检索结果-南通市图书馆

Human umbilical cord mesenchymal stem cells derivedexosomes on VEGF-A in hypoxic-induced mice retinal astrocytes and mice model of retinopathy of prematurity

引用

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1238-1247页

作者： xiao-Tian zhang bo-Wen Zhao Yuan-Long zhang Song Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To observe the effect of human umbilical cord mesenchymal stem cells(hUCMSCs)secretions on the relevant factors in mouse retinal astrocytes,and to investigate the effect of hUCMSCs on the expression of vascular endothelial growth factor-A(VEGF-A)and to observe the therapeutic effect on the mouse model of retinopathy of prematurity(ROP).METHODS:Cultured hUCMSCs and extracted exosomes from them and then retinal astrocytes were divided into control group and hypoxia *** assay,flow cytometry,reverse transcription-polymerase chain reaction(RT-PCR)and Western blot were used to detect related *** mechanisms by which hUCMSCs exosomes affect VEGF-A expression in hypoxia-induced mouse retinal astrocytes were *** last,the efficacy of exosomes of UCMSCs in a mouse ROP model was ***6 was used to comprehensively process data ***:The secretion was successfully extracted from the culture supernatant of hUCMSCs by gradient *** oxygen species(ROS)and hypoxia inducible factor-1α(HIF-1α)of mice retinal astrocytes under different hypoxia time and the expression level of VEGF-A protein and VEGF-A mRNA increased,and the ROP cell model was established after 6h of *** secretions of medium and high concentrations of hUCMSCs can reduce ROS and HIF-1α,the expression levels of VEGF-A protein and VEGF-A mRNA are statistically significant and concentration *** with the ROP cell model group,the expression of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signal pathway related factors in the hUCMSCs exocrine group is significantly *** intravitreal injection of the secretions of medium and high concentrations of hUCMSCs can reduce VEGF-A and HIF-1αin ROP model *** staining shows that the number of retinal neovascularization in ROP mice decreases with the increase of the dose of hUCMSCs ***:In a hypoxia induced

关键词： human umbilical cord mesenchymal stem cells retinal astrocytes retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of Xianglian pill for antibiotic-associated diarrhea: a protocol for systematic review and meta-analysis

引用

Traditional Medicine Research 2021年第5期6卷 27-32页

作者： Xin Zhou Rui Gao xiao-bo zhang Tao Shen Kun-He Xu School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Antibiotic-associated diarrhea is a clinical common symptom of antibiotics overuse and occurs in 5%-70%of *** pill has been traditionally considered as an efficient treatment of diarrhea and gastrointestinal diseases for thousands of ***,no systematic review and meta-analyses have focused on its positive ***,this protocol for systematic review and meta-analysis was developed to evaluate the effect and clinical safety of Xianglian pill on treating antibiotic-associated ***:All randomized controlled trials published in Chinese and English and assessed use of Xianglian pill for antibiotic-associated diarrhea will be *** of PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Chinese Biomedical Literature,Wanfang,and Chinese Science and Technology Periodical Database will be searched for randomized controlled trials from their inception until November 16,*** outcomes will be the incidence of diarrhea and adverse events,and secondary outcomes will be bowel movements and microbiome *** authors will extract data and assess the risk of bias *** ratio will be used to evaluate the results,and meta-analyses will be conducted using STATA 15.0 *** review aims to demonstrate the effectiveness of Xianglian pill in the prevention and treatment of antibiotic-associated diarrhea.

关键词： protocol Xianglian pill Chinese herbal antibiotic-associated diarrhea systematic review traditional Chinese medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-temperature oxidation resistance of Si-coated C/SiC composites

引用

Rare Metals 2024年第9期43卷 4566-4572页

作者： Jie xiao Hua-Yue zhang Sheng-Kai Gong Hui-Bin Xu Hong-bo Guo School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structure Materials and Protective Coatings(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China

In this paper,Si coatings were sprayed onto C/SiC composite substrates by atmospheric plasma spraying(APS).The high-temperature oxidation behavior of the substrate and coating at temperatures of 1100 and 1300℃was also *** C/SiC ceramic matrix composite will be damaged seriously and even failed due to the oxidation of carbon fibers in *** Si coating effectively improved the oxidation resistance of the C/SiC substrate in the high-temperature oxidation *** effect of the thickness of the Si coatings on the oxidation resistance was *** 150-μm coating is proved to enable the substrate to have the lowest oxidation weight loss and the best oxidation resistance after static oxidation for 5 h.

关键词： Ceramic matrix composites(CMCs) Carbon fiber Si coating Oxidation Plasma spray

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the Effect of Ginaton on Reducing Cerebral Vasospasm and Early Brain Injury after Hemorrhagic Stroke by Inhibiting Inflammatory Response

引用

World Journal of Traditional Chinese Medicine 2024年第1期10卷 33-39页

作者： Xue-bo Pang xiao-Lin zhang Mei-Rong Wang Ying Yuan xiao zhang Department of Neurology Xingtai Third HospitalXingtaiChina

Objective:The objective of this study was to investigate the effects and possible mechanisms of action of ginseng on cerebral vasospasm and early brain injury(EBI)following hemorrhagic *** and Methods:Sprague-Dawley(SD)rats(n=48)were randomly divided into sham operation(sham group),subarachnoid hemorrhage(SAH)model(SAH group),normal saline(NS group),and Ginaton(Extract of Ginkgo Biloba Leaves Drops)intervention(gin group)***-1 m RNA and tumor necrosis factor levels were detected using reverse transcription-polymerase chain *** relative expression of m RNA was detected by Western ***:(1)Compared with the sham group,the SAH,NS,and gin groups had different degrees of neurological *** with the SAH and NS groups,the neurological deficits in the gin group were significantly improved(P<0.05).(2)Compared with the sham group,the relative expression levels of MCP-1 m RNA in the SAH,NS,and gin groups were 5.1±0.9,3.4±0.6,and 2.5±0.4,respectively;the relative expression levels of m RNA were 13.3±2.4,11.2±1.8,and 3.8±0.6,respectively.(3)The apoptosis rates of brain tissue in the sham,SAH,NS,and gin groups were 4.8±0.7,54.2±10.3,50.1±7.4,and 28.4±4.5,respectively.(4)Western blot showed that the relative expression levels of toll-like receptor-4(TLR-4)protein in the sham,SAH,NS,and gin groups were 0.29±0.03,0.87±0.15,0.65±0.13,and 0.41±0.17,respectively;the relative expression levels of B protein were 0.21±0.04,0.96±0.14,0.73±0.18,and 0.30±0.05,*** treatment could inhibit TLR-4 and nuclear factor-κB(NF-κB)protein ***:Dona tablets may inhibit activation of the NF-κB signaling pathway,and SAH-induced inflammatory response,so as to reduce cerebral vasospasm and EBI.

关键词： Cerebral hemorrhage early brain injury ginaton neurological deficit nuclear factor-κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiperiod optimization of cooling water system with flexible topology network

引用

Green Chemical Engineering 2024年第4期5卷 461-472页

作者： bo Liu Ruimei zhang Ye Liu Yufei Wang Ali Almansoori xiao Feng School of Chemical Engineering and Environment China University of Petroleum Department of Chemical Engineering Khalifa University of Science and Technology CHN Energy Xinjiang Chemical Co.LTD School of Chemical Engineering & Technology Xi'an Jiaotong University

Cooling water systems(CWSs) are extensively utilized in various industries to eliminate the excess heat and converse energy. Studies on CWSs mainly concentrated on finding the optimal cooler network structure. In addition, some works also considered the optimal design under varied operation conditions. However, in these works, once the optimal design of the cooler's network is determined, its arrangement remains fixed and cannot be adapted to accommodate diverse operating conditions. In this work, a flexible topology network concept is proposed to make the adjustment of network structure possible under different operation conditions. The CWS with integrated air cooler and flexible topology network has better overall performance, represented by a mixed integer nonlinear programming(MINLP) model that require advanced tools such as GAMS software. Case studies revealed that the proposed methodology can realize better energy-saving performance, and improve the economic performance under varied operation conditions. The impact of critical flexible nodes on system configuration and economy is achieved by sensitivity analysis.

关键词： Cooling water systems Flexible network Multiperiod optimization Air cooler

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Strategies for children’s hospital in response to COVID-19 pandemic: perspective and practice at a designated pediatric hospital in Shanghai, China

引用

World Journal of Pediatrics 2020年第6期16卷 556-559页

作者： xiao-bo zhang xiao-Jing Hu xiao-Wen Zhai Ying Gu Lin Yuan Peng Shi xiao-Lin Ge Gong-Bao Liu •Guo-Mei Shen Chuan-Qing Wang Ai-Mei Xia Mei Zeng Guo-Ying Huang Children's Hospital of Fudan University 399 Wan Yuan Road.Shanghai 201102China Shanghai Key Laboratory of Birth Defects ShanghaiChina

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a global pandemic[1-5].As of July 31,2020,there were 17,106,007 infected patients and 668,910 deaths worldwide[6,7].National protocols regarding COVID-19 issued by national-level agencies need to be revised in the field of pediatrics[8].From the perspective of hospital management,identitication and set-up of isolation wards and clinics,modification of workflow and processes,management of staff,allocation of medical resources,and formulation of clinical guidelines and protocols in infection prevention and control(IPC)were addressed as response measures to reduce the risk of transmission to healthcare workers and patients[9].In this paper we describe the strategies and practices implemented at the Children's Hospital of Fudan University in response to this public health *** strategy of response measures is shown in Supplementary Fig.1.

关键词： prevention measures formulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Uterine Artery Embolization for Management of Primary Postpartum Hemorrhage Associated with Placenta Accreta

引用

Chinese Medical Sciences Journal 2016年第4期31卷 228-232页

作者： Zhi-wei Wang xiao-guang Li Jie Pan xiao-bo zhang Hai-feng Shi Ning Yang Zheng-yu Jin Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate the efficacy and safety of uterine artery embolization(UAE) in the management of primary postpartum hemorrhage associated with placenta accreta. Methods We retrospectively reviewed the medical records of patients with placenta accreta between January 2010 and August 2014. Totally 18 women(mean age 30.8±4.2 years) of primary massive postpartum hemorrhage with diagnosis of placenta accrete received treatment of UAE after delivery. Images of DSA and medical records were reviewed. Technical success was defined as control of bleeding after embolization. The complications, control of hemorrhage and recurrent bleeding of the placenta left inside the uterus were retrospectively collected for assessment. Results All patients underwent transcatheter embolization of bilateral uterine arteries. The technical success rate of embolization was 100%. Bleeding was controlled in 17 of 18 patients(94%) during follow-up period(median 18 months, 3-31months) without further bleeding recurred. One patient with placenta percreta undertook an emergent hysterectomy along with surgical bladder repair after UAE because of persistent uterine bleeding. Eight patients had postembolization syndrome and no other complications occurred. Conclusion Uterine artery embolization is an effective and safe treatment for the management of primary postpartum massive hemorrhage associated with placenta accreta.

关键词： uterine artery embolization postpartum hemorrhage placenta accrete

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single base substitution in Os CDC48 is responsible for premature senescence and death phenotype in rice

引用

Journal of Integrative Plant Biology 2016年第1期58卷 12-28页

作者： Qi-Na Huang Yong-Feng Shi xiao-bo zhang Li-Xin Song Bao-Hua Feng Hui-Mei Wang Xia Xu xiao-Hong Li Dan Guo Jian-Li Wu State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China School of Life Sciences Hebei Normal University Shijiazhuang 050024 China

A premature senescence and death 128 （psd128） mutant was isolated from an ethyl methane sulfonate-induced rice IR64 mutant bank. The premature senescence phenotype appeared at the six-leaf stage and the plant died at the early heading stage, psd128 exhibited impaired chloroplast develop- ment with significantly reduced photosynthetic ability, chlorophyll and carotenoid contents, root vigor, soluble protein content and increased malonaldehyde content. Furthermore, the expression of senescence-related genes was significantly altered in psd128. The mutant trait was controlled by a single recessive nuclear gene. Using map- based strategy, the mutation Oryza sativa cell division cycle 48 （OsCDC48） was isolated and predicted to encode a putative AAA-type ATPase with 809 amino-acid residuals. A single base substitution at position C2347T in psd128 resulted in a premature stop codon. Functional complementation could rescue the mutant phenotype. In addition, RNA interference resulted in the premature senescence and death phenotype. OsCDC48 was expressed constitutively in the root, stem, leaf and panicle. Subcellular analysis indicated that OsCDC48：YFP fusion proteins were located both in the cytoplasm and nucleus. OsCDC48 was highly conserved with more than 90% identity in the protein levels among plant species. Our results indicated that the impaired function of OsCDC48 was responsible for the premature senescence and death phenotype.

关键词： Oryza sativa premature senescence and death AAA-ATPase OsCDC48

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Plastic Deformation on Microstructure and Properties of Cu-(1 wt%-6 wt%) Ag Alloy

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 747-753页

作者：茹亚东 zhang Zhongyuan 高召顺 zhang Ling ZUO Tingting XUE Jiangli TANG Zhixiang DA bo LIU Yongsheng xiao Liye Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Physics Shanghai University of Electric PowerShanghai 201306China University of Chinese Academy of Sciences Beijing 100190China International Joint Labora-tory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Research and Services Division of Materials Data and Integrated System National Institute for Materials ScienceTsukuba 305-0047Japan

In the present study,the Cu-(1 wt%-6 wt%)Ag alloys were prepared by melting,forging and wire *** effects of plastic deformation on microstructure evolution and properties of the alloys were *** results show that non-equilibrium eutectic colonies exist in the Cu-(3 wt%-6 wt%)Ag alloy and no eutectic colonies in the 1 wt%-2 wt%Ag containing *** eutectic colonies are aligned along the drawing direction and refined with the increase of draw *** to the refinement of eutectic colonies,the Cu-Ag alloy exhibits higher strength with the increase of draw *** Cu-6Ag alloy exhibits excellent comprehensive properties with a strength of 930 MPa and a conductivity of 82%IACS when the draw ratio reaches 5.7.

关键词： Cu-Ag alloy high strength and high conductivity microstructure eutectic structure strengthening mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficient second and third harmonic generation in dual-layer lithium niobate microdisk resonator

引用

Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 33-38页

作者： Zhenzhong Hao xiao Wu Qiang Luo zhang Li Rui Ma Fang bo Feng Gao Guoquan zhang Jingjun Xu MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China

Lithium niobate thin film frequency doubler has extensive applications in the preparation of classical and quantum *** this study,we successfully fabricated microdisk resonators with a quality factor of 2.2×10^(5) in reverse-polarization dual-layer x-cut lithium niobate for the first *** on the modal phase matching condition,efficient second harmonic generation with a record normalized conversion efficiency of~56000%W-1 and cascaded third harmonic generation with an efficiency of~6500%W-2 were obtained in the microdisk *** with the periodically poled lithium niobate microcavity,the complex domain structure preparation processes are *** work provides a scheme for achieving highly efficient second-order nonlinear effects in non-periodically poled microcavities.

关键词： harmonic lithium niobate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：