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Stanene: A good platform for topological insulator and topological superconductor

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Frontiers of physics 2020年第5期15卷 85-99页

作者： chen-xiao zhao Jin-Feng Ji Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

Two dimenslonal(2D)topological insulators(TIs)and topological superonductors(TSC&)have been intensively studied for recent yars due to their great poterntial for dissipat iouless eloctron transporta-tion and fault-tolerant quantum computing,*** we focus on stanene,the tin analogue of grapbene,to give a brief review of their development a a candidate for both 2D TI and *** is proposed to bea TI with a large gap of 0.3 eW,and its topological properties are sensitive to various factors,e.g..the lattice constants,chemical functionalization and layer thickness,which offer various methods for phase ***,the inverted gap and edge states are observed recently,which are strong evidences for *** addition,stanene is also predicted to be a time reversal invariant TSC by breaking inversion syumetry,supporting belical Majorana edge *** layer dependent superconduetivity of stanene is receatly confirmed by both transport and scauning tumeling microsoopy *** review givs a detailod introduction to stanene and its topological properties and some proepects are also discussed.

关键词： topological insulator topological superconductor stanene

Isotopic characteristics and source analysis of atmospheric ammonia during agricultural periods in the Xichuan area of the Danjiangkou Reservoir

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Journal of Environmental Sciences 2024年第2期136卷 460-469页

作者： xiaoshu chen Tongqian zhao Chunyan xiao xiaoming Guo Feihong chen Institute of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China

Nitrogen deposition is an important means of exogenous nitrogen input in reservoir *** activities around the reservoir lead to a sharp increase in the concentration of ammonia in the atmosphere,which poses a threat to the reservoir water *** the contribution of agricultural ammonia release to atmospheric NH_(x)(gaseous NH_(3)and particulate NH_(4)^(+)),in the reservoir area can provide a theoretical foundation for local reactive nitrogen *** collected atmospheric NH_(3)and NH_(4)^(+)samples during the agricultural periods and analyzed the isotopic characteristics of atmospheric NH_(x)and the contribution rates of different ammonia sources in the Xichuan area of the Danjiangkou *** results showed that the initialδ~(15)N values of NH_(3)(-30.0‰to–7.2‰)and particulate NH_(4)^(+)(–33‰to+4.9‰for finer and coarser particles,respectively)are different,and their contribution ratios from dissimilar ammonia sources are also different,among which NH_(4)^(+)is more susceptible to meteorological ***,since the atmospheric NH_(x)in the Xichuan area is mainly gaseous NH_(3),the final sources of atmospheric ammonia nitrogen source depend on gaseous NH_(3).Agricultural sources(59%-74%)were the main NH_(3)sources in this *** them,the fertilizer use emission was dominant;it had the highest contribution rate in summer during the agricultural period and a more prominent impact in areas with less human *** regulation of the application of high-ammonia releasing fertilizer,especially during the agricultural period in summer,is an effective way to reduce the threat of atmospheric ammonia to water health.

关键词： Danjiangkou reservoir Atmospheric ammonia nitrogen Isotope Ammonia source analysis Agricultural sources

Study on the vertical deformations induced by terrestrial water storage changes in Huang-Huai-Hai river basin

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Geodesy and Geodynamics 2024年第4期15卷 352-365页

作者： Liansheng Deng Yugang xiao Qusen chen Feifei Liao zhao Li School of Electrical and Electronic Information Engineering Hubei Polytechnic UniversityHuangshi 435003China Hubei Luojia Laboratory GNSS Research CenterWuhan UniversityWuhan 430079.China Changjiang Spatial Information Technology Engineering Co. Ltd.Wuhan 430010China

Terrestrial water storage(TWs)variations are associated with water mass movements,which may cause the deformation displacements of the Global Navigation Satellite System(GNSS)*** study investigates the spatio-temporal Tws variations and addresses the relationship between deformation variations observed in the Huang-Huai-Hai River Basin(HHHRB)and local hydrological *** indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small,and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal *** there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE)and GRACE Follow-On(GFO)and the GNSS reflect that the HHHRB is undergoing an uplift process,while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS *** hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5%of the GNSS seasonal variations,with the phases of terrestrial water storage advancing by about one month relative to GNss common signal ***,the decrease of the groundwater storage in the HHHRB has been accelerating since *** reaching its lowest level around mid-2020,it began to rise rapidly,which might be closely related to the implementation of the South-North Water Transfer Central Project.

关键词： Terrestrial waterstorage GRACE GNSS Vertical deformations Huang-Huai-Hairiverbasin

Nitrite-catalyzed economic and sustainable bromocyclization of tryptamines/tryptophols to access hexahydropyrrolo[2,3-b]indoles/tetrahydrofuroindolines in batch and flow

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Chinese Chemical Letters 2024年第7期35卷 247-252页

作者： xiao xiao Biao chen Jia-Wei Li Jun-Bo Zheng Xu Wang Hang zhao Fen-Er chen Institute of Pharmaceutical Science and Technology Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green ***,a controllable cascade transformation of bromocyclization and aromatic bromination has also been smoothly achieved to form dibrominated HPIs and *** could be successfully scaled up under both the batch process and a continuous flow *** most remarkable peculiarity of our process over all previous methods is that the generated water is the major ***,successful application of this new protocol has been demonstrated by the pharmaceutical and natural products syntheses.

关键词： Tryptamines and tryptophols Nitrite Economic and sustainable bromocyclization HPI and TFI structures Bath and flow

Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito-borne viruses

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Insect Science 2024年第3期31卷 663-673页

作者： zhao-Yang Wang Kai-xiao Nie Ji-chen Niu Gong cheng Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua UniversityBejingChina Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenGuangdongChina Department of Pathogen Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesJinanChina

Mosquito-borne viruses(MBVs)are a large class of viruses transmitted mainly through mosquito bites,including dengue virus,Zika virus,Japanese encephalitis virus,West Nile virus,and chikungunya virus,which pose a major threat to the health of people around the *** global warming and extended human activities,the incidence of many MBVs has increased *** saliva contains a variety of bioactive protein *** not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host ***,we review the physiological functions of mosquito salivary proteins(MSPs)in detail,the influence and the underlying mechanism of MSPs on the transmission of MBVs,and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV transmission blocking vaccines.

关键词： immune response mosquito-borne virus mosquito salivary protein saliva vaccine transmission

The tumor immune microenvironment transcriptomic subtypes of colorectal cancer for prognosis and development of precise immunotherapy

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Gastroenterology Report 2020年第5期8卷 381-389,I0002页

作者： Yun-Qiang Tang Tu-Feng chen Yan Zhang xiao-chen zhao Yu-Zi Zhang Guo-Qiang Wang Meng-Li Huang Shang-Li Cai Jing zhao Bo Wei Jun Huang Department of Hepatic-biliary Surgery Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China The Medical Department 3D Medicines Inc.ShanghaiP.R.China Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China Guangdong Institute of Gastroenterology GuangzhouP.R.China

Background:Biomarkers based on immune context may guide prognosis prediction.T-cell inactivation,exclusion,or dysfunction could cause unfavorable tumor microenvironments,which affect immunotherapy and ***,none of the immuno-biomarkers reported to date can differentiate colorectal-cancer(CRC)***,we aimed to classify CRC patients according to the levels of T-cell activation,exclusion,and dysfunction in the tumor ***:RNAseq data of 618 CRC patients from The Cancer Genome Atlas and microarray data of 316 CRC patients from Gene Expression Omnibus were analysed using the Tumor Immune Dysfunction and Exclusion *** clustering was used to classify ***:Based on the expression signatures of myeloid-derived suppressor cells,cancer-associated fibroblasts,M2-like tumor-associated macrophages,cytotoxic T-lymphocytes,and PD-L1,all patients were clustered into four subtypes:cluster 1 had a high level of immune dysfunction,cluster 2 had a low level of immune activation,cluster 3 had intense immune exclusion,and cluster 4 had a high level of immune activation and a moderate level of both dysfunction and exclusion *** with cluster 1,the hazard ratios and 95%confidential intervals for overall survival were 0.63(0.35-1.13)for cluster 2,0.55(0.29-1.03)for cluster 3,and 0.30(0.14-0.64)for cluster 4 in multivariate Cox *** immune clustering and prognosis patterns were obtained upon validation in the GSE39582 *** subgroup analysis,immune clustering was significantly associated with overall survival among stage I/II patients,microsatellite stable/instability-low patients,and patients not treated with adjuvant ***:Our findings demonstrated that classifying CRC patients into different immune subtypes serves as a reliable prognosis predictor and may help to refine patient selection for personalized cancer immunotherapy.

关键词： colorectal cancer immune dysfunction immune exclusion prognosis

Facile SERS screening of melamine in bovine milk with 2D printed AgNPs/glass fabric filter paper as the flexible substrate

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Food Science and Human Wellness 2024年第5期13卷 2595-2600页

作者： Shiyao Wang Yanan zhao xiao Wei Yisheng chen College of Food Science and Engineering Shanxi Agricultural UniversityTaigu 030801China Food Nutrition and Safety Institute Shanxi Agricultural UniversityTaiyuan 030031China School of Food Science and Technology Jiangnan UniversityWuxi 214122China

Melamine is one of the most frequently detected adulterants in dairy *** current study proposes a surface-enhanced Raman spectroscopy(SERS)-based analytical tool for fast and reliable screening of melamine in bovine milk.A hand-held Raman spectrometer was used in conjunction with a substrate composed of silver nanoparticles(AgNPs)that was 2D printed onto glass fiber(GF)filter *** optimized conditions,a sensitive and fingerprint-like signal at 674 cm^(-1) was *** AgNPs/GF substrate exhibited high sensitivity to melamine in milk down to 1.9498×10^(-5)mg/mL,which is well below the USA and EU safety limits(2.5×10^(-3)mg/mL).Remarkably,the proposed technology was also highly reproducible,showing spot-to-spot and block-to-block variations below 3.3%and 4.9%at 674 cm^(-1) in Raman intensity,*** characteristic peak intensity and concentration of melamine showed an acceptable linear relationship(R^(2)=0.9909)within the range of 0.0001-1 mg/***,the method established in this study can provide an efficient and effective method for the quantitative target screening and detection of melamine in dairy products.

关键词： 2D print Melamine Milk Surface-enhanced Raman spectroscopy(SERS) flexible substrate

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Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis

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International Journal of Oral Science 2024年第1期16卷 163-172页

作者： xiao Yang Hui zhao Rui Li Yang chen Zhi Xu Zhengjun Shang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Oral and Maxillofacial-Head and Neck Oncology School of Stomatology–Hospital of StomatologyWuhan UniversityWuhanChina Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that is largely induced by betel quid chewing. However, the lack of available models has challenged studies of angiogenesis in OSF. Here, we found that the expression of thrombospondin 1 (THBS1), an endogenous angiostatic protein, was elevated in the stroma of tissues with OSF. Using a fibroblast-attached organoid (FAO) model, the overexpression of THBS1 in OSF was stably recapitulated in vitro. In the FAO model,treatment with arecoline, a major pathogenic component in areca nuts, enhanced the secretion of transforming growth factor (TGF)-β1 by epithelial cells, which then promoted the expression of THBS1 in fibroblasts. Furthermore, human umbilical vein endothelial cells (HUVECs)were incorporated into the FAO to mimic the vascularized component. Overexpression of THBS1 in fibroblasts drastically suppressed the sprouting ability of endothelial cells in vascularized FAOs (v FAOs). Consistently, treatment with arecoline reduced the expression of CD31in v FAOs, and this effect was attenuated when the endothelial cells were preincubated with neutralizing antibody of CD36, a receptor of THBS1. Finally, in an arecoline-induced rat OSF model, THBS1 inhibition alleviated collagen deposition and the decline in vascularity in vivo. Overall, we exploited an assembled organoid model to study OSF pathogenesis and provide a rationale for targeting THBS1.

关键词： angiogenesis elevated endogenous

The extraction of effective components and an antioxidant activity study of Tulipa edulis

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Food Science and Human Wellness 2024年第1期13卷 276-286页

作者： Doudou Zhang Dong xiao Tingting Yin Shuangzhi zhao Olena Zhur Xun xiao Hailun He Leilei chen Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 102488China School of Life Sciences Central South UniversityChangsha 410013China State Key Laboratory of Coal Resources and Safe Mining University of Mining and TechnologyXuzhou 221116China Institute of Agro-Food Science and Technology Shandong Academy of Agricultural SciencesJinan 250100China

Plant extracts from natural sources are an excellent choice for food additives and natural *** this study,the active components of Tulipa edulis were extracted and analysed,and their antioxidant capacity was ***,the crude extract mixture was separated and purified using a Sephadex LH-20 gel,and the antioxidant activity of the purified products was *** umbilical vein endothelial human umbilical vein endothelial cells(HUVEC)cells were treated with 35 mmol/L glucose to construct a model of oxidative ***,the cells were treated with the active component to observe whether the products of *** could have a good protective effect on HUVEC cells induced by *** analysis was also performed on HUVEC cells after same treatment to explore the possible mechanism of the component F2 protecting HUVEC cells from oxidative stress induced by high *** results showed that component F2 obtained from *** has strong antioxidant ***,F2 can play a strong antioxidant protective role in HUVEC ***,the gene expression of heme oxygenase 1(HO-1),γ-glutamyl cysteine ligase catalytic subunit(GCLC)and NAD(P)H quinone oxidoreductase-1(NQO1)in HUVEC cells was up-regulated after treated with *** study provides reference value for the further development and application of *** and the d evelopment of functional food.

关键词： Tulipa edulis Oxidative stress Purification Antioxidant