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Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation

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World Journal of Gastroenterology 2019年第15期25卷 1865-1877页

作者： Jia-Dong Zheng Yan He Heng-Yuan Yu Yuan-Li Liu Yi-Xuan Ge Xue-Ting Li Xue Li Yan Wang Meng-Ru Guo Yi-Lin Qu xiao-fa qin Ming-Shan Jiang Xiu-Hong Wang Department of Biochemistry and Molecular Biology Heilongjiang Provincial Science and Technology Innovation Team in Higher EducationInstitutes for Infection and Immunity Harbin Medical University GI Biopharma Inc. Department of General Surgery the Second Affiliated Hospital of Harbin Medical University

BACKGROUND Unconjugated bilirubin(UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on the interaction between intestinal flora and organisms and how it influences immune responses remain *** To investigate the role of UCB in intestinal barrier function and immune inflammation in mice with dextran-sulfate-sodium-induced *** Acute colitis was induced by 3%(w/v) dextran sulfate sodium salt in drinking water for 6 d followed by untreated water for 2 d. Concurrently, mice with colitis were administered 0.2 mL UCB(400 μmol/L) by intra-gastric gavage for 7 *** activity index(DAI) was monitored daily. Mice were sacrificed at the end of the experiment. The length of the colon and weight of the spleen were recorded. Serum level of D-lactate, intestinal digestive proteases activity, and changes to the gut flora were analyzed. In addition, colonic specimens were analyzed by histology and for expression of inflammatory markers and *** Mice treated with UCB had significantly relieved severity of colitis, including lower DAI, longer colon length, and lower spleen weight(colon length: 4.92 ±0.09 cm vs 3.9 ± 0.15 cm; spleen weight: 0.33 ± 0.04 vs 0.74 ± 0.04, P factor(TNF) α and interleukin 1β(TNF-α: 52.61 ± 7.81 pg/mg vs 105.04 ± 11.92 pg/mg,interleukin 1β: 13.43 ± 1.68 vs 32.41 ± 4.62 pg/mg,

关键词： Ulcerative colitis Unconjugated bilirubin Intestinal barrier Intestinal homeostasis Digestive proteases Inflammation

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Ti6Al4V钛合金表面真空渗氧处理

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表面技术 2017年第5期46卷 165-170页

作者：杨闯刘静马亚芹肖发琴贵州师范大学材料与建筑工程学院贵阳550025

目的在Ti6Al4V钛合金表层制备硬度高、耐磨性好的硬化层。方法结合真空技术,以高纯的O2为介质,在Ti6Al4V钛合金表面制备致密的渗氧硬化层,采用X衍射仪分析渗氧层的相组成,用金相显微镜观察渗氧层和磨痕组织,用显微硬度计测试渗氧层的显... 详细信息

目的在Ti6Al4V钛合金表层制备硬度高、耐磨性好的硬化层。方法结合真空技术,以高纯的O2为介质,在Ti6Al4V钛合金表面制备致密的渗氧硬化层,采用X衍射仪分析渗氧层的相组成,用金相显微镜观察渗氧层和磨痕组织,用显微硬度计测试渗氧层的显微硬度,用MM-U10A端面磨损试验机研究渗氧层的耐磨性。结果渗氧层物相主要由TiO_2、TiO、Ti_3Al及Al_2O_3组成,温度较低时,形成的渗氧层较薄,温度增加,渗氧层厚度迅速增加,硬度及耐磨性也随之增加。温度为760℃时,表面硬度为基体硬度的2.5倍以上,大于750HV,有效硬化层厚度达60μm以上,其磨损失重仅为未渗氧原样的1/4,表面磨痕细密,没有撕裂情况发生,渗氧层保持完整。温度继续增加,氧化物开始聚集长大,渗氧层组织开始变得疏松,硬度及耐磨性开始下降。结论 Ti6Al4V钛合金表面真空渗氧处理可显著提高其表面硬度,耐磨性改善明显。

关键词： Ti6Al4V钛合金真空渗氧组织硬度耐磨性

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具有偏差变元的广义二阶Rayleigh型中立微分方程的周期解

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数学的实践与认识 2016年第22期46卷 251-258页

作者：姚晓洁秦发金广西科技师范学院数学与计算机科学学院广西来宾546199

研究了一类具有多个偏差变元的广义二阶Rayleigh型中立微分方程的周期解.通过利用重合度理论和不等式分析技巧,获得了方程周期解存在性新的充分条件,推广和改进了早期文献的相关结果.最后,给出一个例子,说明所得结果的可行性.

关键词：广义二阶Rayleigh型中立微分方程多个偏差变元周期解重合度

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PP-R复合材料力学性能及结晶行为的研究

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塑料工业 2017年第5期45卷 87-91页

作者：洪意飞肖发琴付海尹晓刚班大明龚维贵州师范大学材料与建筑工程学院贵州贵阳550025

采用注塑成型法制备PP-R复合材料,并结合扫描电子显微镜(SEM)、示差扫描量热仪(DSC)、偏光显微(POM)及X射线衍射分析仪(XRD)等技术,研究了PP-R复合材料的力学性能及结晶行为。结果表明,成核剂(WBGⅡ)对PP-R复合材料综合性能的影响较为... 详细信息

采用注塑成型法制备PP-R复合材料,并结合扫描电子显微镜(SEM)、示差扫描量热仪(DSC)、偏光显微(POM)及X射线衍射分析仪(XRD)等技术,研究了PP-R复合材料的力学性能及结晶行为。结果表明,成核剂(WBGⅡ)对PP-R复合材料综合性能的影响较为明显。加成核剂(WBGⅡ)后,PP-R(RP2400)的冲击强度(29.76 kJ/m^2)与PP-R(T4401)的冲击强度(28.68 kJ/m^2)分别增为56.63、46.82 kJ/m^2,各自提高了90.29%、63.25%;而对拉伸强度和弯曲强度的影响较小。同时,成核剂(WBGⅡ)的加入,能促进PP-R复合材料晶粒细化,诱导α晶型向β晶型转变,从而改善其冲击韧性。

关键词：无规共聚聚丙烯成核剂力学性能结晶行为

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Revealing the process of storage protein rebalancing in high quality protein maize by proteomic and transcriptomic

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Journal of Integrative Agriculture 2023年第5期22卷 1308-1323页

作者： ZHAO Hai-liang qin Yao xiao Zi-yi SUN qin GONG Dian-ming QIU fa-zhan National Key Laboratory of Crop Genetic Improvement/Hubei Hongshan Laboratory/College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070P.R.China

Quality protein maize(QPM)(Zea mays L.) varieties contain enhanced levels of tryptophan and lysine, exhibiting improved nutritive value for humans and livestock. However, breeding QPM varieties remains challenging due to the complex process of rebalancing storage protein. This study conducted transcriptome and proteome analyses to investigate the process of storage proteins rebalancing in opaque2(o2) and QPM. We found a weak correlation between the transcriptome and proteome, suggesting a significant modulating effect of post-transcriptional events on non-zein protein abundances in Mo17o2 and QPM. These results highlight the advantages of proteomics. Compared with Mo17, 672 differentially expressed proteins(DEPs) were identified both in Mo17o2 and QPM, and several of them were associated with storage protein, starch, and amino acid synthesis. We identified 178 non-zeins as DEPs in Mo17o2 and QPM kernels. The up-regulated non-zein DEPs were enriched in lysine, tryptophan, and methionine, which affected the protein quality. Co-expression network analysis identified regulators of storage protein synthesis in QPM, including O2,PBF1, and several transcription factors. Our results revealed how storage protein rebalancing occurs and identified nonzein DEPs that may facilitate superior-quality QPM breeding.

关键词： quality protein maize opaque2 qy27 protein body storage protein iTRAQ

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Reaction mechanism of lanthanum nitrate-doped Mo–La material during solid–liquid spray doping processing

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Rare Metals 2015年第11期34卷 814-817页

作者： Peng-fa Feng qin-Li Yang xiao-Ming Dang Sha Xi Ya-Qi Wang Jinduicheng Molybdenum Co. Ltd

At three critical temperatures which were obtained by thermo-gravimetry-differential thermal analysis–differential scanning calorimetry（TG/DTG/DSC）curves of lanthanum nitrate crystal, the air thermal decomposition experiments and solid–liquid spray doping simulation procedures of lanthanum nitrate crystal were carried out, and their products were analyzed by X-ray diffraction（XRD）. Meanwhile, the spray doping processing of Mo O2–50 wt% La（NO3）3composite powder was undergone with lanthanum nitrate solution as the dopant,and doped Mo O2powder was analyzed by XRD. The results demonstrate that during the traditional solid–liquid spray doping processing, lanthanum nitrate, in the form of either crystal or aqueous solution, would be converted into La（NO3）3á4H2O by the dehydration reaction, rather than be decomposed to La2O3and NO or NO2. Therefore, it is inferred that the oxynitride gas produced from the process is attributed to the decomposition of residual HNO3in lanthanum nitrate crystal. The source of HNO3is supported by the chemical composition of lanthanum nitrate crystal.

关键词： Solid–liquid spray doping processing Mo O2 Lanthan

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Effect of shot peening on microstructure,nanocrystallization and microhardness of Ti-10V-2Fe-3Al alloy surface

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Journal of Iron and Steel Research International 2019年第1期26卷 52-58页

作者： Hai-zhong Zheng Sheng-hua Guo qin-hao Luo xiao-yong Shu Gui-fa Li National Defense Key Disciplines Laboratory of Light Alloy Processing Science and Technology Nanchang Hangkong UniversityNanchang 330063JiangxiChina

Severe plastic deformation of Ti-10V-2Fe-3Al alloy in the surface region was caused by shot peening at air pressure of 0.6 MPa with processing time ranging from 1 to 45 *** results showed that the thickness of surface deformation layer was proportio nal to the processing time,the microhardness of the shot-peened surface in creased from 280 to 385 HV,and the depth of highly hardening layers arrived at 200μ*** was worth noting that a grain size gradient from nanocrystalline on the surface toward coarse grain in the matrix was obtained during the shot peening process and the minimum grain size in the top surface after shot peening was about 100-200 nm.

关键词： Ti-10V-2Fe-3Al alloy Shot peening treatment Surface nanocrystallization Martensitic transformation Microhardness

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Two-dimensional finite element modeling of seepage-erosion coupled process within unsaturated soil slopes

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Journal of Mountain Science 2022年第2期19卷 446-460页

作者： LEI xiao-qin Key Laboratory of Mountain Hazards and Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengduSichuan 610059China

Fines migration along with rainfall infiltration is a possible cause of failures of slopes composed of loose *** investigate the intrinsic mechanisms,a rigid mathematical model which can fully capture the multi-phasic and multiphysical process is *** this research,the macro and micro physical phenomena of fines migration process within deposited soil slopes under rainfall infiltration were *** on the mixture theory,a seepage-erosion model for unsaturated erodible soils capable to capture these phenomena mathematically was built based on a rigid theoretical *** model was used to simulate a set of rainfall flume tests involving fines migration phenomena with the finite element *** distinct slope failure modes observed experimentally,which were induced by the soil erosion-deposition properties,can be well reproduced by our numerical *** seepage-erosion coupled process during the rainfall infiltration,as well as the intrinsic mechanism responsible for the slope failures,was illustrated in detail based on the numerical *** was shown that the fines migration process can affect the hydro-mechanical response within unsaturated slopes significantly,and therefore special attention should be paid to those soil slopes susceptible to internal erosion.

关键词： Internal erosion Fines migration Rainfall infiltration Slope stability Finite element method

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Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis B virus infection

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World Journal of Gastroenterology 2013年第40期19卷 6888-6893页

作者： xiao-Miao Zhao Yu-Feng Gao qin Zhou fa-Ming Pan Xu Li Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Department of Hepatopathy The Second Affiliated Hospital of Anhui Medical University Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical University

AIM:To identify the relationship between tag single nucleotide polymorphisms(tag SNPs) of interleukin-6(IL-6) gene and susceptibility to chronic hepatitis B virus(HBV) infection in a Han Chinese ***:We performed a case-control study of501 Chinese patients with chronic HBV infection and301 self-limiting HBV-infected individuals as *** DNA was isolated from the whole blood of all subjects using phenol/chloroform with MaXtract highdensity tubes. Tag SNPs were identified using genotype data from the panel(Han Chinese in Beijing) of the phase II HapMap Project. Four tag SNPs in IL-6(rs17147230A/T,rs2066992G/T,rs2069837A/G and rs2069852A/G) were genotyped by the Multiplex Snapshot technique. The genotype and allele frequencies were calculated and ***:Five haplotypes were involved in the analysis,with frequencies higher than 0.03. One of the haplotypes,TTAA,was significantly different between the two groups. Overall haplotype P values were:ATAA,P = 0.605,OR(95%CI) = 1.056(0.860-1.297); TGAG,P = 0.385,OR(95%CI) = 1.179(0.813-1.709); TGGG,P = 0.549,OR(95%CI) = 1.087(0.827-1.429); TTAA,P = 0.004,OR(95%CI) = 0.655(0.491-0.873); TTAG,P = 0.266,OR(95%CI) = 1.272(0.832-1.944). However,the four SNPs showed no significant genotype/allele associations with susceptibility to chronic HBV infection. Overall allele P values were:rs17147230,P = 0.696,OR(95%CI) = 1.041(0.850-1.276); rs2066992,P = 0.460,OR(95%CI)= 1.090(0.868-1.369); rs2069837,P = 0.898,OR(95%CI) = 0.983(0.759-1.274); rs2069852,P = 0.165,OR(95%CI) = 0.859(0.693-1.064). Overall genotype P values were:rs17147230,P = 0.625; rs2066992,P= 0.500; rs2069837,P = 0.853; and rs2069852,P =***:The four tag SNPs of IL-6 gene may be associated with susceptibility to chronic HBV infection in the Han Chinese population.

关键词： Chronic hepatitis B virus infection Interleukin-6 Single nucleotide polymorphism Genetic susceptibility Haplotype

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