network security, this paper develops a general framework for P2P trading in distribution systems with the utility's operation. The model is formulated as a bi-level programming. The utility's operation is an upper level problem, where a calculation method of network usage charges for P2P trading is also proposed. Peers' P2P trading is a lower level problem. An iterative algorithm based on analytical target cascading (ATC) is proposed to solve the model, where the interactions between utility and peers are pres.nted. numerical results on the IEEE 33-bus system demonstrate that the proposed method realizes a liberalized P2P market and ensures.network security in distribution systems.

关键词： Distribution system peer-to-peer trading electricitymarket distributed energyresources(DERs) analytical target cascading(ATC)

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-xiao Zheng Zi-An Zhou Tiao feng Hui Li Cheng-Hua s.n nüWang Yang Tian Yong Zhao shu-Yun Zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of sciences Beijing 100049China Laboratory of Bioinspired smart Interfacial science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaiss.nce/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic scintillators Underwater X-ray imaging Underwater nondestructive testing technology

A global model for evaluating discharge characteristics and performance of hollow cathodes

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Chinese Journal of Aeronautics 2024年第9期37卷 72-84页

作者： feng TIAn Long MIAO Qimeng XIA Zhiwen WU ningfei WAnG xiao HOU school of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 404100China

Hollow cathode,with the highest plasma density,current density,and temperature,becomes one of the most important components in the electro-thruster *** the electric-propulsion thruster performance is directly related to the ionization rate,reliability,and lifetime of the hollow cathode,this paper develops a global model to study the effects of discharge current,gas flow rate,and gas species on the discharge characteristics in the insert and orifice regions of the hollow *** emitter wall temperatures of hollow cathodes predicted by the global model are compared with experimental results from nsTAR thruster neutralization cathodes,confirming the model's *** influence of hollow cathode emitter material and structure sizes on the plasma parameters in the internal regions was also *** simulation results show that there is an optimal matching relationship between the discharge current and gas flow rate to guarantee the maximum ionization *** optimal working region for the hollow cathode has been deter-mined under different energetic,regime and structural *** global model established in this paper can quickly determine the key structure and operating parameters of hollow cathode at the design stage,and provide the theoretical basis for hollow cathode design and development.

关键词： Hollow cathode Global model Electric propulsion Discharge characteristics Optimal matching relationship

Color-polarization s.nergistic target detection method considering shadow interference

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Defence Technology（防务技术） 2024年第7期37卷 50-61页

作者： Bin feng Jinpei xiao Junchao Zhang Lin Li Yunlong Wu Qing Ye school of Automation Northwestern Polytechnical UniversityXi'an710072China school of Automation Central South UniversityChangsha410083China state Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei230037China

Aiming at the problem of shadow interference in UAV's ground reconnaiss.nce,a color and polarization s.nergistic target detection method is proposed for anti-shadow interference,based on the influence of two physical characteristics(wavelength and polarization)under different illuminations.A valid fusion strategy is proposed via integrating two separate detection results on color and polarization ***,a local enhancement and recognition module(LER)is introduced to boost the *** on our built dataset,experimental results show that our method achieves mAPof 87.76%,and12.37%higher than that of color image and 14.68%higher than that of polarization image.

关键词： Electro-optical countermeasure Ground reconnaiss.nce Color-polarization shadow interference Target recognition

shear-thinning Catechol-modified Chitos.n Hydrogel Loaded with silver nanoparticles for Endoscopic submucosal Dissection

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Chinese Journal of Polymer science 2024年第8期42卷 1147-1155页

作者： Wen-Jun feng Yan-He Wu xiao-Yang Liu Zheng-Ke Wang MOE Key Laboratory of Macromolecular s.nthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

shear-thinning hydrogels have emerged for endoscopic submucosal dissection,while wound intervention after surgery has rarely been ***,a catechol-modified chitosa n hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound *** from the shear-thinning and self-healing characteristics,the asprepared hydrogel showed easily endoscopic *** also performed very well as submucosal cushion,which could remain above 70%after injection for 120 min in ex vivo porcine large intestine *** fact,the cushion height of normal saline dramatically decreased to 46%of the initial height at 30 *** nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100%antibacterial effect against *** and *** hemolysis ratio of the hydrogel was calculated to be as low as 0.8%.Combined with good hemocompatibility and cytocompatibility,the as-prepared hydrogel displayed much higher in vivo wound closu re and healing efficacy than normal *** results demonstrated the superiority of the shear-thinning chitos.n hydrogel in facilitating clinical endoscopic submucosal dissection surgery.

关键词： shear-thinning hydrogel Endoscopic mucosal dissection Wound healing Catechol-modified chitos.n silver nanoparticles

self-doping active sites in microbe-derived carbonaceous electrocatalysts for the oxygen reduction reaction performance

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nano Research 2024年第8期17卷 6803-6819页

作者： xiaofeng xiao xiaochun Tian Junpeng Li Fan Yang Rui Bai feng Zhao Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of sciences Beijing 100049China

Microorganisms are rich in heteroatoms,which can be self-doped to form active sites during pyrolysis and loaded on microbederived carbonaceous *** recent years,microbe-derived carbonaceous materials,characterized with abundant selfdoping sites,have been continuously developed as cost-effective electrocatalysts for oxygen reduction reaction(ORR).To fully unlock the catalytic potential of microbe-derived carbonaceous materials,a comprehensive analysis of catalytic sites and mechanisms for ORR is *** paper provides a summary of the ORR catalytic performance of microbe-derived carbonaceous materials reported to date,with a specific focus on the self-doping sites introduced during their pyrolytic *** highlights the mono-or co-doping sites involving nonmetallic elements such as oxygen(O),nitrogen(n),phosphorus(P),and sulfur(s)atoms,as well as covers the doping of metallic iron(Fe)atoms with various coordination configurations in microbe-derived carbonaceous *** the impact of these self-doping sites on ORR catalytic performance can guide the design of doping sites in microbe-derived carbonaceous *** approach has the potential to maximize electrocatalytic activity of microbe-derived carbonaceous materials and contributes to the development of more efficient and cost-effective carbonaceous electrocatalysts.

关键词： electrocatalysis heteroatoms self-doped s.ngle atom catalyst microbe-derived carbonaceous material