检索结果-南通市图书馆

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

引用

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu xiao-jiang hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new sesterterpenoid from the fruits of Phellodendron chinense *** Schneid

引用

Chinese Chemical Letters 2008年第8期19卷 937-939页

作者： Chen Yan Ye Wang xiao jiang hao The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002 China

A new sesterterpenoid phellogine was isolated from the fruits of Phellodendron chinense var. glabriusculum Schneid. Its structure was elucidated on the basis of spectral analysis.

关键词： Phellodendron chinense var. glabriusculum Schneid. Phellogine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Pregnane from Munronia delavayi Franc （Meliaceae）

引用

Journal of Integrative Plant Biology 2006年第9期48卷 1126-1128页

作者： Xiang-Hai Cai xiao-Dong Luo Jun Zhou xiao-jiang hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

To search for pharmacologically active constituents of folk medicine, a new pregnane, 2α,3α,15β-trihydroxy-20（S）-tigloyl-pregnane （compound 1）, and nine known compounds, geranylgeraniol （compound 2）, β-daucosterol （compound 3）, 6-hydroxystigmast-4oen-3-one （compound 4）, sitoindoside Ⅰ （compound 5）, sitoindoside Ⅱ （compound 6）, β-sitosterol （compound 7）, kaempferol （compound 8）, quercetin （compound 9）, and rutin （compound 10）, were isolated from the ethanol extract of whole plants of Munronia delavayi Franch using chromatographic methods. The structures of compounds 1-10 were elucidated on the basis of spectral data.

关键词： chemical constituents Meliaceae Munronia delavayi pregnane 2α,3α,15β-trihydroxy-20(S)-tigloyl-pregnane

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three New Coumarins from Micromelum integerrimum

引用

Chinese Chemical Letters 2001年第7期12卷 603-606页

作者： Hong Ping HE Yun ZOU Yue Mao SHEN xiao Yan hao Guo Yin ZUO xiao jiang hao Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Department of Medicinal Chemistry Guiyang Medical CollegeGuiyangGuizhou 550004 The Kcy Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002.

Three derivatives of micromelin, named hydramicromelins A-C (1-3), were isolated from the aerial part of Micromelum integerrimum (Buch.-Ham) Roem., respectively. Hydramicromelins A-C (1-3) were epimers which possessed the same plane structure and molecular formula. Their structures were elucidated based on MS and NMR data. The relative configurations of 1-3 were established by NOE analysis.

关键词： Micromelum integerrimum Rutaceae coumarin micromelin hydramicromelins A-C

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two new chalcones from Fordia cauliflora

引用

Chinese Chemical Letters 2010年第7期21卷 818-820页

作者： Zhi Yuan Liang xiao Sheng Yang Ye Wang xiao jiang hao Qian Yun Sun The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002China School of Chemistry and Life Science Guizhou Normal CollegeGuiyang 550003China

Two new chalcones,β,2′,4′,5′-tetramethoxychalcone 1,andβ,2′,5′-trimethoxyfurano[4″,5″：3′,4′]-chalcone 2 were obtainedfrom an ethyl acetate-soluble fraction of ethanol extract of the stem of Fordia *** chem... 详细信息

关键词： Fordia cauliflora Chalcone Chemical structures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Monoterpene Glycoside from Paeonia veitchii

引用

Chinese Chemical Letters 2002年第5期13卷 430-431页

作者： Shao Hua WU xiao Dong LUO Yun Bao MA xiao jiang hao Da Gang WU Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

A new monoterpene glycoside, acetoxypaeoniflorin, was isolated from the root cortex of Paeonia veitchii Lynch.. The structure was elucidated by spectral methods.

关键词： Paeonia veitchii Lynch Paeoniaceae monoterpene glycoside acetoxypaeoniflorin.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New 24, 30-Dinortriterpenoid from Paeonia delavayi

引用

Chinese Chemical Letters 2001年第4期12卷 345-346页

作者： Shao Hua WU xiao Dong LUO Yun Bao MA xiao jiang hao Da Gang WU Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

A new triterpenoid. 3 beta. 4 beta. 23-trihydroxy-24, 30-dinorolean-12. 20(29)-dien-28-oic acid. together with five known compounds. 2 alpha. 3 beta. 23-trihydroxy-12-oleanen-28-oic acid-beta -D-glucose glucopyranosyl ester. palbinone. 2-hydroxy-benzoic acid, vanillic acid. syringic acid. were isolated from the roots of Paeonia delavayi Franch. Their structures were characterized by spectral analysis.

关键词： Paeonia delavayi Franch. Paeoniaceae triterpenoid 3 beta,4 beta, 23-trihydroxy-24, 30-dinorolean-12,20(29)-dien-28-oic acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Cytotoxic Sinapyl Alcohol Derivatives fromLigularia nelumbifolia

引用

Chinese Chemical Letters 2002年第3期13卷 201-204页

作者： Yu Zhao Wei LU xiao jiang hao Jun Chao CAI Hong YU DepartmentofNaturalDrugResearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031

Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivative... 详细信息

关键词： Natural products cytotoxicity total synthesis SAR pharmaceutical chemistry sinapyl alcohol derivatives.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon

引用

Chinese Journal of Chemistry 2022年第4期40卷 475-479页

作者： Wen-Fang Yi Tiwalade A.Adelakun Xue Bai Yu Zhang xiao-jiang hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana *** structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD *** unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate *** 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.

关键词： Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kansuinine J,a new macrocyclic diterpenoid from the roots of Euphorbia kansui

引用

Chinese Chemical Letters 2010年第8期21卷 943-946页

作者： Jie Guo Xin Fang Ying Tong Di Hui Ming Hua xiao jiang hao Department of Natural Products Chemistry Shenyang Pharmaceutical University Shenyang 110016 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new macrocyclic diterpenoid,named kansuinine J（1）,was isolated from the roots of Euphorbia *** structure was characterized on the basis of spectroscopic analysis.

关键词： Euphorbia kansui Kansuinine J Macrocyclic diterpenoid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：