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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen xiao-chun hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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Investigation of high rate mechanical flow followed by ignition for high-energy propellant under dynamic extrusion loading

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Defence Technology（防务技术） 2024年第2期32卷 336-347页

作者： Liying Dong Yanqing Wu Kun Yang xiao hou State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

Investigating the ignition response of nitrate ester plasticized polyether(NEPE) propellant under dynamic extrusion loading is of great significant at least for two cases. Firstly, it helps to understand the mechanism and conditions of unwanted ignition inside charged propellant under accident ***, evaluates the risk of a shell crevice in a solid rocket motor(SRM) under a falling or overturning scene. In the present study, an innovative visual crevice extrusion experiment is designed using a dropweight apparatus. The dynamic responses of NEPE propellant during extrusion loading, including compaction and compression, rapid shear flow into the crevice, stress concentration, and ignition reaction, have been firstly observed using a high-performance high-speed camera. The ignition reaction is observed in the triangular region of the NEPE propellant sample above the crevice when the drop weight velocity was 1.90 m/s. Based on the user material subroutine interface UMAT provided by finite element software LS-DYNA, a viscoelastic-plastic model and dual ignition criterion related to plastic shear dissipation are developed and applied to the local ignition response analysis under crevice extrusion conditions. The stress concentration occurs in the crevice location of the propellant sample, the shear stress is relatively large, the effective plastic work is relatively large, and the ignition reaction is easy to occur. When the sample thickness decreases from 5 mm to 2.5 mm, the shear stress increases from 22.3 MPa to 28.6 MPa, the critical value of effective plastic work required for ignition is shortened from 1280 μs to 730 μs, and the triangular area is easily triggering an ignition reaction. The propellant sample with a small thickness is more likely to stress concentration, resulting in large shear stress and effective work, triggering an ignition reaction.

关键词： NEPE propellant Crevice extrusion Shear flow Sample thickness Ignition reaction

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Remote sensing of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang Yong Chen chun-li Chen Yong-ke Zhang Ji-hui Dong Tao Peng xiao-feng Li Ding-fu Zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Southwest Institute of Technical Physics Chengdu 610041SichuanChina School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and *** system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber *** combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric *** static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 *** experiments is conducted with the *** of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 *** test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting sensing Atmospheric pollution

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Boosting oxygen vacancies by modulating the morphology of Au decorated In_(2)O_(3)with enhanced CO_(2)hydrogenation activity to CH_(3)OH

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Journal of Environmental Sciences 2024年第6期140卷 91-102页

作者： Ruxian hou Jiewen xiao Qian Wu Tianyu Zhang Qiang Wang Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

CO_(2)hydrogenation to methanol has become one of the most promising ways for CO_(2)utilization,however,the CO_(2)conversion rate and methanol selectivity of this reaction still need to be improved for industrial *** we investigated the structure-activity relationship for CO_(2)conversion to methanol of In_(2)O_(3)-based catalysts by modulating morphology and decorating *** different Au/In_(2)O_(3)catalysts were prepared,their activity follow the sequence of Au/In_(2)O_(3)-nanosphere(Au/In_(2)O_(3)-NS)>Au/In_(2)O_(3)-nanoplate(Au/In_(2)O_(3)-NP)>Au/In_(2)O_(3)-hollow microsphere(Au/In_(2)O_(3)-HM).Au/In_(2)O_(3)-NS exhibited the best performance with good CO_(2)conversion of 12.7%,high methanol selectivity of 59.8%,and large space time yield of 0.32 g CH_(3)OH/(hr·gcat)at 300℃.The high performance of Au/In_(2)O_(3)-NS was considered as the presence of *** contributes to the creation of more surface oxygen vacancies,which further promoted the CO_(2)adsorption and facilitated CO_(2)activation to form the formate intermediates towards *** work clearly suggests that the activity of In_(2)O_(3)catalyst can be effective enhanced by structure engineering and Au decorating.

关键词： CO_(2)hydrogenation Methanol Au/In_(2)O_(3) Morphology Oxygen vacancies

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Trace Element Mobility in Subducted Marble and Associated Eclogite:Constraints from UHP Rocks in the Shuanghe Area,Central-East China

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Journal of Earth Science 2024年第1期35卷 1-15页

作者： Xingao hou Zhiqiang Yu Shefa Chen Lei Liu Yilin xiao Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

In order to decipher element mobility in UHP meta-sedimentary rocks in the continental subduction zone,major and trace element compositions are investigated for a continuous profile from a representative UHP region in the Dabie *** the lithologic contact zone,contents of K,Ca,LREE,and LILE exhibit varying degrees of downward trends in both marble and eclogite toward the contact zone,indicating that marble and their associated eclogite can release a large amount of K,Ca,and a small number of LILEs and *** is the main Ti phase in both marble and *** rims around rutile can occasionally be seen in *** of Ti and HFSE exhibit a well-coupled relation among marble and eclogite,indicating that substantial Ti and HFSEs were migrated from eclogite to marble,in accord with the capacity of a melt *** and titanites in marble exhibit a relatively limited variation in Nb/Ta ratios(12.9-16.2),similar to those of titanites in eclogite(14.2-16.7),which demonstrates that rutiles and titanites in marble were sourced from eclogite because of short-distance migrations of Ti and *** to the P-T path and the temperature and pressure conditions of the peak metamorphism reported by previous studies,the eclogite associated with marble may not form supercritical fluids in the subduction zone because of the addition of carbonate minerals.

关键词： UHP metamorphism eclogite marble element migration fluid actions geochemistry

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Understanding the Interfacial Energy Structure and Electron Extraction Process in Inverted Organic Solar Cells with Phosphine-Doped Cathode Interlayers

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Chinese Journal of Chemistry 2024年第12期42卷 1347-1354页

作者： Yi Yang Jingwen Wang Yang xiao Bowei Xu Jianhui hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Chemical Resource Engineering College of Materials Science and EngineeringBeijing University of Chemical TechnologyBejing 100029China University of Chinese Academy of Sciences Beijing 100049China

Comprehensive Summary Cathode interlayers(CILs)play an essential role in achieving efficient organic solar cells(OSCs).However,the electronic structure at the electrode/CIL/active layer interfaces and the underlying mechanisms for electron collection remain unclear,which becomes a major obstacle to develop high-performance ***,we investigate the relationship of the electron collection abilities of four cross-linked and n-doped CILs(c-NDI:P0,c-NDI:P1,c-NDI:P2,c-NDI:P3)with their electronic structure of space charge region at heterojunction *** accurately calculating the depletion region width according to the barrier height,doping density and permittivity,we put forward that the optimal thickness of CIL should be consistent with the depletion region width to realize the minimum energy *** a result,the depletion region width is largely reduced from 13 nm to 0.8 nm at the indium tin oxide(ITO)/c-NDI:P0 interface,resulting in a decent PCE of 17.7%for the corresponding inverted OSCs.

关键词： Organic solar cells Cathode interlayer Depletion region width Electric conductivity Electron transport Electron transfer Electron extraction process

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Effect of neutral polymeric bonding agent on tensile mechanical properties and damage evolution of NEPE propellant

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Defence Technology（防务技术） 2024年第2期32卷 357-367页

作者： M.Wubuliaisan Yanqing Wu xiao hou Kun Yang Hongzheng Duan Xinmei Yin State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China The Fourth Institute of China Aerospace Science and Technology Corporation Xi'an710025PR China School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081PR China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyHubei441003PR China

Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of new generations of the NEPE propellant with better mechanical properties. Therefore,understanding the effects of NPBA on the deformation and damage evolution of the NEPE propellant is fundamental to material design and applications. This paper studies the uniaxial tensile and stress relaxation responses of the NEPE propellant with different amounts of NPBA. The damage evolution in terms of interface debonding is further investigated using a cohesive-zone model(CZM). Experimental results show that the initial modulus and strength of the NEPE propellant increase with the increasing amount of NPBA while the elongation decreases. Meanwhile, the relaxation rate slows down and a higher long-term equilibrium modulus is reached. Experimental and numerical analyses indicate that interface debonding and crack propagation along filler-matrix interface are the dominant damage mechanism for the samples with a low amount of NPBA, while damage localization and crack advancement through the matrix are predominant for the ones with a high amount of NPBA. Finally, crosslinking density tests and simulation results also show that the effect of the bonding agent is interfacial rather than due to the overall crosslinking density change of the binder.

关键词： Solid propellant Bonding agent Mechanical properties Damage evolution Cohesive-zone model Interface debonding

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Effects of Hydrogen Charging Time and Pressure on the Hydrogen Embrittlement Susceptibility of X52 Pipeline Steel Material

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 293-307页

作者： Hong-Jiang Wan xiao-Qi Wu Hong-Liang Ming Jian-Qiu Wang En-hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangzhou510530China

The effects of hydrogen charging time and pressure on the hydrogen embrittlement(HE)susceptibility of X52 pipeline steel material are studied by slow strain rate tensile *** fracture morphologies of the specimens are observed by scanning electron *** HE susceptibility of the X52 pipeline steel material increases with an increase in both hydrogen charging time and hydrogen *** a charging time of 96 h,the HE susceptibility index reaches 45.86%,approximately 3.6 times that at a charging time of 0 ***,a charging pressure of 4 MPa results in a HE susceptibility index of 31.61%,approximately 2.5 times higher than that at a charging pressure of 0.3 MPa.

关键词： Hydrogen embrittlement X52 pipeline steel material Tubular specimen Hydrogen charging time Hydrogen charging pressure

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Exosomal microRNAs in hepatocellular carcinoma,expanding research field

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World Journal of Gastroenterology 2024年第20期30卷 2618-2620页

作者： Bo-Hao Zheng xiao-Jian Ni hou-Bao Liu Department of Biliary Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Biliary Tract Disease Center of Zhongshan Hospital Fudan UniversityShanghai 200032China Biliary Tract Disease Institute Fudan UniversityShanghai 200032China Cancer Center Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Biliary Tract Minimal Invasive Surgery and Materials Engineering Research Center Shanghai 200032China

In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in *** extracellular vesicles(exosomes)play important roles in the tumor *** this review,the authors introduce the following points:(1)The composition and function of exosomal microRNAs(miRNAs)of different cell origins in hepatocellular carcinoma(HCC);(2)the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC;and(3)the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of *** addition,the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was *** this review,the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC,which provides a deeper understanding of exosomal miRNAs to the readers.

关键词： Exosomes MicroRNA Hepatocellular carcinoma Liver cancer Tumor microenvironment

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Predictive factors for percutaneous nephrolithotomy bleeding risks

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Asian Journal of Urology 2024年第1期11卷 105-109页

作者： U Phun Loo chun hou Yong Guan Chou Teh Urology Department Sarawak General HospitalKuchingMalaysia

Objective:This study aimed to identify predictive factors for percutaneous nephrolithotomy(PCNL)bleeding *** better risk stratification,bleeding in high-risk patient can be anticipated and facilitates early ***:A prospective observational study of PCNL performed at our institution was *** adults with radio-opaque renal stones planned for PCNL were included except those with coagulopathy,planned for additional *** including gender,co-morbidities,body mass index,stone burden,puncture site,tract dilatation size,operative position,surgeon's seniority,and operative duration were studied using stepwise multivariate regression analysis to identify the predictive factors associated with higher estimated hemoglobin(Hb)***:Overall,4.86%patients(n=7)received packed cells *** mean estimated Hb deficiency was 1.3(range 0-6.5)g/dL and the median was 1.0 g/*** multivariate regression analysis revealed that absence of hypertension(p=0.024),puncture site(p=0.027),and operative duration(p=0.023)were significantly associated with higher estimated Hb ***,the effect sizes are rather small with partial eta-squared of 0.037,0.066,and 0.038,*** power obtained was 0.621,0.722,and 0.625,*** factors studied did not correlate with Hb ***:Hypertension,puncture site,and operative duration have significant impact on estimated Hb deficiency during ***,the effect size is rather small despite adequate study power ***,operative position(supine or prone),puncture number,or tract dilatation size did not correlate with Hb *** mainstay of reducing bleeding in PCNL is still meticulous operative *** study findings also suggest that PCNL can be safely done by urology trainees under supervision in suitably selected patient,without increasing risk of bleeding.

关键词： Percutaneous nephrolithotomy Predictive factor Risk factor Bleeding Blood loss

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