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Construction of a nomogram model to predict technical difficulty in performing laparoscopic sphincter-preserving radical resection for rectal cancer

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World Journal of Gastroenterology 2024年第18期30卷 2418-2439页

作者： xiao-Cong Zhou Shi-Wei guan Fei-yue Ke Gaurav Dhamija Qiang Wang Bang-Fei Chen Medical University(Wenzhou Central Hospital) Wenzhou 325000Zhejiang ProvinceChina Department of Hepatobiliary Surgery The Dingli Clinical Institute of Wenzhou Medical University(Wenzhou Central Hospital)Wenzhou 325000Zhejiang ProvinceChina Postgraduate Training Base Alliance of Wenzhou Medical University Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina School of International Studies Wenzhou Medical UniversityWenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina Department of Radiology The Dingli Clinical Institute of Wenzhou Medical University(Wenzhou Central Hospital)Wenzhou 325000Zhejiang ProvinceChina Department of Colorectal Surgery The Affiliated Zhejiang HospitalZhejiang University School of Medicine(Zhejiang Hospital)Hangzhou 310000Zhejiang ProvinceChina

BACKGROUND Colorectal surgeons are well aware that performing surgery for rectal cancer becomes more challenging in obese patients with narrow and deep pelvic cavities.Therefore,it is essential for colorectal surgeons to have a comprehensive understanding of pelvic structure prior to surgery and anticipate potential surgical difficulties.AIM To evaluate predictive parameters for technical challenges encountered during laparoscopic radical sphincter-preserving surgery for rectal cancer.METHODS We retrospectively gathered data from 162 consecutive patients who underwent laparoscopic radical sphincterpreserving surgery for rectal cancer.Three-dimensional reconstruction of pelvic bone and soft tissue parameters was conducted using computed tomography(CT)scans.Operative difficulty was categorized as either high or low,and multivariate logistic regression analysis was employed to identify predictors of operative difficulty,ultimately creating a nomogram.RESULTS Out of 162 patients,21(13.0%)were classified in the high surgical difficulty group,while 141(87.0%)were in the low surgical difficulty group.Multivariate logistic regression analysis showed that the surgical approach using laparoscopic intersphincteric dissection,intraoperative preventive ostomy,and the sacrococcygeal distance were independent risk factors for highly difficult laparoscopic radical sphincter-sparing surgery for rectal cancer(P<0.05).Conversely,the anterior-posterior diameter of pelvic inlet/sacrococcygeal distance was identified as a protective factor(P<0.05).A nomogram was subsequently constructed,demonstrating good predictive accuracy(C-index=0.834).CONCLUSION The surgical approach,intraoperative preventive ostomy,the sacrococcygeal distance,and the anterior-posterior diameter of pelvic inlet/sacrococcygeal distance could help to predict the difficulty of laparoscopic radical sphincter-preserving surgery.

关键词： Nomogram Rectal cancer Laparoscopic operation Sphincter-preserving surgery Technical difficulty

Roles and application of exosomes in the development,diagnosis and treatment of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 630-642页

作者： xiao-Li guan xiao-Ying guan Zheng-Yi Zhang Department of General Medicine The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Pathology The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and progression of gas-tric cancer(GC)by regulating the growth and proliferation of tumor cells,the tumor-related immune response and tumor angiogenesis.Exosomes transport bioactive molecules including DNA,proteins,and RNA(coding and noncoding)from donor cells to recipient cells,causing reprogramming of the target cells.In this review,we will describe how exosomes regulate the cellular immune respon-se,tumor angiogenesis,proliferation and metastasis of GC cells,and the role and mechanism of exosome-based therapy in human cancer.We will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treat-ment of GC and their relationship with drug resistance.

关键词： Exosomes Gastric cancer Immune regulation Diagnosis Cancer therapy

Target parameter estimation for OTFS-integrated radar and communications based on sparse reconstruction preprocessing

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 742-754页

作者： Zhenkai ZHANG xiaoke SHANG yue xiao Ocean College Jiangsu University of Science and TechnologyZhenjiang 212003China

Orthogonal time-frequency space(OTFS)is a new modulation technique proposed in recent years for high Doppler wireless scenes.To solve the parameter estimation problem of the OTFS-integrated radar and communications system,we propose a parameter estimation method based on sparse reconstruction preprocessing to reduce the computational effort of the traditional weighted subspace fitting(WSF)algorithm.First,an OTFS-integrated echo signal model is constructed.Then,the echo signal is transformed to the time domain to separate the target angle from the range,and the range and angle of the detected target are coarsely estimated by using the sparse reconstruction algorithm.Finally,the WSF algorithm is used to refine the search with the coarse estimate at the center to obtain an accurate estimate.The simulations demonstrate the effectiveness and superiority of the proposed parameterestimation algorithm.

关键词： Integrated radar and communications system Orthogonal time-frequency space Target parameter estimation Sparse reconstruction Weighted subspace fitting

A GMDA clustering algorithm based on evidential reasoning architecture

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG Xin guan xiao YI Shuangming LI Guidong SUN Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-EC)is proposed.First,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is extended.Then,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the target.Finally,the performance of the algorithm is verified by the synthetic dataset and the measured dataset.The experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model

Analysis of China's Electricity Price and Electricity Burden of Basic Industries under the Carbon Peak Target before 2030

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 481-491页

作者： yue Qiu Suyang Zhou Wei Gu xiao-Ping Zhang School of Electrical Engineering Southeast UniversityNanjingChina School of Electronic Electrical and System EngineeringUniversity of BirminghamU.K.

The Chinese government is deepening reformation of electricity prices during the 14th Five Year Plan period and has set a carbon emission reduction target of reaching carbon peak before 2030.In this context,will the carbon emission target influence electricity pricing and will electricity price influence competitiveness of Chinese main industries are two questions needing to be answered.This paper compares China's electricity price level with the selected major countries in the world,and four typical industries are selected to evaluate their electricity burden respectively.Then,the correlation between residential electricity price and industrial electricity price and the influencing factors is analyzed,from the perspectives of scale,structure and technology.According to the model obtained by regression analysis,the electricity price level and corresponding residential and industrial electricity burden in 2025 and 2030 are forecasted.Index Terms-Electricity burden,industrial electricity price,regression analysis,residential electricity price.

关键词： Electricity burden industrial electricity price regression analysis residential electricity price

Attention Markets of Blockchain-Based Decentralized Autonomous Organizations

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1370-1380页

作者： Juanjuan Li Rui Qin Sangtian guan Wenwen Ding Fei Lin Fei-yue Wang State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China IEEE

The attention is a scarce resource in decentralized autonomous organizations(DAOs),as their self-governance relies heavily on the attention-intensive decision-making process of“proposal and voting”.To prevent the negative effects of pro-posers’attention-capturing strategies that contribute to the“tragedy of the commons”and ensure an efficient distribution of attention among multiple proposals,it is necessary to establish a market-driven allocation scheme for DAOs’attention.First,the Harberger tax-based attention markets are designed to facilitate its allocation via continuous and automated trading,where the individualized Harberger tax rate(HTR)determined by the pro-posers’reputation is adopted.Then,the Stackelberg game model is formulated in these markets,casting attention to owners in the role of leaders and other competitive proposers as followers.Its equilibrium trading strategies are also discussed to unravel the intricate dynamics of attention pricing.Moreover,utilizing the single-round Stackelberg game as an illustrative example,the existence of Nash equilibrium trading strategies is demonstrated.Finally,the impact of individualized HTR on trading strategies is investigated,and results suggest that it has a negative correlation with leaders’self-accessed prices and ownership duration,but its effect on their revenues varies under different conditions.This study is expected to provide valuable insights into leveraging attention resources to improve DAOs’governance and decision-making process.

关键词： Attention decentralized autonomous organizations Harberger tax Stackelberg game.

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG yue xiao Yan-wei MA Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and migration.Methods:HaCaT cells were treated with HSYA.Cell proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration assay.The mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,respectively.Circ_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with HSYA.The expression of circ_0084443 was detected by qRT-PCR.Results:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative regulator circ_0084443.

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Design and Implementation of Nonlinear Precoding for MIMO-SDMA Toward 6G Wireless

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China Communications 2024年第1期21卷 69-87页

作者： Chaowu Wu yue xiao Shu Fang Gang Wu National Key Laboratory of Wireless Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G wireless.Our approach aims to effectively mitigate the impact of imperfect channel estimation by leveraging the channel fluctuation mean square error(MSE)for reconstructing a highly accurate precoding matrix at the transmitter.Furthermore,we introduce a simplified receiver structure that eliminates the need for equalization,resulting in reduced interference and notable enhancements in overall system performance.We conduct both computer simulations and experimental tests to validate the efficacy of our proposed approach.The results reveals that the proposed NLP scheme offers significant performance improvements,making it particularly well-suited for the forthcoming 6G wireless.

关键词： MIMO-SDMA nonlinear precoding Tomlinson-Harashima precoding(THP) vector perturbation(VP)

Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect

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Defence Technology（防务技术） 2024年第2期32卷 572-595页

作者： yue Wang Fuping Sun Xian Wang Jinming Hao Kai xiao School of Geospatial Information The PLA Information Engineering UniversityZhengzhou 450001HenanChina

This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.

关键词： Jamming effect Multiple interference sources Collaborative deployment Effect evaluation Defense capability