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Nano Research 2024年第5期17卷 3724-3732页

作者： Bowen Wang Nan zhang Ping xiao Jian zhang Sónia A.C.Carabineiro Junjiang Zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de LisboaLargo da Torre2829-516 CaparicaPortugal

Catalytic transfer hydrogenation(CTH)is a green and efficient pathway for selective hydrogenation of unsaturated aldehydes and ***,managing the abilities of solid catalysts to adsorb substrates and to convert them into desired products is a challenging ***,we report the synthesis of carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites(LFPO-8@C)for CTH of benzaldehyde(BzH)into benzyl alcohol(BzOH),using isopropanol(IPA)as hydrogen *** coating with carbon improves the ability to adsorb/transfer reactants from solution to active sites,and the doping of Pd2+at Fe3+site strengthens the ability of LaFeO_(3) to convert BzH into BzOH.A balanced point between them(i.e.,abilities to adsorb BzH and to convert BzH into BzOH)is obtained at LFPO-8@C,which exhibits a BzOH formation rate of 3.88 mmol·gcat^(-1)·h^(-1) at 180℃ for 3 h,which is 1.50 and 2.72 times faster than those of LFPO-8 and LaFeO_(3)@C.A reaction mechanism is proposed,in which the acidic sites(e.g.,Fe^(4+),oxygen vacancy)are used for the activation of C=O bond of BzH and O-H bond of IPA,and the basic sites(e.g.,lattice oxygen)for the activation ofα-H(O-H)bond of IPA.

关键词： LaFe_(0.92)Pd_(0.08)O_(3) porous carbon catalytic transfer hydrogenation isopropanol reaction mechanism

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen Rui-Ying Jiang Zhan Hua xiao-Wei Wang xiao-Li Shi Ye Wang Qian-Qian feng Jie Luo Wu Ning Yan-fen Shi Da-Kui zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

Thermal comfort in a building with Trombe wall integrated with phase change materials in hot summer and cold winter region without air conditioning

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Energy and Built Environment 2024年第1期5卷 58-69页

作者： Jie Li Yuan zhang Ziyang Zhu Jiangtian Zhu Jing Luo fen Peng xiaoqin Sun School of Energy and Power Engineering Changsha University of Science and TechnologyChangshaHunan 410114PR China

Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal ***,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal *** compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with *** on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were *** the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter *** show that the Trombe wall helped PCMs complete the phase change process *** wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,*** with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions.

关键词： Trombe wall Phase change materials Integrated indoor discomfort duration Integrated discomfort degree-hour Liquid fraction

The Distribution of Surnames in Xiantao City through Isonymy

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Journal of Geodesy and Geoinformation Science 2024年第2期7卷 52-65页

作者： zhang Jingjing ZHU Yan xiao Hong College of Chinese Language and Literature Wuhan UniversityWuhan 430072China College of Literature and Communication China Three Gorges UniversityYichang 443002China School of Foreign Languages China University of GeosciencesWuhan 430072China

The population migration in Hubei Province was frequent in history,accompanied by the migration of surnames,so it is important to study their population *** take Xiantao City as an example to explore the isonymic structure of small and medium-sized cities in *** surname distributions of 223327 residents registered in 2013 were analyzed in 5 towns and 105 villages of *** number of different surnames found was *** for surnames,theα-value reflects the influence of ethnic composition on the abundance of *** correlation between the isonymic distance and the geographic distance between villages was calculated and indicated that Euclidean distance was weakly correlated with the geographic distance(r=0.177±0.012),and the isonymic distance increased with the geographical ***,the dendrogram and PCA built from the matrix of Euclidean distances between villages identified a main surname differentiation between the urban and rural areas.

关键词： Xiantao City surname distribution isonymy isolation by distance urban and rural areas

CO_(2) corrosion of X80 steel welded joints under micro-turbulence induced by welding reinforcement height

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Journal of Iron and Steel Research International 2024年第4期31卷 1015-1032页

作者： xiao-hui Dou Bin Li Zong-hao He Xin-wei zhang Da-lei zhang Yan Li School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Corrosion failure accidents owing to flow erosion and pipeline corrosion frequently occur during *** welding reinforcement height(WRH)can induce locally micro-turbulent flow field,which aggravates local corrosion of welded joints.A high wall shear stress(WsS)experimental setup was established to conduct the online electrochemical corrosion *** influence of WRH sizes on local corrosion of welded joints was studied at different flow *** electrochemical signals of the local corrosion of X80 welded joints at different flow rates were monitored in real time using electrochemical impedance spectroscopy and wire beam *** addition,the corrosion products composition and properties were *** results show that the micro-turbulent flow fields induced by the WRHs can enhance ion mass transfer near the welded *** corrosion products on the WRH surface also present different microscopic morphologies at different flow *** strong flow fields,the locally enhanced wsS can peel off the dense corrosion product partially,leading to the electrochemical distribution of large cathode and small anode,which accelerates the occurrence and development processes of the local corrosion of welded *** scientific guidelines for the corrosion protection of long-distance oil and gas pipelines can be potentially provided.

关键词： X80 steel welded joint Welding reinforcement height Micro-turbulence CO_(2)corrosion-Ion mass transfer

Differentially-grown cobalt regulators cooperatively involved in the tandem catalysis for high-yield production of second amines

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Nano Research 2024年第4期17卷 2444-2450页

作者： Jinhui Xu xiao Wang Ying Wang Fei Wang Lingling zhang Wenjie Cui Shuyan Song Hongjie zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

One-pot tandem catalysis has been regarded as one of the most atomic economic ways to produce secondary amines,the important platform molecules for chemical synthesis and pharmaceutical manufacture,but it is facing serious issues in overall *** promotional effects are highly desired for boosting the activity and regulating the selectivity of conventional tandem *** this work,we report a high-performance tandem catalyst with maximized synergistic effect among each counterpart by preciously manipulating the spatial structure,which involves the active CeO_(2)/Pt component as kernel,the densely-coated N-doped C(NC)layer as selectivity controller,and the differentially-grown Co species as catalytic performance *** comprehensive investigations,the unique growth mechanism and the promotion effect of Co regulators are ***,the surface-landed Co clusters(Cocs)are crucial to selectivity by altering the adsorption configuration of benzylideneaniline ***,the inner Co particles(Cops)are essential for activity by denoting their electrons to neighboring *** from the unique promotion effect,a remarkably-improved catalytic efficiency(100%nitrobenzene conversion with 94%N-benzylaniline selectivity)is achieved at a relatively low temperature of 80℃,which is much better than that of CeO_(2)/Pt(100%nitrobenzene conversion with 12%N-benzylaniline selectivity)and CeO_(2)/Pt/NC(35%nitrobenzene conversion with 94%benzylideneaniline selectivity).

关键词： tandem catalysis CeO_(2) hierarchical structure heterogeneous catalyst dual-site materials

Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu xiao-Peng zhang Gang Liu Wen-Dan Tan Xin-Dan zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

Mesenchymal stem cell-derived exosomes: Versatile nanomaterials for skin wound treatment

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Nano Research 2024年第4期17卷 2836-2856页

作者： Yuzhen xiao Hexi Li Junhui zhang Songyun Yang Chunsen zhang Yizhou Huang Xin Tang Huiqi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China Sports Medicine Center West China HospitalSichuan UniversityChengdu 610041China

Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine ***,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive *** the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound *** hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their *** to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin *** further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive ***,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation.

关键词： exosomes mesenchymal stem cells diabetic wounds burn wounds scar wound healing

Engineering oxygen vacancies on Tb-doped ceria supported Pt catalyst for hydrogen production through steam reforming of long-chain hydrocarbon fuels

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Chinese Journal of Chemical Engineering 2024年第4期68卷 181-192页

作者： Zhourong xiao Changxuan zhang Peng Li Desong Wang Xiangwen zhang Li Wang Jijun Zou Guozhu Li State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryCollege of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Steam reforming of long-chain hydrocarbon fuels for hydrogen production has received great attention for thermal management of the hypersonic vehicle and fuel-cell *** this work,Pt catalysts supported on CeO_(2)and Tb-doped CeO_(2)were prepared by a precipitation *** physical structure and chemical properties of the as-prepared catalysts were characterized by powder X-ray diffraction,scanning electron microscopy,transmission electron microscopy,Raman spectroscopy,H_(2)temperature programmed reduction,and X-ray photoelectron *** results show that Tb-doped CeO_(2)supported Pt possesses abundant surface oxygen vacancies,good inhibition of ceria sintering,and strong metal-support interaction compared with CeO_(2)supported *** catalytic performance of hydrogen production via steam reforming of long-chain hydrocarbon fuels(n-dodecane)was *** with 2Pt/CeO_(2),2Pt/Ce_(0.9)Tb_(0.1)O_(2),and 2Pt/Ce_(0.5)Tb_(0.5)O_(2),the 2Pt/Ce_(0.7)Tb_(0.3)O_(2)has higher activity and stability for hydrogen production,on which the conversion of n-dodecane was maintained at about 53.2%after 600 min reaction under 700℃at liquid space velocity of 9 ml·g^(-1)·h^(-1).2Pt/CeO_(2)rapidly deactivated,the conversion of n-dodecane was reduced to only 41.6%after 600 min.

关键词： Steam reforming n-Dodecane Hydrogen production Pt-based catalyst Oxygen vacancy CeO_(2)

Sn-fused perylene diimides: Synthesis, mechanism, and properties

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Chinese Chemical Letters 2024年第10期35卷 244-248页

作者： Wenzhong zhang Zirui Yan Lingcheng Chen Yi xiao State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The first example of metal Sn-fused perylene diimides(PDI)derivative(Sn-PDI)was designed,synthesized,and *** obtain this type compound,a simple one-pot synthesis,named stannylative cycloaddition reaction,has been successfully developed via a palladium-based catalyst *** novel mechanism exhibits that the reaction experiences oxidative addition,Pd-cyclization,stannylation,Pd-Sn-cyclization,and reductive elimination processes *** stannylative cycloaddition does realize uniqueσ-πhyperconjugation effect and therefore significantly influencing on the photophysical,electrochemical and excited state *** with those of PDI,both of the absorption and fluorescence spectra of Sn-PDI display large red-shifts over 20 *** electron energy levels of Sn-PDI have changed with an uncommon *** Sn-PDI gives a considerably raised highest occupied molecular orbital(HOMO)level of-6.00 eV More importantly,the singlet excitons of Sn-PDI could efficiently intersystem cross(ISC)into triplet state with a long lifetime of 17.8μs,which is far longer than that(4.4 ns)of PDI.

关键词： Functional dyes Perylene diimides Organometallic heterocyclics Hyperconjugation Triplet state