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An Improved Golden Jackal Optimization Algorithm Based on Multi-strategy Mixing for Solving Engineering Optimization Problems

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Journal of Bionic Engineering 2024年第2期21卷 1092-1115页

作者： Jun Wang Wen-chuan Wang Kwok-wing Chau Lin Qiu xiao-xue Hu Hong-fei Zang Dong-mei Xu College of Water Resources North China University of Water Resources and Electric PowerZhengzhou450046People’s Republic of China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China

Nowadays,optimization techniques are required in various engineering domains to find optimal solutions for complex *** a result,there is a growing tendency among scientists to enhance existing nature-inspired algorithms using various evolutionary strategies and to develop new nature-inspired optimization methods that can properly explore the feature *** recently designed nature-inspired meta-heuristic,named the Golden Jackal Optimization(GJO),was inspired by the collaborative hunting actions of the golden jackal in nature to solve various challenging ***,like other approaches,the GJO has the limitations of poor exploitation ability,the ease of getting stuck in a local optimal region,and an improper balancing of exploration and *** overcome these limitations,this paper proposes an improved GJO algorithm based on multi-strategy mixing(LGJO).First,using a chaotic mapping strategy to initialize the population instead of using random parameters,this algorithm can generate initial solutions with good diversity in the search ***,a dynamic inertia weight based on cosine variation is proposed to make the search process more realistic and effectively balance the algorithm's global and local search ***,a position update strategy based on Gaussian mutation was introduced,fully utilizing the guidance role of the optimal individual to improve population diversity,effectively exploring unknown regions,and avoiding the algorithm falling into local *** evaluate the proposed algorithm,23 mathematical benchmark functions,CEC-2019 and CEC2021 tests are *** results are compared to high-quality,well-known optimization *** results of the proposed method are compared from different points of view,including the quality of the results,convergence behavior,and *** superiority and high-quality performance of the proposed method are demonstrated by comparing the ***,to demonstrate

关键词： Golden jackal optimization Chaotic mapping Dynamic inertia weight Dimensional Gaussian variation Muskingum

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Effect of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction

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World Journal of Psychiatry 2024年第8期14卷 1190-1198页

作者： fei-fei Liang xiao-Xia Liu Jiang-Hong Liu Yang Gao Jian-Guo Dai Zi-Hui Sun Department of Geriatrics Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina The Fourth Ward Zhangjiakou Infectious Disease HospitalZhangjiakou 075000Hebei ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina Department of General Medicine Zhangjiakou First Hospital in Hebei ProvinceZhangjiakou 075000Hebei ProvinceChina

BACKGROUND The aging of the population has become increasingly obvious in recent years,and the incidence of cerebral infarction has shown an increasing trend annually,with high death and disability *** To analyze the effects of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral *** Between January 2020 and December 2023,we treated 98 cases of elderly acute insula,patients with cerebral infarction in the cerebral infarction acute phase(3-4 weeks)and for the course of 6 months in Montreal Cognitive Assessment Scale(MoCA)for screening of ***,58 and 40 patients were placed in the cognitive impairment group and without-cognitive impairment group,*** patients with cerebral infarction,magnetic resonance imaging was used to screen and clearly analyze the MoCA scores of two groups of patients with different infarctions,the relationship between the parts of the infarction volume,and analysis of acute insula cognitive disorder in elderly patients with cerebral RESULTS The number of patients with cognitive impairment in the basal ganglia and thalamus was significantly higher than that without cognitive impairment(P<0.05).The total infarct volume in the cognitive impairment group was higher than that in the non-cognitive impairment group,and the difference was statistically significant(P<0.05).The infarct volumes at different sites in the cognitive impairment group was higher than in the non-cognitive impairment group(P<0.05).In the cognitive impairment group,the infarct volumes in the basal ganglia,thalamus,and mixed lesions were negatively correlated with the total MoCA score,with correlation coefficients of-0.67,-0.73,and-0.77,*** In elderly patients with acute insular infarction,infarction in the basal ganglia,thalamus,and mixed lesions were more likely to lead to cognitive dysfunction than in other areas,and patients with large infarct volumes were more like

关键词： Elderly Acute insular infarction Infarction site Cognitive impairment Infarction volume

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Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization

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World Journal of Stem Cells 2024年第3期16卷 287-304页

作者： fei Liu Jing xiao Lei-Hui Chen Yu-Yue Pan Jun-Zhang Tian Zhi-Ren Zhang xiao-Chun Bai School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Health Management Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People’s Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Centre of Reproduction Development and AgingFaculty of Health SciencesUniversity of MacaoMacao 999078China Department of Stomatology Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Zhuhai Institute of Translational Medicine Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND The self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative *** cells can self-organise into microsized organ units,partially modelling tissue function and *** pulp organoids have been used to recapitulate the processes of tooth development and related ***,the lack of vasculature limits the utility of dental pulp *** To improve survival and aid in recovery after stem cell transplantation,we demonstrated the three-dimensional(3D)self-assembly of adult stem cell-human dental pulp stem cells(hDPSCs)and endothelial cells(ECs)into a novel type of spheroid-shaped dental pulp organoid in vitro under hypoxia and conditioned medium(CM).METHODS During culture,primary hDPSCs were induced to differentiate into ECs by exposing them to a hypoxic environment and *** hypoxic pretreated hDPSCs were then mixed with ECs at specific ratios and conditioned in a 3D environment to produce prevascularized dental pulp *** biological characteristics of the organoids were analysed,and the regulatory pathways associated with angiogenesis were *** The combination of these two agents resulted in prevascularized human dental pulp organoids(Vorganoids)that more closely resembled dental pulp tissue in terms of morphology and ***-cell RNA sequencing of dental pulp tissue and RNA sequencing of Vorganoids were integrated to analyse key regulatory pathways associated with *** biomarkers forkhead box protein O1 and fibroblast growth factor 2 were identified to be involved in the regulation of *** In this innovative study,we effectively established an in vitro model of Vorganoids and used it to elucidate new mechanisms of angiogenesis during regeneration,facilitating the development of clinical treatment strategies.

关键词： Human dental pulp stem cells Prevascularized organoids Integrated analyses Angiogenesis Forkhead box protein O1

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Application of radioactive iodine-125 microparticles in hepatocellular carcinoma with portal vein embolus

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2023-2030页

作者： Peng Meng Ji-Peng Ma xiao-fei Huang Kang-Le Zhang The Fourth Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Medical Services Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510062Guangdong ProvinceChina The Third Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina

BACKGROUND Radioactive iodine-125(125I)microparticle therapy is a new type of internal radiation therapy that has shown unique advantages in the treatment of malignant tumors,especially hepatocellular *** with hepatocellular carcinoma frequently experience portal vein embolism,which exacerbates the difficulty and complexity of treatment.125I particles,used in local radiotherapy,can directly act on tumor tissue and reduce damage to surrounding healthy *** retrospective analysis,this study discussed the efficacy and safety of radioactive 125I particles in portal vein embolization patients with hepatocellular carcinoma in order to provide more powerful evidence supporting clinical *** To investigate the effect of transcatheter arterial chemoembolization combined with portal vein 125I particle implantation in the treatment of primary liver cancer patients with portal vein tumor thrombus and its influence on liver *** The clinical data of 96 patients with primary liver cancer combined with portal vein tumor thrombus admitted to our hospital between January 2020 and December 2023 were retrospectively ***-two patients received treatment with transcatheter arterial chemoembolization and implantation of 125I particles in the portal vein(combination group),while 44 patients received treatment with transcatheter arterial chemoembolization alone(control group).The therapeutic effects on tumor lesions,primary liver cancer,and portal vein tumor embolisms were compared between the two *** in relevant laboratory indexes before and after treatment were *** t test was used to compare the measurement data between the two groups,and the χ^(2) test was used to compare the counting data between *** The tumor lesion response rate in the combination group(59.62%vs 38.64%)and the response rate of patients with primary liver cancer complicated with portal vein tumor thrombus(80.77%vs 59.09%)were signi

关键词： Radioactive iodine-125 Hepatocellular carcinoma Transcatheter arterial chemoembolization Portal vein embolus Retrospective study

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Three-dimensional Modeling of Ore-forming Elements and Mineralization Prognosis for the Yechangping Mo Deposit,Henan Province,China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 736-752页

作者： ding Gaoming JI Genyuan YAN Guolong XU Yongzhong WANG Kunming xiao Chun WANG Quanle GUO Dongbao China National Administration of Coal Geology Beijing 100038China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China China Gold Group Geological Co. Ltd.Beijing 100011China China Gold Group ZhongYuan Mining Co. Ltd.SanmenxiaHenan 472000China Lanzhou Mineral Exploration Institute of Gansu Nonferrous Metal Geological Exploration Bureau Lanzhou 730046China

Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep *** approach provides key information for the quantitative prediction of deep mineral localization,three-dimensional fine interpolation,analysis of spatial distribution patterns,and extraction of quantitative mineral-seeking *** Yechangping molybdenum(Mo)deposit is a significant and extensive porphyry-skarn deposit in the East Qinling-Dabie Mo polymetallic metallogenic belt at the southern margin of the North China *** borehole data on oreforming elements underpin deep geochemical *** methodology includes the following steps:(1)Threedimensional geological modeling of the deposit was established.(2)Correlation,cluster,and factor analyses post delineation of mineralization stages and determination of mineral generation sequence to identify(Cu,Pb,Zn,Ag)and(Mo,W,mfe)assemblages.(3)A three-dimensional geochemical block model was constructed for Mo,W,mfe,Cu,Zn,Pb,and Ag using the ordinary kriging method,and the variational function was developed.(4)Spatial distribution and enrichment characteristics analysis of ore-forming elements are performed to extract geological information,employing the variogram and w(Cu+Pb+Zn+Ag)/w(Mo+W)as predictive indicators.(5)Identifying the western,northwestern,and southwestern areas of the mine with limited mineralization potential,contrasted by the northeastern and southeastern areas favorable for mineral exploration.

关键词： 3D geochemical model ore-forming elements geostatistics deep mineralization prediction Yechangping Mo deposit

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Synthesis,Characterization of Polyethylene Ionomers and Their Antibacterial Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1077-1084页

作者： Jia-Jia Wu fei Wang Peng-Qi Wan Li Pan Chun-Sheng xiao Zhe Ma Yue-Sheng Li Tianjin Key Lab Composite&Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Key Lab Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Owing to its high production volume and wide range of application s,polyethylene has gained a great deal of attention,but its low surface energy and non-polar nature have limited its application in some important *** this study,ethylene/11-iodo-1-undecene copolymers were prepared and used as the intermediates to afford a series of imidazolium-based ionomers bearing methanesulfonate(CH_(3)SO_(3)^(-)),trifluoromethanesulfonate(CF_(3)SO_(3)^(-)),or bis(trifluoromethane)sulfonimide(Tf_(2)N^(-))*** tensile test results showed that the stress-at-break(7.8-25.6 MPa)and the elongation-at-break(445%-847%)of the ionomers could be adjusted by changing the counterion species and the ionic group *** importantly,the ionomers exhibited marvelous antibacterial activities against Staphylococcus aureus(***)and Escherichia coli(***).The ionomers bearing Tf_(2)N^(-)exhibited antibacterial activities>99%against both *** and *** when ionic content reached 9.1%.The imidazolium-based ionomers prepared in this work demonstrated excellent comprehensive properties,especially highefficient and broad-spectrum antibacterial ability,exhibiting the potential fo r the application as the antibacterial materials in packaging,medical,and other fields.

关键词： Polyethylene Ionomer Polymerization catalysis Imidazolium Antibacterial material

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Quercetin Alleviates Lipopolysaccharide-Induced Cardiac Inflammation via Inhibiting Autophagy and Programmed Cell Death

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Biomedical and Environmental Sciences 2024年第1期37卷 54-70页

作者： YU Jin Hai HU Guo Liang GUO xiao Quan CAO Hua Bin XIA Zhao fei AMIN Buhe Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045JiangxiChina Internal Medicine Laboratory Department of Veterinary Clinical MedicineCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100091China Department of Cancer Surgery Beijing Shijitan Hospital Affiliated with Capital Medical UniversityBeijing 100038China

Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac *** Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(PBS)vehicle,PBS with ethanol vehicle,LPS(500 ng/egg),LPS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic *** embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western *** They demonstrated that the heart presented inflammatory responses after LPS *** LPS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MYD88,NF-κB1,IFNγ,IL-1β,IL-8,IL-6,IL-10,p38,MMP3,and MMP9)were blocked by quercetin with three *** significantly decreased immunopositivity to TLR4 and MMP9 in the treatment group when compared with the LPS *** significantly decreased protein expressions of TLR4,IFNγ,MMP3,and MMP9 when compared with the LPS *** treatment prevented LPS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LPS *** significantly downregulated autophagyrelated gene expressions(PPARα,SGLT1,APOA4,AMPKα1,AMPKα2,ATG5,ATG7,Beclin-1,and LC3B)and programmed cell death(Fas,Bcl-2,CASP1,CASP12,CASP3,and RIPK1)after LPS *** significantly decreased immunopositivity to APOA4,AMPKα2,and LC3-II/LC3-I in the treatment group when compared with the LPS *** significantly decreased protein expressions of AMPKα1,LC3-I,and *** significantly decreased the protein expression to CASP1 and CASP3 by immunohistochemical investigation or

关键词： Quercetin Lipopolysaccharide Inflammation Autophagy Programmed cell death Myocardiocytes permeability

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Anatomical variation of the posterior septal artery leads to refractory epistaxis

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世界耳鼻咽喉头颈外科杂志英文版 2024年第3期10卷 241-243页

作者： An Dong-Jiao Li Zu-fei Zhao xiao-Chang Liu Jin-Feng Department of Anaesthesiology Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Otorhinolaryngology Head and Neck Surgery Beijing Chaoyang Hospital Capital Medical University Beijing China

Purpose: To report a rare variant of the posterior septal artery (PSA), which supplies blood to the posterior mucosa of the contralateral nasal *** report: A 31-year-old female patient underwent suture removal 14 days after septoplasty and developed left-sided epistaxis 6 h after suture removal. To safely and effectively relieve the patient from epistaxis, the cauterization of the left PSA was performed under general anesthesia. However, 24 h after the first surgical hemostasis, the patient experienced epistaxis again in the right nasal cavity. We have reviewed the patient''s sinus computed tomography again and found a rare variant of PSA, which is the right-sided PSA passing through a bony canal in the left-sided nasal ***: The variant of PSA well explained the failure of the first hemostatic surgery. Therefore, we again performed a cauterization of the right-sided PSA, after which the patient recovered and no further epistaxis ***: When cauterization of PSA is used to manage posterior epistaxis, it is necessary to pay attention to the possible variation in PSA.

关键词： cauterization nasal endoscopy posterior septal artery refractory epistaxis sphenopalatine artery

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Molecular Engineering of Aptamer to Solubilize Hydrophobic Near-Infrared Photosensitizer for Enhanced Cancer Photodynamic Therapy

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CCS Chemistry 2024年第5期6卷 1240-1254页

作者： Rongjun Zhang ding-Kun Ji Defan Yao Zeyu xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200240 Department of Radiology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092 Department of Pharmacology and Chemical Biology School of MedicineShanghai Jiao Tong UniversityShanghai 200025 Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)The Chinese Academy of SciencesHangzhouZhejiang 310022 Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082

Photodynamic therapy(PDT)is a clinically representative treatment strategy for ***,conventional photosensitizers(PSs)are usually hampered by poor water solubility and low targeting ***,we report the precise molecular engineering of aptamer oligonucleotides to solubilize hydrophobic near-infrared(NIR)PSs for enhanced cancer *** pyropheophorbide A(PA)is precisely conjugated to aptamer oligonucleotides by combing DNA solid-phase synthesis technology and Cu-free click *** coupling of insoluble PA to hydrophilic aptamer oligonucleotides vastly improves its solubility to as high as 750μM in water without any cosolvent,resulting in an enhanced NIR fluorescence property(quantum yield=23%)and ***,the targeting ability of aptamer oligonucleotides is not affected by our molecular engineering *** reactive oxygen species(ROS)are produced intracellularly with 660 nm laser irradiation,eliciting mitochondria damage and cell *** growth is effectively inhibited with a single dose of aptamer-PA conjugates without in vivo *** therapeutic effect is more than 20-fold higher than that of *** with traditional formulation,using aptamer oligonucleotides as functional carriers to solubilize hydrophobic NIR PSs is more precise and *** DNA molecular engineering strategy paves a way for the rational design of molecularly targeted medicine for future clinical cancer therapy.

关键词： aptamer aptamer-drug conjugates photosensitive drugs targeted photodynamic therapy cancer theranostics

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Development of lithium-free P2-type high-sodium content cathode materials with enhanced cycle and air stability for sodium-ion batteries

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Rare Metals 2024年第1期43卷 113-123页

作者： Jin-Lv Tian Lin-Rong Wu Hai-Jun Zhao Shou-Dong Xu Liang Chen ding Zhang xiao-Chuan Duan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China

The effect of partial substitution of Mg for Ni on a high-sodium and lithium-free layered P2-type Na_(45/54)Mg_(6)/_(54)Ni_(12/54)Mn_(34/54)O_(2) cathode with high initial Coulombic efficiency and excellent cyclic stability has been investigated in this *** on the crystal structural analysis,the Mg doping can retain the P2 structure up to 4.3 V,thus restraining the detrimental phase transformation of P2-02during the Na-ion intercalation/deintercalation ***,the obtained Mg-doped P2-type cathode exhibits a reversible specific capacity of 109 mAh·g^(-1) at 0.1C between 2.0 and 4.3 V and a retention rate of 81.5% after 200cycles at *** addition,the full cell consisting of Mg-doped P2-type cathode and hard carbon anode shows a capacity retention rate of 85.6% after 100 *** study provides new insight into the development of durable cathode materials for sodium-ion batteries.

关键词： Sodium-ion batteries Cathode material High sodium content Air stability

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