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World Journal of Clinical Cases 2021年第30期9卷 9090-9100页

作者： Yang Gao xiao-di luo xiao-Li Yang Dong Tu Department of Cardiothoracic Surgery 920^(th)Hospital of Joint Logistics Support Force of People’s Liberation Army of ChinaKunming 650032Yunnan ProvinceChina

BACKGROUND The clinical significance of breast cancer susceptibility gene 1(BRCA1)in nonsmall cell lung cancer(NSCLC)patients undergoing surgery remains unclear up to *** To explore the relation of BRCA1 expression with clinicopathological characteristics and survival in patients with resected *** EMBASE,PubMed,Web of Science,and The Cochrane Library databases were searched to identify the relevant *** assess the correlation between the expression of BRCA1 and clinicopathological characteristics and prognosis of patients with resected NSCLC patients,the combined relative risks or hazard ratios(HRs)with their corresponding 95%confidence intervals[CIs]were *** Totally,11 articles involving 1041 patients were included in the *** results indicated that the expression of BRCA1 was significantly correlated with prognosis of resected *** BRCA1 expression signified a shorter overall survival(HR=1.60,95%CI:1.25-2.05;Pdisease-free survival(HR=1.78,95%CI:1.42-2.23;Pdicates a poor prognosis in resected NSCLC ***1 might serve as an independent biomarker to predict clinical outcomes and help to customize optimal adjuvant chemotherapy for NSCLC patients who had received surgical therapy.

关键词： Breast cancer susceptibility gene 1 Non-small cell lung cancer Clinico-pathological characteristics Prognosis Surgery Meta-analysis

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu luo Min Song Lulu An xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

创伤骨科修复中采用伤害控制骨科学原则治疗临床分析

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中国实用医药 2017年第2期12卷 58-60页

作者：周晓忠罗狄鑫孙鸿涛徐汪洋齐勇广东省第二人民医院 510317

目的探讨伤害控制骨科学(DCO)治疗原则在创伤骨科修复中的临床应用效果。方法选择未应用伤害控制原则期间进行治疗的50例患者作为对照组,选择应用伤害控制原则期间进行治疗的55例患者作为观察组。比较两组患者的住院时间、治疗效果、并... 详细信息

目的探讨伤害控制骨科学(DCO)治疗原则在创伤骨科修复中的临床应用效果。方法选择未应用伤害控制原则期间进行治疗的50例患者作为对照组,选择应用伤害控制原则期间进行治疗的55例患者作为观察组。比较两组患者的住院时间、治疗效果、并发症及死亡的发生情况。结果观察组患者的住院时间(18.7±1.6)d明显短于对照组的(25.2±1.5)d,差异具有统计学意义(P<0.05);观察组发生并发症4例,死亡2例,均少于对照组的11例、8例,差异均具有统计学意义(P<0.05)。观察组患者的治疗总有效率为96.36%,远远高于对照组的84.00%,差异具有统计学意义(P<0.05)。结论伤害控制骨科学治疗原则应用于创伤骨科修复中,可以明显缩短患者的住院时间,降低手术中的治疗风险,提高治疗效果,减少并发症的发生,值得在临床进行广泛应用。

关键词：创伤骨科伤害控制原则术中出血量并发症

An air cavity method for increasing the underwater acoustic targets strength of corner reflector

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Defence Technology（防务技术） 2020年第2期16卷 493-501页

作者： Yi luo Xin Chen Da-wei xiao Wu-di Wen Tao-tao Xie Dept.of Weaponry Eng Naval University of EngineeringWuhan 430033China

In order to improve the underwater acoustic target strength of comer reflectors,according to the principle of acoustic impedance mismatch of the boundary layer,the method of using air cavity to increase the underwater acoustic target strength of corner reflectors is *** acoustic reflection coefficients of underwater air layer and single layer metal sheet are calculated and *** results show that the reflection coefficient of single layer metal sheet is greatly affected by frequency and incidence angle,and the reflection coefficient of air layer in water is large and little affected by frequency and incidence *** this basis,a new kind of airfilled cavity corner reflector is *** acoustic scattering characteristics of underwater airfilled cavity comer reflector are calculated cumulatively,and the results are compared with the monolayer metal sheet corner *** simulation results show that the acoustic reflection effect of the airfilled cavity corner reflector is *** order to verify the correctness of the method,the test was carried out in the silencing *** experimental results show that the simulation results are in good agreement with the experimental results,and the airfilled cavity can improve on acoustic reflection performance of the underwater corner reflector.

关键词： Underwater corner reflector Acoustic target strength Air cavity Acoustic impedance mismatch

The changing phenotype of microglia from homeostasis to disease

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Translational Neurodegeneration 2012年第1期1卷 55-67页

作者： xiao-Guang luo Sheng-di Chen Department of Neurology First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Neurology&Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong UniversityShanghai 200025China

It has been nearly a century since the early description of microglia by Rio-Hortega;since then many more biological and pathological features of microglia have been ***,microglia are generally considered to be beneficial to homeostasis at the resting state through their abilities to survey the environment and phagocytose ***,when activated microglia assume diverse phenotypes ranging from fully inflamed,which involves the release of many pro-inflammatory cytokines,to alternatively activated,releasing antiinflammatory cytokines or neurotrophins,the consequences to neurons can range from detrimental to *** to the different experimental sets and conditions,contradictory results have been obtained regarding the controversial question of whether microglia are“good”or“bad.”While it is well understood that the dual roles of activated microglia depend on specific situations,the underlying mechanisms have remained largely unclear,and the interpretation of certain findings related to diverse microglial phenotypes continues to be *** this review we discuss the functions of microglia in neuronal survival and neurogenesis,the crosstalk between microglia and surrounding cells,and the potential factors that could influence the eventual manifestation of microglia.

关键词： Microglia Neuroprotection Phenotypes Senescence Crosstalk

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草鱼幼鱼对异亮氨酸的需要量

水产学报 2009年第5期33卷 813-822页

作者：尚晓迪罗莉文华高文王庆水胥辉西南大学动物科技学院水产系中国水产科学研究院长江水产研究所淡水生态与健康养殖重点开放实验室

以初始体重(8.25±0.37)g的草鱼幼鱼为试验对象,分别采用异亮氨酸(isoleucine,Ile)水平为0.77%、1.07%、1.37%、1.67%、1.97%和2.27%6组等氮(粗蛋白35.25%)半纯化日粮对草鱼进行了72d生长试验,研究其日粮异亮氨酸需要量。结果表明:(1)日... 详细信息

以初始体重(8.25±0.37)g的草鱼幼鱼为试验对象,分别采用异亮氨酸(isoleucine,Ile)水平为0.77%、1.07%、1.37%、1.67%、1.97%和2.27%6组等氮(粗蛋白35.25%)半纯化日粮对草鱼进行了72d生长试验,研究其日粮异亮氨酸需要量。结果表明:(1)日粮Ile水平为1.67%时,草鱼增重率、特定生长率和蛋白质效率最高,饲料系数最低;鱼体空壳率和肥满度达到最大值,内脏指数最小;草鱼体水分、体脂最低,体蛋白、灰分最高;肌肉水分最低,粗蛋白最高。而各水平之间肌肉粗脂肪无显著差异(P>0.05);日粮Ile水平为1.67%时,草鱼肌肉Ile含量和肌肉氨基酸总量最高。(2)随日粮Ile水平增加,肌肉RNA/DNA呈先升后降趋势,Ile1.67%水平组最高;而肝脏谷氨酸脱氢酶却呈先降后升趋势,Ile1.67%水平组最低。血氨在Ile0.77%~1.67%水平组之间处于稳定状态,高于1.67%水平后呈上升趋势。血清白蛋白受日粮Ile水平的影响不显著(P>0.05)。(3)随日粮Ile水平增加,血清甘油三酯和胆固醇均呈先降后升趋势,且在Ile1.67%水平组,两项指标均为最低值,显著低于其他水平组(P<0.05)。根据增重率、特定生长率、饲料系数和蛋白质效率与日粮Ile水平的二次曲线关系,确定草鱼幼鱼日粮(粗蛋白35.25%)Ile适宜需要量范围为1.41%~1.49%(日粮基础)或4.0%~4.23%(日粮蛋白基础)。

关键词：草鱼异亮氨酸生长代谢需求量

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非静水压作用下石膏电学性质的理论研究

原子与分子物理学报 2025年第6期42卷 129-135页

作者：周梅吴雷罗小松何宗润贵州民族大学物理与机电工程学院贵阳550025 重庆大学能源与动力工程学院重庆400044

地球内部广泛存在着差应力,这些外在因素的存在影响着矿物的性质,而矿物的电学性质与结构相变息息相关.为了更加了解地球内部结构与动力学过程,采用第一性原理方法,在等效平衡压0~10 GPa范围内计算地球内部浅层矿物石膏在静水压和非静... 详细信息

地球内部广泛存在着差应力,这些外在因素的存在影响着矿物的性质,而矿物的电学性质与结构相变息息相关.为了更加了解地球内部结构与动力学过程,采用第一性原理方法,在等效平衡压0~10 GPa范围内计算地球内部浅层矿物石膏在静水压和非静水压条件下的电学性质.计算结果表明:静水压和非静水压条件下无水石膏的密度和带隙变化基本一致,但二水石膏的密度和带隙在非静水压为6 GPa附近发生突变,这可能是由于非静水压环境使晶体结构更容易发生畸变,更有利于水分子氢键网络的重新排列和CaSO_(4)层间结构的塌缩,因此非静水压下可能更加有利于二水石膏在高温高压下的脱水反应.这对理解地幔中矿物的脱水和储水产生重大的影响,为理解地幔中矿物的脱氢和储水提供理论依据.

关键词：差应力石膏电学性质第一性原理

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Choroidal thickness in pregnant women : a cross-sectional study

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1200-1206页

作者： Ru Liu Guo-Ping Kuang di-Xian luo xiao-He Lu Department of Ophthalmology Zhujiang Hospital of Southern Medical University Department of Ophthalmology the First People's Hospital of Chenzhou Institute of Translational Medicine the First People's Hospital of Chenzhou

AIM: To investigate choroidal thickness in pregnant women and compare the measurements with those of normal nonpregnant women. METHODS: Using enhanced depth imaging optical coherence tomography (Edi-OCT), choroidal thickness was measured at the fovea and at 1 mm and 3 mm superior, inferior, temporal, and nasal to the fovea in both healthy pregnant women and nonpregnant women. Pearson correlation analysis was performed to evaluate the relationships between subfoveal choroidal thickness (SFCT) and the demographic and ocular parameters. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed-effects model when Meta analyses were conducted. RESULTS: Comparison of choroidal thickness between the groups showed that it was significantly greater in healthy pregnant women's eyes than in normal nonpregnant women's eyes at all locations except at 3 mm superior and 3 mm temporal from the fovea (Pdifference (P=0.008). Pearson correlation analysis showed that age and axial length were significantly related to SFCT in healthy pregnant women, normal nonpregnant women, and all subjects. The results of our cross-sectional study were consistent with the results of the further Meta analysis, with a pooled weighted mean difference (WMD) of 33.66 mu m (95% CI: 26.16 to 41.15) for SFCT. CONCLUSION: Our results, along with the comprehensive Meta-analysis, suggest that choroidal thickness in healthy pregnant women is greater than that in normal nonpregnant women.

关键词： choroidal thickness pregnant optical coherence tomography

Systematic chemical characterization of Xiexin decoctions using high performance liquid chromatography coupled with electrospray ionization mass spectrometry

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Chinese Journal of Natural Medicines 2021年第6期19卷 464-472页

作者： SHEN Li-Juan luo Ke-di WEN Xue-Xun WANG Shu-Fang FAN xiao-Hui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Component Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China

Xiexin decoctions(XXDs)display beneficial anti-inflammatory and anti-diabetic effects,which raises interests on this group of formulae for broad clinical ***,there was no report about systematic analysis of XXDs to elucidate the constitution of chemical components,which hampers further investigations on the therapeutic values of *** this work,crude herbs were extracted and prepared to obtain the XXDs for systemic analysis on their chemical compositions,according to the information described in the ancient Zhang Zhongjing’s herbal ***-MS analysis of five XXDs was carried out to facilitate recognition of the source herbs for compounds in the mixture.A total number of 93 compounds were identified through our methods and their chemical classes encompassed five major groups,including protoberberine alkaloids,flavonoids,stilbenes,anthraquinones and *** current work provided important information about material basis for pharmacological studies on XXDs and would help shed light on relationships between chemical compositions and therapeutic effects.

关键词： Traditional Chinese Medicine Analogous formulae HPLC-MS Xiexin decoctions Systematic chemical characterization

Experiencing winter for spring flowering: A molecular epigenetic perspective on vernalization

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Journal of Integrative Plant Biology 2020年第1期62卷 104-117页

作者： xiao luo Yuehui He National Key Laboratory of Plant Molecular Genetics & Shanghai Center for Plant Stress Biology Center for Excellence in Molecular Plant Sciences The Chinese Academy of Sciences

Many over-wintering plants, through vernalization, overcome a block to flowering and thus acquire competence to flower in the following spring after experiencing prolonged cold exposure or winter cold. The vernalization pathways in different angiosperm lineages appear to have convergently evolved to adapt to temperate climates. Molecular and epigenetic mechanisms for vernalization regulation have been well studied in the crucifer model plant Arabidopsis ***, we review recent progresses on the vernalization pathway in Arabidopsis. In addition, we summarize current molecular and genetic understandings of vernalization regulation in temperate grasses including wheat and Brachypodium, two monocots from Pooideae, followed by a brief discussion on divergence of the vernalization pathways between Brassicaceae and Pooideae.

关键词： winter spring temperate