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Prognostic value of neutrophil-to-lymphocyte ratio in gastric cancer patients undergoing neoadjuvant chemotherapy:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第11期16卷 4477-4488页

作者： Zhen-Hua Wei Min Tuo Chen Ye xiao-fan wu Hong-Hao Wang Wen-Zhen Ren Gao Liu Tian Xiang Hubei Minzu University Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina Department of Breast Surgery Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina Department of Central Hospital of Tujia and Miao Autonomous Prefecture Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastrointestinal Surgery Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina Department of Abdominal Oncology Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina Department of Clinical Laboratory Center Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND In recent studies,accumulating evidence has revealed a strong association between the inflammatory response and the prognosis of many *** is a certain correlation of neutrophil-to-lymphocyte ratio(NLR)with the prognosis in gastric cancer(GC)patients undergoing neoadjuvant chemotherapy(NAC).However,the existing research results have remained *** To explore the relationship between NLR ratio and prognosis of GC patients receiving *** A thorough systematic search was performed in databases such as PubMed,Embase,Web of Science,and Cochrane Library,the search is available until February 29,2024,and studies exploring the interaction of NLR with clinical outcomes were *** studies meeting pre-defined inclusion and exclusion criteria were carefully *** outcomes included progression-free survival(PFS),relapse-free survival,disease-free survival(DFS),and overall survival(OS).The hazard ratio(HR)and its corresponding 95%confidence interval(CI)were utilized for *** Our analysis encompassed 852 patients and incorporated data from 12 cohort *** comprehensive analysis revealed a significant association of high NLR with reduced OS(HR=1.76;95%CI:1.22-2.54,P=0.003),relapsefree survival(HR=3.73;95%CI:1.74-7.96,P=0.0007),and PFS(HR=2.32;95%CI:1.42-3.81,P=0.0008)in ***,this correlation in disease-free survival was not *** demonstrated its crucial role in effectively predicting the OS of GC patients undergoing NAC at different detection times,ages,regions,and NLR *** In GC patients receiving NAC,an elevated NLR is strongly associated with reduced OS and *** has become an effective biomarker for patient prognosis evaluation,providing valuable insights for the treatment strategies of NAC in GC patients.

关键词： Neutrophil-to-lymphocyte ratio Gastric cancer Neoadjuvant chemotherapy Prognostic factors Meta-analysis

Gender differences in the association between elevated serum uric acid, not diuretic-induced, and cardiovascular disease in untreated hypertension patients

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South China Journal of Cardiology 2011年第1期12卷 1-13页

作者： fan xiao-han wu Yan SUN Kai wu Hai-ying ZHOU Xian-liang HUI Ru-tai Hypertension Division Department of Cardiology Cardiovascular Institute & FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Studies have been inconsistent regarding whether hyperuricemia, either diureticor non diuretic-induced, is an independent risk factor for cardiovascular events. The study investigated the association of cardiovascular disease with diuretic- and non diuretic-induced elevated serum uric acid. Methods A community-based cross-section study was conducted in 5,235 treated and untreated hypertensive patients aged 40-75 years. Conventional risk factors, serum uric acid and the presence of cardiovascular disease were determined. Hyperuricemia was defined as serum uric acid levels ≥420 μmol/L in men or ≥360 μmol/L in women. Results Hyperuricemia was more common in men than in women （21.5 % vs. 10.2 %, P 〈 0.001）. After adjustment for age and other conventional risk factors, hyperuricemia was associated with metabolic syndrome, decreased creatinine clearance, and use of diuretics in both genders, as well as age in women and alcohol consumption in men. The presence of coronary artery disease or stroke increased significantly with the increase of quartiles of serum uric acid （8.0 %, 11.0 %, 13.4 %, and 16.8 %, respectively, P 〈 0.01）, and the highest serum uric acid quartile was associated with a 1.8-fold risk for cardiovascular disease （OR： 1.83, 95 % CI： 1.24-2.71） in untreated women. But this association was not observed in untreated men as well as in treated patients using diuretics in both genders. Conclusions Hypeuricemia is markedly associated with metabolic syndrome, decreased creatinine clearance, use of diuretics besides alcohol consumption in men and age in women. Elevated serum uric acid, but not that diuretic-induced, may be associated with increased the risk of cardiovascular disease in untreated hypertensive women.

关键词： hypertension hyperuricemia diuretics cardiovascular disease

Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients

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Chinese Medical Journal 2012年第22期125卷 4014-4017页

作者： fan xiao-hong wu Chi-hong WANG Li-fen ZHENG Ying-ying YAO Ying LU Hai-ying XU xiao-yuan WEI Lai Peking Univ Hosp 1 Dept Infect Dis Beijing 100034 Peoples R China Peking Univ Hosp 1 Dept Nephrol Beijing 100034 Peoples R China Peking Univ Peoples Hosp Inst Hepatol Beijing 100044 Peoples R China

Background Mixed cryoglobulinemia （MC） is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin. Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus （HCV） RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response. Results Twenty-five patients were with MC （43.9%）. Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC~ patients was significantly lower than that in MC- patients （32.0% vs. 75.0%, P=-0.001）. Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC （odds ratio： 6.375; 95% Ch 1.998-20.343, P=0.002） was negatively associated with sustained virological response achievement. Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.

关键词： hepatitis C cryoglobulinemia virological response

基于嵌入式设备的家庭健康监护系统的设计与实现

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浙江工业大学学报 2010年第3期9卷 289-293页

作者：范晓武浙江工业大学信息工程学院浙江杭州310032

针对家庭健康监护的时间长、患者差异性大、综合性强、需求变化快、功能要求灵活、费用要求低廉的应用特点,设计了一种基于嵌入式设备的家庭健康监护系统.该系统以基于嵌入式系统的家庭健康监护仪器为基础,将计算机信息技术与现代医学... 详细信息

针对家庭健康监护的时间长、患者差异性大、综合性强、需求变化快、功能要求灵活、费用要求低廉的应用特点,设计了一种基于嵌入式设备的家庭健康监护系统.该系统以基于嵌入式系统的家庭健康监护仪器为基础,将计算机信息技术与现代医学检测技术相结合,通过移动等通信网络将数字化的心电、呼吸、血压、血糖等信号发送到远程监护中心,并可以及时接收到专业医师的反馈意见和指导,实现了藉由家庭环境下非侵入式生理监测与非察觉式健康监测,同时结合医生针对病人定制的个性化的健康方案的执行,实现医疗进入家庭,预防为主代替治疗为主,使用户在家中实现诊断、监护和治疗.

关键词：嵌入式家庭健康监护系统

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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一种快速的模糊局部C-均值聚类分割算法

计算机科学 2016年第10期43卷 297-303页

作者：侯晓凡吴成茂西安邮电大学电子工程学院西安710121

针对模糊局部C-均值聚类算法计算复杂度高且对大数据样本集进行聚类时极为耗时的特点,提出了快速的模糊局部C-均值聚类分割算法。该算法将目标像素点与其邻域像素点构成的共生矩阵引入模糊局部C-均值算法,得到新的聚类隶属度和聚类中心... 详细信息

针对模糊局部C-均值聚类算法计算复杂度高且对大数据样本集进行聚类时极为耗时的特点,提出了快速的模糊局部C-均值聚类分割算法。该算法将目标像素点与其邻域像素点构成的共生矩阵引入模糊局部C-均值算法,得到新的聚类隶属度和聚类中心表达式。对像素分类时,利用邻域像素隶属度进行滤波处理,进一步改善了算法的抗噪性。实验结果表明,该算法满足了图像分割有效性的需求,相较于模糊局部C-均值聚类算法,该算法具有更好的分割性能和实时性,能更好地满足实际场合图像分割的需要。

关键词：图像分割模糊C-均值聚类直方图共生矩阵

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远程家庭健康监护系统软件的设计与实现

机电工程 2009年第7期26卷 71-73页

作者：范晓武浙江工业大学信息工程学院浙江杭州310014

针对远程家庭健康监护所具有的综合性强、需求变化快、功能要求灵活的应用特点,设计了一种支持动态重构的远程家庭健康系统。该系统首先在面向服务架构(SOA)基础上实现了一种远程服务流程定义架构,可以由医生自己定义服务的内容和服务... 详细信息

针对远程家庭健康监护所具有的综合性强、需求变化快、功能要求灵活的应用特点,设计了一种支持动态重构的远程家庭健康系统。该系统首先在面向服务架构(SOA)基础上实现了一种远程服务流程定义架构,可以由医生自己定义服务的内容和服务的形式,并在远程家庭健康监控仪器上采用面向方面(AOP)技术动态组装操作流程和可视化界面。两者相结合,使得家庭远程健康监护系统中软件功能模块具备了动态演化和动态组装能力,为医生的健康管理提供了极大的灵活性。软件临床应用结果表明,医生可以针对病人进行个性化的健康方案定制。

关键词：远程家庭健康监护系统动态重构面向方面面向服务架构图形用户界面

Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, Yunzhao Zhou, Yunlei wu, Xuanyu Yin, Mengfei Yin, Liting Qu, Shiyuan Zhang, fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device