检索结果-南通市图书馆

Retrospective Analysis of Ultrasound-guided Flexible Ureteroscopy in the Management of Calyceal Diverticular Calculi

引用

Chinese Medical Journal 2016年第17期129卷 2067-2073页

作者： Ji-Qing Zhang Yong Wang Jun-Hui Zhang xiao-dong Zhang Nian-zeng Xing Department of Urology Beijing Chaoyang Hospital Capital Medicar University Beijing 100020 China

Background： Percutaneous nephrolithotomy （PCNL） is the most widely recommended treatment lbr calyceal diverticular calculi, providing excellent stone-free results. However, its invasiveness is not negligible considering its major complication rates. Flexible ureteroscopy （FURS） is currently used to treat calyceal diverticula. However, the greatest drawback of FURS is locating the diverticulum since its neck is narrow and concealed. In such a case, the FURS procedure must be converted to PCNL. The aim of this study was to evaluate ultrasound-guided flexible ureteroscopy （UFURS） identifying diverticulum and the managenlent of calyceal diverticular calculi. Methods： A retrospective analysis was conducted on 24 patients who had calyceal diverticnlar calculi. In all 12 patients in tile UFURS group, direct FURS failed to find evidence of calyceal diverticula but were confirmed with imaging. The other 12 patients in the PCNL group received PCNL plus fulguration of the divenicular walls. Results： Puncture ofcalyceal diverticulum was successful in all 12 UFURS patients. Two patients in this group had postoperative residual calculi and two patients developed lever. In the PCNL group, percutaneous renal access and lithotomy were successful in all 12 patients. One patient in this group had residual calculi, one had perirenal hematoma, and two patients developed fever. No significant difference was found in the operating time （UFURS vs. PCNL, 91.8 ± 24.2 vs. 86.3 ± 18.7 min）, stone-free rate （UFURS vs. PCNL, 9/12 vs. 10/12）, and rate of successful lithotripsy （UFURS vs. PCNL, 10/12 vs. 11/12） between the two groups （all P 〉 0.05）. Postoperative pain scores in the FURS group were significantly lower than that in the PCNL group （2.7 ±1.2 vs. 6.2 ±1.5. P 〈 0.05）. Hospital stay in the UFURS group was significantly shorter than that in the PCNL group （3.4 ± 0.8 vs. 5.4 ± 1.0 days, P 〈 0.05）. All patients were symptom-free following surgery （UFURS vs. PCNL, 10/10 vs. 12/12）. Conclusio

关键词： Calyceal Diverticulum Calyceal Diverticulum Calculi Flexible Ureteroscope Percutaneous Nephrolithotonly Puncture Ultrasound

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

偏心端曲面齿轮副几何设计及分析

引用

北京理工大学学报 2017年第3期37卷 227-232页

作者：林超吴小勇曾东重庆大学机械传动国家重点实验室重庆400044

提出一种能够同时传递相交轴间的转动和移动的端曲面齿轮副.根据齿轮传动有关理论,设计了偏心端曲面齿轮副传动比,推导了偏心端曲面齿轮副节曲线.通过齿轮啮合原理,建立了该齿轮副的啮合方程和齿面方程,研究了偏心端曲面齿轮副压力角的... 详细信息

提出一种能够同时传递相交轴间的转动和移动的端曲面齿轮副.根据齿轮传动有关理论,设计了偏心端曲面齿轮副传动比,推导了偏心端曲面齿轮副节曲线.通过齿轮啮合原理,建立了该齿轮副的啮合方程和齿面方程,研究了偏心端曲面齿轮副压力角的变化规律,并使用SolidWorks的API接口进行二次开发,实现了偏心端曲面齿轮副的三维建模.分析结果表明偏心端曲面齿轮副设计方法能够实现更大的传动比和压力角,满足更多的潜在工程应用.

关键词：端曲面齿轮传动比几何特性压力角

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Postcardiac injury syndrome complicating circumferential pulmonary vein radiofrequency ablation for atrial fibrillation

引用

Chinese Medical Journal 2007年第21期120卷 1940-1942页

作者： TANG Ri-bo LIU xiao-hui dong Jian-zeng LIU Xing-peng KANG Jun-ping MA Chang-sheng Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Postcardiac injury syndrome （PCIS） is characterized by inflammation of the pericardium, pleura and pulmonary parenchyma following a cardiac injury. It has been described in many patients after a variety of cardiac insults including infarction, surgery, trauma, implantation of a pacemaker, percutaneous coronary angioplasty and radiofrequency ablation of cardiac *** report a rare case of PCIS that occurred after circumferential pulmonary vein radiofrequency ablation for atrial fibrillation （AF）.

关键词： postcardiac injury syndrome atrial fibrillation circumferential pulmonary vein ablation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

引用

Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao Yi Hui Ren Woon Genevieve Saw Li zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A von-Neumann-like photonic processor and its application in studying quantum signature of chaos

引用

Light(Science & Applications) 2024年第4期13卷 672-681页

作者： Shang Yu Wei Liu Si-Jing Tao Zhi-Peng Li Yi-Tao Wang Zhi-Peng Zhong Raj BPatel Yu Meng Yuan-Ze Yang Zhao-An Wang Nai-Jie Guo xiao-dong zeng Zhe Chen Liang Xu Ning Zhang xiao Liu Mu Yang Wen-Hao Zhang Zong-Quan Zhou Jin-Shi Xu Jian-Shun Tang Yong-Jian Han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for Quantum Sensing Zhejiang LabHangzhou 310000China. Quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique *** decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been *** is now the opportune time to apply this technology to real-world ***,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a *** we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and *** order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum signature of chaos from two aspects:the signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable *** current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum signature chaos

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原发性痛经的中医治疗

引用

医学信息 2023年第2期36卷 184-188页

作者：肖增栋天津市滨海新区海滨人民医院中医科

原发性痛经是临床常见的疾病，通常是指功能性痛经，是女性生殖系统未出现器质性疾病情况下出现的痛经。原发性痛经临床患者主要表现为月经期间或者月经前后出现显著的腹部以及腰骶疼痛，部分患者伴随恶心、头痛、腹泻、乳房胀痛症状，... 详细信息

原发性痛经是临床常见的疾病，通常是指功能性痛经，是女性生殖系统未出现器质性疾病情况下出现的痛经。原发性痛经临床患者主要表现为月经期间或者月经前后出现显著的腹部以及腰骶疼痛，部分患者伴随恶心、头痛、腹泻、乳房胀痛症状，严重者可能出现剧烈疼痛，甚至发生昏厥，严重影响患者的生活质量和健康安全。临床常规给予西药治疗，药效持续时间断，治疗疗程长，且临床治疗依从性不高，整体治疗疗效不理想。中医治疗原发性痛经可实现标本兼治的目的，且毒副作用小，相比具有更大的优势。本文以下从中医对原发性痛经的病因病机入手，综述中医治疗原发性痛经的研究进展，为中医治疗原发性痛经提供一定的参考依据。

关键词：中医治疗原发性痛经中医外治

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

1999—2013年中国东北植被物候信息遥感监测

引用

自然资源学报 2017年第2期32卷 321-328页

作者：李晓东曾发梁姜琦刚闫守刚吉林大学地球探测科学与技术学院长春130012 白城师范学院吉林白城137000 沈阳农业大学农学院沈阳110866

随着3S技术的迅猛发展,用于地表遥感监测的卫星影像数据浩如烟海,而影像上地表植被长势等隐含信息的提取通常工作量大、耗费时间。论文提出了一种计算机自动提取地表植被物候信息的方法,主要用于对地表植被生长季及其年内长势进行快速... 详细信息

随着3S技术的迅猛发展,用于地表遥感监测的卫星影像数据浩如烟海,而影像上地表植被长势等隐含信息的提取通常工作量大、耗费时间。论文提出了一种计算机自动提取地表植被物候信息的方法,主要用于对地表植被生长季及其年内长势进行快速提取。方法的基本原理是基于NDVI序列数据集,构建时间点对的时长跨度与该点对半方差的函数关系。选择东北松嫩平原地区作为重点试验区,计算了该区域1999—2013年地表植被生长季长度和长势特点,并选择东北地区物候观测数据进行验证分析。结果表明:1)东北地区农耕作物的生长季持续期在107~126 d左右。计算得到的结果与实测数据的最大误差在5 d值域范围内,沼泽植被在160 d以上(误差10 d左右),草地为120~139 d;2)研究区地表植被的生长盛期峰值出现在第150天前后。结果较为真实、合理地反映了研究区域地表植被的物候信息。

关键词：变异函数植被生长季植被长势遥感监测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

引用

Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua zeng Qing Tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于UPLC-Q Exactive四级杆-轨道阱液质联用法快速建立清热灵颗粒中潜在中药质量标志物(Q-Marker)成分库

引用

中草药 2017年第1期48卷 67-74页

作者：周秀娟李燕芳陈莹陈晓虎瞿燕任晓东曾锐西南民族大学药学院四川成都610041 重庆市食品药品检验所重庆401121 成都中医药大学药学院四川成都610016 纽约州立大学石溪分校化学学院美国纽约11794

目的基于中药质量标志物(Q-Marker)理念,使用UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用技术,对清热灵颗粒主要化学成分进行快速识别和鉴定,建立清热灵颗粒的潜在Q-Marker库,为探讨建立中成药清热灵颗粒的系统质量控制方法奠定... 详细信息

目的基于中药质量标志物(Q-Marker)理念,使用UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用技术,对清热灵颗粒主要化学成分进行快速识别和鉴定,建立清热灵颗粒的潜在Q-Marker库,为探讨建立中成药清热灵颗粒的系统质量控制方法奠定基础。方法以50%甲醇作为提取液制备供试液,采用ACQUITYUPLC BEHC_(18)色谱柱(100mm×2.1mm,1.7μm)进行分离,以甲醇-0.1%甲酸水溶液为流动相进行梯度洗脱,质谱采用负离子监测模式、全扫描及自动触发二级质谱扫描的功能,对清热灵颗粒中成分进行识别及鉴定。并采用Autodock vina 1.1.2软件,以H5N1禽流感病毒为神经氨酸酶受体,利用AutoDock Tools 1.5.6程序确定靶蛋白的活性口袋,对所选标志物进行分子对接研究。结果通过高分辨UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用技术共鉴定了39个化学成分,包括黄酮类化合物25个,苯乙醇苷类6个,有机酸4个,三萜类化合物2个,木脂素类2个。32个化学成分为首次在该制剂中鉴别出,其中15个为专属性成分,建议其中的黄芩苷、汉黄芩苷、连翘酯苷A、甘草苷、连翘酯苷E、连翘酯苷B、异甘草苷、黄芩素、连翘苷、汉黄芩素、甘草素11个成分可作为清热灵颗粒的Q-Marker。结论通过高分辨UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用技术,可以快速分析和确定中成药清热灵颗粒的化学成分,建立清热灵颗粒的潜在Q-Marker库。

关键词：中药质量标志物 UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用清热灵颗粒成分库黄芩苷汉黄芩苷连翘酯苷A 甘草苷连翘酯苷E 连翘酯苷B 异甘草苷黄芩素连翘苷汉黄芩素甘草素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

引用

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：