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Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones Through Asymmetric Lactone Hydrogenation

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CCS Chemistry 2024年第10期6卷 2560-2576页

作者： Xiong Wu Hai-Tao Yue xiao-Dong Zuo xiao-hui yang Pu-Cha Yan Jian-Hua Xie Qi-Lin Zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071 Zhejiang Jiuzhou Pharmaceutical Co. Ltd.TaizhouZhejiang 318000

Esters are abundant in natural and synthetic products and their conversion into primary alcohols holds great importance in fine chemical ***,achieving asymmetric hydrogenation(AH)of racemic esters with remote stereocenters via kinetic resolution(KR)remains a formidable challenge due to the difficulties associated with discerning spatially distant *** address this issue,we have designed a hydroxy-assisted strategy that introduces a hydroxy group into racemicβ-aryl esters to facilitate hydrogenation and enhance chiral discrimination through a lactone *** employing chiral Ir-SpiroPAP catalysts,we achieved exceptional AH of racemic 4-substituted chroman-2-ones,lactone form of ortho-hydroxylatedβ-aryl esters,via KR,resulting in impressive selectivity factor(s)values of up to *** approach exhibited significant efficacy for racemic chroman-2-ones containingβ-aryl,alkenyl,alkynyl,and alkyl groups,enabling the synthesis of chiralγ-aryl primary alcohols and the recovery of chiralβ-aryl esters or chroman-2-ones,typically difficult to access using existing *** scalability and broad synthetic applications of this method were exemplified by successfully synthesizing chiral drugs(R)-fesoterodine and enrasentan,alongside various chiral intermediates essential for producing chiral drugs and natural *** promising results highlight the potential of this approach as a powerful tool for synthesizing valuable chiral compounds.

关键词： asymmetric hydrogenation chiralγ-aryl primary alcohols hydrogenation of esters iridium catalysts kinetic resolution

Pathogenesis of primary biliary cholangitis

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Gastroenterology & Hepatology Research 2024年第3期6卷 7-9页

作者： Yong-Fang yang xiao-hui yang Rong-Ping Ye Wei Zhai School of Acupuncture Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Disease overview of primary biliary cholangitis(PBC).PBC is one of the main subgroups of chronic cholestatic liver *** 2015,the designation of PBC was changed from primary biliary cirrhosis to remove the“cirrhosis stigma”to more accurately reflect the disease and its natural course[1,2].PBC is a chronic cholestasis disease mediated by autoimmunity.

关键词： biliary cirrhosis cholangitis

The causes of adverse reactions in traditional Chinese medicine

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Toxicology Advances 2024年第1期6卷 1-2页

作者： Kai-Di Feng Yu-Jie Zeng xiao-hui yang Xin-Ju Li College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more *** occurrence of adverse drug reactions of traditional Chinese medicine will harm the health of patients,leading to a certain incidence rate and mortality rate,and serious adverse drug reactions of traditional Chinese medicine will lead to increased treatment costs of patients,bringing huge economic burden to patients and society[1-3].

关键词： mortality clinical bringing

All-parameters Rayleigh wave inversion

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 517-534页

作者： xiao-hui yang Ka-Veng Yuen State Key Laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China

Since S-wave velocity of the subsurface is an important parameter in near surface applications,many studies have been conducted for its *** the various methods that use surface waves or body waves,Rayleigh wave inversion is the most *** practice,the densities and P-wave velocities of different layers are usually assumed to be known to avoid ill-posed problems,as they have less influence on the dispersion ***,improper assignment of these two groups of parameters leads to inaccurate estimation of the S-wave velocity *** order to address this problem,the all-parameters Rayleigh wave inversion strategy is proposed in which the S-wave velocities,layer thicknesses,densities and P-wave velocities of different layers are included as the unknown parameters for ***,the transitional Markov Chain Monte Carlo(TMCMC)algorithm is applied for the implementation of all-parameters Rayleigh wave *** simulated example and two real-test applications are demonstrated to verify the capability of the proposed method in the estimation of the S-wave velocity profile,the densities and the P-wave ***,it is verified that the proposed method achieved more accurate S-wave velocity profile estimation than the traditional approach.

关键词： all-parameters Rayleigh wave inversion Bayesian S-wave velocity profile TMCMC algorithm uncertainty quantification

Bayesian Rayleigh wave inversion with an unknown number of layers

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Earthquake Engineering and Engineering Vibration 2020年第4期19卷 875-886页

作者： Ka-Veng Yuen xiao-hui yang State Key Laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of Macao999078MacaoChina

Surface wave methods have received much attention due to their efficient, flexible and convenient characteristics. However, there are still critical issues regarding a key step in surface wave inversion. In most existing methods, the number of layers is assumed to be known prior to the process of inversion. However, improper assignment of this parameter leads to erroneous inversion results. A Bayesian nonparametric method for Rayleigh wave inversion is proposed herein to address this problem. In this method, each model class represents a particular number of layers with unknown S-wave velocity and thickness of each layer. As a result, determination of the number of layers is equivalent to selection of the most applicable model class. Regarding each model class, the optimization search of S-wave velocity and thickness of each layer is implemented by using a genetic algorithm. Then, each model class is assessed in view of its efficiency under the Bayesian framework and the most efficient class is selected. Simulated and actual examples verify that the proposed Bayesian nonparametric approach is reliable and efficient for Rayleigh wave inversion, especially for its capability to determine the number of layers.

关键词： Bayesian model class selection generalized r/t coefficients algorithm genetic algorithm inversion of Rayleigh wave number of layers

Synthesis of substitutional hexaboride of lanthanum and cerium La_(1-x)Ce_(x)B_(6) via aluminothermic reduction

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Journal of Rare Earths 2023年第11期41卷 1780-1788,I0005页

作者： Yu Wang xiao-hui yang Jian Cui Guo-Hua Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China

Rare-earth hexaborides(REB_(6))are vital raw materials for cathode materials and high temperature structural ceramics that are widely applied as high-frequency electron tubes and ceramics adaptive for extreme environment,*** this work,single phase substitutional solid solution REB_(6)(LaB_(6),La_(0.75)Ce_(0.25)B_(6).La_(0.5)Ce_(0.5)B_(6),La_(0.25)Ce_(0.75)B_(6) and CeB_(6))powders were prepared with the raw materials of La_(2)O_(3),CeO_(2),B_(4)C and Al powders,after calcining at 1773 K for 4 h and the following alkaline *** substitutional solid solution products have homogeneous distributions of La and Ce in *** microscopic morphology analysis,it is discovered that the formation of solid solution is beneficial for reducing the particle size of product,relative to LaB_(6) and CeB_(6).Moreover,Al flux plays an important role in decarbonizing reaction,and C contents of all products are below 0.4 wt%.

关键词： Hexaboride Substitutional solid solution Aluminothermic reduction Rare earths

A rotary ultrasonic motor using radial bending mode of ring with nested PZT excitation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第3期13卷 189-196页

作者： Ying-xiang LIU Jun-kao LIU Wei-shan CHEN xiao-hui yang State Key Laboratory of Robotics and System Harbin Institute of Technology Horbin 150001 China

This study presents and verifies a new idea for constructing a rotary traveling wave ultrasonic motor （USM） that uses the radial bending mode of a ring. In the new design, 20 trapezoid cross section slots are cut symmetrically in the outer surface of a thick duralumin alloy ring, where 20 PZT stacks are nested. In each slot, two wedging blocks are set between the PZT stack and the two sides of the slot respectively to apply preloading on the PZT ceramics. Two radial bending modes of the stator that have a phase difference of a quarter wavelength on space are generated by using the d33 operating mode of the PZT elements, and then a flexural traveling wave is formed by the superimposing of two standing waves whose amplitudes are equal and phases are different by 90~ temporally. Two conical rotors are pressed to each end of the ring type stator by a coiled spring. The finite element method （FEM） simulation is developed to validate the feasibility of the proposed motor. The maximal speed and torque of the prototype are tested to be 126 r/rain and 0.8 N＇m, respectively.

关键词： Rotary ultrasonic motor Radial bending mode Traveling wave Wedging block clamped structure

Directional Filter for SAR Images Based on Nonsubsampled Contourlet Transform and Immune Clonal Selection

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International Journal of Automation and computing 2009年第3期6卷 245-253页

作者： xiao-hui yang Li-Cheng Jiao Deng-Feng Li Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Institute of Intelligent Information Processing Xidian University Xi＇an 710071 PRC Institute of Applied Mathematics School of Mathematics and Information Sciences Henan University Kaifeng 475004 PRC

A directional filter algorithm for intensity synthetic aperture radar （SAR） image based on nonsubsampled contourlet transform （NSCT） and immune clonal selection （ICS） is presented. The proposed filter mainly focuses on exploiting different features of edges and noises by NSCT. Furthermore, ICS strategy is introduced to optimize threshold parameter and amplify parameter adaptively. Numerical experiments on real SAR images show that there are improvements in both visual effects and objective indexes.

关键词： Directional filter nonsubsampled contourlet transform (NSCT) immune clonal selection optimization (ICSO) syntheticaperture radar (SAR).

Peplau's interpersonal relationship theory combined with bladder function training on patients with prostate cancer

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World Journal of Clinical Cases 2022年第9期10卷 2792-2800页

作者： xiao-hui yang Li-Fen Wu xiao-Yu Yan Ying Zhou Xue Liu Department of Critical Care Medicine Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Urology Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Urology Surgery Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Prostate cancer is a major disease impacting men’s health ***,who is known as“the mother of psychiatric society,”developed an interpersonal relationship theory for *** of this theory in practice has been shown to positively impact patients’quality of life and reduce adverse symptoms after *** To investigate the effects of a nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training on patients with prostate *** Eighty-nine patients with prostate cancer who underwent transurethral resection of the prostate(TURP)participated in this *** patients were admitted to The First Affiliated Hospital of Soochow University or Dushu Lake Hospital Affiliated to Soochow University between January 2020 and April *** were randomized into either the Peplau nursing group(n=44)or a routine nursing group(n=45).The routine nursing group received routine care and bladder function training,while the Peplau care group received care that integrated concepts from the Peplau interpersonal relationship theory as well as bladder function *** urinary incontinence symptoms of the two groups were recorded,and the respective International Prostate Symptom Scores(IPSS),Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being(FACIT-Sp)scores,and quality of life(QOL)scores for each group were compared before and after three months of nursing *** During the intervention period,the duration of urinary incontinence,frequency,number and amount of urinary incontinence were significantly greater in the routine nursing group compared to the Peplau care group(P<0.05).The indicators of the routine nursing group were 7.13±2.42 days,8.23±2.75 times,and 1.24±0.42 L,while those of the Peplau care group were 4.74±1.85 d,4.21±1.26 times,and 0.56±0.11 L,*** three months of intervention,the mean IPSS score of the routine nursing group was si

关键词： Peplau interpersonal relationship theory Bladder function training Prostate cancer Quality of life Nursing