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World Journal of Clinical Cases 2021年第28期9卷 8537-8544页

作者： xiao-chun tao De-Chang Hu Li-Xin Yin Chen Wang Jin-Gen Lu Department of Anorectal LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Necrotizing fasciitis is a fulminant necrotizing soft tissue disease with a high fatality *** always starts with impact on the deep fascia rapidly and might result in secondary necrosis of the subcutaneous tissue,fascia,and ***,timely and multiple surgical operations are needed for the ***,the damage of skin and soft tissue caused by multiple surgical operations may require dermatoplasty and other treatments as a *** SUMMARY Here,we report a case of 50-year-old male patient who was admitted to our hospital with symptoms of necrotizing fasciitis caused by cryptoglandular infection in the perianal and perineal *** symptoms of necrotizing fasciitis,also known as the cardinal features,include hyperpyrexia,excruciatingly painful lesions,demonstration gas in the tissue,an obnoxious foul odor and *** results of postoperative pathology met the *** on the premise of complete debridement,multiple incisions combined with thread-dragging therapy(a traditional Chinese medicine therapy)and intensive supportive therapies including comprising antibiotics,nutrition and fluids were *** outcome of the treatment was *** patient recovered quickly and achieved ideal anal function and *** Timely and effective debridement and multiple incisions combined with thread-dragging therapy are an integrated treatment for necrotizing fasciitis.

关键词： Necrotizing fasciitis Cryptoglandular infection Traditional Chinese medicine Multiple incisions and thread-dragging therapy Integrated treatment Case report

REACTIONS OF 1-ACETOXY ALLYLIC PHOSPHONATES UNDER PALLADIUM(0) CATALYSIS

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Chinese Chemical Letters 1991年第11期2卷 839-840页

作者： Jing Yang ZHU Xi Yan LU xiao chun tao xiao Wei SUN Shanghai Institute of Organic Chemistry Academia Sinica345 Lingling LuShanghai 200032

l-Acetoxy allylic phosphonates rearrange regioselectively to γ-acetoxy α,β-unsaturated phosphonates under the catalysis of Pd(0). l-Acetoxy allylic phosphonates act as the precursors of phosphonatedπ-allylic cations in palladium(0) catalyzed reactions[1]. The reactions of l-acetoxy allylic phosphonates under palladium(0) catalysis with nucleophiles have been reported. 1-4 These reactions are highly regio- and stereoselective. We wish to report here the palladium(0) catalyzed reaction of l-acetoxy allylic phosphonates in the absence of a nucleophile.

关键词： OAC CATALYSIS REACTIONS OF 1-ACETOXY ALLYLIC PHOSPHONATES UNDER PALLADIUM Ph

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肝硬化门静脉血栓形成的危险因素分析

中国临床研究 2021年第3期34卷 341-345,349页

作者：肖春桃李贤秋周贤西南医科大学附属医院消化内科四川泸州646000

目的分析肝硬化门静脉血栓(PVT)形成的独立危险因素,并建立实用性强、适用性广的无创预测模型以期为肝硬化PVT形成防治提供参考依据。方法回顾性分析西南医科大学附属医院2018年9月至2020年4月收治的肝硬化符合纳入排除标准者353例,60... 详细信息

目的分析肝硬化门静脉血栓(PVT)形成的独立危险因素,并建立实用性强、适用性广的无创预测模型以期为肝硬化PVT形成防治提供参考依据。方法回顾性分析西南医科大学附属医院2018年9月至2020年4月收治的肝硬化符合纳入排除标准者353例,60例合并PVT患者为PVT组,随机选择同期120例无PVT患者为对照组,对可能影响PVT形成的因素进行单因素分析及多因素Logistic回归分析,由此建立肝硬化PVT形成的无创预测模型。结果肝炎病毒及酒精是肝硬化的前两位病因,分别占63.89%、16.28%,其中乙型病毒性肝炎占57.78%,是肝硬化的最主要病因。多因素Logistic回归分析显示,血红蛋白(Hb)、D-二聚体、脾静脉内径是PVT形成的独立危险因素(P0.05)。结论乙型病毒性肝炎仍是肝硬化的主要病因,其次为酒精。PVT患者上消化道出血风险明显增加,不利于胃食管静脉曲张出血防治。Hb降低、D-二聚体升高、脾静脉内径增宽是肝硬化门静脉血栓形成的独立危险因素,建议对肝硬化患者动态随访上述指标,必要时行进一步诊治。

关键词：肝硬化门静脉血栓危险因素乙型病毒性肝炎酒精血红蛋白 D-二聚体

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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碱催化多聚甲醛的解聚工艺条件研究

天然气化工—C1化学与化工 2017年第3期42卷 20-22页

作者：肖春妹陶川东刘旋李杰灵泉州师范学院福建泉州362011 西南化工研究设计院有限公司四川成都610225

考察了在碱催化下,温度、pH值等工艺条件对多聚甲醛解聚的影响,研究结果表明:在多聚甲醛解聚过程中,过高的温度和过强的碱性会加速副反应发生,最佳条件是在氮气保护下,T=80℃、pH值为8~9,反应1h,多聚甲醛解聚率接近完全,甲醛收率大于99%。

关键词：多聚甲醛碱催化解聚

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基于矢量法的气缸盖水腔流场数值分析

车用发动机 2008年第4期 36-39页

作者：梁桂华肖春涛回凤娜叶剑大连理工大学动力系内燃机研究所辽宁大连116024

利用CFD软件STAR-CD对同种型号4缸柴油机两种不同结构的气缸盖冷却水腔进行速度场的模拟分析比较,分别得出了具有切向进气道和螺旋进气道气缸盖冷却水腔的速度分布特点,采用一种新方法对多个切面进行速度矢量的比较,速度场更加直观,由... 详细信息

利用CFD软件STAR-CD对同种型号4缸柴油机两种不同结构的气缸盖冷却水腔进行速度场的模拟分析比较,分别得出了具有切向进气道和螺旋进气道气缸盖冷却水腔的速度分布特点,采用一种新方法对多个切面进行速度矢量的比较,速度场更加直观,由此判定两种结构的气缸盖水腔在速度分布方面的优缺点及其对温度分布的影响。

关键词：气缸盖切向进气道螺旋进气道数值模拟速度分布

Rotational properties of the odd-Z transfermium nucleus ^(255)Lr by a particle-number-conserving method in the cranked shell model

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 25-32页

作者： Yu-chun Li xiao-tao He College of Material Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

Experimentally observed ground state band based on the 1/2-[521] Nilsson state and the first exited band based on the 7/2-[514] Nilsson state of the odd-Z nucleus 255Lr are studied by the cranked shell model （CSM） with the paring correlations treated by the particle-number-conserving （PNC） method. This is the first time the detailed theoretical investigations are performed on these rotational bands. Both experimental kinematic and dynamic moments of inertia （f^（1） and ,f^（2） versus rotational frequency are reproduced quite well by the PNC-CSM calculations. By comparing the theoretical kinematic moment of inertia f（1） with the experimental ones extracted from different spin assignments, the spin 17/2- →13/2- is assigned to the lowest-lying 196.6（5） keV transition of the 1/2- [521 ] band, and 15/2→11/2- to the 189（1） keV transition of the 7/2- [514] band, respectively. The proton N = 7 major shell is included in the calculations. The intruder of the high-j low→lj15/2 （1/2-[770]） orbital at the high spin leads to band-crossings at hω = 0.20 （hω~=0.25） MeV for the 7/2-[514]ω= -1/2 （ω= ＋1/2） band, and at hω=0.175 MeV for the 1/2- [521 ] ω= - 1/2 band, respectively. Further investigations show that the band-crossing frequencies are quadrupole deformation dependent.

关键词： rotational band spin assignment band-crossing high-j orbital transfermium nuclei

腹腔镜胆囊切除术中特意分离结扎胆囊动脉的必要性分析

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腹腔镜外科杂志 2017年第2期22卷 126-129页

作者：胡小东李春桃陈果李波西南医科大学第一附属医院四川泸州646000

目的:探讨腹腔镜胆囊切除术特意分离结扎胆囊动脉的必要性。方法:随机选取2015年1月至2016年6月采用"腹腔镜非特异分离结扎胆囊动脉"(非特异法)60例患者(A组)与传统腹腔镜胆囊切除术的60例患者(B组),对比两组手术时间、术中出血量、生... 详细信息

目的:探讨腹腔镜胆囊切除术特意分离结扎胆囊动脉的必要性。方法:随机选取2015年1月至2016年6月采用"腹腔镜非特异分离结扎胆囊动脉"(非特异法)60例患者(A组)与传统腹腔镜胆囊切除术的60例患者(B组),对比两组手术时间、术中出血量、生物夹使用数量、术后住院时间、中转率等情况。结果:A组无一例中转开腹;B组中转3例,中转率5%,均为胆囊炎症期,三角区水肿、粘连严重,分离寻找胆囊动脉时因渗血多而影响视觉,分离、解剖三角区时分离钳不小心划破、撕断血管大出血被迫中转开腹止血。A组术后无胆漏患者,B组术后2例出现胆漏;两组均无肝外胆道严重损伤及术后大出血等严重并发症发生。两组手术时间、术中出血量、生物夹使用数量、术后住院时间差异有统计学意义(P<0.05)。结论:与"传统法"相比,"非特异法"具有手术时间短、出血少、手术耗材使用少等优势,腹腔镜胆囊切除术中可不必特意分离结扎胆囊动脉。

关键词：胆囊切除术,腹腔镜胆囊动脉对比研究

Experimental research on the contact force of the bi-directional pig in oil and gas pipeline

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Petroleum Science 2023年第1期20卷 474-481页

作者： xiao-xiao Zhu chun-Ming Fu Yu-tao Wang Shi-Ming Zhang College of Mechanical and Transportation Engineering China University of Petroleum-BeijingChangpingBeijing102249China

The migration process of the pig in oil and gas pipeline is a complex dynamic *** the pigging operation,the variation of friction force caused by the nonlinear contact between the sealing disc and the pipe wall is the key factor affecting the dynamic characteristics of the pig *** present,the existed pigging models for predicting pigging behavior regard friction as an invariant *** research indicates that the friction force of the pig varies with the contact force and the lubrication ***,the assumption that the friction force is constant cannot reflect the friction dynamic characteristics of the pig during pigging,and will also affect the accuracy of the pigging *** the variation of friction force of pig under different conditions is the basis of establishing the transient dynamic model of a *** a result,in this paper,a method of direct measurement of contact force between the pig and the pipeline is presented,the contact force,the friction force,as well as the friction coefficient of the pig are obtained from the *** results in this paper can help to establish a more accurate dynamic model of pig.

关键词： Pipeline pig Sealing disc Contact force Friction coefficient Experimental rig

Twin pregnancy with sudden heart failure and pulmonary hypertension after atrial septal defect repair: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8350-8356页

作者： chun-xiao Tong tao Meng Department of Obstetrical First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Pulmonary arterial hypertension(PAH)in pregnancy is one of the major obstetric complications and is considered a contraindication to pregnancy as it is classified as a class IV risk in the revised risk classification of pregnancy by the World Health ***,with its adaptive and expectant mechanical and hormonal changes,negatively affects the cardiopulmonary circulation in pregnant *** patients with repaired simple congenital heart disease(CHD)develop other pulmonary and cardiac complications during pregnancy?Can pregnant women with sudden pulmonary hypertension be treated and managed in time?In this paper,we present a case of a 39-year-old woman who underwent cesarean section at 33 wk'gestation and developed PAH secondary to repaired simple *** research began by a PubMed search for"pulmonary hypertension"and"pregnancy"and"CHD"case *** cases were selected to review PAH in pregnancy after correction of CHD *** studies were reviewed,coupled with our own clinical *** SUMMARY Herein,a case involving a woman who underwent atrial septal defect repair at the age of 34,became pregnant five years later,and had a sudden onset of PAH and right heart failure secondary to symptoms of acute peripheral edema in the third trimester of her *** a result,the patient underwent a cesarean section and gave birth to healthy *** three days after cesarean delivery,her cardiac function deteriorated as the pulmonary artery pressure ***-tive postpartum management,including diuresis,significant oxygen uptake,vasodilators,capacity and anticoagulants management,led to improvements in cardiac function and *** patient was discharged from hospital with a stable recovery and transferred to local hospitals for further PAH *** This case served as a reminder to obstetricians of the importance of pregnancy after repair of *** is crucial for patients with CHD to receive early co

关键词： Congenital heart defects Pulmonary hypertension Right heart failure Twin pregnancy Perioperative management Case report