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Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation

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Neural Regeneration Research 2020年第7期15卷 1333-1339页

作者： Shan-Shan Cui xiao-bo feng Bing-Hong Zhang Zhong-Yuan Xia Li-Ying Zhan Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology Zhongnan Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Glucagon-like peptide-1 receptor has anti-apoptotic,anti-inflammatory,and neuroprotective *** is now recognized that the occurrence and development of chronic pain are strongly associated with anti-inflammatory responses;however,it is not clear whether glucagon-like peptide-1 receptor regulates chronic pain via anti-inflammatory *** explored the effects of glucagon-like peptide-1 receptor on nociception,cognition,and neuroinflammation in chronic pain.A rat model of chronic pain was established using left L5 spinal nerve *** glucagon-like peptide-1 receptor agonist exendin-4 was intrathecally injected into rats from 10 to 21 days after spinal nerve *** examinations showed that,after treatment with exendin-4,paw withdrawal frequency of the left limb was significantly reduced,and pain was *** addition,in the Morris water maze test,escape latency increased and the time to reach the platform decreased following exendin-4 *** staining and western blot assays revealed an increase in the numbers of activated microglia and astrocytes in the dentate gyrus of rat hippocampus,as well as an increase in the expression of tumor necrosis factor alpha,interleukin 1 beta,and interleukin *** of these effects could be reversed by exendin-4 *** findings suggest that exendin-4 can alleviate pain-induced neuroinflammatory responses and promote the recovery of cognitive function via the glucagon-like peptide-1 receptor *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Renmin Hospital of Wuhan University of China(approval *** 20171214)on September 22,2017.

关键词： astrocyte chronic pain cognitive impairment exendin-4 hippocampal dentate gyrus microglia Morris water maze neuroinflammation spinal nerve ligation

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Effect of Nalmefene on Delayed Neurocognitive Recovery in Elderly Patients Undergoing Video-assisted Thoracic Surgery with One Lung Ventilation

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Current Medical Science 2020年第2期40卷 380-388页

作者： Meng-yun LI Chao CHEN Zheng gang WANG Jian-juan KE xiao-bo feng Department of Anesthesiology Zhongnan HospitalWuhan UniversiryWuhan 430071China

The intravenous use of nalmefene has been found to exert neuroprotective effect in patients with severe traumatic brain injury and acute cerebral infarction;nonetheless,it is unknown whether nalmefene alleviates delayed neurocognitive *** purpose of the current research was to clarify the impact of nalmefene on delayed neurocognitive recovery in aged patients experiencing video-assisted thoracic surgery(VATS)with intraoperative use of one lung ventilation(OLV).The present study involved 120 paticents undergoing selective VATS,randomized to accept low-dose nalmefene(N1 group,n=40),high-dose nalmefene(N2 group,1n=40)or equal volume of physiologic saline(control group,1=40).A battery of neuropsychological tests were used to estimate cognitive function I day before surgery(o)and 10 days after surgery or before discharge(t).Regional cerebral oxygen saturation(rSO2)was detected 5 min before induction(t),5 min after induction(1),15 and 60 min after onset of OLV(62 and 13),and 15 min after termination of OLV(4).The plasma values of interleukin(IL)-1β,IL-6,tumor necrosis factor(TNF)-a1 and adiponectin(ADP)were also detected prior to induction of anesthesia(T0),1 h,2 h and 6 h after surgery(TI,T2,T3).On 1,delayed neurocognitive recovery occurred in 5/40(12.5%)patients of NI group,in 5/40(12.5%)patients of N2 group and in 13/40(32.5%)patients of control group(PNl group>control group(P<0.05).The result of our present research supports the hypothesis that the perioperative intravenous t

关键词： nalmefene one lung ventilation elderly patients delayed neurocognitive recovery perioperative neurocognitive disorders thoracic surgery

Role of intestinal flora imbalance in pathogenesis of pouchitis

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 764-768页

作者： xiao-bo feng Jun Jiang Min Li Gang Wang Jin-Wei You Jian Zuo 34th District of Forensic Sursery Nanjing General Hospital of Nanjing Military Command State Key Laboratory of Infectious Disease Diagnosis and Treatment First Affiliated Hospital of Medical School of Zhejiang University

Objective: To discuss the role of intestinal flora imbalance in the pathogenesis of pouchitis. Methods: The puochitis rat model was established and the faeces sample and the mucous membrane sample were collected regularly, in which the bacterial nucleic acids were extracted for quantitative analysis of the intestinal flora in the samples through using the real-time quantitative PCR technique and high energy sequencing technology. Results: The disorder phenomenon of the intestinal flora appeared at the 7th day of the experiment, and the pouchitis was presented at the 21 th day of the experiment. At the 31 th day of the experiment, compared to control group and non-pouchitis group, the quantity of Bifidobacterium and the Lactobacillusof the pouchitis model rats in the mucous membrane sample and the faeces sample were significantly decreased(P<0.05), and the Bacteroidetes, Faecalibacterium prausnitzii and 桛 Clostridium leptum subgroup in the mucous membrane of pouchitis were significantly decreased(P<0.05). The Clostridium coccoides group was the main flora in the mucous membrane of pouchitis, the bacterial diversity of non-puochitis group and control group was significantly higher than that of the puochitis group(P<0.05). Conclusions: The intestinal flora imbalance is one of the factors that cause the incidence of the pouhitis; this study provides a clue of the pathogenesis and treatment direction of the intestinal inflammatory disease.

关键词： Intestinal flora Pouchitis Bifidobacterium Lactobacillus Bacteroid

Robotic gastrectomy with transvaginal specimen extraction for female gastric cancer patients

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World Journal of Gastroenterology 2015年第47期21卷 13332-13338页

作者： Shu Zhang Zhi-Wei Jiang Gang Wang xiao-bo feng Jiang Liu Jian Zhao Jie-Shou Li Department of General Surgery Jinling Hospital Medical School Nanjing University

AIM: To describe the application of complete robotic gastrectomy with transvaginal specimen extraction(TVSE) for gastric cancer ***: Between July and November 2014, eight female patients who were diagnosed with gastric adenocarcinoma underwent a TVSE following a full robot-sewn gastrectomy. According to the tumor location, the patients were allocated to two different groups; two patients received robotic total gastrectomy with TVSE and the other six received robotic distal gastrectomy with ***: Surgical procedures were successfully performed in all eight cases without conversion. The mean age was 55.3(range, 42-69) years, and the mean body mass index was 23.2(range, 21.6-26.0) kg/m2. The mean total operative time and blood loss were 224(range, 200-298) min and 62.5(range, 50-150) m L, respectively. The mean postoperative hospital stay was 3.6(range, 3-5) d. The mean number of lymph nodes resected was 23.6(range, 17-27). None was readmitted within 30 d of postoperation. During the follow-up, no stricture developed nor was any anastomotic leakage ***: It is possible to perform a TVSE following a full robot-sewn gastrectomy with standard D2 lymph node resection for female gastric cancer patients.

关键词： Gastric cancer Robotic surgery Transvaginal Natural orifice specimen extraction

Application of Virtual Reality Technology in Disaster Medicine

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Current Medical Science 2019年第5期39卷 690-693页

作者： Yu-yu DUAN Jia-yao ZHANG Mao XIE xiao-bo feng Song XU Zhe-wei YE The Clinical School of Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The occurrence of major emergencies often leads to environmental damage,property damage,health challenges and life *** the tremendous progress we have made in responding to the many challenges posed by disasters in recent years,there are still many *** an emerging technology widely used in recent years,virtual reality(VR)technology is very suitable for many fields of disaster medicine,such as basic education,professional training,psychotherapy,*** purpose of this review article is to introduce the application of VR technology in the disaster medical field and prospect its trend in the future.

关键词： virtual reality disaster medicine education psychotherapy

Application and Prospect of Mixed Reality Technology in Medical Field

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Current Medical Science 2019年第1期39卷 1-6页

作者： Hong-zhi HU xiao-bo feng Zeng-wu SHAO Mao XIE Song XU Xing-huo WU Zhe-wei YE Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Mixed reality(MR)technology is a new digital holographic image technology,which appears in the field of graphics after virtual reality(VR)and augmented reality(AR)technology,a new interdisciplinary *** a new generation of technology,MR has attracted great attention of clinicians in recent *** emergence of MR will bring about revolutionary changes in medical education training,medical research,medical communication,and clinical *** present,MR technology has become the popular frontline information technology for medical *** the popularization of digital technology in the medical field,the development prospects of MR are *** purpose of this review article is to introduce the application of MR technology in the medical field and prospect its trend in the future.

关键词： mixed reality augmented reality virtual reality education surgery

Effects of Lipoxin A4 Pretreatment on Cognitive Function of Aged Rats after Global Cerebral Ischemia Reperfusion

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Current Medical Science 2018年第4期38卷 666-671页

作者： Hui-sheng WU Pei-pei GUO Zhao JIN Xin-yi LI Xin YANG Jan-juan KE Yan-lin WANG xiao-bo feng Department of Anesthesiology Zhongnan Hospital Wuhan University Wuhan 430071 China

The aim of the present study was to investigate the effect of lipoxin A4 （LXA4） pretreatment on cognitive function of aged rats after global cerebral ischemia reperfusion, and to explore its possible mechanism. Thirty-six aged male Sprague-Dawley rats were randomly divided into three groups （n=12 each）： sham-operation group （S group）, global cerebral ischemia reperfusion group （I/R group） and LXA4-pretreatment group （L group）. The rat model of global cerebral ischemia reperfusion was established by occlusion of the bilateral common carotid artery with hypotension. The cognitive function of rats was determined by a step-down type passive avoidance test and Morris Water Maze test on the third day after reperfusion. Rats were sacrificed after Water Maze test and the pathological changes ofhippocampal CA1 region were observed and the related inflammatory mediators were determined. As compared with S group, the escape latency in I/R group was prolonged from the first day to the fifth day, while that in L group was prolonged from the first day to the third day. The retention time in I/R group and L group in the first quadrant was shortened. The reaction time, frequency of reaction mistake and frequency of escape mistake in I/R group increased, and the latent period shortened. The frequency of escape mistake in L group increased, and the damage in the hippocampal CAI region of I/R group and L group was obvious. The levels of S-10013, TNF-α, IL-1β, IL-10 and NF-κB in I/R group and L group increased. As compared with I/R group, the escape latency in L group was shortened from the first day to the fifth day, and the retention time in the first quadrant prolonged. The reaction time, frequency of reaction mistake and frequency of escape mistake in L group decreased, and the latent period prolonged. The damage in the hippocampal CA1 region of L group was alleviated as well. The levels of S-10013, TNF-α, IL-1β and NF-κB in L group decreased, and those of IL-10 increased. It can b

关键词： lipoxin cerebral ischemia reperfusion pretreatment cognitive function

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye xiao-feng Yang Jia-Jia Zhang Hong-bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

The Hilbert expansion of the boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期68卷 39-88页

作者： Feimin Huang Weiqiang Wang Yong Wang feng xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

关键词： boltzmann equation incompressible Euler equations hydrodynamic limit Hilbert expansion specular reflection boundary condition viscous boundary layer Knudsen boundary layer