检索结果-南通市图书馆

Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： xiao-fei sun Xu Zhang Shu-Ping Song Ya-Qun Yao Yan Zhang Cheng-Liang Wang Jing-Jiang sun Qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma:a report of 76 cases

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2013年第10期32卷 561-566页

作者： Yan Chen xiao-fei sun Zi-Jun Zhen Juan Wang Jia Zhu Su-Ying Lu fei-fei sun fei Zhang Peng-fei Li Rui-Qing Cai State Key Laboratory of Oncology in South China Department of Pediatric Oncology Sun Yat-sen University Cancer Center

Pediatric diffuse large B-cell lymphoma(DLBCL)is a highly aggressive disease with unique clinical *** study analyzed the germinal-center type B-cell(GCB)classification and clinical characteristics of Chinese pediatric DLBCL.A total of 76 patients with DLBCL newly diagnosed in sun Yatsen University Cancer Center between February 2000 and May 2011,with an age younger than 18 years,were included in the *** male/female ratio was 3.47:*** median age was 12 years(range,2 to 18 years),and 47(61.8%)patients were at least 10 years *** the 76 patients,48(63.2%)had stage III/IV disease,9(11.8%)had bone marrow involvement,1(1.3%)had central nervous system(CNS)involvement,and 5(6.6%)had bone *** GCB classification was assessed in 45 patients:26(57.8%)were classified as GCB subtype,and 19(42.2%)were classified as non-GCB *** modified B-NHL-BFM-90/95 regimen was administered to 50 patients,and the 4-year event-free survival(EFS)rate was 85.8%.Among these 50 patients,31 were assessed for the GCB classification:17(54.8%)were classified as GCB subtype,with a 4-year EFS rate of 88.2%;14(45.2%)were classified as non-GCB subtype,with a 4-year EFS rate of 92.9%.Our data indicate that bone marrow involvement and stage III/IV disease are common in Chinese pediatric DLBCL patients,whereas the percentage of patients with the GCB subtype is similar to that of patients with the non-GCB *** modified B-NHL-BFM-90/95protocol is an active and effective treatment protocol for Chinese pediatric patients with DLBCL.

关键词： B细胞淋巴瘤临床特征弥漫性中国分类小儿生发中枢神经系统

Survival analysis of children with stage Ⅱ testicular malignant germ cell tumors treated with surgery or surgery combined with adjuvant chemotherapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2015年第2期34卷 86-93页

作者： Su-Ying Lu xiao-fei sun Zi-Jun Zhen Zi-Ke Qin Zhuo-Wei Liu Jia Zhu Juan Wang fei-fei sun State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Pediatric Oncology Sun Yat sen University Cancer Center Department of Urology Sun Yat sen University Cancer Center

For children with stage II testicular malignant germ cell tumors(MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no imaging or pathologic evidence of residual tumor, but in which serum tumor markers either increased or failed to normalize after an appropriate period of half-life time post-surgery. To determine the use of chemotherapy for children with stage II germ cell tumors, we analyzed the outcomes(relapse rate and overall survival) of patients who were treated at the sun Yat-sen University Cancer Center between January 1990 and May 2013. Twenty-four pediatric patients with a median age of 20 months(range, 4 months to 17 years) were enrolled in this study. In 20 cases(83.3%), the tumors had yolk sac histology. For definitive treatment, 21 patients underwent surgery alone, and 3 patients received surgery and adjuvant chemotherapy. No relapse was observed in the 3 patients who received adjuvant chemotherapy, whereas relapse occurred in 16 of the 21 patients(76.2%) treated with surgery alone. There were a total of 2 deaths. Treatment was stopped for 1 patient, who died 3 months later due to the tumor. The other patient achieved complete response after salvage treatment, but developed lung and pelvic metastases 7 months later and died of the tumor after stopping treatment. For children treated with surgery alone and surgery combined with adjuvant chemotherapy, the 3-year event-free survival rates were 23.8% and 100%, respectively(P = 0.042), and the 3-year overall survival rates were 90.5% and 100%, respectively(P = 0.588). These results suggest that adjuvant chemotherapy can help to reduce the recurrence rate and increase the survival rate for patients with stage II germ cell tumors.

关键词：肿瘤标记物手术治疗生殖细胞化疗儿童生存分析恶性睾丸

Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2015年第11期34卷 531-537页

作者： Jia Zhu Juan Wang Zi-Jun Zhen Su-Ying Lu fei Zhang fei-fei sun Peng-fei Li Jun-Ting Huang Rui-Qing Cai xiao-fei sun State Key Laboratory of Oncology in South China Department of Pediatric Oncology Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center

Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South ***: In this retrospective case?based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in sun Yat?sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and ***: Of the 106 patients, 11(10.4%) developed brain metastasis, accounting for 20.0% of 55 patients with relapse or progression. The age at initial diagnosis of the 11 patients ranged from 2 to 10 years(median 4 years), which was younger than that of the patients without brain metastasis(median 5 years, range 1–10 years, P = 0.073). The male to female ratio of the 11 patients was 8:3, which was not signiicantly diferent from that of the patients with?out brain metastasis(P = 0.86). Patients with brain metastasis had higher lactate dehydrogenase levels than those without brain metastasis, but the diferences were not signiicant(P initial diagnosis to the develo= 0.076). Eight patients died, and 3 patients survived. The median interval from thepment of brain metastasis was 18 months(range 6–32 months). The median survival was 4 months(range 1 day to 29 months) after the diagnosis of brain metastasis. The median interval from the manifestation of brain metastasis to death was 3 months(range 1 day to 11 months).Conclusions: High?risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease?free survival.

关键词： Neuroblastoma, Post treatment, Brain metastasis, Stage 4

Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第8期20卷 2062-2070页

作者： xiao-fei sun Lei Gu Wen-Sheng Deng Qing Xu Department of General Surgery Renji HospitalSchool of MedicineShanghai Jiaotong University

AIM: To investigate the effect of T helper (Th) 17/T regulatory (Treg) cells on hepatic fibrosis in mice and its possible mechanism.

关键词： T helper 17 cell Treg cell Carbon tetrachloride Hepatic fibrosis Hepatic stellate cell

Diffusion coefficients of natural gas in foamy oil systems under high pressures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2015年第2期12卷 293-303页

作者： Yan-Yu Zhang xiao-fei sun Xue-Wei Duan Xing-Min Li College of Petroleum Engineering China University of Petroleum School of Geosciences China University of Petroleum The Department of Chemical and Petroleum Engineering University of Calgary Research Institute of Petroleum Exploration and Development PetroChina

The diffusion coefficient of natural gas in foamy oil is one of the key parameters to evaluate the feasibility of gas injection for enhanced oil recovery in foamy oil reservoirs. In this paper, a PVT cell was used to measure diffusion coefficients of natural gas in Venezuela foamy oil at high pressures, and a new method for deter- mining the diffusion coefficient in the foamy oil was de- veloped on the basis of experimental data. The effects of pressure and the types of the liquid phase on the diffusion coefficient of the natural gas were discussed. The results indicate that the diffusion coefficients of natural gas in foamy oil, saturated oil, and dead oil increase linearly with increasing pressure. The diffusion coefficient of natural gas in the foamy oil at 20 MPa was 2.93 times larger than that at 8.65 MPa. The diffusion coefficient of the natural gas in dead oil was 3.02 and 4.02 times than that of the natural gas in saturated oil and foamy oil when the pressure was 20 MPa. However, the gas content of foamy oil was 16.9 times higher than that of dead oil when the dissolution time and pressure were 20 MPa and 35.22 h, respectively.

关键词： Foamy oil Diffusion coefficient - Heavy oil Gas injection High pressure

The clinical characteristics and treatment outcomeof 57 children and adolescents with primary central nervoussystem germ cell tumors

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2014年第8期33卷 395-401页

作者： xiao-fei sun fei Zhang Zi-Jun Zhen Qun-Ying Yang Yun-fei Xia Shao-Xiong Wu Jia Zhu Su-Ying Lu Juan Wang fei-fei sun Rui-Qing Cai Yan Chen Peng-fei Li State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Department of Pediatric Oncology Sun Yat-sen University Cancer Center Department of Neurosurgery Sun Yat-sen University Cancer Center Department of Radiation Oncology Sun Yat-sen University Cancer Center

Primary central nervous system germ cell tumors(CNS-GCTs) in children and adolescents have unique clinical features and methods of treatment compared with those in adults. There is little information about Chinese children and adolescents with CNS-GCTs. Therefore, in this study we retrospectively analyzed the clinical features and treatment outcome of Chinese children and adolescents with primary CNS-GCTs. Between January 2002 and December 2012, 57 untreated patients from a single institution were enrolled. They were diagnosed with CNS-GCTs after pathologic or clinical assessment. Of the 57 patients, 41 were males and 16 were females, with a median age of 12.8 years(range, 2.7 to 18.0 years) at diagnosis; 43(75.4%) had non-germinomatous germ cell tumors(NGGCTs) and 14(24.6%) had germinomas; 44(77.2%) had localized disease and 13(22.8%) had extensive lesions. Fifty-three patients completed the prescribed treatment, of which 18 underwent monotherapy of surgery, radiotherapy, or chemotherapy, and 35 underwent multimodality therapies that included radiotherapy combined with chemotherapy or surgery combined with chemotherapy and/or radiotherapy. PEB(cisplatin, etoposide, and bleomycin) protocol was the major chemotherapy regimen. The median follow-up time was 32.3 months(range, 1.2 to 139 months). Fourteen patients died of relapse or disease progression. The 3-year event-free survival(EFS) and overall survival rates for all patients were 72.2% and 73.8%, respectively. The 3-year EFS was 92.9% for germinomas and 64.8% for NGGCTs(P = 0.064). The 3-year EFS rates for patients with NGGCTs who underwent monotherapy and multimodality therapies were 50.6% and 73.5%, respectively(P = 0.042). Our results indicate that multimodality therapies including chemotherapy plus radiotherapy were better treatment option for children and adolescents with CNS-GCTs.

关键词：中枢神经系统手术治疗生殖细胞临床特点青少年原发性儿童综合治疗

Phase behavior of heavy oil-solvent mixture systems under reservoir conditions

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2020年第6期17卷 1683-1698页

作者： xiao-fei sun Zhao-Yao Song Lin-Feng Cai Yan-Yu Zhang Peng Li School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongPeople’s Republic of China Nanjing Air Fuel Co. Ltd.Nanjing 211113JiangsuPeople’s Republic of China

A novel experimental procedure was proposed to investigate the phase behavior of a solvent mixture(SM)(64 mol%CH4,8 mol%CO2,and 28 mol%C3 H8)with heavy ***,a theoretical methodology was employed to estimate the phase behavior of the heavy oil-solvent mixture(HO-SM)systems with various mole fractions of *** experimental results show that as the mole fraction of SM increases,the saturation pressures and swelling factors of the HO-SM systems considerably increase,and the viscosities and densities of the HO-SM systems *** heavy oil is upgraded in situ via asphaltene precipitation and SM ***,the solvent-enriched oil phase at the top layer of reservoirs can easily be produced from the *** aforementioned results indicate that the SM has promising application potential for enhanced heavy oil recovery via solvent-based *** theoretical methodology can accurately predict the saturation pressures,swelling factors,and densities of HO-SM systems with various mole fractions of SM,with average error percentages of1.77%for saturation pressures,0.07%for swelling factors,and 0.07%for densities.

关键词： Heavy oil Solvent mixture PR-EOS Phase behavior Pressure-volume-temperature(PVT)

Surface Polarization Effects on Collapse Transition of Polyelectrolyte Brushes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1313-1320,I0006页

作者： xiao-fei Xu State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Polyelectrolyte brushes(PEBs)are commonly used to modify surface that have attracted great research *** dielectric permittivity of the grafted surface is typically significantly different from that of solution,which results in surface polarization(SP)effect with a jump of electric *** is thus important to study how SP alters the PEB’s structure and *** this work,the SP effects on PEB structure was studied using a statistical thermodynamic *** free energy functional to describe SP effect was constructed by using the image-charge ***,the electrostatic potential was solved from a modified Poisson-Boltzmann equation taking the ion solvation effect into *** the absence of SP,the thickness of PEB exhibited a continuous collapse transition when decreasing the solvent *** the presence of SP,the collapse became a jump-like *** energy analysis showed that the long-range Coulombic interaction dominated the transition because of the enhanced counterion condensation in the presence of *** theory provides an effective tool to study SP effect on PEBs,and the results explain the underlying physics in PEB collapse transition.

关键词： Surface polarization Polyelectrolyte brush Image charge Ion solvation Polyelectrolyte collapse transition

Safety of in vitro amplified HLA-haploidentical donor immune cell infusions for childhood malignancies

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2013年第12期32卷 661-666页

作者： fei Zhang xiao-fei sun Yong-Qiang Li Zi-Jun Zhen Hai-Xia Zheng Jia Zhu Qi-Jing Wang Su-Ying Lu Jia He Juan Wang Ke Pan Rui-Qing Cai Yan Chen De-Sheng Weng fei-fei sun Jian-Chuan Xia State Key Laboratory of Oncology in South China Department of Pediatric Oncology Department of Biotherapy Sun Yat-sen University Cancer Center

In vitro amplified human leukocyte antigen(HLA)-haploidentical donor immune cell infusion(HDICI)is not commonly used in ***,our study sought to evaluate its safety for treating childhood *** September 2011 and September 2012,12 patients with childhood malignancies underwent HDICI in sun Yat-sen University Cancer *** median patient age was 5.1 years(range,1.7-8.4 years).Of the 12 patients,9 had high-risk neuroblastoma(NB)[7 showed complete response(CR),1 showed partial response(PR),and 1 had progressive disease(PD)after multi-modal therapies],and 3 had Epstein-Barr virus(EBV)-positive lymphoproliferative disease(EBV-LPD).The 12 patients underwent a total of 92 HDICIs at a mean dose of 1.6×108immune cells/kg body weight:71 infusions with natural killer(NK)cells,8 with cytokine-induced killer(CIK)cells,and 13 with cascade primed immune cells(CAPRIs);83 infusions with immune cells from the mothers,whereas 9 with cells from the *** cases(21.7%)of fever,including 6 cases(6.5%)accompanied with chills and 1(1.1%)with febrile convulsion,occurred during infusions and were alleviated after symptomatic *** cases(5.4%)of mild emotion changes were *** other adverse events occurred during and after the completion of *** acute nor chronic graft versus host disease(GVHD)was observed following *** a median of 5.0 months(range,1.0-11.5 months)of follow-up,the 2 NB patients with PR and PD developed PD during *** the other 7 NB patients in CR,2 relapsed in the sixth month of HDICIs,and 5 maintained CR with disease-free survival(DFS)ranging from 4.5 to 11.5 months(median,7.2months).One EBV-LPD patient achieved PR,whereas 2 had stable disease(SD).Our results show that HDICI is a safe immunotherapy for childhood malignancies,thus warranting further studies.

关键词：免疫细胞恶性肿瘤体外扩增安全性 HLA 儿童人类白细胞抗原移植物抗宿主病