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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun Liu Shangde Guo Rong Liu Minfang Guo Qing Wang Zhi chai Baoguo xiao Cungen Ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

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Experience of humanistic nursing in hemodialysis nursing for patients with diabetic kidney disease

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World Journal of Diabetes 2024年第2期15卷 186-195页

作者： xiao-Ying chai xiao-Yan Bao Ying Dai Xing-Xing Dai Yu Zhang Yu-Ling Yang Department of Nephrology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Hemodialysis The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a prevalent complication of diabetes that often requires hemodialysis for *** the field of nursing,there is a growing recognition of the importance of humanistic care,which focuses on the holistic needs of patients,including their emotional,psychological,and social ***,the application of humanistic nursing in the context of hemodialysis for DKD patients remains relatively *** To explore the experience of humanistic nursing in hemodialysis nursing for DKD *** Ninety-six DKD patients treated with hemodialysis from March 2020 to June 2022 were included in the study and divided into the control cluster(48 cases)and the study cluster(48 cases)according to different nursing methods;the control cluster was given routine nursing and the study cluster was given humanized *** variances of negative emotion mark,blood glucose,renal function,the incidence of complications,life mark and nursing satisfaction before and after nur-sing were contrasted between the two *** No significant difference in negative emotion markers between the two clusters were observed before nursing(P>0.05),and the negative emotion markers of the two clusters decreased after *** Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale markers were lower in the study cluster than the control *** healing rate of patients in the study cluster was significantly higher than the control cluster(97.92%vs 85.42%,P0.05).However,after nursing,blood urea nitrogen and serum creatinine(SCr)levels in the study cluster were lower than those in the control cluster(P<0.05).The incidence rate of complications was significantly lower in the study group compared to the control cluster(6.25%vs 20.83%,P<0.05).There was no significant difference in the life markers between the two clusters be

关键词： Diabetic kidney disease Hemodialysis Humanistic nursing Incidence of complication Effect

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DCFNet:An Effective Dual-Branch Cross-Attention Fusion Network for Medical Image Segmentation

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1103-1128页

作者： Chengzhang Zhu Renmao Zhang Yalong xiao Beiji Zou Xian chai Zhangzheng Yang Rong Hu Xuanchu Duan School of Computer Science and Engineering Central South UniversityChangsha410083China School of Humanities Central South UniversityChangsha410083China Xiangya Hospital Central South University Changsha410008China Changsha Aier Eye Hospital Changsha410015China

Automatic segmentation of medical images provides a reliable scientific basis for disease diagnosis and ***,most existing methods that combine the strengths of convolutional neural networks(CNNs)and Transformers have made significant ***,there are some limitations in the current integration of CNN and Transformer technology in two key ***,most methods either overlook or fail to fully incorporate the complementary nature between local and global ***,the significance of integrating the multiscale encoder features from the dual-branch network to enhance the decoding features is often disregarded in methods that combine CNN and *** address this issue,we present a groundbreaking dual-branch cross-attention fusion network(DCFNet),which efficiently combines the power of Swin Transformer and CNN to generate complementary global and local *** then designed the Feature Cross-Fusion(FCF)module to efficiently fuse local and global *** the FCF,the utilization of the Channel-wise Cross-fusion Transformer(CCT)serves the purpose of aggregatingmulti-scale features,and the Feature FusionModule(FFM)is employed to effectively aggregate dual-branch prominent feature regions from the spatial ***,within the decoding phase of the dual-branch network,our proposed Channel Attention Block(CAB)aims to emphasize the significance of the channel features between the up-sampled features and the features generated by the FCFmodule to enhance the details of the *** results demonstrate that DCFNet exhibits enhanced accuracy in segmentation *** to other state-of-the-art(SOTA)methods,our segmentation framework exhibits a superior level of ***’s accurate segmentation of medical images can greatly assist medical professionals in making crucial diagnoses of lesion areas in advance.

关键词： Convolutional neural networks Swin Transformer dual branch medical image segmentation feature cross fusion

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Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： xiaolin chai Yan Sun Yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

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GNN-based temporal knowledge reasoning for UAV mission planning systems

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 12-25页

作者： chai Rong Duan xiaofang Wang Lixuan School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Unmanned aerial vehicles(UAVs)are increasingly applied in various mission scenarios for their versatility,scalability and *** UAV mission planning systems(UMPSs),an efficient mission planning strategy is essential to meet the requirements of UAV ***,rapidly changing environments and unforeseen threats pose challenges to UMPSs,making efficient mission planning *** address these challenges,knowledge graph technology can be utilized to manage the complex relations and constraints among UAVs,missions,and *** paper investigates knowledge graph application in UMPSs,exploring its modeling,representation,and storage concepts and ***,the construction of a specialized knowledge graph for UMPS is ***,the paper delves into knowledge reasoning within UMPSs,emphasizing its significance in timely updates in the dynamic environment.A graph neural network(GNN)-based approach is proposed for knowledge reasoning,leveraging GNNs to capture structural information and accurately predict missing entities or relations in the knowledge *** relation reasoning,path information is also incorporated to improve the accuracy of *** account for the temporal dynamics of the environment in UMPS,the influence of timestamps is captured through the attention *** effectiveness and applicability of the proposed knowledge reasoning method are verified via simulations.

关键词： unmanned aerial vehicle mission planning knowledge graph knowledge reasoning graph neural network

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Minimally invasive reconstruction of extensive mid-lower ureteral strictures using a bilateral Boari flap

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Asian Journal of Urology 2024年第3期11卷 377-383页

作者： Shuaishuai chai Hao Zhang Gong Cheng Jiawei Chen Xincheng Gao Yuancheng Zhou Xingyuan xiao Bing Li Department of Urology Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Objective:To describe and evaluate the technique using bilateral Boari flap ureteroneocystostomy(BBFUNC)for bilateral mid-lower ureteral ***:We retrospectively reviewed five patients who underwent minimally invasive BBFUNC in our institution(Union Hospital,Wuhan,China)between July 2019 and December *** bilateral ureters were mobilized and transected above the stenotic *** bladder was isolated and incised longitudinally from the middle of the anterior ***,an inverted U-shaped bladder flap was created on both sides,fixed onto the psoas tendon,and anastomosed to the ipsilateral distal normal *** double-J stenting,the Boari flaps were tubularized,and the bladder was closed with continuous *** patients’perioperative data and follow-up outcomes were collected,and a descriptive statistical analysis was ***:No case converted to open surgery,and no intraoperative complication *** median surgical time was 230(range 203-294)*** median length of the bladder flaps was 6.2(range 4.3-10.0)cm on the left and 5.5(range 4.7-10.5)cm on the right *** patients had not developed recurrent ureteral stenosis during the median follow-up time of 17(range 16-45)months and had a normal maximum flow rate after *** median post-void residual was 7(range 0-19)*** maximal bladder capacity was decreased in one(20%)***:The present study demonstrates that minimally invasive BBFUNC is feasible and safe in treating is limited.

关键词： Reconstructive surgery Boariflap Ureteral stricture Ureteron-eocystostomy Minimallyinvasive

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From risk control to resilience: developments and trends of urban roads designed as surface flood passages to cope with extreme storms

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 103-120页

作者： Zhiyu Shao Yuexin Li Huafeng Gong Hongxiang chai College of Environment and Ecology Chongqing UniversityChongqing 400030China Key Laboratory of Ecological Environment of Ministry of Education of Three Gorges Reservoir Area Chongqing UniversityChongqing 400030China T.Y.Lin International Engineering Consulting(China)Co.Ltd. Chongqing 400045China

Urban roads can be designated as surface flood passages to transport excess runoff during extreme storms, thereby preventing local flooding, which is known as the major drainage system. However, this practice poses significant risks, including human loss and property damage, due to the high flow rate and velocity carried by roads. Moreover, urban roads with low flood-resilience may significantly hamper the transportation function during severe storms, leading to dysfunction of the city. Therefore, there is an urgent need to transform risk-oriented flood passages into resilient urban road-based flood passages. This paper presents a systematic review of existing methodologies in designing a road network-based flood passage system, along with the discussion of new technologies to enhance system resilience. The study also addresses current knowledge gaps and future directions. The results indicate that flood management measures based on the urban road network should integrate accessibility assessment, lifeline and emergency planning to ensure human well-being outcomes. Furthermore, the special needs and features of vulnerable groups must be taken into serious consideration during the planning stage. In addition, a data-driven approach is recommended to facilitate real-time management and evaluate future works.

关键词： Major drainage Flood mitigation Resilient city Stormwater model Urban flooding

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New patterns of localized excitations in (2+1)-dimensions:The fifth-order asymmetric Nizhnik-Novikov-Veselov equation

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Communications in Theoretical Physics 2024年第8期76卷 11-18页

作者： Jianyong Wang Yuanhua chai Department of Mathematics and Physics Quzhou UniversityQuzhou 324000China Physics Group Jiangshan Middle School of Zhejiang ProvinceQuzhou 324000China

By applying the mastersymmetry of degree one to the time-independent symmetry K_(1), the fifth-order asymmetric Nizhnik-Novikov-Veselov system is derived. The variable separation solution is obtained by using the truncated Painlevé expansion with a special seed solution. New patterns of localized excitations, such as dromioff, instanton moving on a curved line, and tempo-spatial breather, are constructed. Additionally, fission or fusion solitary wave solutions are presented,graphically illustrated by several interesting examples.

关键词： asymmetric Nizhnik-Novikov-Veselov system localized excitations truncated Painlevéexpansion

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Accelerated Sequential Deposition Reaction via Crystal Orientation Engineering for Low-Temperature,High-Efficiency Carbon-Electrode CsPbBr_(3) Solar Cells

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Energy & Environmental Materials 2024年第1期7卷 168-175页

作者： Zeyang Zhang Weidong Zhu Tianjiao Han Tianran Wang Wenming chai Jiaduo Zhu He Xi Dazheng Chen Gang Lu Peng dong Jincheng Zhang Chunfu Zhang Yue Hao State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology&Shaanxi Joint Key Laboratory of Graphene School of MicroelectronicsXidian UniversityXi'an 710071China Guangzhou Wide Bandgap Semiconductor Innovation Center Guangzhou institute of technologyXidian UniversityGuangzhou 510555China Qinghai Huanghe Hydropower Development CO. LTD.Xining810008China

Low-temperature,ambient processing of high-quality CsPbBr_(3)films is demanded for scalable production of efficient,low-cost carbon-electrode perovskite solar cells(PSCs).Herein,we demonstrate a crystal orientation engineering strategy of PbBr_(2)precursor film to accelerate its reaction with CsBr precursor during two-step sequential deposition of CsPbBr_(3)*** a novel strategy is proceeded by adding CsBr species into PbBr_(2)precursor,which can tailor the preferred crystal orientation of PbBr_(2)film from[020]into[031],with CsBr additive staying in the film as CsPb_(2)Br_(5)*** calculations show that the reaction energy barrier of(031)planes of PbBr_(2)with CsBr is lower about 2.28 eV than that of(O2O)***,CsPbBr_(3)films with full coverage,high purity,high crystallinity,micro-sized grains can be obtained at a low temperature of 150℃.Carbon-electrode PSCs with these desired CsPbBr_(3)films yield the record-high efficiency of 10.27%coupled with excellent operation ***,the 1 cm^(2)area one with the superior efficiency of 8.00%as well as the flexible one with the champion efficiency of 8.27%and excellent mechanical bending characteristics are also achieved.

关键词： carbon-electrode perovskite solar cells crystal orientation engineering CsPbBr_(3) low temperature two-step sequential deposition

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Provenance of the Lower Jurassic pyroclastic sediments in the Zigui Basin:Implication for crustal thickening in the eastern Qinling orogenic belt

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Science China Earth Sciences 2024年第1期67卷 196-207页

作者： Rong chai Jianghai YANG Yuansheng DU Chengshan WANG School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100023China School of Earth Sciences China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Geological Sciences Beijing 100037China

The Late Triassic witnessed significant collisional orogenic events in the Qinling orogenic belt,accompanied by magma underplating and tectonic *** processes potentially resulted in substantial crustal thickening and uplift of the Qinling ***,due to the absence of igneous rock records from this period in the eastern section of the Qinling orogen,the changes in crustal thickness during this orogenic process have not been thoroughly investigated.A series of foreland basins emerged during the Early Mesozoic to the south of the East Qinling orogenic *** basins have preserved clastic sedimentary rocks derived from the uplift and erosion of the orogenic *** sedimentary records serve as crucial records to reconstruct the evolutionary history of the Qinling *** further clarify the collisional orogenic process of the Qinling orogenic belt,this study conducted in situ volcanic lithic fragment geochemistry,detrital zircon U-Pb chronology and trace element composition analysis on the sandstones of the Lower Jurassic Tongzhuyuan Formation in the Zigui *** results suggest that the sandstones,which exhibit a significant abundance of volcanic lithic fragments,has a characteristic detrital zircon age group of 250–200 Ma,indicating a major provenance from the Triassic volcanic *** with regional correlation and paleocurrent analysis,the detrital zircon U-Pb age data show that the source area of volcanic rocks should be in the Qinling orogenic belt to the north of the *** interpretation is further supported by the Triassic granitic rocks exposed in the western part of the orogenic belt,representing the magmatism during the Triassic collisional orogenesis in the Qinling *** on the co-varying relationships between present-day crust thickness with the chemical compositions of granite rocks and zircons,the La/Yb ratio of volcanic lithic fragments in the Tongzhuyuan Formation and the Eu/Eu*ratio of detrital zircon

关键词： Qinling orogenic belt Zigui Basin Late Triassic Detrital zircons Crustal thickening

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