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Application of sintilimab combined with anlotinib hydrochloride in the clinical treatment of microsatellite stable colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1925-1935页

作者： Rui Feng De-Xin cheng xiao-chen chen Liu Yang Hao Wu Department of Interventional Medicine Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Cancer Center Department of Radiation OncologyZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Department of Vascular Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Microsatellite stable(MSS)colorectal cancer(CRC)is a common type of tumor with limited treatment *** and anlotinib hydrochloride are two extensively studied anticancer *** To probe the clinical value of combining sintilimab with anlotinib hydrochloride in MSS CRC *** During the period spanning from April 2019 to April 2022,Zhejiang Provincial People’s Hospital accommodated a cohort of 92 patients diagnosed with MSS CRC who were classified into two distinct groups in our study,the observation group and the control *** control group was administered anlotinib hy-drochloride as their designated therapy,whereas the observation group received the additional treatment of sintilimab in conjunction with the therapy assigned to the control *** administration of treatment occurred in cycles consisting of a duration of 3 wk,and the evaluation of effectiveness took place subsequent to the completion of two consecutive cycles of treatment within both groups.A comparative analysis between the two groups was conducted to assess the short-term efficacy and ascertain the incidence of adverse events transpiring throughout the duration of the treatment *** in the levels of carcinoembryonic Life Questionnaire-Core 30 were compared between the two groups prior to and subsequent to ***,a 1-year follow-up was conducted for both groups of patients,and the survival status was recorded and *** The short-term effectiveness displayed by the observation group surpassed that exhibited by the control group,with a statistically significant discrepancy(76.09%vs 50.00%),reaching a significance level denoted as P<*** the administration of treatment,the observation group manifested a considerable reduction in numerous serum indicators,which were found to be lower than the corresponding pretreatment levels within the same group as well as the post-treatment levels observed in the control group(P<0.0

关键词： Microsatellite stability Colorectal cancer Sintilimab Anlotinib hydrochloride Immunity prognosis

Synthesis and Antitumor Activity of an Analog of Phthalascidin

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Chinese Chemical Letters 2006年第10期17卷 1279-1282页

作者： Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi Zhi chen xiao Guang chen Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050

An analog of phthalascidin （Pt-650） was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB, KeTr3 and HCT-8.

关键词： Ecteinascidin phthalascidin tetrahydroisoquinoline antitumor.

Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins

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Chinese Chemical Letters 2007年第11期18卷 1335-1338页

作者： Di Zao Li Yan Li xiao Guang chen chen Gen Zhu Jing Yang Hong Yan Liu Xian Dao Pan Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 possessed the best efficacy on six human cancer cell lines in the six classes of CPTs＇ derivatives. In vivo testing results indicated that 9 had better antitumor activity against mouse liver carcinoma H22 than topotecan.

关键词： Camptothecin Synthesis Heterocyclic acid Antitumor activity

Positive Selection of CAG Repeats of the ATXN2 Gene in Chinese Ethnic Groups

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Journal of Genetics and Genomics 2013年第10期40卷 543-548页

作者： xiao-chen chen Hao Sun Chang-Jun Zhang Ying Zhang Ke-Qin Lin Liang Yu Lei Shi Yu-Fen Tao xiao-Qin Huang Jia-You Chu Zhao-Qing Yang Department of Medical Genetics Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical College935 Jiaoling RoadKunming 650118YunnanChina Reproductive Medicine Center Hubei University of MedicineShiyan 442000China

The ataxin-2 （ATXN2） gene is located on human chromo-some 12q24.1. In normal individuals, the coding region in exon 1 of this gene has fewer than 31 CAG repeats （Yu et al., 2005： Laffita-Mesa et al., 2012）. However, an abnormal expansion of CAG trinucleotide repeats results in the aggre-gation of polyglutamine （polyQ）, which causes spinocer-ebellar ataxia type 2 （SCA2）（Pulst et al., 1996）. The expanded alleles have more than 32 repeats in the affected individuals, and generally there is an inverse correlation between CAG repeat length and age of onset （Pulst et al., 1996）. SCA2 is an autosomal dominant inheritance neurodegenerative disease, whose major clinical feature is progressive cerebellar ataxia. Atrophies of the brainstem and frontal lobe have been frequently detected by magnetic resonance imaging （MRI）（Yamamoto-Watanabe et al., 2010）. This disease has the strong effect on sensory and motor control.

关键词： CAG Gene Positive Selection of CAG Repeats of the ATXN2 Gene in Chinese Ethnic Groups

xiao-Ping chen-A leading figure among Chinese surgeons

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Science China(Life Sciences) 2016年第10期59卷 993-994页

作者： chen xiao-Ping

xiao-Ping chen,male,born in Funan County of China’s eastern Anhui Province in 1953,was considered a reformer and innovator in surgery of the liver,pancreas and biliary *** four decades of research and clinical work,he has made remarkable achievements in regards to the treatment of hepato-pancreato-biliary diseases and has been elected as a member of the Chinese Academy of Sciences in2015 because of his outstanding contributions.

关键词：中国东部外科中国科学院院士医生人物阜南县安徽省肝脏

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复杂地质条件下初始地应力场反演分析方法

华中科技大学学报（自然科学版） 2017年第8期45卷 87-92页

作者：赵辰肖明陈俊涛武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072

为获得较为合理和准确的初始地应力场分布,考虑了复杂地质条件中地形地貌及断层对地应力场的影响,提出了结合地层剥蚀模拟和侧压力系数法的地应力反演分析方法.该方法对侧压力系数法进行了改进,通过逐次开挖地层近似模拟地表剥蚀过程对... 详细信息

为获得较为合理和准确的初始地应力场分布,考虑了复杂地质条件中地形地貌及断层对地应力场的影响,提出了结合地层剥蚀模拟和侧压力系数法的地应力反演分析方法.该方法对侧压力系数法进行了改进,通过逐次开挖地层近似模拟地表剥蚀过程对现今地应力场的影响,并采用了隐含断层单元,将断层力学效应反映在岩体单元中,从而模拟断层附近地应力场的分布规律.最后对水电站地下厂房区域的地应力场进行了反演分析,结果表明:测点反演值与实测值符合良好,反演结果充分反映了河谷及断层区域地应力场的基本分布规律.

关键词：地应力反演分析侧压力系数地层剥蚀断层

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing Yang Jinghui chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

带有补偿环节的串并联混合型飞行模拟器指令分配方法

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电机与控制学报 2017年第7期21卷 113-120页

作者：王晓晨陈维山哈尔滨理工大学自动化学院黑龙江哈尔滨150080 哈尔滨工业大学机器人技术与系统国家重点实验室黑龙江哈尔滨150001

提出了一种串并联混合型飞行模拟器,该模拟器结合了串联机构和并联机构的特点,能够实现高动态大角度机动飞行的运动仿真。针对所提出模拟器的指令分配问题,首先基于伪逆和梯度投影法给出了带有加权的速度层最优解。然后针对各个关节的... 详细信息

提出了一种串并联混合型飞行模拟器,该模拟器结合了串联机构和并联机构的特点,能够实现高动态大角度机动飞行的运动仿真。针对所提出模拟器的指令分配问题,首先基于伪逆和梯度投影法给出了带有加权的速度层最优解。然后针对各个关节的物理约束,基于二次分配的思想设计了补偿环节,使得当某一个关节指令的速度或加速度超限时,可以利用其他未超限的关节进行补偿,这也使得模拟器能够模拟更高动态的运动。给出的指令分配算法能保证在获得期望位姿指令的同时,避免运动学奇异,同时还能充分发挥系统各关节的驱动能力。

关键词：大角度机动飞行运动仿真运动学奇异指令分配

On Gender Differences in Language Learning Styles

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海外英语 2014年第23期 276-277,279页

作者：肖陈陈西华师范大学外国语学院

Language learning style, serving as one of the elements of individual differences in foreign language learning, has substantial significance of research for EFL teaching. Males' and females' language learning styles are quite different. This paper illustrates the gender differences in language learning styles from sensory, cognitive and personality perspectives, and offers some suggestions for EFL teaching.

关键词： language learning styles gender differences EFL te