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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen xiao-dan ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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A Secure Communicating While Jamming Approach for End-to-End Multi-Hop Wireless Communication Network

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Chinese Journal of Electronics 2024年第3期33卷 833-846页

作者： xiao ma dan LI Liang WANG Weijia HAN Nan ZHAO School of Physics and Information Technology Shaanxi Normal University Beijing Aerospace Science and Industry Century Satellite Hi-tech Co. Ltd.Xi'an Branch School of Computer Science Shaanxi Normal University School of Telecommunications Engineering Xidian University

With the rapid development of wireless communications,cellular communication and distributed wireless network are fragile to eavesdropping due to distributed users and transparent ***,to adopt bigger transmit power at a given area to interfere potential eavesdroppers not only incurs huge energy waste but also may suppresses regular communication in this *** this end,we focus on secure communication in multi-hop wireless communication network,and propose two communicating while jamming schemes for secure communication in presence of potential eavesdroppers for the narrow band and broad band point-to-point(P2P) systems respectively with the aid of artificial noise transmitted by a chosen cooperative ***,to achieve the end-to-end(E2E) multi-hop secure communication,we devise the secure network topology discovering *** constructing a proper network topology with at least one proper node as the cooperative interferer in each hop,and then propose the secure transmission path planning scheme to find an E2E secure transmission route from source to destination,*** on the wireless open-access research platform demonstrate the feasibility of the proposed ***,simulations results validate that the proposed schemes can achieve better performance compared with existing methods in both the P2P communication case and E2E multi-hop communication network scenario.

关键词： Wireless communication Network topology Law Simulation Wireless networks Noise Spread spectrum communication

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Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

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Communications in Theoretical Physics 2024年第07期76卷 136-146页

作者： Da-cheng ma Ling-yi Cui Chu-xiao Sun xiao-dan Chi Zheng-Nan XianYu An Du College of Science Northeastern University Department of Basic Science Dalian Naval Academy Department of Physics College of Sciences Shenyang University of Chemical Technology National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern University Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of Education

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature, although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin–Wagner theorem. By use of the spin Green's function method, we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature, whether the decorated edge spins of the system link together or separate from each other. When the width of the nanoribbon achieves infinite limit, the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the nanoribbon. The results reveal that the magnetism of a low-dimensional spin system is different from that of a three-dimensional spin system. When the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally, various useful long-range magnetic orders of the system can be obtained. This work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Heisenberg model long-range magnetic order magnetic anisotropy Nanoribbon transition temperature

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Constructing oxygen deficiency-rich V_(2)O_(3)@PEDOT cathode for high-performance aqueous zinc-ion batteries

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Rare Metals 2024年第2期43卷 635-646页

作者： Dong-Fei Sun Zi-Juan Wang Tian Tian Xin Yu dan-dan Yu xiao-Zhong Zhou Guo-Fu ma Zi-Qiang Lei Key Laboratory of Eco-functional Polymer materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceSchool of College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China

Aqueous zinc-ion batteries(AZIBs)have attracted widespread attention due to the advantages of high safety and environmental *** V_(2)O_(3) is a promising cathode,the strong electrostatic interaction between Zn^(2+) and V_(2)O_(3) crystal,and the sluggish reaction kinetics still limit their application in ***,the oxygen defects rich V_(2)O_(3) with conducive poly(3,4-ethylenedioxythiophene)(PEDOT)shell(V_(2)O_(3)-Od@PEDOT)was fabricated for AZIBs by combining the sulfur-assisted thermal reduction and in-situ polymerization *** introduced oxygen vacancies of V_(2)O_(3)–Od@PEDOT weaken the electrostatic interaction between Zn^(2+) and the host material,improving the interfacial electron transport,while the PEDOT coating enhances the structural stability and conductivity of V_(2)O_(3),thus accelerating the reaction *** on the advantages,V_(2)O_(3)–Od@PEDOT electrode delivers a reversible capacity of 495 mah·g^(−1) at 0.1 A·g^(−1),good rate capability(189 mah·g^(−1)at 8.0 A·g^(−1)),and an impressive cycling stability with 90.1%capacity retention over 1000 cycles at 8.0 A·g^(−1).The strategy may provide a path for exploiting the other materials for high performance AZIBs.

关键词： Oxygen defects V_(2)O_(3) PEDOT Electrochemical self-optimization Aqueous zinc-ion batteries

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A new method for evaluating wedges of steel plates and strips

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1719-1735页

作者： xiao-bao ma xiao-xin ma Tao Wang Zhong-kai Ren Yu-cheng Ren College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Ministry of Education Engineering Research Center of Advanced Metal Composite Forming Technology and Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina China National Heavy machinery Research Institute Co. Ltd.Xi'an 710018ShaanxiChina Faculty of Mechanical Engineering Hebei University of ArchitectureZhangjiakou 075000HebeiChina

To overcome the inaccuracy problem of the traditional wedge evaluation of steel plates and strips caused by the ran-domness of the thicknesses of two local points and improve the reliability of the wedge index,the double-centroid method for the wedge evaluation was proposed,and a model based on the centroid theory was ***,an integral model for the discrete thickness values of the cross-section profiles was *** discussion focused on the distinct characteristics of the two-point method,asymmetric method,and double-centroid method in evaluating the asymmetric distribution of *** three methods were employed to evaluate the wedge values of both the theoretical and measured cross-sections of steel plates and strips,and the accuracies of three wedge evaluation models were analyzed and *** results showed that the double-centroid method objectively reflects the degree and variation characteristics of the wedge values of the cross-sections of steel plates and strips,and this method is feasible,reliable,and outstanding.

关键词： Steel plate and strip Wedge Two-point method Double-centroid method Reliability

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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu xiao-Peng Zhang Gang Liu Wen-dan Tan Xin-dan Zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population

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Biomedical and Environmental Sciences 2024年第2期37卷 196-203页

作者： WANG dan dan WANG An Xin ZHANG xiao Li WEI Wen Bin WU Shou Ling ZHAO Xing Quan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Cardiology Kailuan HospitalTangshan 063001HebeiChina

Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population *** study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular *** We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or *** regression was used to analyze the relationship between retinal metrics and cognitive *** stratified by different vascular statuses were also *** RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(Pmall vessel change in RNFL and CI should be investigated in the future.

关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality

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Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental Sciences 2024年第2期37卷 133-145页

作者： LIU xiao CAO Ying LIN xiao Wan GAO dan Yang MIAO Hui Hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ***,the underlying mechanism is yet *** study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive *** Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control *** tests were conducted 24 h before surgery and 6,9,and 24 h after *** C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala *** In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for *** changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of *** Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of *** identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker

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Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： dan Hong xiao xiao Aijin ma Zhou Chen SiTing Li JunXia Xia YiLing Tian Yingmin Jia Hebei Yangyuan ZhiHui Beverage Co. Ltd. Institution of Chinese Walnut Industry College of Food Science and Technology Hebei Agricultural University Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology School of Food and Health Beijing Technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being considered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a composition of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved cognitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving cognition and memory disorders in elderly mice.

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-xiao Li Hong-Nan Mo Yan-Tong Zhou dan Lv Jing-Tong Zhai Hai-Li Qian Fei ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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