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Total Synthesis of (±)-Inophyllum B

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Chinese Chemical Letters 2002年第8期13卷 714-716页

作者： Qi GAO Lin WANG xiao tian liang Institulc of Matcria Mcdica Pcking Union Medical College&Chinese Acadcmy of Medical SciencesBeiing100050

?-Inophyllum B has been synthesized for the first time by a five-step approach from phloroglucinol, including the Pechmann reaction, Friedel-Crafts acylation, cyclization, chromenylation and Luche reduction

关键词： (±)-Inophyllum B Anti-HIV-1 activity

A Convergent Route for the Synthesis of AF-5

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Chinese Chemical Letters 2003年第7期14卷 670-672页

作者： Da Li YIN Ji Yu GUO xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

AF-5 was synthesized through a convergent method. The key step was the Robinson annulation using a key intermediate pentyl vinyl ketone.

关键词： AF-5 synthesis Robinson annulation.

Two Phenanthroindolizidine Alkaloids from Tylophora atrofolliculata

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Chinese Chemical Letters 2002年第1期13卷 61-64页

作者： Xue Shi HUANG Shi Shan YU xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Two alkaloids tylophoridicine D (1) and tylophoridicine E (2) have been isolated from Tylophora atrofolliculata. The structures of the compounds were elucidated on the basis of spect -roscopic analysis.

关键词： Tylophora atrofolliculata tylophoridicine D tylophoridicine E phenanthroindoli-zidine alkaloid.

Studies on Agarofurans VI. The Introduction of Substituents to C-1 and C-2 Positions of Agarofurans

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Chinese Chemical Letters 2000年第10期11卷 873-874页

作者： Wu Yan ZHANG Ji Yu GUO xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

Agarofuranoids with oxygen functions at C-1 and C-2 were synthesized by allylic oxidation. Ketone 2 gave compound 8 and 9 by Grignard reaction. The configuration of C-2 in 8 and 9 were identified by the CD spectroscop... 详细信息

关键词： agarofuran synthesis

Synthesis of 14-Bromo and 14-Hydroxy Baccatin III Derviatives

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Chinese Chemical Letters 2001年第8期12卷 675-678页

作者： Wei Shuo FANG Qi Cheng FANG xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College1 Xian Nong Tan StreetBeijing 100050

Several 14 alpha- and 14 beta -bromo baccatin III derivatives were synthesized by direct bromination and from silyl enol ether of 13-oxo-7-TES-baccatin III. 14 beta -Hyroxy baccatin III derivative was also obtained fr... 详细信息

关键词： Bromo baccatin III 14-hydroxy baccatin III paclitaxel silyl enol ether

Studies on Agarofurans V. Studies on the Reductive Ring-Opening of 3,4-Epoxide of Agarofurans

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Chinese Chemical Letters 2000年第12期11卷 1041-1044页

作者： Wu Yan ZHANG Ji Yu GUO xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

Reduction of epoxides 1, 2, 3 with LAH and LAH/AlCl3 has been studied. The products of reduction with LAH were controlled by Steric and stereoelectronic effects. The reduction with LAH/AlCl3 seemed to involve an inter... 详细信息

关键词： agarofuran synthesis

Study on the Ring Eulargment Reaction:Synthesis of 7,8,13,13a-tetrahydroisoindolo[1,2-b][3]benzazepine and 5,6,8,9,14,14a-hexahydroisoquino[1,2-b][3]benzazepine

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Chinese Chemical Letters 2001年第1期12卷 7-10页

作者： Yu Xin LIU xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical College 1 Xian NongTan StreetBeijing 100050

A new approach to the synthesis of 7,8,13,13a-tetrahydroisoindolo[1,2-b] [3]benzazepine 5 and 5,6,8,9,14,14a-hexahydroisoquino[1,2-b][3]benzazepine 9 and related compounds is described as using ring expansion of N-he... 详细信息

关键词： Isoindolo[1,2-b]benzazepines Isoquino[1,2-b]benzazepines Ring enlargement Synthesis

Studies on Agarofurans VIII. Synthesis of the Metabolites of 4-Butyl-a-agarofuran

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Chinese Chemical Letters 2002年第1期13卷 19-22页

作者： Chun Li Wu Yan Zhang Ji Yu Guo xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

The structures of five metabolites (2-6) of agarofuran 1 were confirmed by synthesis. The configuration of the secondary hydroxyl in 7 was determined by Horeau抯 method. The configuration of C-2 in compound 4 and 5 ... 详细信息

关键词： Agarofuran metabolite synthesis.

A Highly Regioselective Deacetylation of Taxanes

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Chinese Chemical Letters 2002年第6期13卷 501-504页

作者： Meng ZHANG Da Li YIN Ji Yu GUO xiao tian liang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

A highly regioselective O-deacetylation of taxanes at C-5 position was accomplished by treatment with t-BuOK and a possible mechanism was proposed.

关键词： Paclitaxel taxane deacetylation.